Jerome Kluza
Publications
Thèse précédente encadrée
Dr Paola Corazao
pepite-depot.univ-lille2.fr/nuxeo/site/esupversions/72f9477b-1f3c-42cc-aebb-52e73db0714b
Articles
(56) International Journal of Molecular Sciences.
A new strategy to preserve and assess oxygen consumption in murine tissues. Kluza, J., Peugnet, V., Laine, W., Blanche, D., Kervoaze, G., Rémy, G., Loyens, A., Maboudou, P., Fovez, Q., Grangette, C., Wolowczuk, I., Gosset, P., Garçon, G., Marchetti, P., Pinet, F., Pichavant, M. and Dubois-Deruy, E.
(55) Cancers 2021, 13, 635.
Clinically relevant oxygraphic assay to assess mitochondrial energy metabolism in acute myeloid leukemia patients. Fovez, Q., Laine, W., Goursaud, L., Berthon, C., Germain, N., Degand, C., Sarry, J.E., Quesnel, B., Marchetti, P. and Kluza, J.
(54) Molecular Metabolism 2021, 101410.
Antimetabolic cooperativity with the clinically approved kidrolase and tyrosine kinase inhibitors to eradicate cml stem cells. Trinh, A., Khamari, R., Fovez, Q., Mahon, F.X., Turcq, B., Bouscary, D., Maboudou, P., Joncquel, M., Coiteux, V., Germain, N., Laine, W., Dekiouk, S., Ghesquiere, B., Idziorek, T., Quesne, Q., Kluza, J.*, Marchetti, P*. (* coseniorship author).
(53) Journal of Cellular Biochemistry.
p65/RelA NF-κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics. Touil, Y., Latreche-Carton, C. , EL Bouazzati H., Nugues, A.L., Jouy, N., Thuru, X., Laine, W., Lepretre,F., Figeac, M., Tardivel, M., Kluza, J.; Idziorek, T. and Quesnel, B.
(52) Cell Chemical Biology. November 30, 2021.
Metabolic Targeting of Cancer by a Ubiquinone Uncompetitive Inhibitor of Mitochondrial Complex I. Jain, S., Hu, C., Kluza, J., Ke, W., Tian, G., Giurgiu, M., Bleilevens, A., Rosa Campos, A., Charbono, A., Stickeler, E., Maurer, J., Holinski-Feder, E., Vaisburg, A., Bureik, M., Luo, G., Marchetti, P., Cheng, Y. and Wolf D.A.
(51) Journal of Hazardous Materials, 2022, 423:127246.
Comparison of the in vivo genotoxicity of electronic and conventional cigarettes aerosols after subacute, subchronic and chronic exposures. Platel, A., Dusautoir, R., Kervoaze, G., Dourdin, G., Gateau, E., Talahari, S., Huot, L., Simar, S., Ollivier, A., Laine, W., Kluza, J., Gosset, P., Garçon, G., Antherieu, S., Lo Guidice, J.M. and Nesslany, F.
(50) Nature Cancer 2021 2, 1204–1223 (2021).
Mitochondrial determinants of response and resistance to venetoclax plus cytarabine duplet therapy in acute myeloid leukemia. Bosc, C., Saland, E., Bousard, A., Gadaud, N., Sabatier, N., Cognet, G., Farge, T., Boet, E., Gotanègre, M., Aroua, N., Mouchel, P.L., Larrue, C., Kaphan, E., Sahal, A., Jarrou, L., Tolosini, M., Rambow, F., Polley, N., Cabon, F., Nicot, N., Poillet-Perez, L., Su, X., Fovez, Q., Kluza, J., Argüello, R.F., Mazzotti, C., Avet-Loiseau, H., Vergez, F., Tamburini, J., Fournié, J.J., Wei, Kaoma, T., Marine, J-C., Récher, C., Stuani, L., Joffre, C. and Sarry, J-E.
(49) Environ Int. 2020, 142:105830
Mitochondrial alterations triggered by repeated exposure to fine (PM2.5-0.18) and quasi-ultrafine (PM0.18) fractions of ambient particulate matter. Sotty, J., Kluza, J., De Sousa, C., Tardivel, M., Anthérieu, S., Alleman, L.Y., Canivet, L., Perdrix, E., Loyens, A., Marchetti, P., Lo Guidice, J.M. and Garçon, G.
(48) Int. J. Med. Sci. 2019, Vol. 16.
First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: a preliminary study. Germain, N., Dessein, AF., Vienne,JC., Dobbelaere, D., Mention,K., Joncquel,M., Dekiouk, S., Laine, W., Kluza, J.*, and Marchetti, P.*. (* coseniorship author)
(47) iScience. 2018, 12: 9:1-13.
AMPK is essential for the maintenance of energy levels during synaptic activation. Marinangeli, C., Didier, S., Ahmed, T, Caillerez, R., Verdegem, D., Domise, M., Sauvé, F., Laloux, C., Ghesquière, B., Buée, L., Balschun, D., Kluza, J., Vaingtdeux, V.
(46) Environ Pollut. 2018, 243:1434-1449.
Mitochondrion : a sensitive target for the toxicity of healthy and chronic obstructive pulmonary diseased human bonchial epithelial cells repedtedly exposed to air pollution-derived PM2.5. Leclercq, B., Kluza, J., Antherieu, S., Sotty, J., Alleman, LY., Coddeville, P. Lo Guidice, JM., Marchetti, P., Garçon, G.
(45) Cell Death Dis. 2018, 9:325.
Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors. Khamari, R., Trinh, A., Gabert, PE., Corazao-Rozas, P., Riveros-Cruz, S., Balayssac, S., Malet-Martino, M., Dekiouk, S., Joncquel Chevalier Curt, M., Maboudou, P., Garçon, G., Ravasi, L., Guerreschi, P., Mortier, L., Quesnel, B., Marchetti, P., Kluza, J.
(44) Int J Biochem Cell Biol. 2017, 85:166-174.
