Pascal Mariot
Maître de conférences-HDR
CNU : SECTION 66 - PHYSIOLOGIE
Laboratoire / équipe
Publications
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"citationFull_s":"Anna Kobzar, Nathan Schoonjans, Pascal Mariot, Valerio Farfariello, David Delcroix, et al.. Development of a next-generation bidirectional neurobiohybrid interface with optimized energy efficiency enabling real-time adaptive neuromodulation. <i>Forum Fédération Européenne des Sociétés des Neurosciences, FENS 2024, J.6: Neuromorphic engineering</i>, Jun 2024, Vienne, Austria. <a target=\"_blank\" href=\"https://hal.science/hal-04690305v1\">⟨hal-04690305⟩</a>",
"title_s":["Development of a next-generation bidirectional neurobiohybrid interface with optimized energy efficiency enabling real-time adaptive neuromodulation"],
"authFullName_s":["Anna Kobzar","Nathan Schoonjans","Pascal Mariot","Valerio Farfariello","David Delcroix","Redha Kassi","A. Cappy","Alexis Vlandas","Virginie Hoel","Christel Vanbesien"],
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"citationRef_s":"<i>Physical Review Fluids</i>, 2024, 9 (8), pp.084301. <a target=\"_blank\" href=\"https://dx.doi.org/10.1103/physrevfluids.9.084301\">⟨10.1103/physrevfluids.9.084301⟩</a>",
"citationFull_s":"Anna Ipatova, Alexis Duchesne, H N Yoshikawa, Pascal Mariot, Corenthin Leroy, et al.. Retention or repulsion forces induced by bubbles trapped at the base of an immersed microparticle on a substrate. <i>Physical Review Fluids</i>, 2024, 9 (8), pp.084301. <a target=\"_blank\" href=\"https://dx.doi.org/10.1103/physrevfluids.9.084301\">⟨10.1103/physrevfluids.9.084301⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04673009v1\">⟨hal-04673009⟩</a>",
"title_s":["Retention or repulsion forces induced by bubbles trapped at the base of an immersed microparticle on a substrate"],
"authFullName_s":["Anna Ipatova","Alexis Duchesne","H N Yoshikawa","Pascal Mariot","Corenthin Leroy","Christine Faille","Ichiro Ueno","Georg F Dietze","Farzam Zoueshtiagh"],
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"citationRef_s":"<i>EMBO Journal</i>, In press, 42 (13), pp.e112198. <a target=\"_blank\" href=\"https://dx.doi.org/10.15252/embj.2022112198\">⟨10.15252/embj.2022112198⟩</a>",
"citationFull_s":"Antoine Folcher, Dmitri Gordienko, Oksana Iamshanova, Alexandre Bokhobza, George Shapovalov, et al.. NALCN ‐mediated sodium influx confers metastatic prostate cancer cell invasiveness. <i>EMBO Journal</i>, In press, 42 (13), pp.e112198. <a target=\"_blank\" href=\"https://dx.doi.org/10.15252/embj.2022112198\">⟨10.15252/embj.2022112198⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04122134v1\">⟨hal-04122134⟩</a>",
"title_s":["NALCN ‐mediated sodium influx confers metastatic prostate cancer cell invasiveness"],
"authFullName_s":["Antoine Folcher","Dmitri Gordienko","Oksana Iamshanova","Alexandre Bokhobza","George Shapovalov","Dheeraj Kannancheri-Puthooru","Pascal Mariot","Laurent Allart","Emilie Desruelles","Corentin Spriet","Raquel Diez","Thibauld Oullier","Séverine Marionneau-Lambot","Lucie Brisson","Sandra Geraci","Hathaichanok Impheng","V'Yacheslav Lehen'Kyi","Aurélien Haustrate","Adriana Mihalache","Pierre Gosset","Stéphanie Chadet","Stéphanie Retif","Maryline Laube","Julien Sobilo","Stéphanie Lerondel","Giulia Villari","Guido Serini","Alessandra Fiorio Pla","Sébastien Roger","Gaelle Fromont-Hankard","Mustafa Djamgoz","Philippe Clezardin","Arnaud Monteil","Natalia Prevarskaya"],
