Luc Buee
Publications
Marion Goussard, Kelly Zarka, Bruno Lefebvre, Malika Hamdane, Philippe Marin, Luc Buée, Julien Villeneuve, Marie-Laure Parmentier
Phospho-Tau signature during mitosis: AT8, p-T217 and p-S422 as key phosphoepitopes
2024
Lucia Gaddini, Valentina Chiodi, Andrea Matteucci, Zaira Boussadia, Luc Buee, Sabiha Eddarkaoui, David Blum, Nazzareno Di Carlo, Carla Raggi, Rita Di Benedetto, Patrizia Popoli, Antonella Ferrante
Dipyridamole Ameliorates Memory Impairment and Increases Hippocampal Calbindin Expression in Niemann Pick C1 Mice.
Journal of Neuroscience Research, 2024, Journal of Neuroscience Research, 102, pp.e70011. ⟨10.1002/jnr.70011⟩
Caio Bruno Q. S. Leal, Camila G. M. Zimmer, Vanessa V. C. Sinatti, Ericks S. Soares, Britt Poppe, Adrien Carton de Wiart, Xue Ying Chua, Ronan V. da Silva, Margaret H. Magdesian, Michael S. Rafii, Luc Buee, Rafael M. Bottos
Effects of the therapeutic correction of U1 snRNP complex on Alzheimer's disease
Scientific Reports, 2024, Scientific Reports, 14, ⟨10.1038/s41598-024-81687-2⟩
Sylvain Lehmann, Susanna Schraen-Maschke, Luc Buée, Jean-Sébastien Vidal, Constance Delaby, Christophe Hirtz, Frédéric Blanc, Claire Paquet, Bernadette Allinquant, Stephanie Bombois, Audrey Gabelle, Olivier Hanon
Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease
Molecular Neurodegeneration, 2024, 19 (1), pp.66. ⟨10.1186/s13024-024-00755-3⟩
Liling Delila, Ouada Nebie, Nhi Thao Ngoc Le, Kelly Timmerman, Deng-Yao Lee, Yu-Wen Wu, Ming-Li Chou, Luc Buee, Szu-Yi Chou, David Blum, David Devos, Thierry Burnouf
Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models.
Journal of Biomedical Science, 2024, Journal of Biomedical Science, 31, ⟨10.1186/s12929-024-01072-z⟩
Jonathan Benn, Shi Cheng, Sophie Keeling, Annabel Smith, Marina Vaysburd, Dorothea Böken, Lauren Miller, Taxiarchis Katsinelos, Catarina Franco, Elian Dupré, Clément Danis, Isabelle Landrieu, Luc Buée, David Klenerman, Leo James, William Mcewan
Aggregate-selective removal of pathological tau via clustering-activated degraders
Science, 2024, 385 (6712), pp.1009-1016. ⟨10.1126/science.adp5186⟩
T. J. Zwang, E. D. Sastre, N. Wolf, N. Ruiz-Uribe, B. Woost, Z. Hoglund, Z. Fan, J. Bailey, L. Nfor, Luc Buee, K. P. R. Nilsson, B. T. Hyman, R. E. Bennett
Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology
Cell Reports, 2024, Cell Reports, 43 (8), pp.114574. ⟨10.1016/j.celrep.2024.114574⟩
Victoria Gomez-Murcia, Agathe Launay, Kévin Carvalho, Anaëlle Burgard, Céline Meriaux, Raphaëlle Caillierez, Sabiha Eddarkaoui, Devrim Kilinc, Dolores Siedlecki-Wullich, Mélanie Besegher, Séverine Bégard, Bryan Thiroux, Matthieu Jung, Ouada Nebie, Maxence Wisztorski, Nicole Déglon, Claire Montmasson, Alexis-Pierre Bemelmans, Malika Hamdane, Thibaud Lebouvier, Didier Vieau, Isabelle Fournier, Luc Buee, Sabine Lévi, Luisa Lopes, Anne-Laurence Boutillier, Emilie Faivre, David Blum
Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice
Brain - A Journal of Neurology , 2024, 147 (8), pp.2691-2705. ⟨10.1093/brain/awae113⟩
Vincent Huin, David Blum, Violette Delforge, E. Cailliau, S. Djeziri, Kathy Dujardin, A. Genet, Romain Viard, S. Attarian, G. Bruneteau, J. Cassereau, S. Genestet, A. L. Kaminsky, M. H. Soriani, M. Lefilliatre, P. Couratier, S. Pittion-Vouyovitch, F. Esselin, E. de la Cruz, N. Guy, I. Kolev, P. Corcia, P. Cintas, C. Desnuelle, Luc Buee, V. Danel-Brunaud, David Devos, Anne-Sophie Rolland
Caffeine consumption outcomes on amyotrophic lateral sclerosis disease progression and cognition
Neurobiology of Disease, 2024, Neurobiology of Disease, 199, pp.106603. ⟨10.1016/j.nbd.2024.106603⟩
V. Gomez-Murcia, Agathe Launay, K. Carvalho, A. Burgard, C. Meriaux, Raphaelle Caillierez, Sabiha Eddarkaoui, Devrim Kilinc, Dolores Siedlecki, Melanie Besegher, S. Bégard, Bryan Thiroux, M. Jung, Ouada Nebie, Maxence Wisztorski, N. Déglon, C. Montmasson, A. P. Bemelmans, Malika Hamdane, Thibaud Lebouvier, Didier Vieau, Isabelle Fournier, Luc Buee, S. Lévi, L. V. Lopes, A. L. Boutillier, Emilie Faivre, David Blum
Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice
Brain - A Journal of Neurology , 2024, Brain - A Journal of Neurology, 147 (8), pp.2691-2705. ⟨10.1093/brain/awae113⟩
Luc Buée, B. Lefebvre, Thomas Rico
METHODS FOR DECREASING THERAPEUTIC ACQUIRED RESISTANCE TO CHEMOTHERAPY AND/OR RADIOTHERAPY
France, Patent n° : WO2024133723A1. 2024
L. Vaillant-Beuchot, F. Eysert, B. Duval, P. F. Kinoshita, R. Pardossi-Piquard, C. Bauer, Sabiha Eddarkaoui, Luc Buee, F. Checler, M. Chami
The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease
Cell Death and Disease, 2024, Cell Death and Disease, 15, pp.367. ⟨10.1038/s41419-024-06742-2⟩
I. Paiva, J. Seguin, I. Grgurina, A. K. Singh, B. Cosquer, D. Plassard, L. Tzeplaeff, S. Le Gras, Ludovica Cotellessa, C. Decraene, J. Gambi, R. Alcala-Vida, M. Eswaramoorthy, Luc Buee, J. C. Cassel, Paolo Giacobini, David Blum, K. Merienne, T. K. Kundu, A. L. Boutillier
Dysregulated expression of cholesterol biosynthetic genes in Alzheimer's disease alters epigenomic signatures of hippocampal neurons
Neurobiology of Disease, 2024, Neurobiology of Disease, 198, pp.106538. ⟨10.1016/j.nbd.2024.106538⟩
N. T. N. Le, C. L. Han, L. Delila, Ouada Nebie, H. T. Chien, Y. W. Wu, Luc Buee, David Blum, T. Burnouf
Proteomics of human platelet lysates and insight from animal studies on platelet protein diffusion to hippocampus upon intranasal administration.
