Jean-Claude Sirard
Publications
Laura Negrier, Marine Roche, Damien Lannoy, C. Berneron, L. Pacqueu, Christophe Carnoy, A. Guillon, B. Hamzé, Jean-Claude Sirard, Bertrand Décaudin, Pascal Odou, Cecile Danel
Physicochemical stability of a polysorbate-80-containing solvent compounded in the hospital pharmacy and used to reconstitute a biologic for nebulisation.
European Journal of Hospital Pharmacy, 2025, Eur J Hosp Pharm, ⟨10.1136/ejhpharm-2024-004441⟩
Mara Baldry, Yasmine Zeroual, Delphine Cayet, Jeoffrey Pardessus, Daphne Soulard, Frederic Wallet, Delphine Beury, David Hot, Ronan Macloughlin, Nathalie Heuzé-Vourc’h, Jean-Claude Sirard, Christophe Carnoy
Targeted delivery of flagellin by nebulization offers optimized respiratory immunity and defense against pneumococcal pneumonia
Antimicrobial Agents and Chemotherapy, 2024, Antimicrobial Agents and Chemotherapy, 68 (12), pp.e0086624. ⟨10.1128/aac.00866-24⟩
Elaa Chkhaydem, Isabelle Fleurot, Vanaïque Guillory, Emmanuel Kut, Céline Barc, Olivier Boulesteix, Alain Deslis, Alexis Pléau, Mara Baldry, Marie Couralet, Guillaume Beaumont, Jean-Claude Sirard, Pascal Barbry, Sascha Trapp, Ignacio Caballero-Posadas
Flagellin treatment: an immunomodulation strategy for controllong swine influenza infection
9. International Influenza Meeting:" From bench to bedside", Sep 2024, Münster (DE), Germany.
Charlotte Costa, Jean-Claude Sirard, Paddy Gibson, Jan-Willem Veening, Erida Gjini, Mara Baldry
Triggering Toll-Like Receptor 5 Signaling During Pneumococcal Superinfection Prevents the Selection of Antibiotic Resistance
Journal of Infectious Diseases, 2024, pp.jiae239. ⟨10.1093/infdis/jiae239⟩
Ana Raquel Maia, Adeline Cezard, Delphine Fouquenet, Virginie Vasseur, Benoit Briard, Jean-Claude Sirard, Mustapha Si-Tahar, Virginie Hervé
Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy, 2024, 68 (5), pp.e01361-23. ⟨10.1128/aac.01361-23⟩
Xue Liu, Laurye van Maele, Laura Matarazzo, Daphnée Soulard, Vinicius Alves Duarte da Silva, Vincent de Bakker, Julien Dénéréaz, Florian Bock, Michael Taschner, Jinzhao Ou, Stephan Gruber, Victor Nizet, Jean-Claude Sirard, Jan-Willem Veening
A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection
Cell Host & Microbe, 2024, 32 (3), pp.304-314.e8. ⟨10.1016/j.chom.2024.02.002⟩
Christine van Linge, Katina Hulme, Hessel Peters-Sengers, Jean-Claude Sirard, Wil Goessens, Menno de Jong, Colin Russell, Alex de Vos, Tom van der Poll
Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells
International Journal of Molecular Sciences, 2023, 25 (1), pp.309. ⟨10.3390/ijms25010309⟩
Melanie Mondeme, Yasmine Zeroual, Daphne Soulard, Benjamin Hennart, Delphine Beury, Jean-Michel Saliou, Christophe Carnoy, Jean-Claude Sirard, Christelle Faveeuw
Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function.
