nicolas Willand

Professeur des universités CNU : SECTION 86 - SCIENCES DU MÉDICAMENT ET DES AUTRES PRODUITS DE SANTÉ

U1177 - MEDICAMENTS ET MOLECULES POUR AGIR SUR LES SYSTEMES VIVANTS - M2SV

Publications

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Journal of Biological Chemistry, 2024, J Biol Chem, pp.107431. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jbc.2024.107431\">⟨10.1016/j.jbc.2024.107431⟩</a>. <a target=\"_blank\" href=\"https://hal.univ-lille.fr/hal-04625214v1\">⟨hal-04625214⟩</a>", "title_s":["Small molecule MarR modulators potentiate metronidazole antibiotic activity in aerobic E. coli by inducing activation by the nitroreductase NfsA."], "authFullName_s":["Thibault Caradec","Coline Ple","Giuseppe Sicoli","Ravil Petrov","Elizabeth Pradel","Cécilia Sobieski","Rudy Antoine","Maylis Orio","Adrien Herledan","Nicolas Willand","Ruben Hartkoorn"], "halId_s":"hal-04625214", "docType_s":"ART", "producedDateY_i":2024 },{ "citationRef_s":"European Journal of Medicinal Chemistry, 2023, 256, pp.115413. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2023.115413\">⟨10.1016/j.ejmech.2023.115413⟩</a>", "citationFull_s":"Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo, et al.. Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance. European Journal of Medicinal Chemistry, 2023, 256, pp.115413. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2023.115413\">⟨10.1016/j.ejmech.2023.115413⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04093378v1\">⟨hal-04093378⟩</a>", "title_s":["Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance"], "authFullName_s":["Francesca Ruggieri","Nina Compagne","Kevin Antraygues","Maxime Eveque","Marion Flipo","Nicolas Willand"], "halId_s":"hal-04093378", "docType_s":"ART", "producedDateY_i":2023 },{ "citationRef_s":"BIOTRANS, Jun 2023, La Rochelle, France", "citationFull_s":"Juan Rodriguez Mosheim, Francesca Ruggieri, Catherine Humeau, Philippe Hance, Nicolas Willand, et al.. BIOCATALYTIC APPROACH TO CHEMOSELECTIVE ACYLATION OF SESQUITERPENE LACTONES FROM CHICORY: TOWARDS NEW ESTERS. BIOTRANS, Jun 2023, La Rochelle, France. <a target=\"_blank\" href=\"https://hal.univ-lille.fr/hal-04562021v1\">⟨hal-04562021⟩</a>", "title_s":["BIOCATALYTIC APPROACH TO CHEMOSELECTIVE ACYLATION OF SESQUITERPENE LACTONES FROM CHICORY: TOWARDS NEW ESTERS"], "authFullName_s":["Juan Rodriguez Mosheim","Francesca Ruggieri","Catherine Humeau","Philippe Hance","Nicolas Willand","Jean-Louis Hilbert","Egon Heuson","Renato Froidevaux"], "halId_s":"hal-04562021", "docType_s":"POSTER", "producedDateY_i":2023 },{ "citationRef_s":"Pharmaceuticals, 2023, 16 (3), pp.335. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ph16030335\">⟨10.3390/ph16030335⟩</a>", "citationFull_s":"Léo Faïon, Kamel Djaout, Catalin Pintiala, Catherine Piveteau, Florence Leroux, et al.. Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification. Pharmaceuticals, 2023, 16 (3), pp.335. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/ph16030335\">⟨10.3390/ph16030335⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04007450v1\">⟨hal-04007450⟩</a>", "title_s":["Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification"], "authFullName_s":["Léo Faïon","Kamel Djaout","Catalin Pintiala","Catherine Piveteau","Florence Leroux","Alexandre Biela","Stéphanie Slupek","Rudy Antoine","Monika Záhorszká","Francois-Xavier Cantrelle","Xavier Hanoulle","Jana Korduláková","Benoit Deprez","Nicolas Willand","Alain Baulard","Marion Flipo"], "halId_s":"hal-04007450", "docType_s":"ART", "producedDateY_i":2023 },{ "citationRef_s":"European Journal of Medicinal Chemistry, 2022, 238, pp.114515. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2022.114515\">⟨10.1016/j.ejmech.2022.114515⟩</a>", "citationFull_s":"Kevin Antraygues, Mathieu Maingot, Birgit Schellhorn, Vincent Trebosc, Marc Gitzinger, et al.. Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration. European Journal of Medicinal Chemistry, 2022, 238, pp.114515. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2022.114515\">⟨10.1016/j.ejmech.2022.114515⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04017312v1\">⟨hal-04017312⟩</a>", "title_s":["Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration","Conception et synthèse de prodrogues hydrosolubles de la rifabutine pour administration intraveineuse"], "authFullName_s":["Kevin Antraygues","Mathieu Maingot","Birgit Schellhorn","Vincent Trebosc","Marc Gitzinger","Benoit Déprez","Olivier Defert","Glenn E Dale","Marilyne Bourotte","Sergio Lociuro","Nicolas Willand"], "halId_s":"hal-04017312", "docType_s":"ART", "producedDateY_i":2022 },{ "citationRef_s":"Science Translational Medicine, 2022, 14 (643), <a target=\"_blank\" href=\"https://dx.doi.org/10.1126/scitranslmed.aaz6280\">⟨10.1126/scitranslmed.aaz6280⟩</a>", "citationFull_s":"Marion Flipo, Rosangela Frita, Marilyne Bourotte, María Martínez-Martínez, Markus Boesche, et al.. The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis. Science Translational Medicine, 2022, 14 (643), <a target=\"_blank\" href=\"https://dx.doi.org/10.1126/scitranslmed.aaz6280\">⟨10.1126/scitranslmed.aaz6280⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04465505v1\">⟨hal-04465505⟩</a>", "title_s":["The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis"], "authFullName_s":["Marion Flipo","Rosangela Frita","Marilyne Bourotte","María Martínez-Martínez","Markus Boesche","Gary Boyle","Geo Derimanov","Gerard Drewes","Pablo Gamallo","Sonja Ghidelli-Disse","Stephanie Gresham","Elena Jiménez","Jaime de Mercado","Esther Pérez-Herrán","Esther Porras-de Francisco","Joaquín Rullas","Patricia Casado","Florence Leroux","Catherine Piveteau","Mehdi Kiass","Vanessa Mathys","Karine Soetaert","Véronique Megalizzi","Abdalkarim Tanina","René Wintjens","Rudy Antoine","Priscille Brodin","Vincent Delorme","Martin Moune","Kamel Djaout","Stéphanie Slupek","Christian Kemmer","Marc Gitzinger","Lluis Ballell","Alfonso Mendoza-Losana","Sergio Lociuro","Benoît Déprez","David Barros-Aguirre","Modesto Remuiñán","Nicolas Willand","Alain Baulard"], "halId_s":"hal-04465505", "docType_s":"ART", "producedDateY_i":2022 },{ "citationRef_s":"Drug Discovery Today, 2021, 26 (2), pp.315-328. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.drudis.2020.11.026\">⟨10.1016/j.drudis.2020.11.026⟩</a>", "citationFull_s":"Benjamin Guieu, Jean-Pierre Jourdan, Aurore Dreneau, Nicolas Willand, Christophe Rochais, et al.. Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy. Drug Discovery Today, 2021, 26 (2), pp.315-328. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.drudis.2020.11.026\">⟨10.1016/j.drudis.2020.11.026⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03969988v1\">⟨hal-03969988⟩</a>", "title_s":["Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy"], "authFullName_s":["Benjamin Guieu","Jean-Pierre Jourdan","Aurore Dreneau","Nicolas Willand","Christophe Rochais","Patrick Dallemagne"], "halId_s":"hal-03969988", "docType_s":"ART", "producedDateY_i":2021 },{ "citationRef_s":"Molecules, 2021, 26 (19), pp.6083. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/molecules26196083\">⟨10.3390/molecules26196083⟩</a>", "citationFull_s":"Benoit Deprez, Damien Bosc, Julie Charton, Cyril Couturier, Rebecca Deprez-Poulain, et al.. Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry. Molecules, 2021, 26 (19), pp.6083. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/molecules26196083\">⟨10.3390/molecules26196083⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04465890v1\">⟨hal-04465890⟩</a>", "title_s":["Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry"], "authFullName_s":["Benoit Deprez","Damien Bosc","Julie Charton","Cyril Couturier","Rebecca Deprez-Poulain","Marion Flipo","Florence Leroux","Baptiste Villemagne","Nicolas Willand"], "halId_s":"hal-04465890", "docType_s":"ART", "producedDateY_i":2021 },{ "citationRef_s":"European Journal of Medicinal Chemistry, 2020, 200, pp.112440. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2020.112440\">⟨10.1016/j.ejmech.2020.112440⟩</a>", "citationFull_s":"Léo Faion, Kamel Djaout, Rosangela Frita, Catalin Pintiala, Francois-Xavier Cantrelle, et al.. Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening. European Journal of Medicinal Chemistry, 2020, 200, pp.112440. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2020.112440\">⟨10.1016/j.ejmech.2020.112440⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-02988077v1\">⟨hal-02988077⟩</a>", "title_s":["Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening"], "authFullName_s":["Léo Faion","Kamel Djaout","Rosangela Frita","Catalin Pintiala","Francois-Xavier Cantrelle","Martin Moune","Alexandre Vandeputte","Kevin Bourbiaux","Catherine Piveteau","Adrien Herledan","Alexandre Biela","Florence Leroux","Laurent Kremer","Mickael Blaise","Abdalkarim Tanina","René Wintjens","Xavier Hanoulle","Benoit Déprez","Nicolas Willand","Alain R Baulard","Marion Flipo"], "halId_s":"hal-02988077", "docType_s":"ART", "producedDateY_i":2020 },{ "citationRef_s":"ACS Infectious Diseases, 2020, 6 (3), pp.366-378. <a target=\"_blank\" href=\"https://dx.doi.org/10.1021/acsinfecdis.9b00277\">⟨10.1021/acsinfecdis.9b00277⟩</a>", "citationFull_s":"Baptiste Villemagne, Arnaud Machelart, Ngoc Chau Tran, Marion Flipo, Martin Moune, et al.. Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. ACS Infectious Diseases, 2020, 6 (3), pp.366-378. <a target=\"_blank\" href=\"https://dx.doi.org/10.1021/acsinfecdis.9b00277\">⟨10.1021/acsinfecdis.9b00277⟩</a>. <a target=\"_blank\" href=\"https://cnrs.hal.science/hal-03096012v1\">⟨hal-03096012⟩</a>", "title_s":["Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity"], "authFullName_s":["Baptiste Villemagne","Arnaud Machelart","Ngoc Chau Tran","Marion Flipo","Martin Moune","Florence Leroux","Catherine Piveteau","Alexandre Wohlkönig","René Wintjens","Xue Li","Ruxandra Gref","Priscille Brodin","Benoit Deprez","Alain Baulard","Nicolas Willand"], "halId_s":"hal-03096012", "docType_s":"ART", "producedDateY_i":2020 },{ "citationRef_s":"European Journal of Medicinal Chemistry, 2019, 167, pp.426-438. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2019.02.023\">⟨10.1016/j.ejmech.2019.02.023⟩</a>", "citationFull_s":"Hugues Prevet, Martin Moune, Abdalkarim Tanina, Christian Kemmer, Adrien Herledan, et al.. A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2. European Journal of Medicinal Chemistry, 2019, 167, pp.426-438. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2019.02.023\">⟨10.1016/j.ejmech.2019.02.023⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03102744v1\">⟨hal-03102744⟩</a>", "title_s":["A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2"], "authFullName_s":["Hugues Prevet","Martin Moune","Abdalkarim Tanina","Christian Kemmer","Adrien Herledan","Rosangela Frita","Alexandre Wohlkönig","Marilyne Bourotte","Baptiste Villemagne","Florence Leroux","Marc Gitzinger","Alain R. Baulard","Benoit Déprez","René Wintjens","Nicolas Willand","Marion Flipo"], "halId_s":"hal-03102744", "docType_s":"ART", "producedDateY_i":2019 },{ "citationRef_s":"Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis, pp.131-152, 2019, <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/bs.armc.2019.06.003\">⟨10.1016/bs.armc.2019.06.003⟩</a>", "citationFull_s":"Nicolas Willand, Marion Flipo, Baptiste Villemagne, Alain Baulard, Benoit Deprez. Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance. Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis, pp.131-152, 2019, <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/bs.armc.2019.06.003\">⟨10.1016/bs.armc.2019.06.003⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03102772v1\">⟨hal-03102772⟩</a>", "title_s":["Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance"], "authFullName_s":["Nicolas Willand","Marion Flipo","Baptiste Villemagne","Alain Baulard","Benoit Deprez"], "halId_s":"hal-03102772", "docType_s":"COUV", "producedDateY_i":2019 },{ "citationRef_s":"Organic & Biomolecular Chemistry, 2019, 17 (20), pp.5129 - 5137. <a target=\"_blank\" href=\"https://dx.doi.org/10.1039/c9ob00680j\">⟨10.1039/c9ob00680j⟩</a>", "citationFull_s":"Alexandra Pastor, Arnaud Machelart, Xue Li, Nicolas Willand, Alain Baulard, et al.. A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation. Organic & Biomolecular Chemistry, 2019, 17 (20), pp.5129 - 5137. <a target=\"_blank\" href=\"https://dx.doi.org/10.1039/c9ob00680j\">⟨10.1039/c9ob00680j⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03009695v1\">⟨hal-03009695⟩</a>", "title_s":["A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation"], "authFullName_s":["Alexandra Pastor","Arnaud Machelart","Xue Li","Nicolas Willand","Alain Baulard","Priscille Brodin","Ruxandra Gref","Didier Desmaele"], "halId_s":"hal-03009695", "docType_s":"ART", "producedDateY_i":2019 },{ "citationRef_s":"ACS Nano, 2019, 13 (4), pp.3992-4007. <a target=\"_blank\" href=\"https://dx.doi.org/10.1021/acsnano.8b07902\">⟨10.1021/acsnano.8b07902⟩</a>", "citationFull_s":"Arnaud Machelart, Giuseppina Salzano, Xue Li, Aurore Demars, Anne-Sophie Debrie, et al.. Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis. ACS Nano, 2019, 13 (4), pp.3992-4007. <a target=\"_blank\" href=\"https://dx.doi.org/10.1021/acsnano.8b07902\">⟨10.1021/acsnano.8b07902⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-02367420v1\">⟨hal-02367420⟩</a>", "title_s":["Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis"], "authFullName_s":["Arnaud Machelart","Giuseppina Salzano","Xue Li","Aurore Demars","Anne-Sophie Debrie","Mario Menendez-Miranda","Elisabetta Pancani","Samuel J Jouny","Eik Hoffmann","Nathalie Deboosere","Imène Belhaouane","Carine Rouanet","Sophie Simar","Smaïl Talahari","Valerie Giannini","Baptiste Villemagne","Marion Flipo","Roland Brosch","Fabrice Nesslany","Benoit Déprez","Eric Muraille","Camille Locht","Alain Baulard","Nicolas Willand","Laleh Majlessi","Ruxandra Gref","Priscille Brodin"], "halId_s":"hal-02367420", "docType_s":"ART", "producedDateY_i":2019 },{ "citationRef_s":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2018, 1867 (3), pp.248-258. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.bbapap.2018.12.003\">⟨10.1016/j.bbapap.2018.12.003⟩</a>", "citationFull_s":"Abdalkarim Tanina, Alexandre Wohlkönig, Sameh H. Soror, Marion Flipo, Baptiste Villemagne, et al.. A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2018, 1867 (3), pp.248-258. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.bbapap.2018.12.003\">⟨10.1016/j.bbapap.2018.12.003⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03177329v1\">⟨hal-03177329⟩</a>", "title_s":["A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR"], "authFullName_s":["Abdalkarim Tanina","Alexandre Wohlkönig","Sameh H. Soror","Marion Flipo","Baptiste Villemagne","Hugues Prevet","Benoit Déprez","Martin Moune","Hélène Perée","Franck Meyer","Alain R. Baulard","Nicolas Willand","René Wintjens"], "halId_s":"hal-03177329", "docType_s":"ART", "producedDateY_i":2018 },{ "citationRef_s":"European Journal of Medicinal Chemistry, 2018, 159, pp.35-46. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2018.09.038\">⟨10.1016/j.ejmech.2018.09.038⟩</a>", "citationFull_s":"Marion Prieri, Rosangela Frita, Nicolas Probst, Alix Sournia-Saquet, Marilyne Bourotte, et al.. Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis. European Journal of Medicinal Chemistry, 2018, 159, pp.35-46. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ejmech.2018.09.038\">⟨10.1016/j.ejmech.2018.09.038⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-01963620v1\">⟨hal-01963620⟩</a>", "title_s":["Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis"], "authFullName_s":["Marion Prieri","Rosangela Frita","Nicolas Probst","Alix Sournia-Saquet","Marilyne Bourotte","Benoit Deprez","Alain R. Baulard","Nicolas Willand"], "halId_s":"hal-01963620", "docType_s":"ART", "producedDateY_i":2018 },{ "citationRef_s":"Scientific Reports, 2017, 7 (1), pp.5390. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41598-017-05453-3\">⟨10.1038/s41598-017-05453-3⟩</a>", "citationFull_s":"Joana Costa-Gouveia, Elisabetta Pancani, Samuel Jouny, Arnaud Machelart, Vincent Delorme, et al.. Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. Scientific Reports, 2017, 7 (1), pp.5390. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41598-017-05453-3\">⟨10.1038/s41598-017-05453-3⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-02367442v1\">⟨hal-02367442⟩</a>", "title_s":["Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles"], "authFullName_s":["Joana Costa-Gouveia","Elisabetta Pancani","Samuel Jouny","Arnaud Machelart","Vincent Delorme","Giuseppina Salzano","Raffaella Iantomasi","Catherine Piveteau","Christophe J Queval","Ok-Ryul Song","Marion Flipo","Benoît Déprez","Jean-Paul Saint-André","José Hureaux","Laleh Majlessi","Nicolas Willand","Alain Baulard","Priscille Brodin","Ruxandra Gref"], "halId_s":"hal-02367442", "docType_s":"ART", "producedDateY_i":2017 },{ "citationRef_s":"International Journal of Pharmaceutics, 2017, 531 (2), pp.577-587. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpharm.2017.05.030\">⟨10.1016/j.ijpharm.2017.05.030⟩</a>", "citationFull_s":"Giuseppina Salzano, Jitendra Wankar, Stefano Ottani, Baptiste Villemagne, Alain Baulard, et al.. Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs. International Journal of Pharmaceutics, 2017, 531 (2), pp.577-587. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpharm.2017.05.030\">⟨10.1016/j.ijpharm.2017.05.030⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04463021v1\">⟨hal-04463021⟩</a>", "title_s":["Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs"], "authFullName_s":["Giuseppina Salzano","Jitendra Wankar","Stefano Ottani","Baptiste Villemagne","Alain Baulard","Nicolas Willand","Priscille Brodin","Ilse Manet","Ruxandra Gref"], "halId_s":"hal-04463021", "docType_s":"ART", "producedDateY_i":2017 },{ "citationRef_s":"Science, 2017, 355 (6330), pp.1206-1211. <a target=\"_blank\" href=\"https://dx.doi.org/10.1126/science.aag1006\">⟨10.1126/science.aag1006⟩</a>", "citationFull_s":"Nicolas Blondiaux, Martin Moune, Matthieu Desroses, Rosangela Frita, Marion Flipo, et al.. Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science, 2017, 355 (6330), pp.1206-1211. <a target=\"_blank\" href=\"https://dx.doi.org/10.1126/science.aag1006\">⟨10.1126/science.aag1006⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-03102877v1\">⟨hal-03102877⟩</a>", "title_s":["Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420"], "authFullName_s":["Nicolas Blondiaux","Martin Moune","Matthieu Desroses","Rosangela Frita","Marion Flipo","Vanessa Mathys","Karine Soetaert","Mehdi Kiass","Vincent Delorme","Kamel Djaout","Vincent Trebosc","Christian Kemmer","René Wintjens","Alexandre Wohlkönig","Rudy Antoine","Ludovic Huot","David Hot","Mireia Coscolla","Julia Feldmann","Sebastien Gagneux","Camille Locht","Priscille Brodin","Marc Gitzinger","Benoit Déprez","Nicolas Willand","Alain Baulard"], "halId_s":"hal-03102877", "docType_s":"ART", "producedDateY_i":2017 },{ "citationRef_s":"Tetrahedron Letters, 2016, 57 (26), pp.2888-2894. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.tetlet.2016.05.065\">⟨10.1016/j.tetlet.2016.05.065⟩</a>", "citationFull_s":"Hugues Prevet, Marion Flipo, Pascal Roussel, Benoit Déprez, Nicolas Willand. 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hal-04625214