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"citationFull_s":"Nathan Schoonjans, Virginie Hoel, Dimitri Henniquau, Vanessa Avramovic, Mohamed Lamine Fayçal Bellaredj, et al.. Communicating with living neurons using a next-generation bidirectional neurobiohybrid interface with optimized energy efficiency. <i>Neurofrance 2023</i>, May 2023, Lyon, France. <a target=\"_blank\" href=\"https://hal.science/hal-04119733v1\">⟨hal-04119733⟩</a>",
"title_s":["Communicating with living neurons using a next-generation bidirectional neurobiohybrid interface with optimized energy efficiency","Communiquer avec des neurones vivants avec une interface neurobiohybride bidirectionnelle de nouvelle génération avec une efficacité énergétique optimisée"],
"authFullName_s":["Nathan Schoonjans","Virginie Hoel","Dimitri Henniquau","Vanessa Avramovic","Mohamed Lamine Fayçal Bellaredj","Pascal Mariot","Valerio Farfariello","David Delcroix","Rédha Kassi","A. Cappy","Alexis Vlandas","Christel Vanbesien"],
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"citationFull_s":"Nathan Schoonjans, Virginie Hoel, Dimitri Henniquau, Vanessa Avramovic, Mohamed Bellaredj, et al.. Challenges in developping a bidirectional neurobiohybrid system based on an original artificial neuron with optimized energy efficiency. <i>Nature conferences : Technologies for Neuroengineering 2022</i>, Oct 2022, Virtual event, France. <a target=\"_blank\" href=\"https://hal.science/hal-03850841v1\">⟨hal-03850841⟩</a>",
"title_s":["Challenges in developping a bidirectional neurobiohybrid system based on an original artificial neuron with optimized energy efficiency"],
"authFullName_s":["Nathan Schoonjans","Virginie Hoel","Dimitri Henniquau","Vanessa Avramovic","Mohamed Bellaredj","Pascal Mariot","Valerio Farfariello","David Delcroix","Rédha Kassi","Alexis Vlandas","Christel Vanbesien"],
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"citationRef_s":"<i>IEEE Lille Engineering for Medicine and Biology Conference</i>, Apr 2022, Lille, France",
"citationFull_s":"Nathan Schoonjans, Virginie Hoel, Dimitri Henniquau, Vanessa Avramovic, Mohamed Bellaredj, et al.. Interfacing artificial and biological neurons: first step towards the development of autonomous implantable neurobiohybrid medical devices. <i>IEEE Lille Engineering for Medicine and Biology Conference</i>, Apr 2022, Lille, France. <a target=\"_blank\" href=\"https://hal.science/hal-03770329v1\">⟨hal-03770329⟩</a>",
"title_s":["Interfacing artificial and biological neurons: first step towards the development of autonomous implantable neurobiohybrid medical devices"],
"authFullName_s":["Nathan Schoonjans","Virginie Hoel","Dimitri Henniquau","Vanessa Avramovic","Mohamed Bellaredj","Pascal Mariot","Valerio Farfariello","David Delcroix","Redha Kassi","A. Cappy","Alexis Vlandas","Christel Vanbesien"],
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"citationFull_s":"Nathan Schoonjans, Virginie Hoel, Dimitri Henniquau, Vanessa Avramovic, Mohamed Bellaredj, et al.. Enabling a bidirectional communication between artificial and biological neurons using a novel neurobiohybrid interface. <i>GDR BioComp PhD Forum 2021</i>, GDR BioComp, Nov 2021, Grenoble (virtual), France. <a target=\"_blank\" href=\"https://hal.science/hal-03450052v1\">⟨hal-03450052⟩</a>",