Metabolic rewiring in cancer cells overexpressing the glucocorticoid-induced leucine zipper protein (GILZ): Activation of mitochondrial oxidative phosphorylation and sensitization to oxidative cell death induced by mitochondrial targeted drugs. André, F., Trinh, A., Balayssac, S., Maboudou, P., Dekiouk, S., Malet-Martino, M., Quesnel, B., Idziorek, T., Kluza, J., Marchetti, P.
(43) PLoS One. 2016, 11:e0163694.
Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner. Errea, A., Cayet, D., Marchetti, P., Tang, C., Kluza, J., Offermanns, S., Sirard, JC., Rumbo, M.
(42) Oncotarget. 2016, 7:39473-39485.
Mitochondrial oxidative phosphorylation controls cancer cell's life and death decisions upon exposure to MAPK inhibitors.Corazao-Rozas, P., Guerreschi, P., André, F., Gabert, PE., Lancel, S., Dekiouk, S., Fontaine, D., Tardivel, M., Savina, A., Quesnel, B., Mortier, L., Marchetti, P., Kluza, J.
(41) Melanoma Res. 2016, 26:245-53.
Patient-derived tumor xenograft strategies for informed management of patients with metastatic melanoma.Qassemyar, A., Gabert, PE., Kluza, J., Duquennoy-Martinot, V., Mortier, L., Marchetti, P., Guerreschi, P.
(40) Respir Res. 2016, 17:94.
Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response. Le Rouzic O., Koné B., Kluza, J., Marchetti, P., Hennegrave, F., Olivier, C., Kervoaze, G., Vilain, E., Mordacq, C., Just, N., Perez, T., Bautin, N., Pichavant, M., Gosset P.
(39) Biochem Biophys Res Commun. 2016, 478:513-20.
GILZ overexpression attenuates endoplasmic reticulum stress-medied cell death via the activation of mitochondrial oxidative phosphorylation. André, F., Corazao-Rozas, P., Idziorek, T., Quesnel, B., Kluza, J., Marchetti, P.
(38) Cell Discov. 2015, 1:15030.
CD271 promotes melanoma cell survival and drives acquired resistance to B-RAF inhibitor, vemurafenib, by activating NF-KB pathway.a, M., Kluza, J., Marchetti, P., Imbert, V., Cheli, Y., Bertolotto, C., Ballotti, R., and Rocchi, S.
(37) Nat Commun. 2015, 6:7629.
Farnesoid X Receptor Inhibits Glucagon-Like Peptide-1 Production by Enteroendocrine L-cells.Trabelsi, MS., Daoudi, M. , Prawitt, J., Ducastel, S., Touche, V., Sayin, SI., Perino, A., Brighton, RC., Sebti, Y., Kluza, J., Briand, O., Dehondt, H., Vallez, E., Dorchies, E., Baud, G., Spinelli, V., Hennuyer, N., Caron, S., Bantubungi, K., Caiazzo, R., Reimann, F., Marchetti, P., Lefebvre, P. , Backhed, F., Gribble, FM., Schoonjans, K., Pattou, F., Tailleux, A., Staels, B. and Lestavel, S.
(36) Mar Drugs. 2014, 12:779-98.
Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production. Ballot, C., Martoriati, A., Jendoubi, M., Buche, S., Formstecher, P., Mortier, L., Kluza, J., Marchetti, P.
(35) Antioxid Redox Signal. 2014, 21:195-210.
Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease. ,Devos, D., Moreau, C., Devedjian, JC., Kluza, J., Petrault, M., Laloux, C., Jonneaux, A., Ryckewaert, G., Garçon, G., Rouaix, N., Duhamel, A., Jissendi, P., Dujardin, K., Auger, F., Ravasi, L., Hopes, L., Grolez, G., Firdaus, W., Sablonnière, B., Strubi-Vuillaume, I., Zahr, N., Destée, A., Corvol, JC., Pöltl, D., Leist, M., Rose, C., Defebvre, L., Marchetti, P., Cabantchik, ZI., Bordet, R.
(34) Oncotarget. 2013 ; 4(11):1986-98.
Mitochondrial oxidative stress is the Achille's heel of melanoma cells resistant to Braf-mutant inhibit. Corazao-Rozas, P., Guerreschi, P., Jendoubi, M., André, F., Jonneaux, A., Scalbert, C., Garçon, G., Malet-Martino, M., Balayssac, S., Rocchi, S., Savina, A., Formstecher, P., Mortier, L., Kluza, J., Marchetti, P.
(33) Melanoma Res. 2013 Oct;23(5):373-80.
Patient-derived tumor xenograft model to guide the use of BRAF inhibitors in metastatic melanoma. Guerreschi, P., Scalbert, C., Qassemyar, A., Kluza, J., Ravasi, L., Huglo, D., Martinot-Duquennoy, V., Formstecher, P., Marchetti, P., Mortier, L.
(32) Cancer Res. 2012 ; 72(19):5035-47.
Inactivation of the HIF-1a-Mediated PDK3 pathway shifts metastatic melanoma cells toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants. Kluza, J., Corazao-Rozas, P., Jendoubi, M., Maire, C., Guerreschi, P., Jonneaux, A., Ballot, C., Balayssac, S., Valable, S., Touil, Y., Corroyer-Dulmont, A., Bernaudin, M., Mallet-Martino, M., Martin de Lassalle, E., Maboudou, P., Formstecher, P., Polakowska, R., Mortier, L. and Marchetti, P.
(31) PLoS One. 2012 ; 7(1):e29798.
Mitochondrial electron transport is the cellular target of the oncology drug elesclomol. Blackman, RK., Cheung-Ong, K., Gebbia, M., Proia, DA., He, S., Kepros, J., Jonneaux, A., Marchetti, P., Kluza, J., Rao, PE., Wada, Y., Giaever, G., Nislow, C.
(30) Apoptosis. 2012 ; 17(4):364-76.
Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II. Ballot, C., Jendoubi, M., Kluza, J., Jonneaux, A., Laine, W., Formstecher, P., Bailly, C., Marchetti, P.
(29) PLoS One. 2011 ; 6(7):e21924.
Exploiting mitochondrial dysfunction for effective elimination of Imatinib-resistant leukemic cells. Kluza, J., Jendoubi, M., Jonneaux, A., Idziorek, T., Joha, S., Mallet-Martino, M., Balayssac, S., Ballot, B., Maboudou, P., Briand, G., Formstecher, P., Quesnel, B. and Marchetti, P.
(28) Neuroscience. 2011 ; 172: 110-7.
Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patients. Moreau, C., Gosset, P., Kluza, J., Brunaud-Danel, V., Lassalle, P., Marchetti, P., Defebvre, L., Destée, A., Devos D.
(27) Biochemistry. 2011 ; 50(15):3127-36.
Hx, a novel fluorescent, minor groove and sequence specific recognition element: design, synthesis, and DNA binding properties of p-anisylbenzimidazole- imidazole/pyrrole-containing polyamides. Chavda, S., Liu, Y., Babu, B., Davis, R., Sielaff, A., Ruprich, J., Westrate, L., Tronrud, C., Ferguson, A., Franks, A., Tzou, S., Adkins, C., Rice, T., Mackay, H., Kluza, J., Tahir, SA., Lin, S., Kiakos, K., Bruce, CD., Wilson, WD., Hartley JA., Lee, M.
(26) Bioorg Med Chem. 2010 ; 18(15):5553-61.
Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamid Franks, A., Tronrud, C., Kiakos, K., Kluza, J., Munde, M., Brown, T., Mackay, H., Wilson, WD., Hochhauser, D., Hartley, JA., Lee M.
(25) Bioorg Med Chem. 2010 ; 18(14): 5016-24.
A novel achiral seco- cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation. Chavda, S., Babu, B., Yanow, SK., Jardim, A., Spithill, TW., Kiakos, K., Kluza, J., Hartley, JA., Lee M.
(24) Apoptosis. 2010 ; 15(7): 769-81.
Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D. Ballot, C., Kluza, J., Lancel, S., Martoriati, A., Hassoun, SM., Mortier, L., Vienne, JC., Briand, G., Formstecher, P., Bailly, C., Nevière, R., Marchetti, P.
(23) Mol Cancer Ther. 2009 ; 8(12): 3307-17.
Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D. Ballot, C., Kluza, J., Martoriati, A., Nyman, U., Formstecher, P., Joseph, B., Bailly, C., Marchetti, P.
(22) Med Chem. 2009 ; 5(3):216-26.
Polyamide curvature and DNA sequence selective recognition: use of 4-aminobenzamide to adjust curvature. , Lajiness, J., Sielaff, A., Mackay, H., Brown, T., Kluza, J., Nguyen, B., Wilson, W.D., Lee, M., Hartley, JA.
(21) Biochemistry. 2009 ; 48(24):5679.
Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity. Westrate, L., Mackay, H., Brown, T., Nguyen, B., Kluza, J., Wilson, W.D., Lee, M., Hartley JA.
(20) Bioorg Med Chem. 2008 ; 16:9145-53.
Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studi. Mackay, H., Brown, T., Uthe, PB., Westrate, L., Sielaff, A., Jones, J., Lajiness, JP., Kluza, J., O'Hare, C., Nguyen, B., Davis, Z., Bruce, C., Wilson, WD., Hartley, JA., Lee, M.
(19) Mol Cancer Ther. 2008 ; 7:1319-28.
Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78. Kotecha, M., Kluza, J., Wells, G., O'Hare, CC., Forni, C., Mantovani, R., Howard, PW., Morris, P., Thurston, DE., Hartley, JA., Hochhauser, D.
(18) Biorg Med Chem. 2008 ; 16:5266-76.
Modifying the N-Terminus of Polyamides: Interesting DNA Minor-Groove Binding Properties of PyImPyIm. Brown, T., Mackay, H., Turlington, M., Sutterfield, A., Smith,T., Sielaff, A., Westrate, L., Bruce, C., Kluza, J., O’Hare, C., Hartley, J.A., Nguyen, B., Wilson, D., and Lee, M.
(17) Bioorg Med Chem. 2008 ; 16:2093-102.
Targeting the Inverted CCAAT Box-2 of the Topoismomerase IIα Gene: DNA Sequence Selective Recognition by Polyamide Recognition by a Polyamide-Intercaltor as a staggered. Mackay, H., Brown, T., Sexton, J.S., Kotecha, M., Binh, N., Wilson, W.D., Kluza,. J., Savic, B., O’Hare, C., Hochhauser,D., Lee, M., and Hartley J.A.
(16) Oncogene. 2008 ; 27:1981-92.
Overcoming Chemoresistance of Non Small Cell Lung Carcinoma Through Restoration Of An AIF Dependent Apoptotic Pathway. Gallego, M.A., Ballot, C., Kluza, J., Hadjji, N., Martoriati, A., Castéra, L., Obriot, H., Cuevas, C., Formstecher, P., Joseph B., Kroemer, G., Bailly, C., and Marchetti, P.
(15) Bioorg Med Chem. 2007 ; 15:474-83.
Synthesis and biophysical evaluation of minor- groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin. Brown, T., Taherbhai, Z., Sexton, J., Sutterfield, A., Turlington, M., Jones, J., Stallings, L., Stewart, M., Buchmueller, K., Mackay, H., O'hare, C., Kluza, J., Nguyen, B, Wilson, D., Lee, M., Hartley, J.A.
(14) Chembiochem. 2006 ; 7:1722-29.
Synthesis and Evaluation of an Intercalator-Polyamide Hairpin Designed to target the Inverted CCAAT Box 2 in the Topoisomerase IIalpha Promoter. Flores, L.V., Staples, A.M., Mackay, H., Howard, C.M., Uthe, P.B., Sexton, J.S. 3rd, Buchmueller, K.L., Wilson, W.D., O'hare, C., Kluza, J., Hochhauser, D., Hartley, J.A., Lee, M.
(13) Cancer Res. 2006 ; 66:3177-87.
Cancer cell mitochondria are direct pro-apoptotic targets for the marine antitumor drug lamellarin D. Kluza, J., Gallego, M.A., Loyens, A., Beauvillain, J.C., Fernandez Sousa-Faro, J.M., Cuevas, C., Marchetti,P., and Bailly, C.
(12) Anticancer Drugs. 2006 ; 17:155-64.
Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukaemia cells with tafluposide or etoposide. Kluza, J., Mazinghien, R., Irwin, H., Hartley, J.A., and Bailly, C.
(11) Cancer letters. 2005 ; 221:165-75.
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein_mediated drug efflux. . Vanhuyse, M., Kluza, J., Tardy, C., Otera, G., Cuevas, C., Bailly, C, and Lansiaux, A.
(10) Eur J Pharmacol. 2005 ; 525:32-40.
Induction of apoptosis by the plant alkaloid sampangine in human HL-60 leukemia cells is mediated by reactive oxygen species. Kluza, J., Mazinghien, R., Degardin, K., Lansiaux, A., Clark, A.M., and Bailly, C.
(9) Circulation. 2005 ; 111:2596-604.
Ventrucular myocyte caspases are directly responsible for endotoxin induced cardiac dysfunction. Lancel, S., Joulin, O., Favory, R., Goossens, J.F., Kluza, J., Chopin, C., Formstecher, P., Marchetti, P., and Neviere, R.
(8) Oncogene. 2004 ; 23:7018-30.
Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells. Kluza, J., Marchetti, P. Gallego, M.A., Lancel, S., Fournier, C., Loyens, A., Beauvillain, J.C., and Bailly, C.
(7) Org Biomol Chem. 2004 ; 2:1476-1483.
Synthesis of diphenylcarbazoles as cytotoxic DNA binding agents. Jacquemard, U., Routier, S., Tatibouet, A., Kluza, J., Laine, W., Bal, C., Bailly, C. and Merour, J.Y.
(6) Ann N. Y. Acad Sci. 2003 ; 1010:331-4.
Apoptosis induced by the alkaloid sampangine in HL-60 leukemia cells: correlation between the effects on the cell cycle progression and changes of mitochondrial potential. Kluza, J., Clark, A.M., and Bailly, C.
(5) Eur J Pharm Sci 2003 ; 20:383-391.
Cytotoxicity and DNA binding properties of the plant alkaloid burasaine. Kluza, J., Baldeyrou, B., Colson, P., Rasoanaivo, P., Mambu, L., Frappier, F., and Bailly, C.
(4) Biochem Pharmacol. 2003 ; 65:25-34.
Plasma stability of two glycosyl indolocarbazole antitumor agents. Goossens, J.F., Kluza ,J., Vezin,H., Kouach,M., Briand,G., Baldeyrou,B., Wattez,N., and Bailly,C.
(3) Biochem Pharmacol. 2002 ; 63:1443-1452.
Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1. Kluza, J., Lansiaux, A., Wattez, N., Hildebrand, M.P., Leonce, S., Pierre, A., Hickman, J.A., and Bailly, C.
(2) Mol Cell Biol Res. Commun. 2000 ; 4:37-42.
Relationship between cell cycle changes and variations of the mitochondrial membrane potential induced by etoposide Facompre, M., Wattez, N., Kluza, J., Lansiaux, A., and Bailly, C.
(1) Cancer Res. 2000 ; 60 : 4077-4084.
Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103. Kluza, J., Lansiaux, A., Wattez, N., Mahieu, C., Osheroff, N., and Bailly, C.
Review
Biology (Basel) 2020, 9(12), 474.
Lipid Metabolism and Resistance to Anticancer Treatment.
Germain, N., Dhayer, M., Boileau, M., Fovez, Q., Kluza, J. and Marchetti, P.
FASEB J. 2020 Aug 17.
Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non-transformed and cancer cells.
Marchetti, P., Fovez, Q., Germain, N., Khamari, R. and Kluza, J.
Biochim Biophys Acta. 2018, 1862:999-1005.
Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors.
Marchetti, P., Trinh, A., Khamari, R., Kluza, J.
Int J Cell Biol. 2015; 2283145.
Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics.
Marchetti, P., Guerreschi, P., Mortier, L., Kluza, J.
Curr Cancer Drug Targets. 2014; 14(4):357-70.
Metabolic features of melanoma: a gold mine of new therapeutic targets?
Marchetti, P., Guerreschi, P., Kluza, J., Mortier, L.
Chapitre de livre
Methods in Molecular Biology. Humana Press 2018, 1732:289-305.
Study of AMPK-Regulated Metabolic Fluxes in Neurons Using the Seahorse XFe Analyzer.
Marinangeli, C., Kluza, J., Marchetti, P., Buée, L., Vingtdeux, V.
Identification and Data Processing Methods in Metabolomics. Future Science Group: London, UK, Chapter 10, 140–153 (2015).
Normalization and scaling effects on 1H NMR spectra in a metabolomics analysis of leukemic cells.
Cruz, T., Lalande, J., Balayssac, S., Kluza, J., Gilard, V., Marchetti, P. and Malet-Martino, M.
Cancer Drug Design and Discovery. Academic Press, 2007, Chapter 8.
Camptothecins for drug design, cancer cell death and gene targeting.
Kluza, J., Arimondo, B.A., David-Cordonnier, M.H. and Bailly C.
Modern Alkaloids: Structure, Isolation, Synthesis and Biology. Wiley-VCH, 2007, 171-187.
Lamellarin alkaloids: structure and pharmacological properties.
Kluza, J., Marchetti, M. and Bailly, C.
Methods in Molecular Biology - Oligonucleotide synthesis. Herdewijn, P. Eds., Humana Press. 2005 ; 288:319-42.
DNAse I Footprinting of Small Molecule Binding Sites on DNA.
Bailly, C., Kluza, J., Martin, C., Ellis, T., and Waring, M.J.
Communications sous forme de posters
56th Congress of the European Societies of Toxicology (EUROTOX 2021)- virtual congress
Long-term respiratory impact of electronic cigarette. Dusautoir, R., Zarcone, G., Platel, A., Kervoaze, G., Laine, W., Kluza, J., Nesslany, F., Gosset, P., Garçon, G., Anthérieu, S., Lo Guidice, J.M. Toxicology Letters,Volume 350, Supplement, 2021, Page S78, ISSN 0378-4274.
ERS Lung Science Conference (2020, 5–8 March), Estoril, Portugal.
Validation of a new strategy to maintain functional mitochondrial metabolism in conserved murine heart and lung tissues. Kluza, J., Peugnet, V., Laine, W., Kervoaze, G., Remy, G., Wolowczuck, I., Gosset, P., Garçon, G., Marchetti, P., Pinet, F., Deruy, E., Pichavant, M. ERJ Open Research 2020 6: 10. DOI: 10.1183/23120541.lsc-2020.10
62nd ASH Annual Meeting (Decembre 2020)
Mitochondrial Spare Reserve Capacity : A New Predictive Metabolic Biomarker for Aggressiveness of Acute Myeloid Leukemia. Fovez, Q., Quesnel, B., Laine, W., Khamari, K., Berthon, C., Goursaud, L., Germain, N., Preudhomme, C., Marchetti, P. and Kluza, J. DOI: 10.1182/blood-2020-139510
62nd ASH Annual Meeting (Decembre 2020)
Antimetabolic Cooperativity with l-Asparaginase and Tyrosine KinaseInhibitor Quizartinib to Eradicate Persistant FLT3-ITD Leukemic Cells. Fovez, Q., Khamari, R., Trinh, A., Laine, W., Quesnel, B., Marchetti, P. and Kluza, J. DOI: 10.1182/blood-2020-139696
3rd Metabolism & Cancer Symposium. Marseille (Avril 2019).
Metabolic regulation of mitochondrial spare capacity: a potential biomarker of AML persistence. Fovez, Q., Khamari, R., Trinh, A., Germain, N., Laine, W., Berthon, C., Quesnel, B., Marchettin P. and Kluza, J.
Lyon, France (2019)
4th CRCL Symposium, Lyon (02-04/10).
Metabolic regulation of mitochondrial spare capacity: a potential biomarker of AML persistence. Fovez, Q., Khamari, R., Trinh, A., Germain, N., Laine, W., Berthon, C., Quesnel, B., Marchetti, P. and Kluza, J.
2ème journée scientifique - Climibio - Université de Lille.
Alteration of mitochondrial dynamic/function as an early lung toxicity mechanism of particulate matter. Sotty, J., Kluza, J., De Sousa, C., Alleman, L-Y., Canivet, L., Perdrix, E., Loyens, A., Marchetti, P., Lo-Guidice, J.-M., Garçon, G.
11ème Forum du Cancéropôle Est.
A new derivative of troglitazone affects energy metabolism of triple negative breast cancer cells: potential interest for anticancer treatment. Muller, C. , Grandemange, S., Kluza, J., Bost, F., Piquard, E., De Fays, E., Boisbrun, M., Flament S., Mazerbourg
AACR Annual Meeting (April 14-18, 2018); Chicago, IL
Role of PD-L1 immunoregulatory protein in breast cancer cells metabolic reprogramming
Berthe, J., Kluza, J., El Bouazzati, H., Briche, I., Thuru, X., Aliegue-Zouitina, S., and Quesnel, Q.
Amsterdam, Pays-Bas (2018)
Meeting of the European Association for Cancer Research. EACR (30/06-03/07)
Mitochondrial metabolism: a key factor of myeloid leukemic cell response upon exposure to tyrosine kinase inhibitors. Trinh, A., Khamari, R., Coiteux, V., Manier, S., Fovez, Q., Joncquel, M., Dekiouk, S., Laine, W., Idziorek, T., Quesnel, B., Kluza, J. and Marchetti, P. PO-264 Jun 1st 2018
Paris (2018)
28th International Congress of the European-Respiratory-Society (ERS) (15-19/09)
Mitochondrion: a critical target for the toxicity of air pollution-derived PM2.5 in healthy and COPD human bronchial epithelial cells. Leclercq, B., Kluza, J., Antherieu, S,. Sotty, J., Alleman, L., Coddeville, P., Lo Guidice, JM., Marchetti, P., Garcon, G. EUROPEAN RESPIRATORY JOURNAL Volume: 52 Supplement: 62 Meeting Abstract: PA1201 Published: SEP 15 2018
Lille (2018).
Congrès Annuel de la Société Française de Toxicologie, (27-28/11).
Mitochondrial alterations triggered by repeated exposure to fine (PM2.5-0.18) and ultrafine (PM0.18) fractions of air pollution-derived particulate matter. Sotty J., Kluza, J., De Sousa, C., Alleman, L.Y., Canivet, L., Perdrix, E., Loyens A., Marchetti, P., Lo-Guidice, J.-M., Garçon, G.
Deauville, France (2018)
11ème journée scientifique du Cancéropôle Nord Ouest (23-25/05)
Poster 1:Mitochondrial metabolism: a key factor of myeloid leukemic cell response upon exposure to tyrosine kinase inhibitors. Trinh, A., Khamari, R., Coiteux, V., Manier, S., Fovez, Q., Joncquel, M., Dekiouk, S., Laine, W., Idziorek, T., Quesnel, B., Kluza, J. and Marchetti, P
Poster 2:Monitoring of mitochondrial dependency in FLT3ITD unveiled by FLT3 tyrosine kinase inhibition in acute myeloid leukemia. Khamari, R., Trinh, A., Fovez, Q., Dekiouk, S., Laine, W., Quesnel, B., Marchetti, P. and Kluza, J.
