Publications

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France, Patent n° : EP23306103. 2023. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-04542066\">⟨inserm-04542066⟩</a>", "title_s":["NOVEL PYRAZOLE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS"], "authFullName_s":["Xavier Thuru", "Frédérique Klupsch", "Christian Bailly", "Régis Millet", "Raphael Le Biannic", "Bruno Quesnel"], "halId_s":"inserm-04542066", "docType_s":"PATENT", "producedDateY_i":2023}, { "citationRef_s":"Molecules, 2023, 28 (8), pp.3491. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/molecules28083491\">⟨10.3390/molecules28083491⟩</a>", "citationFull_s":"Romain Regnault, Frédérique Klupsch, Hassiba El-Bouazzati, Romain Magnez, Raphaël Le Biannic, et al.. Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties. Molecules, 2023, 28 (8), pp.3491. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/molecules28083491\">⟨10.3390/molecules28083491⟩</a>. <a target=\"_blank\" href=\"https://hal.univ-lille.fr/hal-04139041\">⟨hal-04139041⟩</a>", "title_s":["Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties"], "authFullName_s":["Romain Regnault", "Frédérique Klupsch", "Hassiba El-Bouazzati", "Romain Magnez", "Raphaël Le Biannic", "Natascha Leleu-Chavain", "Hania Ahouari", "Herve Vezin", "Régis Millet", "Jean-François Goossens", "Xavier Thuru", "Christian Bailly"], "halId_s":"hal-04139041", "docType_s":"ART", "producedDateY_i":2023}, { "citationRef_s":"Biochemical Pharmacology, 2023, 209, pp.115445. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.bcp.2023.115445\">⟨10.1016/j.bcp.2023.115445⟩</a>", "citationFull_s":"Christian Bailly, Xavier Thuru, Laurence Goossens, Jean-François Goossens. Soluble TIM-3 as a biomarker of progression and therapeutic response in cancers and other of human diseases. Biochemical Pharmacology, 2023, 209, pp.115445. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.bcp.2023.115445\">⟨10.1016/j.bcp.2023.115445⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03990928\">⟨hal-03990928⟩</a>", "title_s":["Soluble TIM-3 as a biomarker of progression and therapeutic response in cancers and other of human diseases"], "authFullName_s":["Christian Bailly", "Xavier Thuru", "Laurence Goossens", "Jean-François Goossens"], "halId_s":"hal-03990928", "docType_s":"ART", "producedDateY_i":2023}, { "citationRef_s":"Biomedicine hub = Biomed Hub, 2023, 8 (1), pp.1-9. <a target=\"_blank\" href=\"https://dx.doi.org/10.1159/000528499\">⟨10.1159/000528499⟩</a>", "citationFull_s":"Xavier Thuru, Romain Magnez, Gérard Vergoten, Christian Bailly. A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition. Biomedicine hub = Biomed Hub, 2023, 8 (1), pp.1-9. <a target=\"_blank\" href=\"https://dx.doi.org/10.1159/000528499\">⟨10.1159/000528499⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-03990317\">⟨inserm-03990317⟩</a>", "title_s":["A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition"], "authFullName_s":["Xavier Thuru", "Romain Magnez", "Gérard Vergoten", "Christian Bailly"], "halId_s":"inserm-03990317", "docType_s":"ART", "producedDateY_i":2023}, { "citationRef_s":"Cancers, 2022, 14 (14), pp.3368. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cancers14143368\">⟨10.3390/cancers14143368⟩</a>", "citationFull_s":"Xavier Thuru, Romain Magnez, Hassiba El-Bouazzati, Gérard Vergoten, Bruno Quesnel, et al.. Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors. Cancers, 2022, 14 (14), pp.3368. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cancers14143368\">⟨10.3390/cancers14143368⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03857329\">⟨hal-03857329⟩</a>", "title_s":["Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors"], "authFullName_s":["Xavier Thuru", "Romain Magnez", "Hassiba El-Bouazzati", "Gérard Vergoten", "Bruno Quesnel", "Christian Bailly"], "halId_s":"hal-03857329", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"European Journal of Medicinal Chemistry, 2022, 236, pp.114343. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2022.114343\">⟨10.1016/j.ejmech.2022.114343⟩</a>", "citationFull_s":"Raphaël Le Biannic, Romain Magnez, Frédérique Klupsch, Natascha Leleu-Chavain, Bryan Thiroux, et al.. Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction. European Journal of Medicinal Chemistry, 2022, 236, pp.114343. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2022.114343\">⟨10.1016/j.ejmech.2022.114343⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03641793\">⟨hal-03641793⟩</a>", "title_s":["Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction"], "authFullName_s":["Raphaël Le Biannic", "Romain Magnez", "Frédérique Klupsch", "Natascha Leleu-Chavain", "Bryan Thiroux", "Morgane Tardy", "Hassiba El Bouazzati", "Xavier Dezitter", "Nicolas Renault", "Gérard Vergoten", "Christian Bailly", "Bruno Quesnel", "Xavier Thuru", "Régis Millet"], "halId_s":"hal-03641793", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"Molecules, 2022, Molecules, 27 (10), pp.3316. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/molecules27103316\">⟨10.3390/molecules27103316⟩</a>", "citationFull_s":"Natascha Leleu, Romain Regnault, Hania Ahouari, Raphael Le Biannic, Mostafa Kouach, et al.. Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents. Molecules, 2022, Molecules, 27 (10), pp.3316. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/molecules27103316\">⟨10.3390/molecules27103316⟩</a>. <a target=\"_blank\" href=\"https://hal.univ-lille.fr/hal-03714935\">⟨hal-03714935⟩</a>", "title_s":["Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents"], "authFullName_s":["Natascha Leleu", "Romain Regnault", "Hania Ahouari", "Raphael Le Biannic", "Mostafa Kouach", "Frederique Klupsch", "Romain Magnez", "Herve Vezin", "Xavier Thuru", "Christian Bailly", "Jean-Francois Goossens", "Régis Millet"], "halId_s":"hal-03714935", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"SEPARATION SCIENCE PLUS, 2022, SEPARATION SCIENCE PLUS, <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/sscp.202200031\">⟨10.1002/sscp.202200031⟩</a>", "citationFull_s":"Romain Regnault, Mostafa Kouach, Laurence Goossens, Xavier Thuru, Christian Bailly, et al.. Mono- and bis-edaravone adducts formed in the presence of vanillin in an aqueous solution. SEPARATION SCIENCE PLUS, 2022, SEPARATION SCIENCE PLUS, <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/sscp.202200031\">⟨10.1002/sscp.202200031⟩</a>. <a target=\"_blank\" href=\"https://hal.univ-lille.fr/hal-04201660\">⟨hal-04201660⟩</a>", "title_s":["Mono- and bis-edaravone adducts formed in the presence of vanillin in an aqueous solution"], "authFullName_s":["Romain Regnault", "Mostafa Kouach", "Laurence Goossens", "Xavier Thuru", "Christian Bailly", "Jean-Francois Goossens"], "halId_s":"hal-04201660", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"Cells, 2022, 11 (6), pp.1018. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cells11061018\">⟨10.3390/cells11061018⟩</a>", "citationFull_s":"Antoine Marchand, Alessia Sarchione, Panagiotis Athanasopoulos, Hélène Bauderlique-Le Roy, Liesel Goveas, et al.. A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively. Cells, 2022, 11 (6), pp.1018. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cells11061018\">⟨10.3390/cells11061018⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-03625821\">⟨inserm-03625821⟩</a>", "title_s":["A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively"], "authFullName_s":["Antoine Marchand", "Alessia Sarchione", "Panagiotis Athanasopoulos", "Hélène Bauderlique-Le Roy", "Liesel Goveas", "Romain Magnez", "Matthieu Drouyer", "Marco Emanuele", "Franz Ho", "Maxime Liberelle", "Patricia Melnyk", "Nicolas Lebègue", "Xavier Thuru", "R. Jeremy Nichols", "Elisa Greggio", "Arjan Kortholt", "Thierry Galli", "Marie-Christine Chartier-Harlin", "Jean-Marc Taymans"], "halId_s":"inserm-03625821", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"International Journal of Molecular Sciences, 2022, 23 (14), pp.7672. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ijms23147672\">⟨10.3390/ijms23147672⟩</a>", "citationFull_s":"Romain Magnez, Christian Bailly, Xavier Thuru. Microscale Thermophoresis as a Tool to Study Protein Interactions and Their Implication in Human Diseases. International Journal of Molecular Sciences, 2022, 23 (14), pp.7672. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ijms23147672\">⟨10.3390/ijms23147672⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03857337\">⟨hal-03857337⟩</a>", "title_s":["Microscale Thermophoresis as a Tool to Study Protein Interactions and Their Implication in Human Diseases"], "authFullName_s":["Romain Magnez", "Christian Bailly", "Xavier Thuru"], "halId_s":"hal-03857337", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"Science Immunology, 2022, 7 (78), pp.ade5686. <a target=\"_blank\" href=\"https://dx.doi.org/10.1126/sciimmunol.ade5686\">⟨10.1126/sciimmunol.ade5686⟩</a>", "citationFull_s":"Silvia Gaggero, Jonathan Martinez-Fabregas, Adeline Cozzani, Paul Fyfe, Malo Leprohon, et al.. IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Science Immunology, 2022, 7 (78), pp.ade5686. <a target=\"_blank\" href=\"https://dx.doi.org/10.1126/sciimmunol.ade5686\">⟨10.1126/sciimmunol.ade5686⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04276595\">⟨hal-04276595⟩</a>", "title_s":["IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein"], "authFullName_s":["Silvia Gaggero", "Jonathan Martinez-Fabregas", "Adeline Cozzani", "Paul Fyfe", "Malo Leprohon", "Jie Yang", "F. Emil Thomasen", "Hauke Winkelmann", "Romain Magnez", "Alberto Conti", "Stephan Wilmes", "Elizabeth Pohler", "Manuel van Gijsel Bonnello", "Xavier Thuru", "Bruno Quesnel", "Fabrice Soncin", "Jacob Piehler", "Kresten Lindorff-Larsen", "Rahul Roychoudhuri", "Ignacio Moraga", "Suman Mitra"], "halId_s":"hal-04276595", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"Journal of Cellular Biochemistry, 2022, 123 (3), pp.543-556. <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/jcb.30198\">⟨10.1002/jcb.30198⟩</a>", "citationFull_s":"Yasmine Touil, Céline Latreche‐carton, Hassiba El Bouazzati, Anne‐lucie Nugues, Nathalie Jouy, et al.. p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics. Journal of Cellular Biochemistry, 2022, 123 (3), pp.543-556. <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/jcb.30198\">⟨10.1002/jcb.30198⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03641788\">⟨hal-03641788⟩</a>", "title_s":["p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics"], "authFullName_s":["Yasmine Touil", "Céline Latreche‐carton", "Hassiba El Bouazzati", "Anne‐lucie Nugues", "Nathalie Jouy", "Xavier Thuru", "William Laine", "Frederic Lepretre", "Martin Figeac", "Meryem Tardivel", "Jérôme Kluza", "Thierry Idziorek", "Bruno Quesnel"], "halId_s":"hal-03641788", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"Movement Disorders, 2022, <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/mds.29124\">⟨10.1002/mds.29124⟩</a>", "citationFull_s":"Ilda Coku, Eugénie Mutez, Sabiha Eddarkaoui, Sébastien Carrier, Antoine Marchand, et al.. Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.. Movement Disorders, 2022, <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/mds.29124\">⟨10.1002/mds.29124⟩</a>. <a target=\"_blank\" href=\"https://u-picardie.hal.science/hal-03703786\">⟨hal-03703786⟩</a>", "title_s":["Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease."], "authFullName_s":["Ilda Coku", "Eugénie Mutez", "Sabiha Eddarkaoui", "Sébastien Carrier", "Antoine Marchand", "Claire Deldycke", "Liesel Goveas", "Guillaume Baille", "Mélissa Tir", "Romain Magnez", "Xavier Thuru", "Gaëlle Vermeersch", "Wim Vandenberghe", "Luc Buée", "Luc Defebvre", "Bernard Sablonnière", "Marie-Christine Chartier-Harlin", "Jean-Marc Taymans", "Vincent Huin"], "halId_s":"hal-03703786", "docType_s":"ART", "producedDateY_i":2022}, { "citationRef_s":"European Journal of Medicinal Chemistry, 2021, 226, pp.113835. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2021.113835\">⟨10.1016/j.ejmech.2021.113835⟩</a>", "citationFull_s":"Manon Sturbaut, Fabrice Bailly, Mathilde Coevoet, Pasquale Sileo, Martine Pugniere, et al.. Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors. European Journal of Medicinal Chemistry, 2021, 226, pp.113835. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2021.113835\">⟨10.1016/j.ejmech.2021.113835⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03429462\">⟨hal-03429462⟩</a>", "title_s":["Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors"], "authFullName_s":["Manon Sturbaut", "Fabrice Bailly", "Mathilde Coevoet", "Pasquale Sileo", "Martine Pugniere", "Maxime Liberelle", "Romain Magnez", "Xavier Thuru", "Marie-Christine Chartier-Harlin", "Patricia Melnyk", "Muriel Gelin", "Frédéric Allemand", "Jean-François Guichou", "Philippe Cotelle"], "halId_s":"hal-03429462", "docType_s":"ART", "producedDateY_i":2021}, { "citationRef_s":"Cancers, 2021, 13 (24), pp.6365. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cancers13246365\">⟨10.3390/cancers13246365⟩</a>", "citationFull_s":"Christian Bailly, Xavier Thuru, Bruno Quesnel. Modulation of the Gal-9/TIM-3 Immune Checkpoint with α-Lactose. Does Anomery of Lactose Matter?. Cancers, 2021, 13 (24), pp.6365. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cancers13246365\">⟨10.3390/cancers13246365⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03641796\">⟨hal-03641796⟩</a>", "title_s":["Modulation of the Gal-9/TIM-3 Immune Checkpoint with α-Lactose. Does Anomery of Lactose Matter?"], "authFullName_s":["Christian Bailly", "Xavier Thuru", "Bruno Quesnel"], "halId_s":"hal-03641796", "docType_s":"ART", "producedDateY_i":2021}, { "citationRef_s":"Frontiers in Cell and Developmental Biology, 2021, 9, pp.740550. <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fcell.2021.740550\">⟨10.3389/fcell.2021.740550⟩</a>", "citationFull_s":"Thomas Rico, Melissa Gilles, Alban Chauderlier, Thomas Comptdaer, Romain Magnez, et al.. Tau Stabilizes Chromatin Compaction. 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Free Radical Biology and Medicine, 2021, 171, pp.1-10. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.freeradbiomed.2021.05.002\">⟨10.1016/j.freeradbiomed.2021.05.002⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03226670\">⟨hal-03226670⟩</a>", "title_s":["Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin"], "authFullName_s":["Jean-François Goossens", "Xavier Thuru", "Christian Bailly"], "halId_s":"hal-03226670", "docType_s":"ART", "producedDateY_i":2021}, { "citationRef_s":"France, Patent n° : WO2021009384. 2021", "citationFull_s":"Xavier Thuru, Bruno Quesnel, Romain Magnez, Régis Millet, Natascha Leleu-Chavain, et al.. NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS. France, Patent n° : WO2021009384. 2021. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-04542080\">⟨inserm-04542080⟩</a>", "title_s":["NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS"], "authFullName_s":["Xavier Thuru", "Bruno Quesnel", "Romain Magnez", "Régis Millet", "Natascha Leleu-Chavain", "Frédérique Klupsch"], "halId_s":"inserm-04542080", "docType_s":"PATENT", "producedDateY_i":2021}, { "citationRef_s":"France, Patent n° : WO2021009384 (A1). 2021", "citationFull_s":"Xavier Thuru, Bruno Quesnel, Magnez Romain, Régis Millet, Natascha Leleu-Chavain, et al.. NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS. France, Patent n° : WO2021009384 (A1). 2021. <a target=\"_blank\" href=\"https://hal.science/hal-03857440\">⟨hal-03857440⟩</a>", "title_s":["NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS"], "authFullName_s":["Xavier Thuru", "Bruno Quesnel", "Magnez Romain", "Régis Millet", "Natascha Leleu-Chavain", "Frédérique Klupsch"], "halId_s":"hal-03857440", "docType_s":"PATENT", "producedDateY_i":2021}, { "citationRef_s":"Cancers, 2021, 13 (12), pp.3034. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cancers13123034\">⟨10.3390/cancers13123034⟩</a>", "citationFull_s":"Christian Bailly, Xavier Thuru, Bruno Quesnel. Soluble Programmed Death Ligand-1 (sPD-L1): A Pool of Circulating Proteins Implicated in Health and Diseases. 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