Journal of Leukocyte Biology, 2023, Journal of Leukocyte Biology, 115 (3), pp.463-475. ⟨10.1093/jleuko/qiad125⟩
Vikrant Minhas, Arnau Domenech, Dimitra Synefiaridou, Daniel Straume, Max Brendel, Gonzalo Cebrero, Xue Liu, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Camilo Perez, Nicolas Gisch, Sven Hammerschmidt, Leiv Sigve Håvarstein, Jan-Willem Veening
Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence
PLoS Biology, 2023, 21 (1), pp.e3001990. ⟨10.1371/journal.pbio.3001990⟩
Mélanie Mondemé, Christophe Carnoy, Jean-Claude Sirard, Christelle Faveeuw
Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity
Infection and Immunity, 2023, 91 (2), pp.e00503-22. ⟨10.1128/iai.00503-22⟩
Liselot Dewachter, Julien Dénéréaz, Xue Liu, Vincent de Bakker, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Jan-Willem Veening
Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq
eLife, 2022, 11, ⟨10.7554/eLife.75607⟩
Isabelle Fleurot, Raquel López-Gálvez, Pascal Barbry, Antoine Guillon, Mustapha Si-Tahar, Andrea Bähr, Nikolai Klymiuk, Jean-Claude Sirard, Ignacio Caballero
TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium
Journal of Cystic Fibrosis, 2022, 21 (2), pp.e117-e121. ⟨10.1016/j.jcf.2021.08.002⟩
Claire Mackowiak, Tiffany Marchiol, Hana Cipcic Paljetak, Louis Fauconnier, Jennifer Palomo, Thomas Secher, Corinne Panek, Delphine Sedda, Florence Savigny, François Erard, Alessandra Bragonzi, Francois Huaux, Tobias Stoeger, Herbert B Schiller, Jean-Claude Sirard, M Le Bert, Isabelle Couillin, Valérie Quesniaux, Dieudonnée Togbe, Bernhard Ryffel
Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
ImmunoHorizons , 2021, 5 (5), pp.273 - 283. ⟨10.4049/immunohorizons.2000095⟩
Raquel López-Gálvez, Isabelle Fleurot, Pablo Chamero, Sascha Trapp, Olivier Michel, Claire Chevaleyre, Céline Barc, Mickael Riou, Christelle Rossignol, Antoine Guillon, Mustapha Si-Tahar, Tobias May, Pascal Barbry, Andrea Bähr, Nikolai Klymiuk, Jean Claude Sirard, Ignacio Caballero
Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa
American Journal of Respiratory Cell and Molecular Biology, 2021, 65 (4), pp.378-389. ⟨10.1165/rcmb.2021-0125OC⟩
Fiordiligie Casilag, Laura Matarazzo, Sebastian Franck, Martin Figeac, Robin Michelet, Charlotte Kloft, Christophe Carnoy, Jean-Claude Sirard
The Biosynthetic Monophosphoryl Lipid A Enhances the Therapeutic Outcome of Antibiotic Therapy in Pneumococcal Pneumonia.
ACS Infectious Diseases, 2021, Online ahead of print. ⟨10.1021/acsinfecdis.1c00176⟩
Claire Mackowiak, Tiffany Marchiol, Hana Cipcic Paljetak, Louis Fauconnier, Jennifer Palomo, Thomas Secher, Corinne Panek, Delphine Sedda, Florence Savigny, François Erard, Alessandra Bragonzi, Francois Huaux, Tobias Stoeger, Herbert B. Schiller, Jean Claude Sirard, Marc Le Bert, Isabelle Couillin, Valérie Quesniaux, Dieudonnée Togbe, Bernhard Ryffel
Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
ImmunoHorizons , 2021, 5 (5), pp.273-283. ⟨10.4049/immunohorizons.2000095⟩
Robin Michelet, Moreno Ursino, Sandrine Boulet, Sebastian Franck, Fiordiligie Casilag, Mara Baldry, Jens Rolff, Madelé van Dyk, Sebastian Wicha, Jean-Claude Sirard, Emmanuelle Comets, Sarah Zohar, Charlotte Kloft
The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia
Pharmaceutics, 2021, 13 (5), pp.601. ⟨10.3390/pharmaceutics13050601⟩
Wanhai Qin, Xanthe Brands, Cornelis Van’t Veer, Alex F. de Vos, Jean Claude Sirard, Joris J. T. H. Roelofs, Brendon P. Scicluna, Tom van Der Poll
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection
PLoS Pathogens, 2021, 17 (4), ⟨10.1371/journal.ppat.1009491⟩