Pornichet, France (2018)
Congrès Meetochondrie (27-30/05)
Poster 1:Mitochondrial metabolism: a key factor of myeloid leukemic cell response upon exposure to tyrosine kinase inhibitors. Trinh, A., Khamari, R., Coiteux, V., Manier, S., Fovez, Q., Joncquel, M., Dekiouk, S., Laine, W., Idziorek, T., Quesnel, B., Kluza, J. and Marchetti, P.
Poster 2:Monitoring of mitochondrial dependency in FLT3ITD unveiled by FLT3 tyrosine kinase inhibition in acute myeloid leukemia. Khamari, R., Trinh, A., Fovez, Q., Dekiouk, S., Laine, W., Quesnel, B., Marchetti, P. and Kluza, J.
Cambridge, United Kingdom (2018)
Cancer and Metabolism 2018, Jun 2018
Muller, C., Grandemange, S., Kluza, J., Bost, F., Piquard, E., et al. Energy metabolism alteration and anticancer treatment: study of a troglitazone derivative in triple-negative breast cancer cells.
Reims, France (2018)
11ème Forum du Cancéropôle Est, Nov 2018
Muller, C., Grandemange, S., Kluza, J., Bost, F., Piquard, E. et al. A new derivative of troglitazone affects energy metabolism of triple negative breast cancer cells: potential interest for anticancer treatment.
Deauville, France (2017)
10ème journée scientifique du Cancéropôle Nord Ouest (10-12/05)
Development of new therapeutic strategies based on anti-metabolic cooperativity in myeloid leukemia . Trinh, A., Coiteux, V., Marcapura, C., Manier, S., Joncquel, M., Khamari; R., Dekiouk, S., Idziorek, T., Quesnel, Q. Kluza, J. and Marchetti, P.
Hossegor, France (2017)
Congrès Meetochondrie (Congrès Hossegor 14-17/05)
Development of new therapeutic strategies based on anti-metabolic cooperativity in myeloid leukemia . Trinh, A., Coiteux, V., Marcapura, C., Manier, S., Joncquel, M., Khamari; R., Dekiouk, S., Idziorek, T., Quesnel, Q. Kluza, J. and Marchetti, P.
Florence, Italie (2017)
EACR 2017 – (24-27/06)
Role of PD-L1 immunoregulatory protein in breast cancer cells metabolic reprogramming
Berthe, J. , Kluza, J., El Bouazzati, H., Briche , I.,
Thuru, X., Galiègue-Zouitina, S., Quesnel, B.
Bordeaux, France (2015)
Société francophone du diabète (24-27/03)
Le récepteur nucléaire FXR diminue la capacité des cellules L entéroendocrines à répondre au glucose. Lestavel, S., Trabelsi, M-S., Daoudi, M., Touche, V., Briand, O., Dehondt, H., Kluza, J., Brighton, C. A., Caron-Houde, S., Tailleux, A., Staels, B.
Istanbul, Turkey (2014)
Joint Congress of European Neurology (31/05-3/06)
Modifying effect of ceruloplasmin polymorphism on iron chelation response in Parkinson's disease: PP1186 Grolez, G., Meguig, S., Moreau, C., Sablonnière, B., Strubi-Vuilhaume, I. Ryckewaert, G., Jissendi, P., Hopes, L., Dujardin, K., Devedjian, J-C, Kluza, J, Jonneaux, A., Petrault, M, Garçon, G.; Rouaix, ., Duhamel, A., Auger, F. Ravasi,L., Firdaus, W., Zahr, N, Destée, A., Corvol, J-C, Pöltl, D., Leist, M., Rose, C. Marchetti, P., Cabantchik I.Z, Bordet, R., Defebvre, L., Devos, D.. European Journal of Neurology. 21():444, MAY 2014
Stockholm, Sweden (2015)
51st EASD Annual Meeting (14-18/09).
Farnesoid X receptor inhibits glucagon-like peptide-1. Lestavel, S., Trabelsi, MS, Daoudi, M., Ducastel, S., Touche, V., Briand, O., Sayin, SI., Perino, A., Brighto, SA., Kluza, J., Baud, G., Tailleux, A., Staels, B Meeting abstract: Diabetologia (2015) 58 (Suppl 1):S1–S607
Stockholm, SWEDEN (2014)
18th International Congress of Parkinson's Disease and Movement Disorders (08/12)
Modifying effect of ceruloplasmin polymorphism on iron chelation response in Parkinson's disease: PP1186 Grolez, G., Meguig, S., Moreau, C., Sablonnière, B., Strubi-Vuilhaume, I. Ryckewaert, G., Jissendi, P., Hopes, L., Dujardin, K., Devedjian, J-C, Kluza, J, Jonneaux, A., Petrault, M, Garçon, G.; Rouaix, ., Duhamel, A., Auger, F. Ravasi,L., Firdaus, W., Zahr, N, Destée, A., Corvol, J-C, Pöltl, D., Leist, M., Rose, C. Marchetti, P., Cabantchik I.Z, Bordet, R., Defebvre, L., Devos, D. MOVEMENT DISORDERS Volume: 29 Supplement: 1 Pages: S241-S241 Meeting Abstract: 652 Published: MAY 2014
Bologna, Italy (2013)
PBA-RDPA 2013 Bologna, (30/06-3/7).
Malet-Martino, M., Cruz, T., Balayssac, S., Kluza, J., Marchetti, P., Gilard, V. 1H NMR-BASED METABOLOMIC ANALYSIS OF A HUMAN MELANOMA CELL LINE.
Grenoble, France (2013)
1st international congress Resistance to targeted therapies (3-4/10)
Corazao-Rozas, P., Jendoubi, M., Guerreschi, P., André, F., Jonneaux, A., Tardivel, M., Qassemyar, A., Fontaine, D., Dekiouk, S., Formstecher, P., Mortier, L., Marchetti P., and Kluza, J.. Metabolic alterations in vemurafenib sensitive and resistant BRAFV600E melanoma cells.
Lyon, France (2013)
1st Symposium of the Cancer Research Center of Lyon (13-15/02)
Corazao-Rozas, P., Jendoubi, M., Guerreschi, P., André, F., Jonneaux, A., Tardivel, M., Qassemyar, A., Fontaine, D., Dekiouk, S., Formstecher, P., Mortier, L., Marchetti P., and Kluza, J.. Metabolic alterations in vemurafenib sensitive and resistant BRAFV600E melanoma cells.
London, United Kingdom (2013)
5th Congress of the International BioIron Society (14/04-18/04)
Moreau, C., Devedjian, JC., Kluza, J., Laloux, C., Jonneaux, A., Petrault, M., Ryckewaert, G ., Dujardin, K., Garçon, G., Rouaix, N., Duhamel, A., Jissendi, P., Sablonniere, B. Corvol, JC., Rose, C. Defebvre, L. Marchetti, P., Cabantchik, I., Bordet, R., Devos, D. Targeting brain chelatable ion as therapeutic strategy for parkinson’s diseasr. , AMERICAN JOURNAL OF HEMATOLOGY Volume: 88 Issue: 5 Pages: E36-E36 Published: MAY 2013
Paris, France (2013)
11th International Congress on Targeted Anticancer Therapies (TAT) (04/03-06/03)
Kluza, J., Jendoubi, M., Corazao-Rozas, P., Andre, F., Jonneaux, A., Guerreschi, P., Formstecher, P. Mortier, L. ,Marchetti, P. Mitochondrial metabolic reprogramming of melanoma cells exposed to BRAFV600E inhibitor. ANNALS OF ONCOLOGY Volume: 24 Supplement: 1 Pages: 30-30 Published: MAR 2013
Dublin, Ireland (2012)
Movement Disorder (17-21/06)
Moreau C., Devos D., Kluza J ., Laloux C., Petrault M., Devedjian J.C., Ryckewaert G., Garçon G., Rouaix N., Jissendi P., Dujardin K., Kreisler A., Simonin C., Destée A., Defebvre L., Marchetti P. and Bordet R. Disease modifying strategy based upon iron chelation in Parkinson's disease: A translational study.
New Orleans, USA (2012)
American Academy of Neurology (21-28/04).
Moreau C., Devos D., Kluza J ., Laloux C., Petrault M., Devedjian J.C., Ryckewaert G., Garçon G., Rouaix N., Jissendi P., Dujardin K., Kreisler A., Simonin C., Destée A., Defebvre L., Marchetti P. and Bordet R. Disease modifying strategy based upon iron chelation in Parkinson's disease: A translational study.
Journées dermatologiques de Paris (2012)
Effet antitumoral induit par l’association dichloroacétate+elesclomol chez des souris SCID atteintes de mélanome métastatique.
C. Scalbert, J. Kluza, C. Maire, P. Guerreschi, L. Mortier, P. Marchetti,
Journées dermatologiques de Paris (2012)
Impact du vemurafénib sur l’activité glycolytique du mélanome estimée par la TEP au 18-FDG.
Deregnaucourt, D., Maire, C., Huglo, D., Kluza, J., Marchetti, P., Mortier, L.
Barcelona, Spain (2012)
Meeting of the European Association for Cancer Research EACR (07-10/07)
Mitochondrial metabolic reprogramming of melanoma cells exposed to BRAFV600E inhibitor. Kluza, J., Jendoubi, M., Corazao-Rozas, P., André, F., Jonneaux, A., Guerreschi, P., Formstecher, P., Mortier, L., and Marchetti, P.
Besançon, France (2011)
Annual Congress of the French-Speaking-Society-for-Dermatological-Research (23-24/06)
Maire, C., Kluza, J., Jendoubi, M., et al. HIF-1 alpha is an important orchestrator of bioenergetic metabolism in melanoma ; Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 131 Issue: 10 Pages: 2152-2152 Published: OCT 2011
Denver, USA (2011)
242nd National Meeting of the American-Chemical-Society (ACS) (28/08-01/09AUG 28)
Chavda, ,Liu, Y , Babu, Davis, R ,Sielaff, Ruprich, , Westrate, L ,Tronrud, ,Ferguson, A ,Franks, ,Tzou, , Adkins, C , Rice, Mackay, H, Kluza, J , Tahir, S, Lin, S , Kiakos, K, Bruce, Wilson, D , Hartley, JA , Lee, M. Hx, a novel fluorescent, minor groove and sequence specific recognition element: Design, synthesis, and DNA binding properties of p-anisylbenzimidazole imidazole/pyrrole-containing polyamides. THE AMERICAN CHEMICAL SOCIETY Volume: 242 Meeting Abstract: 385-ORGN Published: AUG 28 2011
La Colle sur Loup, France (2010)
Congrès MeetOchondrie (2-5/05)
Kluza J., Maire C., Jendoubi M., Corazoa P., Guerreschi P., Touil Y., Polakowska R., Briand G., Mortier L., Formstecher P., and Marchetti P. Rôle de HIF-1 dans la répression des fonctions énergétiques mitochondriales dans le mélanome métastatique.
Le Touquet, France (2010)
Journée cancéropole Nord Ouest – 5-6/05.
Kluza, J., Jendoubi, M., Idzioreck, T., Balayssac, S., Mallet-Martino, M., Mabaudou, P., Formstecher, P., Quesnel B., and Marchetti, P. Exploiting oxidative stress resulting from mitochondrial dysfunction to sensitive Imatinib-resistant cells to chemotherapy.
Aussois, France (2010)
Congrès MeetOchondrie (9-12/05)
Kluza, J., Jendoubi, M ., Idziorek, T., Balayssac, S., Mallet-Martino, M., Mabaudou, P., Formstecher, P., Quesnel B., and Marchetti, P. Exploiting oxidative stress resulting from mitochondrial dysfunction to sensitive Imatinib-resistant cells to chemotherapy.