APL Bioengineering, 2024, APL Bioengineering, 8, pp.026111. ⟨10.1063/5.0196553⟩
Thomas Comptdaer, Meryem Tardivel, Claire Schirmer, Luc Buee, Marie-Christine Galas
Cell redistribution of G quadruplex-structured DNA is associated with morphological changes of nuclei and nucleoli in neurons during tau pathology progression
Brain Pathology, 2024, Brain Pathology, pp.e13262. ⟨10.1111/bpa.13262⟩
S. Lehmann, Susanna Schraen, Jean-Sébastien Vidal, Constance Delaby, Luc Buee, Frédéric Blanc, Claire Paquet, Bernadette Allinquant, Stephanie Bombois, Audrey Gabelle, O. Hanon
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
Journal of Neurology, Neurosurgery and Psychiatry, 2024, Journal of Neurology, Neurosurgery and Psychiatry, 95 (11), pp.1046-1053. ⟨10.1136/jnnp-2024-333467⟩
N. Basheer, Luc Buee, J. P. Brion, T. Smolek, M. K. Muhammadi, J. Hritz, T. Hromadka, I. Dewachter, S. Wegmann, Isabelle Landrieu, P. Novak, A. Mudher, N. Zilka
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
Acta Neuropathologica Communications, 2024, Acta Neuropathologica Communications, 12 (1), pp.52. ⟨10.1186/s40478-024-01748-5⟩
A. P. Longhini, A. Dubose, S. Lobo, V. Vijayan, Y. Bai, E. K. Rivera, J. Sala-Jarque, A. Nikitina, D. C. Carrettiero, M. T. Unger, O. R. Sclafani, V. Fu, E. R. Beckett, M. Vigers, Luc Buée, Isabelle Landrieu, S. Shell, J. E. Shea, S. Han, K. S. Kosik
Precision proteoform design for 4R tau isoform selective templated aggregation
Proceedings of the National Academy of Sciences of the United States of America, 2024, Proceedings of the National Academy of Sciences of the United States of America, 121 (15), pp.e2320456121. ⟨10.1073/pnas.2320456121⟩
Justine Mortelecque, O. Zejneli, S. Bégard, M. C. Simões, Lea El Hajjar, Marine Nguyen, Francois-Xavier Cantrelle, Xavier Hanoulle, J. C. Rain, Morvane Colin, C. M. Gomes, Luc Buee, Isabelle Landrieu, Clement Danis, Elian Dupre
A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein
Journal of Biological Chemistry, 2024, Journal of Biological Chemistry, 300 (4), pp.107163. ⟨10.1016/j.jbc.2024.107163⟩
M. Ali, P. Garcia, L. P. Lunkes, A. Sciortino, M. Thomas, T. Heurtaux, K. Grzyb, R. Halder, D. Coowar, A. Skupin, Luc Buee, David Blum, M. Buttini, E. Glaab
Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations.
Cell Death Discovery, 2024, Cell Death Discovery, 10 (1), pp.119. ⟨10.1038/s41420-024-01885-9⟩
Susanna Schraen, Alain Duhamel, J. S. Vidal, Nassima Ramdane, L. Vaudran, C. Dussart, Luc Buee, Bernard Sablonniere, C. Delaby, B. Allinquant, A. Gabelle, Stephanie Bombois, S. Lehmann, O. Hanon
The free plasma amyloid Aβ1–42/Aβ1–40 ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma Aβ1–42/Aβ1–40 ratio. The BALTAZAR study
Neurobiology of Disease, 2024, Neurobiology of Disease, 193, pp.106459. ⟨10.1016/j.nbd.2024.106459⟩
K. Menšíková, R. Rosales, C. Colosimo, P. Spencer, A. Lannuzel, Y. Ugawa, R. Sasaki, S. Giménez-Roldán, R. Matej, L. Tuckova, D. Hrabos, K. Kolarikova, R. Vodicka, R. Vrtel, M. Strnad, P. Hlustik, P. Otruba, M. Prochazka, M. Bares, S. Boluda, Luc Buee, G. Ransmayr, P. Kaňovský
Reply to: Questioning the cycad theory of Kii ALS-PDC causation
Nature Reviews Neurology, 2024, Nature Reviews Neurology, 20, pp.195-196. ⟨10.1038/s41582-024-00938-y⟩
Jian Jing Siew, Hui-Mei Chen, Feng-Lan Chiu, Chia-Wei Lee, Yao-Ming Chang, Hung-Lin Chen, Thi Ngoc Anh Nguyen, Hung-Ting Liao, Mengyu Liu, Hsiao-Tien Hagar, Yung-Chen Sun, Hsing-Lin Lai, Min-Hao Kuo, David Blum, Luc Buee, Lee-Way Jin, Shih-Yu Chen, Tai-Ming Ko, Jie-Rong Huang, Hung-Chih Kuo, Fu-Tong Liu, Yijuang Chern
Galectin-3 aggravates microglial activation and tau transmission in tauopathy.
The Journal of clinical investigation, 2024, The Journal of clinical investigation, 134, ⟨10.1172/JCI165523⟩
C. E. Sexton, G. Bitan, K. R. Bowles, M. Brys, Luc Buee, M. B. Maina, C. D. Clelland, A. D. Cohen, J. F. Crary, J. L. Dage, K. Diaz, B. Frost, L. Gan, A. M. Goate, L. I. Golbe, O. Hansson, C. M. Karch, H. C. Kolb, R. La Joie, S. E. Lee, D. Matallana, B. L. Miller, C. U. Onyike, Y. T. Quiroz, J. E. Rexach, J. D. Rohrer, A. Rommel, G. Sadri-Vakili, S. E. Schindler, J. A. Schneider, R. A. Sperling, C. E. Teunissen, S. C. Weninger, S. L. Worley, H. Zheng, M. C. Carrillo
Novel avenues of tau research
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024, Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 20 (3), pp.2240-2261. ⟨10.1002/alz.13533⟩
Violaine Bortolin, Zeyni Mansuroglu, Laurine Conquet, Gaetano Calcagno, Fanny Lambert, Jose Pablo Marin-Obando, Helena Segrt, Mary Savino, Reyene Menidjel, Sylvie Souès, Luc Buée, Florence Niedergang, Marie-Christine Galas, Xavier Montagutelli, Eliette Bonnefoy
Protein kinase R induced by type I interferons is a main regulator of reactive microglia in Zika virus infection
Glia, In press, ⟨DOI: 10.1002/glia.24619⟩
Justine Mortelecque, Orgeta Zejneli, Séverine Bégard, Nguyen Marine, François-Xavier Cantrelle, Xavier Hanoulle, Jean-Christophe Rain, Morvane Colin, Luc Buée, Isabelle Landrieu, Clément Danis, Elian Dupré
Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein
2023
Mahdi Ghazal, Anna Susloparova, Camille Lefebvre, Michel Daher Mansour, Najami Ghodhbane, Alexis Melot, Corentin Scholaert, David Guérin, Sebastien Janel, Nicolas Barois, Morvane Colin, Luc Buée, Pierre Yger, Sophie Halliez, Yannick Coffinier, Sébastien Pecqueur, Fabien Alibart
Electropolymerization processing of side-chain engineered EDOT for high performance microelectrode arrays
Biosensors and Bioelectronics, 2023, 237, pp.115538. ⟨10.1016/j.bios.2023.115538⟩
Iain Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Marwaha, Manon Graffeuil, Laurie Lau, Jeanette Norman, David Chatelet, Luc Buee, James Nicoll, David Blum, Guillaume Dorothee, Delphine Boche
Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology
Brain - A Journal of Neurology , 2023, pp.awad309. ⟨10.1093/brain/awad309⟩
K. Menšíková, J. C. Steele, R. Rosales, C. Colosimo, P. Spencer, A. Lannuzel, Y. Ugawa, R. Sasaki, S. Giménez-Roldán, R. Matej, L. Tuckova, D. Hrabos, K. Kolarikova, R. Vodicka, R. Vrtel, M. Strnad, P. Hlustik, P. Otruba, M. Prochazka, M. Bares, S. Boluda, Luc Buee, G. Ransmayr, P. Kaňovský
Endemic parkinsonism: clusters, biology and clinical features
Nature Reviews Neurology, 2023, Nature Reviews Neurology, ⟨10.1038/s41582-023-00866-3⟩
Mahdi Ghazal, Corentin Scholaert, Corentin Dumortier, Camille Lefebvre, Nicolas Barois, Sebastien Janel, Mehmet Tarhan, Morvane Colin, Luc Buée, Sophie Halliez, Sébastien Pecqueur, Yannick Coffinier, F. Alibart, Pierre Yger
Precision of neuronal localization in 2D cell cultures by using high-performance electropolymerized microelectrode arrays correlated with optical imaging
Biomedical Physics & Engineering Express, 2023, 9 (3), pp.035016. ⟨10.1088/2057-1976/acb93e⟩