Sebastian Franck, Robin Michelet, Fiordiligie Casilag, Jean Claude Sirard, Sebastian G. Wicha, Charlotte Kloft
A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice
Pharmaceutics, 2021, 13 (4), pp.1-12. ⟨10.3390/pharmaceutics13040469⟩
Magdiel Pérez-Cruz, Bachirou Koné, Rémi Porte, Christophe Carnoy, Julien Tabareau, Pierre Gosset, François Trottein, Jean Claude Sirard, Muriel Pichavant, Philippe Gosset
The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice
PLoS ONE, 2021, 16 (3), ⟨10.1371/journal.pone.0236216⟩
I. Ramirez-Moral, X. Yu, J. M. Butler, M. van Weeghel, N. A. Otto, B. Lima Ferreira, L. Van Maele, Jean Claude Sirard, A. F. de Vos, M. D. de Jong, R. H. Houtkooper, T. van Der Poll
mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin
Mucosal Immunology, 2021, 14 (3), pp.594-604. ⟨10.1038/s41385-021-00377-8⟩
Thomas Belcher, Hana Kammoun, Loïc Coutte, Anne-Sophie Debrie, Nathalie Mielcarek, Jean-Claude Sirard, Stephane Cauchi, Camille Locht
Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice
Vaccine, In press, ⟨10.1016/j.vaccine.2021.01.025⟩
Robin A. Sorg, Clement Gallay, Laurye van Maele, Jean Claude Sirard, Jan-Willem Veening
Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (44), pp.27608-27619. ⟨10.1073/pnas.1920015117⟩
Aneesh Vijayan, Laurye van Maele, Delphine Fougeron, Delphine Cayet, Jean Claude Sirard
The GM-CSF released by airway epithelial cells orchestrates the mucosal adjuvant activity of flagellin
Journal of Immunology, 2020, pp.ji2000746
Anne-Sophie Debrie, Nathalie Mielcarek, Sophie Lecher, Xavier Roux, Jean Claude Sirard, Camille Locht
Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4
Journal of Immunology, 2019, pp.ji1901102. ⟨10.4049/jimmunol.1901102⟩
Isabelle Fleurot, Mickael Riou, Claire Chevaleyre, Sandrine Melo, Michel Olivier, Christelle Rossignol, Céline Barc, Jérémy Pezant, Alexis Pleau, Alain Deslis, Nikolai Klymiuk, Jean Claude Sirard, Ignacio Caballero
Novel approaches boosting innate immunity against Pseudomonas aeruginosa
15. Congrès National de la Société Française de Microbiologie (SFM), Société Française de Microbiologie (SFM). FRA., Sep 2019, Paris, France. pp.436
Laurye van Maele, Delphine Fougeron, Delphine Cayet, Aurélie Chalon, Diego Piccioli, Catherine Collignon, Jean Claude Sirard, Arnaud Didierlaurent
Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01
European Journal of Immunology, 2019, 49 (12), pp.2134-2145. ⟨10.1002/eji.201948234⟩
Sebastian Franck, Tania Fuhrmann-Selter, Jan Joseph, Robin Michelet, Fiordiligie Casilag, Jean Claude Sirard, Sebastian Wicha, Charlotte Kloft
A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume
Talanta, 2019, 201, pp.253-258. ⟨10.1016/j.talanta.2019.03.098⟩
Laura Matarazzo, Fiordiligie Casilag, Rémi Porte, Frederic Wallet, Delphine Cayet, Christelle Faveeuw, Christophe Carnoy, Jean Claude Sirard
Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia
Frontiers in Immunology, 2019, 10, pp.723. ⟨10.3389/fimmu.2019.00723⟩
Anne-France Georgel, Delphine Cayet, Andrés Pizzorno, Manuel Rosa-Calatrava, Christophe Paget, Valentin Sencio, Jean Dubuisson, François Trottein, Jean Claude Sirard, Christophe Carnoy
Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir
Antiviral Research, 2019, 168, pp.28-35. ⟨10.1016/j.antiviral.2019.05.002⟩
Marina Elizabeth Biedma, Delphine Cayet, Julien Tabareau, Andrés Rossi, Karolina Ivičak-Kocjan, Griselda Moreno, Agustina Errea, Daphnée Soulard, Gustavo Parisi, Roman Jerala, Paula Berguer, Martin Rumbo, Jean Claude Sirard
Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants
Vaccine, 2019, 37 (4), pp.652-663. ⟨10.1016/j.vaccine.2018.12.009⟩