"title_s":["Enabling a bidirectional communication between artificial and biological neurons using a novel neurobiohybrid interface"],
"authFullName_s":["Nathan Schoonjans","Virginie Hoel","Dimitri Henniquau","Vanessa Avramovic","Mohamed Bellaredj","Pascal Mariot","Valerio Farfariello","David Delcroix","Rédha Kassi","A. Cappy","Alexis Vlandas","Christel Vanbesien"],
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"citationFull_s":"Dimitri Henniquau, Nathan Schoonjans, Rédha Kassi, David Delcroix, Vanessa Avramovic, et al.. Connecter des neurones artificiels et des neurones vivants: développement d’une interface fonctionnelle. <i>GDR BioComp PhD Forum 2021</i>, GDR BioComp, Nov 2021, Grenoble (virtual), France. <a target=\"_blank\" href=\"https://hal.science/hal-03455151v1\">⟨hal-03455151⟩</a>",
"title_s":["Connecter des neurones artificiels et des neurones vivants: développement d’une interface fonctionnelle"],
"authFullName_s":["Dimitri Henniquau","Nathan Schoonjans","Rédha Kassi","David Delcroix","Vanessa Avramovic","Valerio Farfariello","Pascal Mariot","A. Cappy","Alexis Vlandas","Christel Vanbesien","Virginie Hoel"],
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"citationRef_s":"<i>International Journal of Molecular Sciences</i>, 2019, 20 (24), pp.6344. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ijms20246344\">⟨10.3390/ijms20246344⟩</a>",
"citationFull_s":"Lucile Noyer, Loic Lemonnier, Pascal Mariot, Dimitra Gkika. Partners in Crime: Towards New Ways of Targeting Calcium Channels. <i>International Journal of Molecular Sciences</i>, 2019, 20 (24), pp.6344. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ijms20246344\">⟨10.3390/ijms20246344⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04210077v1\">⟨hal-04210077⟩</a>",
"title_s":["Partners in Crime: Towards New Ways of Targeting Calcium Channels"],
"authFullName_s":["Lucile Noyer","Loic Lemonnier","Pascal Mariot","Dimitra Gkika"],
"halId_s":"hal-04210077",
"docType_s":"ART",
"producedDateY_i":2019
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"citationRef_s":"Marie-Hélène Canu; Vincent Bérézowski; Patrick Duriez; Cécile Langlet; Pascal Mariot; Olivier Pétrault. Dunod, 2018, 978-2100767083",
"citationFull_s":"Marie-Hélène Canu, Vincent Bérézowski, Patrick Duriez, Cécile Langlet, Pascal Mariot, et al.. Mémo visuel de physiologie humaine. Marie-Hélène Canu; Vincent Bérézowski; Patrick Duriez; Cécile Langlet; Pascal Mariot; Olivier Pétrault. Dunod, 2018, 978-2100767083. <a target=\"_blank\" href=\"https://hal.science/hal-04216629v1\">⟨hal-04216629⟩</a>",
"title_s":["Mémo visuel de physiologie humaine"],
"authFullName_s":["Marie-Hélène Canu","Vincent Bérézowski","Patrick Duriez","Cécile Langlet","Pascal Mariot","Olivier Petrault"],
"halId_s":"hal-04216629",
"docType_s":"OUV",
"producedDateY_i":2018
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"citationRef_s":"<i>Molecular Carcinogenesis</i>, 2017, 56 (8), pp.1851-1867. <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/mc.22642\">⟨10.1002/mc.22642⟩</a>",
"citationFull_s":"Eric Vancauwenberghe, Lucile Noyer, Sandra Derouiche, Loïc Lemonnier, Pierre Gosset, et al.. Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). <i>Molecular Carcinogenesis</i>, 2017, 56 (8), pp.1851-1867. <a target=\"_blank\" href=\"https://dx.doi.org/10.1002/mc.22642\">⟨10.1002/mc.22642⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04210362v1\">⟨hal-04210362⟩</a>",