Romain Perbet, Valentin Zufferey, Elodie Leroux, Enea Parietti, Jeanne Espourteille, Lucas Culebras, Sylvain Perriot, Renaud Du Pasquier, Séverine Bégard, Vincent Deramecourt, Nicole Déglon, Nicolas Toni, Luc Buée, Morvane Colin, Kevin Richetin
Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System
Cells, 2023, 12 (7), pp.985. ⟨10.3390/cells12070985⟩
Bruno Lefebvre, Thomas Rico, Luc Buée
METHODS FOR IMPROVING THE EFFICACY OF HDAC INHIBITOR THERAPY AND PREDICTING THE RESPONSE TO TREATMENT WITH HDAC INHIBITOR
France, Patent n° : WO2023041805A1. 2023
Marie Tautou, Florian Descamps, Paul-Emmanuel Larchanché, Luc Buée, Jamal El Bakali, Patricia Melnyk, Nicolas Sergeant
A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APPSwe/PSEN1ΔE9 Mice Model of Amyloid Pathology
International Journal of Molecular Sciences, 2023, 24 (6), pp.5285. ⟨10.3390/ijms24065285⟩
Thomas Rico, Marine Denecha, Raphaelle Caillierez, Thomas Comptdaer, Eric Adriaenssens, Luc Buée, Bruno Lefebvre
Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents
Cancers, 2023, 15 (1), pp.116. ⟨10.3390/cancers15010116⟩
Thomas Rico, Marine Denechaud, Raphaelle Caillierez, Thomas Comptdaer, Eric Adriaenssens, Luc Buée, Bruno Lefebvre
Cancers
Cancers, 2022, 15 (1), pp.116. ⟨10.3390/cancers15010116⟩
Edmone Dewaeles, Kévin Carvalho, Sandy Fellah, Jaewon Sim, Nihad Boukrout, Raphaelle Caillierez, Hariharan Ramakrishnan, Cynthia van der Hauwaert, Jhenkruthi Vijaya Shankara, Nathalie Martin, Noura Massri, Agathe Launay, Joseph Folger, Clémentine de Schutter, Romain Larrue, Ingrid Loison, Marine Goujon, Matthieu Jung, Stéphanie Le Gras, Victoria Gomez-Murcia, Emilie Faivre, Julie Lemaire, Anne Garat, Nicolas Beauval, Patrice Maboudou, Viviane Gnemmi, Jean-Baptiste Gibier, Luc Buée, Corinne Abbadie, Francois Glowacki, Nicolas Pottier, Michael Perrais, Rodrigo Cunha, Jean-Sébastien Annicotte, Geoffroy Laumet, David Blum, Christelle Cauffiez
Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects
The Journal of clinical investigation, 2022, 132 (22), pp.e152924. ⟨10.1172/JCI152924⟩
Christophe Mesangeau, Pascal Carato, Nicolas Renault, Mathilde Coevoet, Paul-Emmanuel Larchanché, Amélie Barczyk, Luc Buée, Nicolas Sergeant, Patricia Melnyk
Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles
International Journal of Molecular Sciences, 2022, 23 (21), pp.13111. ⟨10.3390/ijms232113111⟩
Maria Manfredi-Lozano, Valerie Leysen, Michela Adamo, Isabel Paiva, Renaud Rovera, Jean-Michel Pignat, Fatima Ezzahra Timzoura, Michael Candlish, Sabiha Eddarkaoui, Samuel Malone, Mauro Silva, Sara Trova, Monica Imbernon, Laurine Decoster, Ludovica Cotellessa, Manuel Tena-Sempere, Marc Claret, Ariane Paoloni-Giacobino, Damien Plassard, Emmanuelle Paccou, Nathalie Vionnet, James Acierno, Aleksandra Maleska Maceski, Antoine Lutti, Frank Pfrieger, S. Rasika, Federico Santoni, Ulrich Boehm, Philippe Ciofi, Luc Buée, Nasser Haddjeri, Anne-Laurence Boutillier, Jens Kuhle, Andrea Messina, Bogdan Draganski, Paolo Giacobini, Nelly Pitteloud, Vincent Prevot
GnRH replacement rescues cognition in Down syndrome
Science, 2022, 377 (6610), pp.eabq4515. ⟨10.1126/science.abq4515⟩
Jessica Pressey, Floriane Louboutin, Marion Russeau, Emily Faivre, Claire Montmasson, Kervin Carvalho, Luc Buée, David Blum, Sabine Lévi
Opposite effects of neuronal and glial A2A receptors on glutamatergic synapse remodeling during synaptogenesis
FENS, Jul 2022, PARIS, France
Hamza Benderradji, Anne-Laure Barbotin, M. Leroy-Billiard, J. Prasivoravong, F. Marcelli, C. Decanter, Geoffroy Robin, V. Mitchell, J. M. Rigot, Antonino Bongiovanni, Florent Sauve, Luc Buee, Claude-Alain Maurage, M. Cartigny, Arnauld Villers, Vincent Prevot, Sophie Jonard-Catteau, Nicolas Sergeant, Paolo Giacobini, Pascal Pigny, C. Leroy
Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men.
Journal of Clinical Endocrinology and Metabolism, 2022, The Journal of clinical endocrinology & metabolism, 107 (7), p. 1878-1887. ⟨10.1210/clinem/dgac218⟩
Ouada Nebie, Luc Buée, David Blum, Thierry Burnouf
Can the administration of platelet lysates to the brain help treat neurological disorders?
Cellular and Molecular Life Sciences, 2022, 79 (7), pp.379. ⟨10.1007/s00018-022-04397-w⟩
Shu-Mei Chen, Tsung-Chin Hsu, Chee-Ho Chew, Wan-Ting Huang, Amanda Lin Chen, Yung-Feng Lin, Sabiha Eddarkaoui, Luc Buée, Chien-Chung Chen
Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer’s Disease
International Journal of Molecular Sciences, 2022, 23 (12), pp.6855. ⟨10.3390/ijms23126855⟩
Isabel Paiva, Lucrezia Cellai, Céline Meriaux, Lauranne Poncelet, Ouada Nebie, Jean-Michel Saliou, Anne-Sophie Lacoste, Anthony Papegaey, Hervé Drobecq, Stéphanie Le Gras, Marion Schneider, Enas Malik, Christa Müller, Emilie Faivre, Kevin Carvalho, Victoria Gomez-Murcia, Didier Vieau, Bryan Thiroux, Sabiha Eddarkaoui, Thibaud Lebouvier, Estelle Schueller, Laura Tzeplaeff, Iris Grgurina, Jonathan Seguin, Jonathan Stauber, Luisa Lopes, Luc Buée, Valérie Buée-Scherrer, Rodrigo Cunha, Rima Ait-Belkacem, Nicolas Sergeant, Jean-Sébastien Annicotte, Anne-Laurence Boutillier, David Blum
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription
The Journal of clinical investigation, 2022, 132 (12), ⟨10.1172/JCI149371⟩
Lee-Hsin Wang, Chien-Yu Lin, Yu-Mei Lin, Luc Buée, Nicolas Sergeant, David Blum, Yijuang Chern, Guey-Shin Wang
Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration
Journal of Neuroscience, 2022, pp.JN-RM-2006-21. ⟨10.1523/JNEUROSCI.2006-21.2022⟩
Matthieu Rousset, Sandrine Humez, Cyril Laurent, Luc Buée, David Blum, Thierry Cens, Michel Vignes, Pierre Charnet
Mammalian Brain Ca2+ Channel Activity Transplanted into Xenopus laevis Oocytes
Membranes, 2022, 12 (5), pp.496. ⟨10.3390/membranes12050496⟩
Laëtitia Degiorgis, Eléna Chabran, Marion Sourty, Luc Buée, Frédéric Blanc, Laura Harsan
Translational exploration of dynamic functional connectivity changes in Alzheimer’s disease patients and Thy-Tau22 mice at the prodromal stage
Joint Annual Meeting ISMRM-ESMRMB and ISMRT 31st Annual Meeting, May 2022, Londres, United Kingdom
Victoria Gomez-Murcia, Kevin Carvalho, Bryan Thiroux, Raphaëlle Caillierez, Melanie Besegher, Nicolas Sergeant, Luc Buée, Emile Faivre, David Blum
Impact of chronic doxycycline treatment in the APP/PS1 mouse model of Alzheimer's disease
Neuropharmacology, 2022, 209, pp.108999. ⟨10.1016/j.neuropharm.2022.108999⟩
Hamza Benderradji, E. Vernotte, Gustavo Soto-Ares, J. P. Woillez, Arnaud Jannin, Romain Perbet, Melodie-Anne Karnoub, B. Soudan, Richard Assaker, Luc Buee, Vincent Prevot, Claude-Alain Maurage, Pascal Pigny, Marie-Christine Vantyghem, Emilie Merlen, C. Cortet
Efficacy of lanreotide 120 mg primary therapy on tumor shrinkage and ophthalmologic symptoms in acromegaly after one month.
