Jean-Marc Taymans
Publications
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"citationRef_s":"<i>Chemical Science</i>, 2025, Chemical Science, 16 (8), pp.3430. <a target=\"_blank\" href=\"https://dx.doi.org/10.1039/d4sc07532c\">⟨10.1039/d4sc07532c⟩</a>",
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"title_s":["Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1"],
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"citationRef_s":"<i>Cell Death and Disease</i>, 2024, Cell Death and Disease, 15, pp.752. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41419-024-07124-4\">⟨10.1038/s41419-024-07124-4⟩</a>",
"citationFull_s":"Lucia Iannotta, Rachel Fasiczka, Giulia Favetta, Yibo Zhao, Elena Giusto, et al.. PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner. <i>Cell Death and Disease</i>, 2024, Cell Death and Disease, 15, pp.752. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41419-024-07124-4\">⟨10.1038/s41419-024-07124-4⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-05013704v1\">⟨hal-05013704⟩</a>",
"title_s":["PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner"],
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"citationRef_s":"<i>Frontiers in Molecular Neuroscience</i>, 2024, Frontiers in Molecular Neuroscience, 17, <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fnmol.2024.1479278\">⟨10.3389/fnmol.2024.1479278⟩</a>",
"citationFull_s":"Jean-Marc Taymans, Deniz Yilmazer-Hanke. Editorial: Editors' showcase: molecular signalling and pathways.. <i>Frontiers in Molecular Neuroscience</i>, 2024, Frontiers in Molecular Neuroscience, 17, <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fnmol.2024.1479278\">⟨10.3389/fnmol.2024.1479278⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04976046v1\">⟨hal-04976046⟩</a>",
"title_s":["Editorial: Editors' showcase: molecular signalling and pathways."],
"authFullName_s":["Jean-Marc Taymans","Deniz Yilmazer-Hanke"],
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"citationRef_s":"<i>Expert Opinion on Therapeutic Patents</i>, 2024, Expert Opinion on Therapeutic Patents, 34 (9), pp.1-16. <a target=\"_blank\" href=\"https://dx.doi.org/10.1080/13543776.2024.2378076\">⟨10.1080/13543776.2024.2378076⟩</a>",
"citationFull_s":"Margaux Morez, Antonio Jesus Lara Ordonez, Patricia Melnyk, Maxime Liberelle, Nicolas Lebegue, et al.. Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson's disease: a patent review of the literature to date.. <i>Expert Opinion on Therapeutic Patents</i>, 2024, Expert Opinion on Therapeutic Patents, 34 (9), pp.1-16. <a target=\"_blank\" href=\"https://dx.doi.org/10.1080/13543776.2024.2378076\">⟨10.1080/13543776.2024.2378076⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04792985v1\">⟨hal-04792985⟩</a>",
"title_s":["Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson's disease: a patent review of the literature to date."],
"authFullName_s":["Margaux Morez","Antonio Jesus Lara Ordonez","Patricia Melnyk","Maxime Liberelle","Nicolas Lebegue","Jean-Marc Taymans"],
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"citationRef_s":"<i>Frontiers in Molecular Neuroscience</i>, 2024, Frontiers in Molecular Neuroscience, 17, pp.1414816. <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fnmol.2024.1414816\">⟨10.3389/fnmol.2024.1414816⟩</a>",
"citationFull_s":"Ciria C. Hernandez, Luis E. Gimenez, Tim Strassmaier, Marc Rogers, Jean-Marc Taymans. Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies.. <i>Frontiers in Molecular Neuroscience</i>, 2024, Frontiers in Molecular Neuroscience, 17, pp.1414816. <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fnmol.2024.1414816\">⟨10.3389/fnmol.2024.1414816⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04636342v1\">⟨hal-04636342⟩</a>",
"title_s":["Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies."],
"authFullName_s":["Ciria C. Hernandez","Luis E. Gimenez","Tim Strassmaier","Marc Rogers","Jean-Marc Taymans"],