Ranin Beshara, Valentin Sencio, Daphnée Soulard, Adeline Barthélémy, Josette Fontaine, Thibault Pinteau, Lucie Deruyter, Mohamad Bachar Ismail, Christophe Paget, Jean-Claude Sirard, François Trottein, Christelle Faveeuw
Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection
PLoS Pathogens, 2018, 14 (10), pp.e1007360. ⟨10.1371/journal.ppat.1007360⟩
Khalil Farhat, Gwennaëlle Bodart, Chantal Charlet-Renard, Christophe Desmet, Michel Moutschen, Yves Beguin, Frederic Baron, Pierrette Melin, Pascale Quatresooz, Anne-Simone Parent, Daniel Desmecht, Jean-Claude Sirard, Roberto Salvatori, Henri Martens, Vincent Geenen
Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae
Frontiers in Immunology, 2018, 9, pp.2175. ⟨10.3389/fimmu.2018.02175⟩
Fabien Bastaert, Saadé Kheir, Vinciane Saint-Criq, Bérengère Villeret, Pham My-Chan Dang, Jamel El-Benna, Jean-Claude Sirard, Romé Voulhoux, Jean-Michel Sallenave
Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation
Frontiers in Immunology, 2018, 9, pp.1675. ⟨10.3389/fimmu.2018.01675⟩
Isabelle Fleurot, Sandrine Melo, Michel Olivier, Claire Chevaleyre, Christophe Carnoy, Jean Claude Sirard, Ignacio Caballero
Flagellin pre-stimulation modulates the immune response to pathogens in pig airway epithelial cells
11. Symposium of the French Domestic Animal Immunology Network (IAD 2018), Mar 2018, Tours, France. , 56 p., 2018
Aneesh Vijayan, Martin Rumbo, Christophe Carnoy, Jean-Claude Sirard
Compartmentalized Antimicrobial Defenses in Response to Flagellin
Trends in Microbiology, 2017, 9, pp.143 - 153. ⟨10.1016/j.tim.2017.10.008⟩
Catherine Sabatel, Coraline Radermecker, Laurence Fievez, Genevieve Paulissen, Svetoslav Chakarov, Claudia Fernandes, Sabine Olivier, Marie Toussaint, Dimitri Pirottin, Xue Xiao, Pascale Quatresooz, Jean-Claude Sirard, Didier Cataldo, Laurent Gillet, Hicham Bouabe, Christophe J Desmet, Florent Ginhoux, Thomas Marichal, Fabrice Bureau
Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
Immunity, 2017, 46 (3), pp.457-473. ⟨10.1016/j.immuni.2017.02.016⟩
Rémi Porte, Laurye van Maele, Natalia Muñoz-Wolf, Benoit Foligné, Laure Dumoutier, Julien Tabareau, Delphine Cayet, Pierre Gosset, Nicolas Jonckheere, Isabelle van Seuningen, José A Chabalgoity, Michel Simonet, Mohamed Lamkanfi, Christophe Renauld, Jean-Claude Sirard, Christophe Carnoy
Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.
Infection and Immunity, 2017, 85 (2), pp.e00806-16. ⟨10.1128/IAI.00806-16⟩
Carolina Iraporda, David E Romanin, Ana A Bengoa, Agustina J Errea, Delphine Cayet, Benoit Foligné, Jean-Claude Sirard, Graciela L Garrote, Analía G Abraham, Martín Rumbo
Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model.
Frontiers in Immunology, 2016, 7, pp.651. ⟨10.3389/fimmu.2016.00651⟩
Agustina Errea, Delphine Cayet, Philippe Marchetti, Cong Tang, Jerome Kluza, Stefan Offermanns, Jean-Claude Sirard, Martin Rumbo
Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.
PLoS ONE, 2016, 11 (11), pp.e0163694. ⟨10.1371/journal.pone.0163694⟩
Natalia Muñoz-Wolf, Analía Rial, Delphine Fougeron, Julien Tabareau, Jean-Claude Sirard, José A Chabalgoity
Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.
Future Microbiology, 2016, 11 (9), pp.1167-77. ⟨10.2217/fmb-2016-0045⟩
Rémi Porte, Delphine Fougeron, Natalia Muñoz-Wolf, Julien Tabareau, Anne-France Georgel, Fréderic Wallet, Christophe Paget, François Trottein, José A Chabalgoity, Christophe Carnoy, Jean-Claude Sirard
A toll-like receptor 5 agonist improves the efficacy of antibiotics in the treatment of primary and influenza-associated pneumococcal mouse infections.
Antimicrobial Agents and Chemotherapy, 2015, 59 (10), pp.6064-6072. ⟨10.1128/AAC.01210-15⟩
Delphine Fougeron, Laurye van Maele, Pascal Songhet, Delphine Cayet, David Hot, Nico van Rooijen, Hans-Joachim Mollenkopf, Wolf-Dietrich Hardt, Arndt G. Benecke, Jean-Claude Sirard
Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract
Vaccine, 2015, 33 (29), pp.3331-41. ⟨10.1016/j.vaccine.2015.05.022⟩
Agathe Goubard, Caroline Loïez, Jun Abe, Caroline Fichel, Stéphanie Herwegh, Christelle Faveeuw, Rémi Porte, Delphine Cayet, Florent Sebbane, Sylvie Penet, Benoit Foligné, Pierre Desreumaux, Hirohisa Saito, Jean-Claude Sirard, Michel Simonet, Christophe Carnoy
Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells.
Infection and Immunity, 2015, 83 (5), pp.2053-64. ⟨10.1128/IAI.02339-14⟩
Magdalena Matusiak, Nina van Opdenbosch, Lieselotte Vande Walle, Jean-Claude Sirard, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (5), pp.1541-1546. ⟨10.1073/pnas.1417945112⟩
Laurye van Maele, Delphine Fougeron, Laure Janot, Arnaud Didierlaurent, Delphine Cayet, Jullien Tabareau, Martin Rumbo, S. Corvo-Chamaillard, S. Boulenouar, S. Jeffs, L. Vande Walle, M. Lamkanfi, Y. Lemoine, François Erard, D. Hot, T. Hussell, Bernhard Ryffel, Arndt G. Benecke, Jean-Claude Sirard
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.
Mucosal Immunology, 2013, epub ahead of print. ⟨10.1038/mi.2013.66⟩
Griselda Moreno, Agustina Errea, Laurye van Maele, Roy Roberts, Hélène Léger, Jean Claude Sirard, Arndt Benecke, Martin Rumbo, Daniela Hozbor
Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection.
Microbes and Infection, 2013, 15 (10-11), pp.708-18. ⟨10.1016/j.micinf.2013.06.010⟩
Stoyan Ivanov, Joelle Renneson, Josette Fontaine, Adeline Barthelemy, Christophe Paget, Elodie Macho Fernandez, Fany Blanc, Carl de Trez, Laurye van Maele, Laure Dumoutier, Michel-René Huerre, Gérard Eberl, Mustapha Si-Tahar, Pierre Gosset, Jean Christophe Renauld, Jean Claude Sirard, Christelle Faveeuw, François Trottein
Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.
Journal of Virology, 2013, 87 (12), pp.6911-24. ⟨10.1128/JVI.02943-12⟩
Jean-Philippe Corre, Alejandro Piris-Gimenez, Marie Moya-Nilges, Gregory Jouvion, Agnes Fouet, Ian J. Glomski, Michèle Mock, Jean-Claude Sirard, Pierre L. Goossens
In vivo germination of Bacillus anthracis spores during murine cutaneous infection.
Journal of Infectious Diseases, 2013, 207 (3), pp.450-7. ⟨10.1093/infdis/jis686⟩
Maria L. Knudsen, Daniel X. Johansson, Linda Kostic, Eva K. L. Nordström, Karin Tegerstedt, Anna Pasetto, Steven E. Applequist, Karl Ljungberg, Jean-Claude Sirard, Peter Liljeström
The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.
PLoS ONE, 2013, 8 (6), pp.e65964. ⟨10.1371/journal.pone.0065964⟩
Boas Felmy, Pascal Songhet, Emma Marie Caroline Slack, Andreas J. Müller, Marcus Kremer, Laurye van Maele, Delphine Cayet, Mathias Heikenwalder, Jean-Claude Sirard, Wolf-Dietrich Hardt
NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.
PLoS ONE, 2013, 8 (10), pp.e77204. ⟨10.1371/journal.pone.0077204⟩
Martina Crispo, Laurye van Maele, Julien Tabareau, Delphine Cayet, Agustina Errea, Ana María Ferreira, Martin Rumbo, Jean Claude Sirard
Transgenic mouse model harboring the transcriptional fusion ccl20-luciferase as a novel reporter of pro-inflammatory response.
