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Samir Jawhara

Ingénieur de recherche

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Article dans une revue scientifique

Publications

♦ Jawhara S. Healthy Diet and Lifestyle Improve the Gut Microbiota and Help Combat Fungal Infection. Microorganisms. 2023 Jun 11;11(6):1556.  doi: 10.3390/microorganisms11061556. https://pubmed.ncbi.nlm.nih.gov/37375058/

♦ Camaioni L, Lambert  D, Sendid B, Billamboz  B, Jawhara S. Antifungal Properties of Hydrazine-Based Compounds against Candida albicans. Antibiotics (Basel). 2023 Jun 12;12(6):1043.  doi: 10.3390/antibiotics12061043. https://pubmed.ncbi.nlm.nih.gov/37370362/

♦ Jawhara, S. Editorial of Special Issue "Human Pathogenic Fungi: Host-Pathogen Interactions and Virulence". Microorganisms. 2023 Apr 7;11(4):963.  doi: 10.3390/microorganisms11040963. https://pubmed.ncbi.nlm.nih.gov/37110386/

♦ Charlet R, Le Danvic C, Sendid B, Nagnan-Le Meillour P, Jawhara S. Oleic Acid and Palmitic Acid from Bacteroides thetaiotaomi-cron and Lactobacillus johnsonii Exhibit Anti-Inflammatory and Antifungal Properties. Microorganisms 2022. https://pubmed.ncbi.nlm.nih.gov/36144406/ 

♦ Jawhara S, How Gut Bacterial Dysbiosis Can Promote Candida albicans Overgrowth during Colonic Inflammation. Microorganisms 2022, 10(5), 1014; https://doi.org/10.3390/microorganisms10051014. https://pubmed.ncbi.nlm.nih.gov/35630457/ 

♦ Mena L, Billamboz M, Charlet R, Desprès B, Sendid B, Ghinet A, Jawhara S, Two New Compounds Containing Pyridinone or Triazine Heterocycles Have Antifungal Properties against Candida albicans. Antibiotics. 2022 Jan 8;11(1):72.  doi: 10.3390/antibiotics11010072. https://pubmed.ncbi.nlm.nih.gov/35052949/ 

♦ Mery A, Jawhara S, François N, Cornu M, Poissy J, Martinez-Esparza M, Poulain D, Sendid B, Guerardel Y,Identification of fungal trehalose for the diagnosis of invasive candidiasis by mass spectrometry. Chim Biophys Acta Gen Sub. 2022 Apr;1866(4):130083. https://pubmed.ncbi.nlm.nih.gov/35033574/ 

♦ Billamboz M, Fatima Z, Hameed S, Jawhara S. Promising Drug Candidates and New Strategies for Fighting Against the Emerging Superbug Candida auris. Microorganisms. 2021 Mar 18;9(3):634. doi: 10.3390/microorganisms9030634. https://pubmed.ncbi.nlm.nih.gov/33803604/ 

♦ Jawhara S. How to boost the immune defence prior to respiratory virus infections with the special focus on coronavirus infections. Gut Pathog. 2020 Oct 12;12:47. doi: 10.1186/s13099-020-00385-2. https://pubmed.ncbi.nlm.nih.gov/33062058/ 

♦ Jawhara S. Can Drinking Microfiltered Raw Immune Milk From Cows Immunized Against SARS-CoV-2 Provide Short-Term Protection Against COVID-19? Front Immunol. 2020 Jul 28;11:1888. doi: 10.3389/fimmu.2020.01888. https://pubmed.ncbi.nlm.nih.gov/32849647/ 

♦ Jawhara S. Could Intravenous Immunoglobulin Collected From Recovered Coronavirus Patients Protect Against COVID-19 and Strengthen the Immune System of New Patients? Int J Mol Sci. 2020 Mar 25;21(7):2272.  doi: 10.3390/ijms21072272. https://pubmed.ncbi.nlm.nih.gov/32218340/ 

♦ Sendid B, Salvetat N, Sarter H, Loridant S, Cunisse C, François N, Aijjou R, Gelé P, Leroy J, Deplanque D, Jawhara S, Weissmann D, Desreumaux P, Gower-Rousseau C, Colombel JF, Poulain D. A Pilot Clinical Study on Post-Operative Recurrence Provides Biological Clues for a Role of Candida Yeasts and Fluconazole in Crohn's Disease. Fungi (Basel). 2021 Apr 22;7(5):324. doi: 10.3390/jof7050324. https://pubmed.ncbi.nlm.nih.gov/33922391/ 