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"citationRef_s":"<i>npj Parkinson's Disease</i>, 2024, 10 (1), pp.12. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41531-023-00624-8\">⟨10.1038/s41531-023-00624-8⟩</a>",
"citationFull_s":"Yahaira Naaldijk, Belén Fernández, Rachel Fasiczka, Elena Fdez, Coline Leghay, et al.. A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells. <i>npj Parkinson's Disease</i>, 2024, 10 (1), pp.12. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41531-023-00624-8\">⟨10.1038/s41531-023-00624-8⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04418763v1\">⟨hal-04418763⟩</a>",
"title_s":["A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells"],
"authFullName_s":["Yahaira Naaldijk","Belén Fernández","Rachel Fasiczka","Elena Fdez","Coline Leghay","Ioana Croitoru","John Kwok","Yanisse Boulesnane","Amelie Vizeneux","Eugenie Mutez","Camille Calvez","Alain Destée","Jean-Marc Taymans","Ana Vinagre Aragon","Alberto Bergareche Yarza","Shalini Padmanabhan","Mario Delgado","Roy Alcalay","Zac Chatterton","Nicolas Dzamko","Glenda Halliday","Javier Ruiz-Martínez","Marie-Christine Chartier-Harlin","Sabine Hilfiker"],
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"citationRef_s":"<i>Frontiers in Molecular Neuroscience</i>, 2023, 16, <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fnmol.2023.1269387\">⟨10.3389/fnmol.2023.1269387⟩</a>",
"citationFull_s":"Lucia Iannotta, Marco Emanuele, Giulia Favetta, Giulia Tombesi, Laurine Vandewynckel, et al.. PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation. <i>Frontiers in Molecular Neuroscience</i>, 2023, 16, <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fnmol.2023.1269387\">⟨10.3389/fnmol.2023.1269387⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04418786v1\">⟨hal-04418786⟩</a>",
"title_s":["PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation"],
"authFullName_s":["Lucia Iannotta","Marco Emanuele","Giulia Favetta","Giulia Tombesi","Laurine Vandewynckel","Antonio Jesús Lara Ordóñez","Jean-Michel Saliou","Matthieu Drouyer","William Sibran","Laura Civiero","R. Jeremy Nichols","Panagiotis S Athanasopoulos","Arjan Kortholt","Marie-Christine Chartier-Harlin","Elisa Greggio","Jean-Marc Taymans"],
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"citationRef_s":"<i>J Parkinsons Dis</i>, 2023, J Parkinsons Dis, 9 (1), pp.104. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41531-023-00544-7\">⟨10.1038/s41531-023-00544-7⟩</a>",
"citationFull_s":"Jean-Marc Taymans, M. Fell, T. Greenamyre, W. D. Hirst, A. Mamais, et al.. Perspective on the current state of the LRRK2 field.. <i>J Parkinsons Dis</i>, 2023, J Parkinsons Dis, 9 (1), pp.104. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41531-023-00544-7\">⟨10.1038/s41531-023-00544-7⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04727882v1\">⟨hal-04727882⟩</a>",
"title_s":["Perspective on the current state of the LRRK2 field."],
"authFullName_s":["Jean-Marc Taymans","M. Fell","T. Greenamyre","W. D. Hirst","A. Mamais","S. Padmanabhan","I. Peter","H. Rideout","A. Thaler"],
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"citationFull_s":"Jean-Marc Taymans, Eugénie Mutez, William Sibran, Laurine Vandewynckel, Claire Deldycke, et al.. Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers. <i>npj Parkinson's Disease</i>, 2023, 9 (1), pp.21. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41531-023-00445-9\">⟨10.1038/s41531-023-00445-9⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04335821v1\">⟨hal-04335821⟩</a>",
"title_s":["Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers"],
"authFullName_s":["Jean-Marc Taymans","Eugénie Mutez","William Sibran","Laurine Vandewynckel","Claire Deldycke","Séverine Bleuse","Antoine Marchand","Alessia Sarchione","Coline Leghay","Alexandre Kreisler","Clémence Simonin","James Koprich","Guillaume Baille","Luc Defebvre","Kathy Dujardin","Alain Destée","Marie-Christine Chartier-Harlin"],