Clinical Endocrinology, 2022, Clinical Endocrinology, ⟨10.1111/cen.14748⟩
Thibaut Gauvrit, Hamza Benderradji, Luc Buée, David Blum, Didier Vieau
Early-Life Environment Influence on Late-Onset Alzheimer’s Disease
Frontiers in Cell and Developmental Biology, 2022, 10, pp.834661. ⟨10.3389/fcell.2022.834661⟩
Hamza Benderradji, Sarra Kraiem, Emilie Courty, Sabiha Eddarkaoui, Cyril Bourouh, Emilie Faivre, Laure Rolland, Emilie Caron, Mélanie Besegher, Frederik Oger, Theo Boschetti, Kévin Carvalho, Bryan Thiroux, Thibaut Gauvrit, Emilie Nicolas, Victoria Gomez-Murcia, Anna Bogdanova, Antonino Bongiovanni, Anne Muhr-Tailleux, Steve Lancel, Kadiombo Bantubungi, Nicolas Sergeant, Jean-Sebastien Annicotte, Luc Buée, Didier Vieau, David Blum, Valérie Buée-Scherrer
Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model
Frontiers in Molecular Neuroscience, 2022, 15, pp.841892. ⟨10.3389/fnmol.2022.841892⟩
Ludovic Arandel, Magdalena Matloka, Arnaud F Klein, Frédérique Rau, Alain Sureau, Michel Ney, Aurélien Cordier, Maria Kondili, Micaela Polay-Espinoza, Naira Naouar, Arnaud Ferry, Mégane Lemaitre, Séverine Begard, Morvane Colin, Chloé Lamarre, Hélène Tran, Luc Buée, Joëlle Marie, Nicolas Sergeant, Denis Furling
Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats
Nature Biomedical Engineering, 2022, 6 (2), pp.207-220. ⟨10.1038/s41551-021-00838-2⟩
Paulo da Costa, Malika Hamdane, Luc Buée, Franck Martin
Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey
Biomedicines, 2022, 10 (2), pp.241. ⟨10.3390/biomedicines10020241⟩
Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, Christiane Baret-Rose, Jean-Marc Tréluyer, Hendy Abdoul, Patrick Gelé, Christine Delmaire, Frédéric Blanc, Jean-François Mangin, Luc Buée, Jacques Touchon, Jacques Hugon, Bruno Vellas, Evelyne Galbrun, Athanase Benetos, Gilles Berrut, Elena Paillaud, David Wallon, Giovanni Castelnovo, Lisette Volpe-Gillot, Marc Paccalin, Philippe Robert, Olivier Godefroy, Vincent Camus, Joël Belmin, Pierre Vandel, Jean-Luc Novella, Emmanuelle Duron, Anne-Sophie Rigaud, Susanna Schraen-Maschke, Audrey Gabelle
Plasma Amyloid Beta Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment: The BALTAZAR Study
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2022, 18, pp.2537-2550. ⟨10.1002/alz.12613⟩
Clément Danis, Elian Dupré, Orgeta Zejneli, Raphaëlle Caillierez, Alexis Arrial, Séverine Bégard, Justine Mortelecque, Sabiha Eddarkaoui, Anne Loyens, François-Xavier Cantrelle, Xavier Hanoulle, Jean-Christophe Rain, Morvane Colin, Luc Buée, Isabelle Landrieu
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
Molecular Therapy, 2022, ⟨10.1016/j.ymthe.2022.01.009⟩
Ilda Coku, Eugénie Mutez, Sabiha Eddarkaoui, Sébastien Carrier, Antoine Marchand, Claire Deldycke, Liesel Goveas, Guillaume Baille, Mélissa Tir, Romain Magnez, Xavier Thuru, Gaëlle Vermeersch, Wim Vandenberghe, Luc Buée, Luc Defebvre, Bernard Sablonnière, Marie-Christine Chartier-Harlin, Jean-Marc Taymans, Vincent Huin
Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.
Movement Disorders, 2022, ⟨10.1002/mds.29124⟩
Ariunjargal Nyam-Erdene, Ouada Nebie, Liling Delila, Luc Buée, David Devos, Szu-Yi Chou, David Blum, Thierry Burnouf
Characterization and Chromatographic Isolation of Platelet Extracellular Vesicles from Human Platelet Lysates for Applications in Neuroregenerative Medicine
ACS Biomaterials Science and Engineering, 2021, 7 (12), pp.5823-5835. ⟨10.1021/acsbiomaterials.1c01226⟩
Suzanne Lam, Fanny Petit, Anne-Sophie Hérard, Susana Boluda, Sabiha Eddarkaoui, Martine Guillermier, Luc Buée, Charles Duyckaerts, Stéphane Haïk, Jean-Luc Picq, Marc Dhenain
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
Acta Neuropathologica Communications, 2021, 9 (1), pp.165. ⟨10.1186/s40478-021-01266-8⟩
Élodie Leroux, Romain Perbet, Luc Buée, Morvane Colin
Les vésicules extracellulaires
Médecine/Sciences, 2021, 37 (12), pp.1133-1138. ⟨10.1051/medsci/2021205⟩
Clément Danis, Elian Dupré, Orgeta Zejneli, Raphaëlle Caillierez, Alexis Arrial, Séverine Bégard, Anne Loyens, Justine Mortelecque, François-Xavier Cantrelle, Xavier Hanoulle, Jean-Christophe Rain, Morvane Colin, Luc Buée, Isabelle Landrieu
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
2021
Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarasse
P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy
Progress in Neurobiology, 2021, 206, pp.102139. ⟨10.1016/j.pneurobio.2021.102139⟩
Thomas Rico, Melissa Gilles, Alban Chauderlier, Thomas Comptdaer, Romain Magnez, Maggy Chwastyniak, Herve Drobecq, Florence Pinet, Xavier Thuru, Luc Buée, Marie-Christine Galas, Bruno Lefebvre
Tau Stabilizes Chromatin Compaction
Frontiers in Cell and Developmental Biology, 2021, 9, pp.740550. ⟨10.3389/fcell.2021.740550⟩
Claire Sexton, Heather Snyder, Dirk Beher, Adam Boxer, Pat Brannelly, Jean‐pierre Brion, Luc Buée, Angela Cacace, Gaël Chételat, Martin Citron, Sarah Devos, Kristophe Diaz, Howard Feldman, Bess Frost, Alison Goate, Michael Gold, Bradley Hyman, Keith Johnson, Celeste Karch, Diana Kerwin, Walter Koroshetz, Irene Litvan, Huw Morris, Catherine Mummery, James Mutamba, Marc Patterson, Yakeel Quiroz, Gil Rabinovici, Amy Rommel, Melanie Shulman, Leticia Toledo‐sherman, Stacie Weninger, Kristin Wildsmith, Susan Worley, Maria Carrillo
Current directions in tau research: Highlights from Tau 2020
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, Online ahead of print. ⟨10.1002/alz.12452⟩
Elodie Leroux, Romain Perbet, Raphaëlle Caillerez, Kevin Richetin, Sarah Lieger, Jeanne Espourteille, Thomas Bouillet, Séverine Bégard, Clément Danis, Anne Loyens, Nicolas Toni, Nicole Déglon, Vincent Deramecourt, Susanna Schraen-Maschke, Luc Buée, Morvane Colin
Extracellular vesicles: major actors of heterogeneity in tau spreading among human tauopathies
Molecular Therapy, 2021, pp.S1525-0016(21)00475-5. ⟨10.1016/j.ymthe.2021.09.020⟩
Helena Brigas, Miguel Ribeiro, Joana Coelho, Rui Gomes, Victoria Gomez-Murcia, Kevin Carvalho, Emilie Faivre, Sara Costa-Pereira, Julie Darrigues, Afonso Antunes de Almeida, Luc Buée, Jade Dunot, Hélène Marie, Paula Pousinha, David Blum, Bruno Silva-Santos, Luísa Lopes, Julie Ribot
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease
Cell Reports, 2021, 36 (9), pp.109574. ⟨10.1016/j.celrep.2021.109574⟩
Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelmans
THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency
Neurobiology of Disease, 2021, 155, pp.105398. ⟨10.1016/j.nbd.2021.105398⟩
Marie Tautou, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanché, Jamal El Bakali, Liesel Mary Goveas, Mélanie Dumoulin, Chloé Lamarre, David Blum, Luc Buée, Patricia Melnyk, Nicolas Sergeant
A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration
Frontiers in Pharmacology, 2021, 12, pp.679335. ⟨10.3389/fphar.2021.679335⟩
Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum, Yijuang Chern
Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
Acta Neuropathologica Communications, 2021, 9 (1), pp.112. ⟨10.1186/s40478-021-01213-7⟩
