My research career is characterized by a shift in my interests from atomic physics to systemic biology and medical research, by an extension of my analysis tools which, initially purely theoretical, now include experimental components, by openness to applied research, whether industrial or medical. The pivotal years of these developments are 2006 with the transition to systemic biology activities and 2014 with the transition to experimental and applied activities. This research journey is reflected in my teaching career which, starting from a specialization in mathematics and mechanics, is oriented towards teaching experimental sciences and technological tools for health. The practice of research in an interdisciplinary context, mixing diverse profiles: theoreticians and experimenters, physicists and biologists, finds are echoed in the attraction for differentiated pedagogies centered on group work and problem-based learning.

I obtained a doctorate from the University of Lille in December 2004 with very honorable mention following the defense of my thesis concerning quantum dynamics in light potentials under the supervision of JC Garreau and V Zehnlé (PhLAM UMR 8523 laboratory). These theoretical results in the thematic of atoms cooled by Laser allowed me to develop strong skills of mathematical and numerical analysis.. Following my doctorate, I worked for a year at the Free University of Brussels, in the Department of Theoretical Nonlinear Optics, as a full-time researcher. In collaboration with Paul Mandel, I worked on theoretical proposals for the realization of "left-handed" materials using quantum coherences.

Motivated by the emergence of systemic biology as a new field of research, and attracted by teaching, I then joined the PhLAM laboratory of the University of Lille 1 as a Temporary Research Attaché (ATER) then Lecturer (Oct. 2006) to collaborate with Marc Lefranc who was setting up a new research activity concerning the modeling of circadian clocks. Together, we have thus proposed a detailed modeling of the circadian clock of a new single-celled organism which will become a reference model in Biology: the micro alga ostreococcus tauri. This work, at the crossroads of biology and nonlinear dynamics, gave rise to seven articles.

Since 2014, my research activities have focused on two themes. A first activity, biology-health oriented, concerns the response of human cells to stresses which are defined as a harmful modification of the cellular environment. The goal is to understand and predict cell adaptation and mortality. These studies are carried out by experimental (which I coordinate) and theoretical (which I carry out) investigations. The prediction of cell death, allowing the precise definition of the lethal dose, is an important issue in anti-cancer therapies. The specificity of our approach lies in the description of the heterogeneity of the population. The second activity, technology-health oriented, concerns optofluidics, combining optics and microfluidics to act selectively on living cells. This theme was initiated by an industrial research project with a biotechnology company. It was then reinforced by participation in a European project (ERC nanobubble 2015-2020) concerning high-speed photoporation in a microfluidic device (a thesis in progress M Layachi). My involvement in these activities concerns, research strategy, writing publications and activity reports, planning experiences, modeling, image analysis, supervision of students and post-docs.