"title_s":["Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF)"],
"authFullName_s":["Eric Vancauwenberghe","Lucile Noyer","Sandra Derouiche","Loïc Lemonnier","Pierre Gosset","Laura Sadofsky","Pascal Mariot","Marine Warnier","Alexandre Bokhobza","Christian Slomianny","Brigitte Mauroy","Jean‐louis Bonnal","Etienne Dewailly","Philippe Delcourt","Laurent Allart","Emilie Desruelles","Natalia Prevarskaya","Morad Roudbaraki"],
"halId_s":"hal-04210362",
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"citationRef_s":"<i>Cancer Prevention Research</i>, 2017, 10 (3), pp.177-187. <a target=\"_blank\" href=\"https://dx.doi.org/10.1158/1940-6207.CAPR-16-0257\">⟨10.1158/1940-6207.CAPR-16-0257⟩</a>",
"citationFull_s":"Sandra Derouiche, Pascal Mariot, Marine Warnier, Eric Vancauwenberghe, Gabriel Bidaux, et al.. Activation of TRPA1 Channel by Antibacterial Agent Triclosan Induces VEGF Secretion in Human Prostate Cancer Stromal Cells. <i>Cancer Prevention Research</i>, 2017, 10 (3), pp.177-187. <a target=\"_blank\" href=\"https://dx.doi.org/10.1158/1940-6207.CAPR-16-0257\">⟨10.1158/1940-6207.CAPR-16-0257⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03060361v1\">⟨hal-03060361⟩</a>",
"title_s":["Activation of TRPA1 Channel by Antibacterial Agent Triclosan Induces VEGF Secretion in Human Prostate Cancer Stromal Cells"],
"authFullName_s":["Sandra Derouiche","Pascal Mariot","Marine Warnier","Eric Vancauwenberghe","Gabriel Bidaux","Pierre Gosset","Brigitte Mauroy","Jean-Louis Bonnal","Christian Slomianny","Philippe Delcourt","Etienne Dewailly","Natalia Prevarskaya","Morad Roudbaraki"],
"halId_s":"hal-03060361",
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"citationFull_s":"Marine Warnier, Florian Gackiere, Morad Roudbaraki, Pascal Mariot. Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation. <i>Journal of Cell Signaling</i>, 2017, 01 (02), <a target=\"_blank\" href=\"https://dx.doi.org/10.4172/2576-1471.1000113\">⟨10.4172/2576-1471.1000113⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04216587v1\">⟨hal-04216587⟩</a>",
"title_s":["Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation"],
"authFullName_s":["Marine Warnier","Florian Gackiere","Morad Roudbaraki","Pascal Mariot"],
"halId_s":"hal-04216587",
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"citationRef_s":"<i>European Biophysics Journal</i>, 2016, 45 (7), pp.765-777. <a target=\"_blank\" href=\"https://dx.doi.org/10.1007/s00249-016-1173-7\">⟨10.1007/s00249-016-1173-7⟩</a>",
"citationFull_s":"Oksana Iamshanova, Pascal Mariot, V’yacheslav Lehen’kyi, Natalia Prevarskaya. Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines. <i>European Biophysics Journal</i>, 2016, 45 (7), pp.765-777. <a target=\"_blank\" href=\"https://dx.doi.org/10.1007/s00249-016-1173-7\">⟨10.1007/s00249-016-1173-7⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04122731v1\">⟨hal-04122731⟩</a>",
"title_s":["Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines"],
"authFullName_s":["Oksana Iamshanova","Pascal Mariot","V’yacheslav Lehen’kyi","Natalia Prevarskaya"],