Ouada Nebie, Kevin Carvalho, Lassina Barro, Liling Delila, Emilie Faivre, Ting-Yi Renn, Ming-Li Chou, Yu-Wen Wu, Ariunjargal Niem-Redene, Szu-Yi Chou, Luc Buée, Chaur-Jong Hu, Chih-Wei Peng, David Devos, David Blum, Thierry Burnouf
Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment
Brain - A Journal of Neurology , 2021, pp.awab205. ⟨10.1093/brain/awab205⟩
Marie Tautou, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanché, Mélanie Dumoulin, Chloé Lamarre, David Blum, Luc Buée, Patricia Melnyk, Nicolas Sergeant
A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration
2021
Laëtitia Degiorgis, Eléna Chabran, Marion Sourty, Meltem Karatas, David Blum, Luc Buée, Frédéric Blanc, Laura Harsan
Prodromal changes in hippocampal functional connectivity in AD patients and Thy-tau22 mice: a translational exploration
Alzheimer's disease and Parkinson's disease conference, Mar 2021, En ligne, France
Anna Susloparova, Sophie Halliez, Séverine Begard, Morvane Colin, Luc Buée, Sébastien Pecqueur, F. Alibart, V. Thomy, S. Arscott, Emiliano Pallecchi, Yannick Coffinier
Low impedance and highly transparent microelectrode arrays (MEA) for in vitro neuron electrical activity probing
Sensors and Actuators B: Chemical, 2021, 327, pp.128895. ⟨10.1016/j.snb.2020.128895⟩
Vincent Damotte, Sven J. van Der Lee, Vincent Chouraki, Benjamin Grenier-Boley, Jeannette Simino, Hieab Adams, Giuseppe Tosto, Charles White, Natalie Terzikhan, Carlos Cruchaga, Maria J. Knol, Shuo Li, Susanna Schraen, Megan L. Grove, Claudia Satizabal, Najaf Amin, Claudine Berr, Steven Younkin, Rebecca F. Gottesman, Luc Buee, Alexa Beiser, David S. Knopman, Andre Uitterlinden, Charles Decarli, Jan Bressler, Anita Destefano, Jean-Francois Dartigues, Qiong Yang, Eric Boerwinkle, Christophe Tzourio, Myriam Fornage, M. Arfan Ikram, Philippe Amouyel, Phil de Jager, Christiane Reitz, Thomas H. Mosley, Jean-Charles Lambert, Sudha Seshadri, Cornelia M. van Duijn
Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, In press, ⟨10.1002/alz.12333⟩
Kevin Richetin, Pascal Steullet, Mathieu Pachoud, Romain Perbet, Enea Parietti, Mathischan Maheswaran, Sabiha Eddarkaoui, Séverine Bégard, Catherine Pythoud, Maria Rey, Raphaëlle Caillierez, Kim Q Do, Sophie Halliez, Paola Bezzi, Luc Buée, Geneviève Leuba, Morvane Colin, Nicolas Toni, Nicole Déglon
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
Nature Neuroscience, 2020, 23 (12), pp.1567-1579. ⟨10.1038/s41593-020-00728-x⟩
Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah Croteau, Marie-Christine Galas, Vilhelm Bohr
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy
Acta Neuropathologica Communications, 2020, 8 (1), ⟨10.1186/s40478-020-00896-8⟩
Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah Croteau, Marie-Christine Galas, Vilhelm Bohr
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy
Acta Neuropathologica Communications, 2020, 8 (1), pp.25. ⟨10.1186/s40478-020-00896-8⟩
Laetitia Degiorgis, Meltem Karatas, Marion Sourty, Emilie Faivre, Julien Lamy, Vincent Noblet, Thomas Bienert, Marco Reisert, Dominik von Elverfeldt, Luc Buée, David Blum, Anne-Laurence Boutillier, Jean-Paul Armspach, Frédéric Blanc, Laura-Adela Harsan
Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice
Brain - A Journal of Neurology , 2020, ⟨10.1093/brain/awaa312⟩
Loan Vaillant-Beuchot, Arnaud Mary, Raphaëlle Pardossi-Piquard, Alexandre Bourgeois, Inger Lauritzen, Fanny Eysert, Paula Fernanda Kinoshita, Julie Cazareth, Céline Badot, Konstantina Fragaki, Renaud Bussiere, Cécile Martin, Rosanna Mary, Charlotte Bauer, Sophie Pagnotta, Véronique Paquis-Flucklinger, Valérie Buée-Scherrer, Luc Buée, Sandra Lacas-Gervais, Frédéric Checler, Mounia Chami
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains
Acta Neuropathologica, 2020, ⟨10.1007/s00401-020-02234-7⟩
Tariq Ahmed, Ann van Der Jeugd, Raphaëlle Caillierez, Luc Buée, David Blum, Rudi D’hooge, Detlef Balschun
Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy
Frontiers in Molecular Neuroscience, 2020, 13, pp.570223. ⟨10.3389/fnmol.2020.570223⟩
Joke Verelst, Nick Geukens, Sabiha Eddarkaoui, Dorien Vliegen, Elien de Smidt, Joëlle Rosseels, Vanessa Franssens, Sofie Molenberghs, Cindy Francois, Erik Stoops, Maria Bjerke, Sebastiaan Engelborghs, Mohamed Laghmouchi, Sofie Carmans, Luc Buée, Eugeen Vanmechelen, Joris Winderickx, Debby Thomas
A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms
Frontiers in Molecular Biosciences, 2020, 7, pp.48. ⟨10.3389/fmolb.2020.00048⟩
Ouada Nebie, Lassina Barro, Yu-Wen Wu, Folke Knutson, Luc Buee, David Devos, Michael T Heneka, Chih-Wei Peng, David Blum, Thierry Burnouf
Heat-treated human platelet pellet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation in vitro
Platelets, 2020, 1, pp.1-12. ⟨10.1080/09537104.2020.1732324⟩
Audrey Hector, Christina Mcanulty, Maude‐éloïse Piché‐lemieux, Claire Alves‐pires, Valérie Buée‐scherrer, Luc Buée, Jonathan Brouillette
Tau hyperphosphorylation induced by the anesthetic agent ketamine/xylazine involved the calmodulin‐dependent protein kinase II
FASEB Journal, 2020, 34 (2), pp.2968-2977. ⟨10.1096/fj.201902135R⟩
Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buee, Bart de Strooper, Mark Fiers
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
EMBO Molecular Medicine, 2020, pp.e10606. ⟨10.15252/emmm.201910606⟩
Mégane Homa, Anne Loyens, Sabiha Eddarkaoui, Emilie Faivre, Vincent Deramecourt, Claude-Alain Maurage, Luc Buée, Vincent Huin, Bernard Sablonnière
The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals
The Cerebellum, In press, Ahead of print. ⟨10.1007/s12311-020-01112-y⟩
Victoria Gomez-Murcia, Ursula Sandau, Barbara Ferry, Sandrine Parrot, Cyril Laurent, Marie Basquin, Luc Buée, Detlev Boison, David Blum
Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy
Neurobiology of Aging, 2020, 94, pp.265-270. ⟨10.1016/j.neurobiolaging.2020.06.004⟩
Enrico Faldini, Tariq Ahmed, Luc Buée, David Blum, Detlef Balschun
Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models
Acta Neuropathologica Communications, 2019, 7 (1), pp.202. ⟨10.1186/s40478-019-0813-4⟩
Charlotte Gary, Suzanne Lam, Anne-Sophie Herard, James E Koch, Fanny Petit, Pauline Gipchtein, Stephen J Sawiak, Raphaëlle Caillierez, Sabiha Eddarkaoui, Morvane Colin, Fabienne Aujard, Jean-Philippe Deslys, French Neuropathology Network, Emmanuel Brouillet, Luc Buée, Emmanuel E Comoy, Fabien Pifferi, Jean-Luc Picq, Marc Dhenain
Encephalopathy induced by Alzheimer brain inoculation in a non-human primate
Acta Neuropathologica Communications, 2019, 7 (1), ⟨10.1186/s40478-019-0771-x⟩
Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, Jean-Christophe Devedjian, Aurélie Jonneaux, Ming-Li Chou, Régis Bordet, Luc Buee, Folke Knutson, David Blum, Thierry Burnouf
The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates
Journal of Biomedical Science, 2019, 26 (1), pp.89. ⟨10.1186/s12929-019-0579-9⟩
Yann Fichou, Youssra K Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée, Isabelle Landrieu
The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?