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"citationRef_s":"<i>Cell Reports</i>, 2023, 42 (3), pp.112221. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.celrep.2023.112221\">⟨10.1016/j.celrep.2023.112221⟩</a>",
"citationFull_s":"Francesca Filippini, Sébastien Nola, Ahmed Zahraoui, Kevin Roger, Mansoore Esmaili, et al.. Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs. <i>Cell Reports</i>, 2023, 42 (3), pp.112221. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.celrep.2023.112221\">⟨10.1016/j.celrep.2023.112221⟩</a>. <a target=\"_blank\" href=\"https://u-paris.hal.science/hal-04090504v1\">⟨hal-04090504⟩</a>",
"title_s":["Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs"],
"authFullName_s":["Francesca Filippini","Sébastien Nola","Ahmed Zahraoui","Kevin Roger","Mansoore Esmaili","Ji Sun","José Wojnacki","Anaïs Vlieghe","Philippe Bun","Stéphanie Blanchon","Jean-Christophe Rain","Jean-Marc Taymans","Marie-Christine Chartier-Harlin","Chiara Guerrera","Thierry Galli"],
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"citationRef_s":"<i>Cells</i>, 2022, 11 (6), pp.1018. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cells11061018\">⟨10.3390/cells11061018⟩</a>",
"citationFull_s":"Antoine Marchand, Alessia Sarchione, Panagiotis Athanasopoulos, Hélène Bauderlique-Le Roy, Liesel Goveas, et al.. A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively. <i>Cells</i>, 2022, 11 (6), pp.1018. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cells11061018\">⟨10.3390/cells11061018⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-03625821v1\">⟨inserm-03625821⟩</a>",
"title_s":["A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively"],
"authFullName_s":["Antoine Marchand","Alessia Sarchione","Panagiotis Athanasopoulos","Hélène Bauderlique-Le Roy","Liesel Goveas","Romain Magnez","Matthieu Drouyer","Marco Emanuele","Franz Ho","Maxime Liberelle","Patricia Melnyk","Nicolas Lebègue","Xavier Thuru","R. Jeremy Nichols","Elisa Greggio","Arjan Kortholt","Thierry Galli","Marie-Christine Chartier-Harlin","Jean-Marc Taymans"],
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"citationRef_s":"<i>Movement Disorders</i>, 2022, <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/mds.29124\">⟨10.1002/mds.29124⟩</a>",
"citationFull_s":"Ilda Coku, Eugénie Mutez, Sabiha Eddarkaoui, Sébastien Carrier, Antoine Marchand, et al.. Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.. <i>Movement Disorders</i>, 2022, <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/mds.29124\">⟨10.1002/mds.29124⟩</a>. <a target=\"_blank\" href=\"https://u-picardie.hal.science/hal-03703786v1\">⟨hal-03703786⟩</a>",
"title_s":["Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease."],
"authFullName_s":["Ilda Coku","Eugénie Mutez","Sabiha Eddarkaoui","Sébastien Carrier","Antoine Marchand","Claire Deldycke","Liesel Goveas","Guillaume Baille","Mélissa Tir","Romain Magnez","Xavier Thuru","Gaëlle Vermeersch","Wim Vandenberghe","Luc Buée","Luc Defebvre","Bernard Sablonnière","Marie-Christine Chartier-Harlin","Jean-Marc Taymans","Vincent Huin"],
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"citationRef_s":"<i>International Journal of Molecular Sciences</i>, 2021, 22 (13), pp.6760. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ijms22136760\">⟨10.3390/ijms22136760⟩</a>",
"citationFull_s":"Noémie Cresto, Camille Gardier, Marie-Claude Gaillard, Francesco Gubinelli, Pauline Roost, et al.. The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo. <i>International Journal of Molecular Sciences</i>, 2021, 22 (13), pp.6760. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ijms22136760\">⟨10.3390/ijms22136760⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03452142v1\">⟨hal-03452142⟩</a>",
"title_s":["The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo"],