♦ Sendid B, Lecointe K, Collot M, Danzé PM, Damiens S, Drucbert AS, Fradin C, Vilcot JP, Grenouillet F, Dubar F, de Ruyck J, Jawhara S, Mallet JM, Poulain D. Dissection of the anti-Candida albicans mannan immune response using synthetic oligomannosides reveals unique properties of β-1,2 mannotriose protective epitopes. Sci Rep. 2021 May 24;11(1):10825. doi: 10.1038/s41598-021-90402-4. https://pubmed.ncbi.nlm.nih.gov/34031516/ 

♦ Jawhara S. How Fungal Glycans Modulate Platelet Activation via Toll-Like Receptors Contributing to the Escape of Candida albicans from the Immune Response. Antibiotics (Basel). 2020 Jul 7;9(7):385. doi: 10.3390/antibiotics9070385. https://pubmed.ncbi.nlm.nih.gov/32645848/

♦Charlet R, Bortolus C, Sendid B, Jawhara S. Bacteroides thetaiotaomicron and Lactobacillus johnsonii Modulate the Intestinal Inflammation and Eliminate Fungi Through Their Enzymatic Hydrolysis of Fungal Cell Wall. Sci Rep. 2020 Jul 13;10(1):11510. doi: 10.1038/s41598-020-68214-9. https://pubmed.ncbi.nlm.nih.gov/32661259/

♦ Dumortier C, Charlet R, Bettaieb A, Jawhara S. H89 Treatment Reduces Intestinal Inflammation and Candida albicans Overgrowth in Mice. Microorganisms. 2020 Dec 19;8(12):2039. doi: 10.3390/microorganisms8122039. https://pubmed.ncbi.nlm.nih.gov/33352792/ 

♦Dufrénoy P, Charlet R, Hechelski M, Daïch A, Waterlot C, Jawhara S, Ghinet A. New efficient eco-friendly supported catalysts for the synthesis of amides with antioxidant and anti-inflammatory properties. ChemMedChem.2020 Mar 5;15(5):459-467.  doi: 10.1002/cmdc.201900641.  Epub 2020 Feb 12. https://pubmed.ncbi.nlm.nih.gov/32022481/ 

♦ Leroy J, Bortolus C, Lecointe C, Parny M, Charlet R, Sendid B, Jawhara S. Fungal chitin reduces platelet activation mediated via TLR8 stimulation. Front Cell Infect Microbiol. 2019 Nov 12;9:383. doi: 10.3389/fcimb.2019.00383. eCollection 2019. https://pubmed.ncbi.nlm.nih.gov/31781518/ 

♦ Homerin G, Jawhara S, Baudelet D, Dufrénoy P, Rigo B, Millet R, DEZITTER X, Furman C, Ragé G, Lipka E, Farce A, Renault N, Sendid B, Charlet R, Leroy J, Phanithavong M, Richeval C, Wiart J-F, Allorge D, Adriouch S, Vouret-Craviari V, Ghinet A. Pyroglutamide-Based P2RX7 Receptor Antagonists Targeting Inflammatory Bowel Disease. J Med Chem. 2019 Sep 27. doi: 10.1021/acs.jmedchem.9b00584. https://pubmed.ncbi.nlm.nih.gov/31525963/ 

♦ Charlet R, Sendid B, Kaveri SV, Poulain D, Bayry J, Jawhara S. Intravenous Immunoglobulin Therapy Eliminates Candida albicans and Maintains Intestinal Homeostasis in a Murine Model of Dextran Sulfate Sodium-Induced Colitis. Int J Mol Sci. 2019 Mar 23;20(6). pii: E1473. doi: 10.3390/ijms20061473.

♦ Bortolus C, Billamboz M, Charlet R, Lecointe K, Sendid B, Ghinet A15,16,17, Jawhara S. A Small Aromatic Compound Has Antifungal Properties and Potential Anti-Inflammatory Effects against Intestinal Inflammation. Int J Mol Sci. 2019 Jan 14;20(2). pii: E321. doi: 10.3390/ijms20020321.

♦ Charlet R, Bortolus C, Barbet M, Sendid B, Jawhara S. A decrease in anaerobic bacteria promotes Candida glabrata overgrowth while β-glucan treatment restores the gut microbiota and attenuates colitis. Gut Pathog. 2018 Dec 3;10:50. doi: 10.1186/s13099-018-0277-2. eCollection 2018.