Acta Neuropathologica Communications, 2019, 7 (1), ⟨10.1186/s40478-019-0682-x⟩
Morvane Colin, Simon Dujardin, Susanna Schraen-Maschke, Guy Meno-Tetang, Charles Duyckaerts, Jean-Philippe Courade, Luc Buee
From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
Acta Neuropathologica, 2019, Epub ahead of print. ⟨10.1007/s00401-019-02087-9⟩
Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín Mcmanus, Dario Tejera, Angelika Griep, Francesco Santarelli, Frederic Brosseron, Sabine Opitz, James Stunden, Maximilian Merten, Rakez Kayed, Douglas Golenbock, David Blum, Eicke Latz, Luc Buée, Michael T. Heneka
NLRP3 inflammasome activation drives tau pathology
Nature, 2019, 575 (7784), pp.669-673. ⟨10.1038/s41586-019-1769-z⟩
Kevin Carvalho, Emilie Faivre, Marie Pietrowski, Xavier Marques, Victoria Gomez-Murcia, Aude Deleau, Vincent Huin, Jan Hansen, Stanislav Kozlov, Clément Danis, Mariana Temido-Ferreira, Joana Coelho, Céline Mériaux, Sabiha Eddarkaoui, Stéphanie Le Gras, Mélanie Dumoulin, Lucrezia Cellai, Isabelle Landrieu, Yijuang Chern, Malika Hamdane, Luc Buee, Anne-Laurence Boutillier, Sabine Lévi, Annett Halle, Luisa Lopes, David Blum
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor
Brain - A Journal of Neurology , 2019, 142 (11), pp.3636-3654. ⟨10.1093/brain/awz288⟩
Stefania Zappettini, Emilie Faivre, Antoine Ghestem, Sébastien Carrier, Luc Buee, David Blum, Monique Esclapez, Christophe Bernard
Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy
Frontiers in Cellular Neuroscience, 2019, 13, pp.438. ⟨10.3389/fncel.2019.00438⟩
Stefania Zappettini, Emilie Faivre, Antoine Ghestem, Sébastien Carrier, Luc Buee, David Blum, Monique Esclapez, Christophe Bernard
Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy
Frontiers in Cellular Neuroscience, 2019, 13, pp.438. ⟨10.3389/fncel.2019.00438⟩
Vincent Huin, Claire-Marie Dhaenens, Mégane Homa, Kévin Carvalho, Luc Buée, Bernard Sablonnière
Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases
Journal of Caffeine and Adenosine Research, 2019, 9 (3), pp.73-88. ⟨10.1089/caff.2019.0011⟩
Nicolas Sergeant, Valérie Vingtdeux, Sabiha Eddarkaoui, Marion Gay, Caroline Evrard, Nicolas Le Fur, Cyril Laurent, Raphaëlle Caillierez, Hélène Obriot, Paul-Emmanuel Larchanché, Amaury Farce, Mathilde Coevoet, Pascal Carato, Mostafa Kouach, Amandine Descat, Patrick Dallemagne, Valérie Buée-Scherrer, David Blum, Malika Hamdane, Luc Buee, Patricia Melnyk
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease
Neurobiology of Disease, 2019, 129, p.217-233. ⟨10.1016/j.nbd.2019.03.028⟩
Elian Dupré, Clément Danis, Alexis Arrial, Xavier Hanoulle, Mégane Homa, François-Xavier Cantrelle, Hamida Merzougui, Morvane Colin, Jean-Christophe Rain, Luc Buée, Isabelle Landrieu
Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies
ACS Chemical Neuroscience, 2019, 10 (9), pp.3997-4006. ⟨10.1021/acschemneuro.9b00217⟩
Isabel Paiva, Kévin Carvalho, Patricia R. Santos, Lucrezia Cellai, Maria Angeliki S. Pavlou, Gaurav Jain, Thorsten Gnad, Alexander Pfeifer, Didier D. Vieau, André Fischer, Luc Buee, Tiago Outeiro, David Blum
A2A R‐induced transcriptional deregulation in astrocytes: An in vitro study
Glia, 2019, 67 (12), pp.2329-2342. ⟨10.1002/glia.23688⟩
Marie Albert, Georges Mairet-Coello, Clément Danis, Sarah Lieger, Raphaëlle Caillierez, Sébastien Carrier, Emilie Skrobala, Isabelle Landrieu, Anne Michel, Mathieu Schmitt, Martin Citron, Patrick Downey, Jean-Philippe Courade, Luc Buee, Morvane Colin
Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody
Brain - A Journal of Neurology , 2019, 142 (6), pp.1736-1750. ⟨10.1093/brain/awz100⟩
Marie Pietrowski, Xavier Marques, Victoria Gomez-Murcia, Aude Deleau, Mariana Temido-Ferreira, E. Coelho Joana, Stéphanie Le Gras, Bank Neuroceb Brain, Yijuang Chern, Malika Hamdane, Luc Buée, Anne-Laurence Boutillier, Sabine Lévi, Annett Halle, David Lopes Luisa V. And Blum
Neuronal adenosine A2A receptor overexpression exacerbates Tau-related memory deficits in a model of Tauopathy
GDR Mémoire, May 2019, Marseille, France
Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aurélie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaëlle Caillierez, Emmanuelle Vallez, Bart Staels, Didier D. Vieau, Detlef Balschun, Luc Buee, David Blum
Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model
Neurobiology of Disease, 2019, 125, pp.14-22. ⟨10.1016/j.nbd.2019.01.008⟩
Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aurélie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaelle Caillierez, Emmanuelle Vallez, Bart Staels, Didier Vieau, Detlef Balschun, Luc Buee, David Blum
Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model
Neurobiology of Disease, 2019, 125, pp.14-22. ⟨10.1016/j.nbd.2019.01.008⟩
Manon Domise, Florent Sauvé, Sébastien Didier, Raphaëlle Caillerez, Séverine Bégard, Sébastien Carrier, Morvane Colin, Claudia Marinangeli, Luc Buee, Valérie Vingtdeux
Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process
Cell Death and Disease, 2019, 10 (3), pp.221. ⟨10.1038/s41419-019-1464-x⟩
Maud Gratuze, Aurélie Joly-Amado, Luc Buee, Didier D. Vieau, David Blum
Tau, Diabetes and Insulin
Tau Biology, pp.259-287, 2019, ⟨10.1007/978-981-32-9358-8_21⟩
Francisco J. Fernandez-Gomez, Helene Tran, Claire-Marie Dhaenens, Marie-Laure Caillet-Boudin, Susanna Schraen-Maschke, David Blum, Bernard Sablonniere, Valérie Buée-Scherrer, Luc Buee, Nicolas Sergeant
Myotonic Dystrophy: an RNA Toxic Gain of Function Tauopathy?