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"citationFull_s":"Oksana Iamshanova, Pascal Mariot, V'Yacheslav Lehen'Kyi, Natalia Prevarskaya. Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines. <i>Springer Berlin / Heidelberg</i>, 2016, [Epub ahead of print]. <a target=\"_blank\" href=\"https://dx.doi.org/10.1007/s00249-016-1173-7\">⟨10.1007/s00249-016-1173-7⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-01375711v1\">⟨inserm-01375711⟩</a>",
"title_s":["Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines"],
"authFullName_s":["Oksana Iamshanova","Pascal Mariot","V'Yacheslav Lehen'Kyi","Natalia Prevarskaya"],
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"citationRef_s":"<i>Oncotarget</i>, 2016, 7 (20), pp.29063-29080. <a target=\"_blank\" href=\"https://dx.doi.org/10.18632/oncotarget.8666\">⟨10.18632/oncotarget.8666⟩</a>",
"citationFull_s":"Gabriel Bidaux, Anne-Sophie Borowiec, Charlotte Dubois, Philippe Delcourt, Céline Schulz, et al.. Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells. <i>Oncotarget</i>, 2016, 7 (20), pp.29063-29080. <a target=\"_blank\" href=\"https://dx.doi.org/10.18632/oncotarget.8666\">⟨10.18632/oncotarget.8666⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03060359v1\">⟨hal-03060359⟩</a>",
"title_s":["Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells"],
"authFullName_s":["Gabriel Bidaux","Anne-Sophie Borowiec","Charlotte Dubois","Philippe Delcourt","Céline Schulz","Fabien Vanden Abeele","Gilbert Lepage","Emilie Desruelles","Alexandre Bokhobza","Etienne Dewailly","Christian Slomianny","Morad Roudbaraki","Laurent Héliot","Jean-Louis Bonnal","Brigitte Mauroy","Pascal Mariot","Loïc Lemonnier","Natalia Prevarskaya"],
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"citationRef_s":"<i>RSC Advances</i>, 2016, 6 (2), pp.1600-1610. <a target=\"_blank\" href=\"https://dx.doi.org/10.1039/C5RA24662H\">⟨10.1039/C5RA24662H⟩</a>",
"citationFull_s":"Kostiantyn Turcheniuk, Tetiana Dumych, Rostyslav Bilyy, Volodymyr Turcheniuk, Julie Bouckaert, et al.. Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites. <i>RSC Advances</i>, 2016, 6 (2), pp.1600-1610. <a target=\"_blank\" href=\"https://dx.doi.org/10.1039/C5RA24662H\">⟨10.1039/C5RA24662H⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-01693288v1\">⟨hal-01693288⟩</a>",
"title_s":["Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites"],
"authFullName_s":["Kostiantyn Turcheniuk","Tetiana Dumych","Rostyslav Bilyy","Volodymyr Turcheniuk","Julie Bouckaert","Volodymyr Vovk","Valentyna Chopyak","Vladimir Zaitsev","Pascal Mariot","Natasha Prevarskaya","Rabah Boukherroub","Sabine Szunerits"],
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"citationRef_s":"Dunod, 2016, Tout en fiches, 9782100740321",
"citationFull_s":"Marie-Hélène Canu, Vincent Berezowski, Patrick Duriez, Cécile Langlet, Pascal Mariot, et al. (Dir.). Physiologie humaine - Tout le cours en fiches. Dunod, 2016, Tout en fiches, 9782100740321. <a target=\"_blank\" href=\"https://hal.univ-lorraine.fr/hal-01782848v1\">⟨hal-01782848⟩</a>",
"title_s":["Physiologie humaine - Tout le cours en fiches"],
"authFullName_s":["Marie-Hélène Canu","Vincent Berezowski","Patrick Duriez","Cécile Langlet","Pascal Mariot","Olivier Pétrault"],
"halId_s":"hal-01782848",
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"citationRef_s":"<i>Journal of Cell Signaling</i>, 2016, 01 (04), <a target=\"_blank\" href=\"https://dx.doi.org/10.4172/2576-1471.1000126\">⟨10.4172/2576-1471.1000126⟩</a>",