♦Sendid B*, Jawhara S*, Sarter H, Maboudou P, Thierny C, Gower-Rousseau C, Colombel JF, Poulain D. Uric acid levels are independent of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease: A reappraisal of the role of S. cerevisiae in this setting. Virulence. 2018;9(1):1224-1229. doi: 10.1080/21505594.2018.1496779. * Equally contributed

♦ Charlet R, Pruvost Y, Tumba G, Istel F, Poulain D, Kuchler K, Sendid B, Jawhara S. Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response. Sci Rep. 2018 Feb 20;8(1):3316. doi: 10.1038/s41598-018-21422-w.

♦ Choteau L, Vancraeyneste H, Dubuquoy L, Romani L, Le Roy D, Jouault D, Poulain D, Sendid B, Calandra T, Roger T, Jawhara S. TLR6 deficiency confers protection against Candida albicans colonization and intestinal inflammation during experimental colitis. Gut Pathog. 2017 Feb 15;9:9. doi: 10.1186/s13099-017-0158-0

♦ Choteau L, Vasseur F, Lepretre F, Figeac M, Gower-Rousseau C, Dubuquoy L, Poulain D, Colombel JF, Sendid B, Jawhara S. Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn's Disease Patients. Sci Rep. 2016 Jul 12;6:29636. doi: 10.1038/srep29636.

♦ Vancraeyneste H, Charlet R, Guerardel Y, Choteau L, Bauters A, Tardivel M, François N, Dubuquoy L, Soloviev D, Poulain D, Sendid B, Jawhara S. Short fungal fractions of β-1,3 glucans affect platelet activation, Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H725-34. doi: 10.1152/ajpheart.00907.2015.

♦ Jawhara S, Pluskota E, Cao W, Plow F.E, Soloviev A. D. Distinct Roles of Integrins αXβ2 and αMβ2 on Leukocyte Subpopulations During Inflammation and Antimicrobial Responses. Infect Immun. 2016 Dec 29;85(1). pii: e00644-16.

♦ Choteau L, Melissa P, Dubuquoy L, Takahashi K, Colombel J-F, Jouault T, Poulain D, Sendid B, Jawhara S.Role of Mannose Binding Lectin in intestinal homeostasis and pathogen elimination. Mucosal Immunol. 2015 Oct 7. doi: 10.1038/mi.2015.100.

♦ Sendid B, Poissy J, François N, Mery A, Courtecuisse S, Krzewinski F, Jawhara S, Guerardel Y*, Poulain D*. Preliminary evidence for a serum disaccharide signature of invasive Candida albicans infection detected by MALDI Mass Spectrometry. Clin Microbiol Infect. 2015 Jan;21(1):88.e1-6. doi: 10.1016/j.cmi.2014.08.010. Epub 2014 Oct 12.

♦ Hoarau G, Bougnoux ME, Fily A, François N, Loridant S, Jawhara S, d'Enfert C, Poulain D, Sendid B. Genetic diversity among Candida albicans isolates associated with vertical transmission in preterm triplets. Mycopathologia. 2014 Oct;178(3-4):285-90. doi: 10.1007/s11046-014-9803-z. Epub 2014 Aug 24.

♦ Mear JB, Gosset P, Kipnis E, Faure E, Dessein R, Jawhara S, Fradin C, Faure K, Poulain D, Sendid B, Guery B. Candida albicans airway exposure primes the lung innate immune response against pseudomonas aeruginosa infection through innate lymphoid cell recruitment and interleukin-22-associated mucosal response. Infect Immun. 2014 Jan;82(1):306-15. doi: 10.1128/IAI.01085-13. Epub 2013 Oct 28.

♦ Jawhara S, Habib K, Maggiotto F, Pignede G, Vandekerckove P, Maes E, Dubuquoy L, Fontaine T, Guerardel Y, Poulain D. Modulation of intestinal inflammation by yeasts and cell wall extracts: strain dependence and unexpected anti-inflammatory role of glucan fractions. PLoS One. 2012;7(7):e40648. Epub 2012 Jul 27.

♦ Jawhara S, Pluskota E, Verbovetskiy D, Skomorovska-Prokvolit O, Plow EF, Soloviev DA. Integrin αXβ₂ is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections. J Immunol. 2012 Sep 1;189(5):2468-77. doi: 10.4049/jimmunol.1200524. Epub 2012 Jul 27.

♦ Damiens S, Poissy J, François N, Salleron J, Jawhara S, Jouault T, Poulain D, Sendid B. Mannose-Binding Lectin Levels and Variation During Invasive Candidiasis. J Clin Immunol. 2012 Dec;32(6):1317-23. doi: 10.1007/s10875-012-9748-2. Epub 2012 Jul 26.

♦ Jawhara S, Mogensen E, Maggiotto F, Fradin C, Sarazin A, Dubuquoy L, Maes E, Guérardel Y, Janbon G, Poulain D. Murine model of dextran sulfate sodium-induced colitis reveals Candida glabrata virulence and contribution of β-mannosyltransferases. J Biol Chem. 2012 Mar 30;287(14):11313-24. Epub 2012 Jan 30.

♦ Ader F★, Jawhara S★, Nseir S, Kipnis E, Faure K, Vuotto F, Chemani C, Sendid B, Poulain D, Guery B. Short term Candida albicans colonization reduces Pseudomonas aeruginosa-related lung injury and bacterial burden in a murine model. Crit Care. 2011 Jun 20;15(3):R150.★ Equally contributed.

♦ Soloviev DA, Jawhara S, Fonzi WA. Regulation of innate immune response to Candida albicans infections by αMβ2-Pra1p interaction. Infect Immun. 2011 Apr;79(4):1546-58. Epub 2011 Jan 18 (Featured in the cover journal).

♦ Poulain D, Sendid B, Standaert-Vitse A, Fradin C, Jouault T, Jawhara S, Colombel JF. Yeasts: neglected pathogens. Dig Dis. 2009;27 Suppl 1:104-10. Epub 2010 Mar 4.

♦ Jawhara S, Thuru X., Standaert-Vitse A, Joulault T, Mordon S, Sendid B, Desreumaux P, Poulain D. Colonization of mice by Candida albicans is promoted by chemically-induced colitis and augments inflammatory responses through galectin-3, J Infect Dis. 2008 Apr 1;197(7):972-80.

♦ Jawhara S, Poulain D. Saccharomyces boulardii decreases inflammation and intestinal colonization by Candida albicans in a mouse model of chemically-induced colitis Med Mycol. 2007 Sep 18:1-10.

♦ Jawhara S, Mordon S. Monitoring of bactericidal action of laser by in vivo imaging of bioluminescent E. coli in a cutaneous wound infection, ASLMS. Lasers Med Sci. 2006 Sep;21(3):153-9.

♦ Jawhara S, Mordon S. In vivo imaging of bioluminescent Escherichia coli in a cutaneous wound infection model for evaluation of an antibiotic therapy, Antimicrob Agents Chemother. 2004 Sep; 48(9):3436-41.

Journal Highlights (la presse vulgarisée scientifique ou blogs)

· Jawhara S, Contre le Covid-19, un chercheur lillois propose la piste de la sérothérapie.  La voix du Nord. Mars 2020. https://www.lavoixdunord.fr/732689/article/2020-03-28/contre-le-covid-19-un-chercheur-lillois-propose-la-piste-de-la-serotherapie

· Jawhara S, Covid-19: un chercheur lillois propose de vacciner… les vaches. La voix du Nord. Juillet 2020. https://www.lavoixdunord.fr/843896/article/2020-07-26/covid-19-un-chercheur-lillois-propose-de-vacciner-les-vaches

· Jawhara S, IgG antibodies, Encyclopedia. March 2020. https://encyclopedia.pub/849

· Jawhara S, Boosting immunity against coronavirus? Dr Michael Dixon’s infinite wisdom on the pandemic. Blogs April 2020. https://edzardernst.com/2020/04/boosting-immunity-against-coronavirus-dr-michael-dixons-infinite-wisdom-on-the-pandemic/

· Jawhara S, Fungal chitin treatment reestablishes the anaerobic bacteria and decreases the intestinal inflammation in mice. Atlas of Science. February 2019. https://atlasofscience.org/fungal-chitin-treatment-reestablishes-the-anaerobic-bacteria-and-decreases-the-intestinal-inflammation-in-mice/

· Jawhara S, Fungal-derived oligoglucosides protect Candida albicans from the immune system attack. Atlas of Science. November 2016. https://atlasofscience.org/fungal-derived-oligoglucosides-protect-candida-albicans-from-the-immune-system-attack/

· Jawhara S., Mordon S., American Society for Microbiology. Source: Microbe Magazine. Published: October 2004.