Paris, France (2010)
Congrès Jeune Chercheur Association pour la recherche sur le cancer (7/10)
Kluza, J., Maire, C., Jendoubi., M, Guerreshi, P, Balayssac, S., Mallet-Martino, Samuel Valable., Touil,. Y, Polokowska.,. R., Touil, .Y, Mortier,. L, Formstecher, P. and Marchetti, P. Rôle de HIF-1 dans la répression des fonctions énergétiques et apoptotiques des mitochondries dans les mélanomes
Reims, France (2009)
Annual Congress of the French-Speaking Society-for-Dermatological-Research (03-05/06)
Ballot, C., Kluza, J., Martoriati, A., et al. Dual anticancer effects of the alkaloid Lamellarin-D in melanoma cells. Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 129 Issue: 10 Pages: 2529-2529 Published: OCT 2009
Budapest, HUNGARY (2009)
39th Annual European-Society-for-Dermatological-Research (10/09)
Ballot, C., Kluza, J., Martoriati, A., Buche, S., Formstecher, P., Marchetti, P., Mortier, L. Dual anticancer effects of the alkaloid Lamellarin-D in melanoma cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 129 Pages: S75-S75 Published: SEP 2009
Salt Lake City, UT (USA (2009)
237th American Chemical Society national meeting & exposition, March (22 -26/03).
Davis, R., Sielaff, A., Ruprich, J ., Westrate, L., Tronrud, C., Ferguson, A., Brown, T., Mackay, H., Kluza, J., Liu, Y. ,Wilson, D, Hartley, JA., Lee, M. Design, synthesis, biophysical and biological studies of fluorescent Hoechst-polyamide hybrid molecules. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 237 Meeting Abstract: 239-MEDI Published: MAR 22 2009.
Lyon, France (2008)
20th Meeting of the European Association for Cancer (05-08/07)
Ballot, C., Martoriati, A., Kluza, J., et al. Apoptosis and senescence are triggered by Lamellarin-D in cancer Source: EJC SUPPLEMENTS Volume: 6 Issue: 9 Pages: 98-99.
Boston, USA (2007)
234th National ACS meeting, Boston, MA, (August 19-23)
Brown, T., Mackay, H., Turlington, M., Sutterfield, A., Smith, T., Westrate, L., Sielafft, A., Bruce, CD., Kluza, J., O'Hare, C., Nguyen, B., Hartley, J., Wilson, D., Lee, M. Modifications of the N-terminus of polyamides resulted in compounds with enhanced DNA binding sequence specificity. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 234 Meeting Abstract: 957-ORGN Published: AUG 19 2007
O'Hare, C., Uthe, P., Mackay, H., Blackmon, K, Jones, J., Brown, T, Westrate, L., Sielaff, A., Lajiness, J., Nguyen, B.,Wilson, D, Kluza, J. , Hartley, J., Lee, M. Sequence recognition in the minor groove of DNA by covalently linked H-pin polyamides: The effect of H-pin linkage, linker length, and N-terminus modification on selectivity and affinity. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 234 Meeting Abstract: 28-CARB Published: AUG 19 2007
Sexton, J., Mackay, H., Brown, T., Kotecha, M., O'Hare, C., Kluza, J., Hochhauser, D., Hartley, J., Nguyen, B., Wilson, D., Lee, M. Regulation of the topoisomerase II alpha gene using polyamides that binds to the inverted CCAAT box present in the promoter. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 234 Meeting Abstract: 309-MEDI Published: AUG 19 2007
Sielaff, A.,Cooper, A., Mackay, H., Brown, T., O'Hare, C., Kluza, J., Kotecha, M., Le, M., Hochhauser, D., Hartley, JA., Lee, M. Binding of f-PIP and JH-37 to the inverted CCAAT box-2 of the topoisomerase II promoter. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 233 Pages: 613-613 Meeting Abstract: 134-MEDI Published: MAR 25 2007
Westrate, L., Mackay, H., Nguyen, B., Wilson, WD., Kluza, J., Hartley, J., Lee, M. Brown, T. Investigating the role of the N-terminus formamido group of distamycin. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 233 Meeting Abstract: 688-ORGN Published: MAR 25 2007
Orlando, USA, (2004)
AACR 95th Annual meeting (27-31/03)
Kluza, J., Marchetti, P., Lansiaux, A., Otero, G., Cuevas, C. and Bailly C. Direct mitochondrial perturbations induced by the topoisomerase I poison lamellarin D in P388 leukemia cells sensitive and resistant to camptothecin.
Strasbourg, France (2003)
Association Francaise de cytométrie, 9ème congrès. (7-10/10)
Kluza, J., Lansiaux, A., Degardin, K., Clark, A. and Bailly, C. Apoptose induite par la Sampangine dans un modèle de cellules leucémiques HL-60.
Bruxelles, Belgium (2003)
XVIIème journée Franco-Belges de Pharmacochimie : 22-23/05
Kluza, J., Lansiaux, A., Degardin, K., Clark, A., and Bailly C. Apoptosis induced by the alkaloid Sampangine: Correlation between the effects on the cell cycle progression and changes of mitochondrial membrane potential.
Luxembourg, Luxembourg-ville (2003)
Cellular and molecular biology meeting, Apoptosis (29-31/01)
Kluza, J., Clark, A. and Bailly, C. Apoptosis induced by the alkaloid sampagine in HL-60 leukemia cells : Correlation between the effects on the cell cycle progression and changes of mitochondrial potential.
Lille, France (2002)
3ème Réunion du Réseau Lillois de Cancérologie (29/05)
Kluza, J., Marchetti, C., Lansiaux, A., Fournier, C., Loyens, A., Beauvillain, J.C., Bailly,C. Altérations nucléaires et mitochondriales lors de l’apoptose des cellules cancéreuses MTLN3 et des cellules cardiaques H9C2 induite par la doxorubicine.
San Francisco, USA (2000)
AACR 91th Annual meeting, San Francisco (USA): (3-7/04)
Kluza, J., Lansiaux, L., Wattez, N., Mahieu, C., Osheroff, N., and Bailly, C. Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103 : Proc Am Ass Cancer Res 2000 ; 41 : 5225.