"citationFull_s":"Eric Vancauwenberghe, Helene Lallet Daher, Sandra Derouiche, Pascal Mariot, Pierre Gosset, et al.. Involvement of Ion Channels in Endothelin-1-induced Signalling in Human Prostate Cancer Cells. <i>Journal of Cell Signaling</i>, 2016, 01 (04), <a target=\"_blank\" href=\"https://dx.doi.org/10.4172/2576-1471.1000126\">⟨10.4172/2576-1471.1000126⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04216581v1\">⟨hal-04216581⟩</a>",
"title_s":["Involvement of Ion Channels in Endothelin-1-induced Signalling in Human Prostate Cancer Cells"],
"authFullName_s":["Eric Vancauwenberghe","Helene Lallet Daher","Sandra Derouiche","Pascal Mariot","Pierre Gosset","Philippe Delcourt","Brigitte Mauroy","Jean Louis Bonnal","Laurent Allart","Natalia Prevarskaya","Morad Roudbaraki"],
"halId_s":"hal-04216581",
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"citationRef_s":"<i>T-type Calcium Channels in Basic and Clinical Science</i>, Springer Vienna, pp.51-71, 2015, <a target=\"_blank\" href=\"https://dx.doi.org/10.1007/978-3-7091-1413-1_4\">⟨10.1007/978-3-7091-1413-1_4⟩</a>",
"citationFull_s":"Marine Warnier, Florian Gackière, Morad Roudbaraki, Pascal Mariot. Role of T-Type Calcium Channels in Neuroendocrine Differentiation. <i>T-type Calcium Channels in Basic and Clinical Science</i>, Springer Vienna, pp.51-71, 2015, <a target=\"_blank\" href=\"https://dx.doi.org/10.1007/978-3-7091-1413-1_4\">⟨10.1007/978-3-7091-1413-1_4⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04216594v1\">⟨hal-04216594⟩</a>",
"title_s":["Role of T-Type Calcium Channels in Neuroendocrine Differentiation"],
"authFullName_s":["Marine Warnier","Florian Gackière","Morad Roudbaraki","Pascal Mariot"],
"halId_s":"hal-04216594",
"docType_s":"COUV",
"producedDateY_i":2015
},{
"citationRef_s":"France, Patent n° : WO2015079185A1. 2015",
"citationFull_s":"Pascal Mariot, Morad Roudbaraki, Natalia Prevarskaya, Marine Warnier. Nouveau biomarqueur du cancer de la prostate. France, Patent n° : WO2015079185A1. 2015. <a target=\"_blank\" href=\"https://hal.science/hal-04210830v1\">⟨hal-04210830⟩</a>",
"title_s":["Nouveau biomarqueur du cancer de la prostate"],
"authFullName_s":["Pascal Mariot","Morad Roudbaraki","Natalia Prevarskaya","Marine Warnier"],
"halId_s":"hal-04210830",
"docType_s":"PATENT",
"producedDateY_i":2015
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"citationRef_s":"<i>Oncogene</i>, 2015, 34 (42), pp.5383 - 5394. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/onc.2014.467\">⟨10.1038/onc.2014.467⟩</a>",
"citationFull_s":"M Warnier, M Roudbaraki, S Derouiche, P Delcourt, A Bokhobza, et al.. CACNA2D2 promotes tumorigenesis by stimulating cell proliferation and angiogenesis. <i>Oncogene</i>, 2015, 34 (42), pp.5383 - 5394. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/onc.2014.467\">⟨10.1038/onc.2014.467⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04210352v1\">⟨hal-04210352⟩</a>",
"title_s":["CACNA2D2 promotes tumorigenesis by stimulating cell proliferation and angiogenesis"],
"authFullName_s":["M Warnier","M Roudbaraki","S Derouiche","P Delcourt","A Bokhobza","N Prevarskaya","Pascal Mariot"],
"halId_s":"hal-04210352",
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"producedDateY_i":2015
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