PLoS ONE, 2013, 8 (11), pp.e78447. ⟨10.1371/journal.pone.0078447⟩
Stoyan Ivanov, Josette Fontaine, Christophe Paget, Elodie Macho Fernandez, Laurye van Maele, Joelle Renneson, Isabelle Maillet, Natalia Muñoz Wolf, Analia Rial, Hélène Léger, Bernhard Ryffel, Benoit Frisch, José A. Chabalgoity, Jean Claude Sirard, Arndt Benecke, Christelle Faveeuw, François Trottein
Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide.
Journal of Infectious Diseases, 2012, 206 (5), pp.723-34. ⟨10.1093/infdis/jis413⟩
Juan M. Marqués, Analía Rial, Natalia Muñoz, Francois-Xavier Pellay, Laurye van Maele, Hélène Léger, Teresa Camou, Jean-Claude Sirard, Arndt Benecke, José A. Chabalgoity
Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity.
Immunobiology, 2012, 217 (4), pp.420-9. ⟨10.1016/j.imbio.2011.10.012⟩
Laure Dumoutier, Magali de Heusch, Ciriana Orabona, Naoko Satoh-Takayama, Gerard Eberl, Jean-Claude Sirard, James P. Di Santo, Jean-Christophe Renauld
IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality.
European Journal of Immunology, 2011, 41 (4), pp.1075-85. ⟨10.1002/eji.201040878⟩
Natalia Munoz, Laurye van Maele, Juan Marqués, Analia Rial, Jean-Claude Sirard, Jose Alejandro Chabalgoity
Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection.
Infection and Immunity, 2010, 78 (10), pp.4226-4233. ⟨10.1128/IAI.00224-10⟩
Laurye van Maele, Christophe Carnoy, Delphine Cayet, Pascal Songhet, Laure Dumoutier, Isabel Ferrero, Laure Janot, François Erard, Julie Bertout, Hélène Leger, Florent Sebbane, Arndt Benecke, Jean-Christophe Renauld, Wolf-Dietrich Hardt, Bernhard Ryffel, Jean-Claude Sirard
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.
Journal of Immunology, 2010, 185 (2), pp.1177-85. ⟨10.4049/jimmunol.1000115⟩
Céline Beauvillain, Francesca Meloni, Jean-Claude Sirard, Simon Blanchard, Ulrich Jarry, Mari Scotet, Giovanni Magistrelli, Yves Delneste, Vincenzo Barnaba, Pascale Jeannin
The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells
Journal of Hepatology, 2010, 52 (5), pp.644-51. ⟨10.1016/j.jhep.2009.11.031⟩
Kathrin Endt, Bärbel Stecher, Samuel Chaffron, Emma Slack, Nicolas Tchitchek, Arndt Benecke, Laurye van Maele, Jean-Claude Sirard, Andreas J. Mueller, Mathias Heikenwalder, Andrew J. Macpherson, Richard Strugnell, Christian von Mering, Wolf-Dietrich Hardt
The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea.
PLoS Pathogens, 2010, 6 (9), pp.e1001097. ⟨10.1371/journal.ppat.1001097⟩
Pascal Songhet, Manja Barthel, Till A Röhn, Laurye van Maele, Delphine Cayet, Jean-Claude Sirard, Martin Bachmann, Manfred Kopf, Wolf-Dietrich Hardt
IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium.
PLoS ONE, 2010, 5 (11), pp.e13804. ⟨10.1371/journal.pone.0013804⟩
Laure Janot, Jean-Claude Sirard, Thomas Secher, Nicolas Noulin, Lizette Fick, Shizuo Akira, Satoshi Uematsu, Arnaud Didierlaurent, Tracy Hussell, Bernhard Ryffel, François Erard
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
European Journal of Immunology, 2009, 39 (6), pp.1587-96. ⟨10.1002/eji.200838907⟩
Jean-Claude Sirard, Arnaud Didierlaurent, Delphine Cayet, Frédéric Sierro, Martin Rumbo
Toll-like receptor 5- and lymphotoxin beta receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics.
Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1789 (5), pp.386-94. ⟨10.1016/j.bbagrm.2009.03.001⟩
Clément Nempont, Delphine Cayet, Martin Rumbo, Coralie Bompard, Vincent Villeret, Jean-Claude Sirard
Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.
Journal of Immunology, 2008, 181 (3), pp.2036-2043. ⟨10.4049/jimmunol.181.3.2036⟩
Arnaud Didierlaurent, John Goulding, Seema Patel, Robert Snelgrove, Lionel Low, Magali Bebien, Toby Lawrence, Leonie S. van Rijt, Bart N. Lambrecht, Jean-Claude Sirard, Tracy Hussell
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.