"authFullName_s":["Noémie Cresto","Camille Gardier","Marie-Claude Gaillard","Francesco Gubinelli","Pauline Roost","Daniela Molina","Charlène Josephine","Noëlle Dufour","Gwenaëlle Auregan","Martine Guillermier","Suéva Bernier","Caroline Jan","Pauline Gipchtein","Philippe Hantraye","Marie-Christine Chartier-Harlin","Gilles Bonvento","Nadja van Camp","Jean-Marc Taymans","Karine Cambon","Géraldine Liot","Alexis-Pierre Bemelmans","Emmanuel Brouillet"],
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"citationFull_s":"Liesel Goveas, Eugénie Mutez, Marie-Christine Chartier-Harlin, Jean-Marc Taymans. Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells. <i>Cells</i>, 2021, 10 (5), pp.981. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cells10050981\">⟨10.3390/cells10050981⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04335944v1\">⟨hal-04335944⟩</a>",
"title_s":["Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells"],
"authFullName_s":["Liesel Goveas","Eugénie Mutez","Marie-Christine Chartier-Harlin","Jean-Marc Taymans"],
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"citationRef_s":"<i>Neurobiology of Disease</i>, 2021, 157, pp.105426. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.nbd.2021.105426\">⟨10.1016/j.nbd.2021.105426⟩</a>",
"citationFull_s":"Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris van den Haute, Marco Emanuele, et al.. Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation. <i>Neurobiology of Disease</i>, 2021, 157, pp.105426. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.nbd.2021.105426\">⟨10.1016/j.nbd.2021.105426⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-03373115v1\">⟨hal-03373115⟩</a>",
"title_s":["Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation"],
"authFullName_s":["Matthieu Drouyer","Marc F. Bolliger","Evy Lobbestael","Chris van den Haute","Marco Emanuele","Réginald Lefebvre","William Sibran","Tina de Wit","Coline Leghay","Eugénie Mutez","Nicolas Dzamko","Glenda M. Halliday","Shigeo Murayama","Alain Martoriati","Katia Cailliau-Maggio","Jean-Francois Bodart","Marie-Christine Chartier-Harlin","Veerle Baekelandt","R. Jeremy Nichols","Jean-Marc Taymans"],
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"citationRef_s":"<i>Biochemical Journal</i>, 2019, 476 (19), pp.2797-2813. <a target=\"_blank\" href=\"https://dx.doi.org/10.1042/BCJ20190315\">⟨10.1042/BCJ20190315⟩</a>",
"citationFull_s":"Belén Fernández, Antonio Jesús Lara Ordóñez, Elena Fdez, Eugénie Mutez, Thomas Comptdaer, et al.. Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients. <i>Biochemical Journal</i>, 2019, 476 (19), pp.2797-2813. <a target=\"_blank\" href=\"https://dx.doi.org/10.1042/BCJ20190315\">⟨10.1042/BCJ20190315⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04335984v1\">⟨hal-04335984⟩</a>",
"title_s":["Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients"],
"authFullName_s":["Belén Fernández","Antonio Jesús Lara Ordóñez","Elena Fdez","Eugénie Mutez","Thomas Comptdaer","Coline Leghay","Alexandre Kreisler","Clémence Simonin","Laurine Vandewynckel","Luc Defebvre","Alain Destée","Séverine Bleuse","Jean-Marc Taymans","Marie-Christine Chartier-Harlin","Sabine Hilfiker"],
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"citationRef_s":"<i>Scientific Reports</i>, 2017, 7 (1), pp.8667. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41598-017-09126-z\">⟨10.1038/s41598-017-09126-z⟩</a>",
"citationFull_s":"Kushal Sejwal, Mohamed Chami, Hervé Rémigy, Renée Vancraenenbroeck, William Sibran, et al.. Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes. <i>Scientific Reports</i>, 2017, 7 (1), pp.8667. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41598-017-09126-z\">⟨10.1038/s41598-017-09126-z⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-01592830v1\">⟨inserm-01592830⟩</a>",
"title_s":["Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes"],
"authFullName_s":["Kushal Sejwal","Mohamed Chami","Hervé Rémigy","Renée Vancraenenbroeck","William Sibran","Rosmarie Sütterlin","Paul Baumgartner","Robert Mcleod","Marie-Christine Chartier-Harlin","Veerle Baekelandt","Henning Stahlberg","Jean-Marc Taymans"],
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