Thibault Caradec, Coline Ple, Giuseppe Sicoli, Ravil Petrov, Elizabeth Pradel, Cécilia Sobieski, Rudy Antoine, Maylis Orio, Adrien Herledan, Nicolas Willand, Ruben Hartkoorn

Small molecule MarR modulators potentiate metronidazole antibiotic activity in aerobic E. coli by inducing activation by the nitroreductase NfsA.

Journal of Biological Chemistry, 2024, J Biol Chem, pp.107431. ⟨10.1016/j.jbc.2024.107431⟩

hal-04093378

Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo, Nicolas Willand

Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance

European Journal of Medicinal Chemistry, 2023, 256, pp.115413. ⟨10.1016/j.ejmech.2023.115413⟩

hal-04562021

Juan Rodriguez Mosheim, Francesca Ruggieri, Catherine Humeau, Philippe Hance, Nicolas Willand, Jean-Louis Hilbert, Egon Heuson, Renato Froidevaux

BIOCATALYTIC APPROACH TO CHEMOSELECTIVE ACYLATION OF SESQUITERPENE LACTONES FROM CHICORY: TOWARDS NEW ESTERS

BIOTRANS, Jun 2023, La Rochelle, France

hal-04007450

Léo Faïon, Kamel Djaout, Catalin Pintiala, Catherine Piveteau, Florence Leroux, Alexandre Biela, Stéphanie Slupek, Rudy Antoine, Monika Záhorszká, Francois-Xavier Cantrelle, Xavier Hanoulle, Jana Korduláková, Benoit Deprez, Nicolas Willand, Alain Baulard, Marion Flipo

Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification

Pharmaceuticals, 2023, 16 (3), pp.335. ⟨10.3390/ph16030335⟩

hal-04017312

Kevin Antraygues, Mathieu Maingot, Birgit Schellhorn, Vincent Trebosc, Marc Gitzinger, Benoit Déprez, Olivier Defert, Glenn E Dale, Marilyne Bourotte, Sergio Lociuro, Nicolas Willand

Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration

European Journal of Medicinal Chemistry, 2022, 238, pp.114515. ⟨10.1016/j.ejmech.2022.114515⟩

hal-04465505

Marion Flipo, Rosangela Frita, Marilyne Bourotte, María Martínez-Martínez, Markus Boesche, Gary Boyle, Geo Derimanov, Gerard Drewes, Pablo Gamallo, Sonja Ghidelli-Disse, Stephanie Gresham, Elena Jiménez, Jaime de Mercado, Esther Pérez-Herrán, Esther Porras-de Francisco, Joaquín Rullas, Patricia Casado, Florence Leroux, Catherine Piveteau, Mehdi Kiass, Vanessa Mathys, Karine Soetaert, Véronique Megalizzi, Abdalkarim Tanina, René Wintjens, Rudy Antoine, Priscille Brodin, Vincent Delorme, Martin Moune, Kamel Djaout, Stéphanie Slupek, Christian Kemmer, Marc Gitzinger, Lluis Ballell, Alfonso Mendoza-Losana, Sergio Lociuro, Benoît Déprez, David Barros-Aguirre, Modesto Remuiñán, Nicolas Willand, Alain Baulard

The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis

Science Translational Medicine, 2022, 14 (643), ⟨10.1126/scitranslmed.aaz6280⟩

hal-03969988

Benjamin Guieu, Jean-Pierre Jourdan, Aurore Dreneau, Nicolas Willand, Christophe Rochais, Patrick Dallemagne

Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy

Drug Discovery Today, 2021, 26 (2), pp.315-328. ⟨10.1016/j.drudis.2020.11.026⟩

hal-04465890

Benoit Deprez, Damien Bosc, Julie Charton, Cyril Couturier, Rebecca Deprez-Poulain, Marion Flipo, Florence Leroux, Baptiste Villemagne, Nicolas Willand

Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry

Molecules, 2021, 26 (19), pp.6083. ⟨10.3390/molecules26196083⟩

hal-02988077

Léo Faion, Kamel Djaout, Rosangela Frita, Catalin Pintiala, Francois-Xavier Cantrelle, Martin Moune, Alexandre Vandeputte, Kevin Bourbiaux, Catherine Piveteau, Adrien Herledan, Alexandre Biela, Florence Leroux, Laurent Kremer, Mickael Blaise, Abdalkarim Tanina, René Wintjens, Xavier Hanoulle, Benoit Déprez, Nicolas Willand, Alain R Baulard, Marion Flipo

Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening

European Journal of Medicinal Chemistry, 2020, 200, pp.112440. ⟨10.1016/j.ejmech.2020.112440⟩

hal-03096012

Baptiste Villemagne, Arnaud Machelart, Ngoc Chau Tran, Marion Flipo, Martin Moune, Florence Leroux, Catherine Piveteau, Alexandre Wohlkönig, René Wintjens, Xue Li, Ruxandra Gref, Priscille Brodin, Benoit Deprez, Alain Baulard, Nicolas Willand

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity

ACS Infectious Diseases, 2020, 6 (3), pp.366-378. ⟨10.1021/acsinfecdis.9b00277⟩

hal-03102744

Hugues Prevet, Martin Moune, Abdalkarim Tanina, Christian Kemmer, Adrien Herledan, Rosangela Frita, Alexandre Wohlkönig, Marilyne Bourotte, Baptiste Villemagne, Florence Leroux, Marc Gitzinger, Alain R. Baulard, Benoit Déprez, René Wintjens, Nicolas Willand, Marion Flipo

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2

European Journal of Medicinal Chemistry, 2019, 167, pp.426-438. ⟨10.1016/j.ejmech.2019.02.023⟩

hal-03102772

Nicolas Willand, Marion Flipo, Baptiste Villemagne, Alain Baulard, Benoit Deprez

Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance

Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis, pp.131-152, 2019, ⟨10.1016/bs.armc.2019.06.003⟩

hal-03009695

Alexandra Pastor, Arnaud Machelart, Xue Li, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref, Didier Desmaele

A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation

Organic & Biomolecular Chemistry, 2019, 17 (20), pp.5129 - 5137. ⟨10.1039/c9ob00680j⟩

hal-02367420

Arnaud Machelart, Giuseppina Salzano, Xue Li, Aurore Demars, Anne-Sophie Debrie, Mario Menendez-Miranda, Elisabetta Pancani, Samuel J Jouny, Eik Hoffmann, Nathalie Deboosere, Imène Belhaouane, Carine Rouanet, Sophie Simar, Smaïl Talahari, Valerie Giannini, Baptiste Villemagne, Marion Flipo, Roland Brosch, Fabrice Nesslany, Benoit Déprez, Eric Muraille, Camille Locht, Alain Baulard, Nicolas Willand, Laleh Majlessi, Ruxandra Gref, Priscille Brodin

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ACS Nano, 2019, 13 (4), pp.3992-4007. ⟨10.1021/acsnano.8b07902⟩

hal-03177329

Abdalkarim Tanina, Alexandre Wohlkönig, Sameh H. Soror, Marion Flipo, Baptiste Villemagne, Hugues Prevet, Benoit Déprez, Martin Moune, Hélène Perée, Franck Meyer, Alain R. Baulard, Nicolas Willand, René Wintjens

A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2018, 1867 (3), pp.248-258. ⟨10.1016/j.bbapap.2018.12.003⟩

hal-01963620

Marion Prieri, Rosangela Frita, Nicolas Probst, Alix Sournia-Saquet, Marilyne Bourotte, Benoit Deprez, Alain R. Baulard, Nicolas Willand

Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis

European Journal of Medicinal Chemistry, 2018, 159, pp.35-46. ⟨10.1016/j.ejmech.2018.09.038⟩

hal-02367442

Joana Costa-Gouveia, Elisabetta Pancani, Samuel Jouny, Arnaud Machelart, Vincent Delorme, Giuseppina Salzano, Raffaella Iantomasi, Catherine Piveteau, Christophe J Queval, Ok-Ryul Song, Marion Flipo, Benoît Déprez, Jean-Paul Saint-André, José Hureaux, Laleh Majlessi, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Scientific Reports, 2017, 7 (1), pp.5390. ⟨10.1038/s41598-017-05453-3⟩

hal-04463021

Giuseppina Salzano, Jitendra Wankar, Stefano Ottani, Baptiste Villemagne, Alain Baulard, Nicolas Willand, Priscille Brodin, Ilse Manet, Ruxandra Gref

Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs

International Journal of Pharmaceutics, 2017, 531 (2), pp.577-587. ⟨10.1016/j.ijpharm.2017.05.030⟩

hal-03102877

Nicolas Blondiaux, Martin Moune, Matthieu Desroses, Rosangela Frita, Marion Flipo, Vanessa Mathys, Karine Soetaert, Mehdi Kiass, Vincent Delorme, Kamel Djaout, Vincent Trebosc, Christian Kemmer, René Wintjens, Alexandre Wohlkönig, Rudy Antoine, Ludovic Huot, David Hot, Mireia Coscolla, Julia Feldmann, Sebastien Gagneux, Camille Locht, Priscille Brodin, Marc Gitzinger, Benoit Déprez, Nicolas Willand, Alain Baulard

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420

Science, 2017, 355 (6330), pp.1206-1211. ⟨10.1126/science.aag1006⟩

hal-02263701

Hugues Prevet, Marion Flipo, Pascal Roussel, Benoit Déprez, Nicolas Willand

Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space

Tetrahedron Letters, 2016, 57 (26), pp.2888-2894. ⟨10.1016/j.tetlet.2016.05.065⟩

hal-02309782

Baptiste Villemagne, Marion Flipo, Nicolas Blondiaux, Celine Crauste, Sandra Malaquin, Florence Leroux, Catherine Piveteau, Vincent Villeret, Priscille Brodin, Bruno O. Villoutreix, Olivier Sperandio, Sameh H. Soror, Alexandre Wohlkönig, René Wintjens, Benoit Deprez, Alain R. Baulard, Nicolas Willand

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches

Journal of Medicinal Chemistry, 2014, 57 (11), pp.4876-4888. ⟨10.1021/jm500422b⟩

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Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands

Analytical Biochemistry, 2014, 452, pp.54-66. ⟨10.1016/j.ab.2014.02.011⟩

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Baptiste Villemagne, Céline Crauste, Marion Flipo, Alain R. Baulard, Benoit Déprez, Nicolas Willand

Tuberculosis: The drug development pipeline at a glance

European Journal of Medicinal Chemistry, 2012, 51, pp.1-16. ⟨10.1016/j.ejmech.2012.02.033⟩

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Xavier Carette, Nicolas Blondiaux, Eve Willery, Sylviane Hoos, Nathalie Lecat-Guillet, Zoé Lens, Alexandre Wohlkönig, René Wintjens, Sameh H Soror, Frédéric Frénois, Bertrand Dirié, Vincent Villeret, Patrick England, Guy Lippens, Benoit Deprez, Camille Locht, Nicolas Willand, Alain R Baulard

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

Nucleic Acids Research, 2011, 40 (7), pp.3018 - 3030. ⟨10.1093/nar/gkr1113⟩

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Patrick Toto, Jean-Claude Gesquiere, Nicolas Cousaert, Benoit Déprez, Nicolas Willand

UFU ('Ullmann-Finkelstein-Ullmann'): a new multicomponent reaction

Tetrahedron Letters, 2006, 47 (28), pp.4973-4978. ⟨10.1016/j.tetlet.2006.04.041⟩

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Patrick Toto, Jean-Claude Gesquiere, Benoit Déprez, Nicolas Willand

Synthesis of N-(iodophenyl)-amides via an unprecedented Ullmann-Finkelstein tandem reaction

Tetrahedron Letters, 2005, 47, pp.1181-1186. ⟨10.1016/j.tetlet.2005.12.022⟩

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Nicolas Cousaert, Patrick Toto, Nicolas Willand, Benoit Déprez

Efficient, protection-free Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles