Patricia Melnyk
Professeure des universités
CNU : SECTION 85 - SCIENCES PHYSICO-CHIMIQUES ET INGÉNIERIE APPLIQUÉE À LA SANTÉ
Laboratoire / équipe
Publications
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"citationFull_s":"Margaux Morez, Antonio Jesus Lara Ordonez, Patricia Melnyk, Maxime Liberelle, Nicolas Lebegue, et al.. Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson's disease: a patent review of the literature to date.. <i>Expert Opinion on Therapeutic Patents</i>, 2024, Expert Opinion on Therapeutic Patents, 34 (9), pp.1-16. <a target=\"_blank\" href=\"https://dx.doi.org/10.1080/13543776.2024.2378076\">⟨10.1080/13543776.2024.2378076⟩</a>. <a target=\"_blank\" href=\"https://hal.univ-lille.fr/hal-04792985v1\">⟨hal-04792985⟩</a>",
"title_s":["Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson's disease: a patent review of the literature to date."],
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"citationFull_s":"Isabelle Van Seuningen, Nicolas Stoup, Maxime Liberelle, Leila Moum, Nicolas Renault, et al.. Discovery of the first peptide ligand targeting the EGF2 domain of MUC4 that rescues accessibility and sensitivity of pancreatic cancer cells to Herceptin targeted therapy. <i>XXXVIIèmes Journées Scientifiques Annuelles du Club Français du Pancréas (CFP)</i>, Club Français du Pancréas; La Cité des Échanges, Marcq-en-Barœul, Sep 2023, Lille, France. <a target=\"_blank\" href=\"https://hal.science/hal-04547238v1\">⟨hal-04547238⟩</a>",
"title_s":["Discovery of the first peptide ligand targeting the EGF2 domain of MUC4 that rescues accessibility and sensitivity of pancreatic cancer cells to Herceptin targeted therapy"],
"authFullName_s":["Isabelle Van Seuningen","Nicolas Stoup","Maxime Liberelle","Leila Moum","Nicolas Renault","Thomas Meynard","Patricia Melnyk","Nicolas Jonckheere","Nicolas Lebègue"],
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"citationFull_s":"Pasquale Sileo, Clémence Simonin, Patricia Melnyk, Marie-Christine Chartier-Harlin, Philippe Cotelle. Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders. <i>Cells</i>, 2022, 11 (22), pp.3631. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cells11223631\">⟨10.3390/cells11223631⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04345657v1\">⟨hal-04345657⟩</a>",
"title_s":["Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders"],
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"citationFull_s":"Christophe Mesangeau, Pascal Carato, Nicolas Renault, Mathilde Coevoet, Paul-Emmanuel Larchanché, et al.. Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles. <i>International Journal of Molecular Sciences</i>, 2022, 23 (21), pp.13111. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ijms232113111\">⟨10.3390/ijms232113111⟩</a>. <a target=\"_blank\" href=\"https://univ-poitiers.hal.science/hal-04035715v1\">⟨hal-04035715⟩</a>",
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"citationFull_s":"Bénédicte Oxombre, Farima Madouri, Anne-Sophie Journe, Severine Ravez, Eloise Woitrain, et al.. Safe and Efficient Sigma1 Ligand: A Potential Drug Candidate for Multiple Sclerosis.. <i>International Journal of Molecular Sciences</i>, 2022, International Journal of Molecular Sciences, 23 (19), pp.11893. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ijms231911893\">⟨10.3390/ijms231911893⟩</a>. <a target=\"_blank\" href=\"https://hal.univ-lille.fr/hal-04144548v1\">⟨hal-04144548⟩</a>",
"title_s":["Safe and Efficient Sigma1 Ligand: A Potential Drug Candidate for Multiple Sclerosis."],
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"authFullName_s":["Romain Marteau","Severine Ravez","Darius Mazhari Dorooee","Hind Bouchaoui","Karine Porte","Jean-Christophe Devedjian","Patricia Melnyk","Raphaël Frederick","Jamal El Bakali"],
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"authFullName_s":["Raphaël Bolteau","Romain Duroux","Amelie Laversin","Brandon Vreulz","Anna Shiriaeva","Benjamin Stauch","Gye Won Han","Vadim Cherezov","Nicolas Renault","Amélie Barczyk","Severine Ravez","Mathilde Coevoet","Patricia Melnyk","Maxime Liberelle","Said Yous"],
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"citationFull_s":"Benjamin Zagiel, Patricia Melnyk, Philippe Cotelle. Progress with YAP/TAZ-TEAD inhibitors: a patent review (2018-present). <i>Expert Opinion on Therapeutic Patents</i>, 2022, 32 (8), pp.899-912. <a target=\"_blank\" href=\"https://dx.doi.org/10.1080/13543776.2022.2096436\">⟨10.1080/13543776.2022.2096436⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04478432v1\">⟨hal-04478432⟩</a>",
"title_s":["Progress with YAP/TAZ-TEAD inhibitors: a patent review (2018-present)"],
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"authFullName_s":["Sylvain Marc","Christophe Mésangeau","Mathilde Coevoet","Amélie Barczyk","Stéphane Burlet","Philippe Verwaerde","Cecilia Estrella","Cyrille Brantis","Nicolas Sergeant","Pascal Carato","Patricia Melnyk"],
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"citationFull_s":"Manon Sturbaut, Fabrice Bailly, Mathilde Coevoet, Pasquale Sileo, Martine Pugniere, et al.. Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors. <i>European Journal of Medicinal Chemistry</i>, 2021, 226, pp.113835. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2021.113835\">⟨10.1016/j.ejmech.2021.113835⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03429462v1\">⟨hal-03429462⟩</a>",
"title_s":["Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors"],
"authFullName_s":["Manon Sturbaut","Fabrice Bailly","Mathilde Coevoet","Pasquale Sileo","Martine Pugniere","Maxime Liberelle","Romain Magnez","Xavier Thuru","Marie-Christine Chartier-Harlin","Patricia Melnyk","Muriel Gelin","Frédéric Allemand","Jean-François Guichou","Philippe Cotelle"],
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"citationFull_s":"Floriane Gibault, Manon Sturbaut, Mathilde Coevoet, Martine Pugnière, Ashley Burtscher, et al.. Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex. <i>ChemMedChem</i>, 2021, 16 (18), pp.2823-2844. <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/cmdc.202100153\">⟨10.1002/cmdc.202100153⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04481612v1\">⟨hal-04481612⟩</a>",
"title_s":["Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex"],
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"citationFull_s":"Marie Tautou, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanché, Jamal El Bakali, et al.. A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration. <i>Frontiers in Pharmacology</i>, 2021, 12, pp.679335. <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fphar.2021.679335\">⟨10.3389/fphar.2021.679335⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-03366685v1\">⟨inserm-03366685⟩</a>",
"title_s":["A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration"],
"authFullName_s":["Marie Tautou","Sabiha Eddarkaoui","Florian Descamps","Paul-Emmanuel Larchanché","Jamal El Bakali","Liesel Mary Goveas","Mélanie Dumoulin","Chloé Lamarre","David Blum","Luc Buée","Patricia Melnyk","Nicolas Sergeant"],
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"title_s":["A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration"],
"authFullName_s":["Marie Tautou","Sabiha Eddarkaoui","Florian Descamps","Paul-Emmanuel Larchanché","Mélanie Dumoulin","Chloé Lamarre","David Blum","Luc Buée","Patricia Melnyk","Nicolas Sergeant"],
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"citationRef_s":"<i>Cancers</i>, 2021, 13 (22), pp.5746. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cancers13225746\">⟨10.3390/cancers13225746⟩</a>",
"citationFull_s":"Nicolas Stoup, Maxime Liberelle, Céline Schulz, Sumeyye Cavdarli, Romain Vasseur, et al.. The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis. <i>Cancers</i>, 2021, 13 (22), pp.5746. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/cancers13225746\">⟨10.3390/cancers13225746⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03641795v1\">⟨hal-03641795⟩</a>",
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