Journal of Experimental Medicine, 2008, 205 (2), pp.323-9. ⟨10.1084/jem.20070891⟩
Jean-Claude Sirard, Cécile Vignal, Rodrigue Dessein, Mathias Chamaillard
Nod-like receptors: cytosolic watchdogs for immunity against pathogens.
PLoS Pathogens, 2007, 3 (12), pp.e152. ⟨10.1371/journal.ppat.0030152⟩
Aizhen Guo, Melissa A. Lasaro, Jean-Claude Sirard, Jean-Pierre Kraehenbuhl, Dieter M. Schifferli
Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells.
Microbiology, 2007, 153 (Pt 4), pp.1059-69. ⟨10.1099/mic.0.2006/000331-0⟩
Benoit Foligne, Georgia Zoumpopoulou, Joelle Dewulf, Amena Ben Younes, Fabrice Chareyre, Jean-Claude Sirard, Bruno Pot, Corinne Grangette
A key role of dendritic cells in probiotic functionality.
PLoS ONE, 2007, 2 (3), pp.e313. ⟨10.1371/journal.pone.0000313⟩
Rachel A. Luu, Komal Gurnani, Renu Dudani, Rajagopal Kammara, Henk van Faassen, Jean-Claude Sirard, Lakshmi Krishnan, Subash Sad
Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.
Journal of Immunology, 2006, 177 (3), pp.1516-1525. ⟨10.4049/jimmunol.177.3.1516⟩
Martin Rumbo, Clément Nempont, Jean-Pierre Kraehenbuhl, Jean-Claude Sirard
Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5.
FEBS Letters, 2006, 580 (12), pp.2976-84. ⟨10.1016/j.febslet.2006.04.036⟩
Jean-Claude Sirard, Mariela Bayardo, Arnaud Didierlaurent
Pathogen-specific TLR signaling in mucosa: mutual contribution of microbial TLR agonists and virulence factors.
European Journal of Immunology, 2006, 36, pp.260-3. ⟨10.1002/eji.200535777⟩
Arnaud Didierlaurent, Brian Brissoni, Dominique Velin, Natalia Aebi, Aubry Tardivel, Edgar Käslin, Jean Claude Sirard, Georgi S. Angelov, Jürg Tschopp, Kimberly Burns
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.
Molecular and Cellular Biology, 2006, 26, pp.735-42. ⟨10.1128/MCB.26.3.735-742.2006⟩
Marie Le Borgne, Nathalie Etchart, Anne Goubier, Sergio A. Lira, Jean Claude Sirard, Nico van Rooijen, Christophe Caux, Smina Aït-Yahia, Alain Vicari, Dominique Kaiserlian, Bertrand Dubois
Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.
Immunity, 2006, 24, pp.191-201. ⟨10.1016/j.immuni.2006.01.005⟩
Arnaud Didierlaurent, Michel Simonet, Jean-Claude Sirard
Innate and acquired plasticity of the intestinal immune system.
Cellular and Molecular Life Sciences, 2005, 62 (12), pp.1285-7. ⟨10.1007/s00018-005-5032-4⟩
Martin Rumbo, Françoise Courjault-Gautier, Frédéric Sierro, Jean-Claude Sirard, Emanuela Felley-Bosco
Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells.
FEBS Journal, 2005, 272 (2), pp.444-53. ⟨10.1111/j.1742-4658.2004.04484.x⟩
Martin Rumbo, Pascale Anderle, Arnaud Didierlaurent, Frédéric Sierro, Nathalie Debard, Jean-Claude Sirard, Daniela Finke, Jean-Pierre Kraehenbuhl
How the gut links innate and adaptive immunity.
Annals of the New York Academy of Sciences, 2004, 1029, pp.16-21. ⟨10.1196/annals.1309.003⟩
Hugo Cruz Ramos, Martin Rumbo, Jean-Claude Sirard
Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa.
Trends Microbiol, 2004, 12 (11), pp.509-17. ⟨10.1016/j.tim.2004.09.002⟩
Marta Marchetti, Jean Claude Sirard, Philippe Sansonetti, Eric Pringault, Sophie Kerneis
Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo
Microbes and Infection, 2004, 6 (6), pp.521-528. ⟨10.1016/j.micinf.2004.02.009⟩
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