Tau Biology, pp.207-216, 2019, ⟨10.1007/978-981-32-9358-8_17⟩
Marie-Christine Galas, Eliette Bonnefoy, Luc Buée, Bruno Lefebvre
Emerging Connections Between Tau and Nucleic Acids
Tau Biology, pp.135-143, 2019, ⟨10.1007/978-981-32-9358-8_12⟩
Santosh Jadhav, Jesus Avila, Michael Schöll, Gabor Kovacs, Enikö Kövari, Rostislav Skrabana, Lewis Evans, Eva Kontsekova, Barbara Malawska, Rohan de Silva, Luc Buee, Norbert Zilka
A walk through tau therapeutic strategies
Acta Neuropathologica Communications, 2019, 7 (1), pp.22. ⟨10.1186/s40478-019-0664-z⟩
Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhes‐hamon, Audrey Coens, Luc Buée, Philippe Hantraye, Antoine Triller, Ronald Melki
Clustering of Tau fibrils impairs the synaptic composition of $\alpha$3‐Na$^+$/K$^+$‐ATP ase and AMPA receptors
EMBO Journal, 2019, 38 (3), pp.e99871. ⟨10.15252/embj.201899871⟩
Annerieke Sierksma, Ashley Lu, Evgenia Salta, Elke Vanden Eynden, Zsuzsanna Callaerts-Vegh, Rudi D’hooge, David Blum, Luc Buée, Mark Fiers, Bart de Strooper
Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology
Molecular Neurodegeneration, 2018, 13 (1), pp.54. ⟨10.1186/s13024-018-0285-1⟩
Annerieke Sierksma, Ashley Lu, Evgenia Salta, Elke Vanden Eynden, Zsuzsanna Callaerts-Vegh, Rudi D’hooge, David Blum, Luc Buee, Mark Fiers, Bart de Strooper
Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology
Molecular Neurodegeneration, 2018, 13 (1), pp.54. ⟨10.1186/s13024-018-0285-1⟩
Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, Cédrick Lachaud, Sébastien Carrier, Sarah Lieger, Jose Gonzalez, Vincent Deramecourt, Nicole Déglon, Claude-Alain Maurage, Matthew Frosch, Bradley Hyman, Morvane Colin, Luc Buée
Different tau species lead to heterogeneous tau pathology propagation and misfolding
Acta Neuropathologica Communications, 2018, 6 (1), pp.132. ⟨10.1186/s40478-018-0637-7⟩
Sebastien Didier, Florent Sauve, Manon Domise, Luc Buee, Claudia Marinangeli, Valerie Vingtdeux
Amp-activated protein kinase controls immediate early genes expression following synaptic activation through the pka/creb pathway
International Journal of Molecular Sciences, 2018, 19 (2), pp.3716. ⟨10.3390/ijms19123716⟩
Snehajyoti Chatterjee, Raphaelle Cassel, Anne Schneider‐anthony, Karine Mérienne, Brigitte Cosquer, Laura Tzeplaeff, Sarmistha Halder Sinha, Manoj Kumar, Piyush Chaturbedy, Muthusamy Eswaramoorthy, Stephanie Le Gras, Céline Keime, Olivier Bousiges, Patrick Dutar, Petnoi Petsophonsakul, Claire Rampon, Jean‐christophe Cassel, Luc Buée, David Blum, Tapas Kundu, Anne‐laurence Boutillier
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator
EMBO Molecular Medicine, 2018, 10 (11), pp.e8587. ⟨10.15252/emmm.201708587⟩
Aurélie Joly-Amado, Maud Gratuze, Hamza Benderradji, Didier D. Vieau, Luc Buee, David Blum
[Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies]
Médecine/Sciences, 2018, 34 (11), pp.929-935. ⟨10.1051/medsci/2018238⟩
Aurélie Joly-Amado, Maud Gratuze, Hamza Benderradji, Didier D. Vieau, Luc Buée, David Blum
Relation mutuelle entre Tau et signalisation centrale de l’insuline
Médecine/Sciences, 2018, 34 (11), pp.929-935. ⟨10.1051/medsci/2018238⟩
Marion Gay, Caroline Evrard, Florian Descamps, Pascal Carato, Nicolas Renault, Mathilde Coevoet, Sabiha Eddarkaoui, Catherine Baud, Paul-Emmanuel Larchanché, Luc Buée, Jamal El Bakali, Valérie Vingtdeux, Nicolas Sergeant, Patricia Melnyk
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors
European Journal of Medicinal Chemistry, 2018, 159, pp.104-125. ⟨10.1016/j.ejmech.2018.08.092⟩
Houda Benhelli-Mokrani, Zeyni Mansuroglu, Alban Chauderlier, Benoit Albaud, David Gentien, Sabrina Sommer, Claire Schirmer, Lucie Laqueuvre, Thibaut Josse, Luc Buée, Bruno Lefebvre, Marie-Christine Galas, Sylvie Souès, Eliette Bonnefoy
Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions
Nucleic Acids Research, 2018, ⟨10.1093/nar/gky929⟩
Houda Benhelli-Mokrani, Zeyni Mansuroglu, Alban Chauderlier, Benoit Albaud, David Gentien, Sabrina Sommer, Claire Schirmer, Lucie Laqueuvre, Thibaut Josse, Luc Buée, Bruno Lefebvre, Marie-Christine Galas, Sylvie Souès, Eliette Bonnefoy
Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions
Nucleic Acids Research, 2018, ⟨10.1093/nar/gky929⟩
Lucrezia Cellai, Kevin Carvalho, Emilie Faivre, Aude Deleau, Didier D. Vieau, Luc Buee, David Blum, Céline Mériaux, Victoria Gomez-Murcia
The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
Frontiers in Neuroscience, 2018, 12, pp.520. ⟨10.3389/fnins.2018.00520⟩
Luc Cellai, Kevin Carvalho, Emilie Faivre, Aude Deleau, Didier Vieau, Luc Buée, David Blum, Céline Mériaux, Victoria Gomez-Murcia
The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
Frontiers in Neuroscience, 2018, 12, pp.520. ⟨10.3389/fnins.2018.00520⟩
Alban Chauderlier, Melissa Gilles, Andrea Spolcova, Raphaëlle Caillierez, Maggy Chwastyniak, Michel Kress, Hervé Drobecq, Eliette Bonnefoy, Florence Pinet, Dominique Weil, Luc Buée, Marie-Christine Galas, Bruno Lefebvre
Tau/DDX6 interaction increases microRNA activity
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2018, 1861 (8), pp.762-772. ⟨10.1016/j.bbagrm.2018.06.006⟩
Alban Chauderlier, Melissa Gilles, Andrea Spolcova, Raphaelle Caillierez, Maggy Chwastyniak, Michel Kress, Herve Drobecq, Eliette Bonnefoy, Florence Pinet, Dominique Weil, Luc Buée, Marie-Christine Galas, Bruno Lefebvre
Tau/DDX6 interaction increases microRNA activity
BBA - Biochimica et Biophysica Acta, 2018, 1861 (8), pp.762-772. ⟨10.1016/j.bbagrm.2018.06.006⟩
Mariana Ferreira, Diana Ferreira, Vânia Batalha, Inês Marques-Morgado, Joana Coelho, Pedro Pereira, Rui Gomes, Andreia Pinto, Sara Carvalho, Paula Canas, Laetitia Cuvelier, Valerie Buée, Emilie Faivre, Younis Baqi, Christa Müller, José Pimentel, Serge N. Schiffmann, Luc Buée, Michael Bader, Tiago Outeiro, David Blum, Rodrigo Cunha, Hélène Marie, Paula Pousinha, Luísa Lopes
Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
Molecular Psychiatry, 2018, 25 (8), pp.1876-1900. ⟨10.1038/s41380-018-0110-9⟩
Emilie Faivre, Joana Coelho, Katja Zornbach, Enas Malik, Younis Baqi, Marion Schneider, Luc Cellai, Kevin Carvalho, Shéhérazade Sebda, Martin Figeac, Sabiha Eddarkaoui, Raphaëlle Caillierez, Yijuang Chern, Michael T. Heneka, Nicolas Sergeant, Christa Müller, Annett Halle, Luc Buée, Luisa Lopes, David Blum
Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2018, 11, pp.235. ⟨10.3389/fnmol.2018.00235⟩
Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, Jean-Marc Tréluyer, Patrick Gelé, Christine Delmaire, Frédéric Blanc, Jean-François Mangin, Luc Buee, Jacques Touchon, Jacques Hugon, Bruno Vellas, Evelyne Galbrun, Athanase Benetos, Gilles Berrut, Elena Paillaud, David Wallon, Giovanni Castelnovo, Lisette Volpe-Gillot, Marc Paccalin, Philippe-Henri Robert, Olivier Godefroy, Thierry Dantoine, Vincent Camus, Joël Belmin, Pierre Vandel, Jean-Luc Novella, Emmanuelle Duron, Anne-Sophie Rigaud, Suzanna Schraen-Maschke, Audrey Gabelle
Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018, 14 (7), pp.858-868. ⟨10.1016/j.jalz.2018.01.004⟩
David Blum, Yijuang Chern, Maria Rosaria Domenici, Luc Buée, Chien-Yu Lin, William Rea, Sergi Ferré, Patrizia Popoli
The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease
Journal of Caffeine and Adenosine Research, 2018, 8 (2), pp.43 - 58. ⟨10.1089/caff.2018.0006⟩
Olivier Vercruysse, Claire Paquet, Audrey Gabelle, Xavier Delbeuck, Frederic Blanc, David Wallon, Julien Dumurgier, Eloi Magnin, Olivier Martinaud, Barbara Jung, Olivier Bousiges, Sylvain Lehmann, Constance Delaby, Muriel Quillard-Murain, Katell Peoc H, Jean-Louis Laplanche, Elodie Bouaziz-Amar, Didier Hannequin, Bernard Sablonniere, Luc Buee, Jacques Hugon, Susanna Schraen, Florence Pasquier, Stephanie Bombois, Katell Peoc`h
Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF Biomarkers
Current Alzheimer Research, 2018, 15 (7), pp.691-700. ⟨10.2174/1567205015666180110113238⟩
Olivier Vercruysse, Claire Paquet, Eloi Gabelle, Xavier Delbeuck, Frédéric Blanc, David Wallon, Julien Dumurgier, Eloi Magnin, Olivier Martinaud, Barbara Jung, Olivier Bousiges, Sylvain Lehmann, Constance Delaby, Muriel Quillard-Murain, Katell Peoc'H, Jean-Louis Laplanche, Elodie Bouaziz-Amar, Didier Hannequin, Bernard Sablonniere, Luc Buée, Jacques Hugon, Susanna Schraen, Florence Pasquier, Stéphanie Bombois
Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF Biomarkers
Current Alzheimer Research, 2018, 15 (7), pp.691 - 700. ⟨10.2174/1567205015666180110113238⟩
Marion Gay, Pascal Carato, Mathilde Coevoet, Nicolas Renault, Paul-Emmanuel Larchanché, Amelie Barczyk, Saïd Yous, Luc Buée, Nicolas Sergeant, Patricia Melnyk
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism
Bioorganic and Medicinal Chemistry, 2018, 26 (8), pp.2151-2164. ⟨10.1016/j.bmc.2018.03.016⟩
Chia-Chia Lee, Ching-Pang Chang, Chun-Jung Lin, Hsing-Lin Lai, Yu-Han Kao, Sin-Jhong Chen, Hui-Mei Chen, Yu-Ping Liao, Emilie Faivre, Luc Buée, David Blum, Jim-Min Fang, Yijuang Chern
Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease
Molecular Neurobiology, 2018, ⟨10.1007/s12035-018-1030-z⟩
Cyril Laurent, Luc Buée, David Blum
Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
Biomedical journal, 2018, 41 (1), pp.21 - 33. ⟨10.1016/j.bj.2018.01.003⟩
Maud Gratuze, Aurélie Joly-Amado, Didier Vieau, Luc Buée, David Blum
Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ?
Neuroendocrinology, 2018, ⟨10.1159/000487641⟩
Marie D’orange, Gwenaëlle Auregan, Dimitri Cheramy, Mylène Gaudin-Guérif, Sarah Lieger, Martine Guillermier, Lev Stimmer, Charlène Joséphine, Anne-Sophie Herard, Marie-Claude Gaillard, Fanny Petit, Maren Christine Kiessling, Christoph Schmitz, Morvane Colin, Luc Buée, Fany Panayi, Elsa Diguet, Emmanuel Brouillet, Philippe Hantraye, Alexis-Pierre Bemelmans, Karine Cambon
Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat
Brain - A Journal of Neurology , 2018, 141 (2), pp.535-549. ⟨10.1093/brain/awx342⟩
Emmanuelle Duron, Jean-Sébastien Vidal, Dominique Grousselle, Audrey Gabelle, Sylvain Lehmann, Florence Pasquier, Stéphanie Bombois, Luc Buée, Bernadette Allinquant, Susanna Schraen-Maschke, Christiane Baret, Anne-Sophie Rigaud, Olivier Hanon, Jacques Epelbaum
Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aβ1–42 and Tau Proteins in Elderly Patients With Mild Cognitive Impairment
Frontiers in Aging Neuroscience, 2018, 10, pp.297. ⟨10.3389/fnagi.2018.00297⟩
Caroline Evrard, Pascal Kieulen-Campard, Mathilde Coevoet, Rémi Opsomer, Bernadette Tasiaux, Patricia Melnyk, Jean-Noël Octave, Luc Buee, Nicolas Sergeant, Valérie Vingtdeux
Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing
Frontiers in Cellular Neuroscience, 2018, 12, pp.435. ⟨10.3389/fncel.2018.00435⟩
Anna Susloparova, Yannick Coffinier, F. Alibart, V. Thomy, S. Arscott, Emiliano Pallecchi, Séverine Bégard, Sophie Halliez, Morvane Colin, Luc Buee
Fabrication of new transparent MEAs made from pure PEDOT:PSS and their optical/electrical properties for neurons' activity assessment in the frame of Alzheimer disease case study
Frontiers in Cellular Neuroscience, 2018, 12, ⟨10.3389/conf.fncel.2018.38.00035⟩
Alban Chauderlier, Lucie Delattre, Luc Buée, Marie-Christine Galas
In Vivo Hyperthermic Stress Model: An Easy Tool to Study the Effects of Oxidative Stress on Neuronal Tau Functionality in Mouse Brain
Methods Mol Biol., pp.369-373, 2017, ⟨10.1007/978-1-4939-6598-4_25⟩
Ioannis Sotiropoulos, Marie-Christine Galas, Joana Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher, Luc Buée
Atypical, non-standard functions of the microtubule associated Tau protein
Acta Neuropathologica Communications, 2017, 5 (1), ⟨10.1186/s40478-017-0489-6⟩
Ioannis Sotiropoulos, Marie-Christine Galas, Joana Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesús Avila, Miguel Medina, Amrit Mudher, Luc Buée
Atypical, non-standard functions of the microtubule associated Tau protein
Acta Neuropathologica Communications, 2017, 5 (1), ⟨10.1186/s40478-017-0489-6⟩
Vincent Huin, Vincent Deramecourt, Dominique Caparros-Lefebvre, Claude Alain Maurage, Charles Duyckaerts, Eniko Kovari, Valérie Buée-Scherrer, Julien Labreuche, Florence Pasquier, Hélène Behal, Luc Buée, Claire-Marie Dhaenens, Bernard Sablonnière
Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer’s disease and progressive supranuclear palsy brains
Scientific Reports, 2017, 7 (1), pp.12589. ⟨10.1038/s41598-017-12955-7⟩
Cyril Laurent, Guillaume Dorothee, Stéphane Hunot, Elodie Martin, Cecile Delarasse, Luc Buée, David Blum
Tau et troubles cognitifs
Médecine/Sciences, 2017, 33 (10), pp.817 - 819. ⟨10.1051/medsci/20173310002⟩
Elodie Marciniak, Antoine Leboucher, Emilie Caron, Tariq Ahmed, Anne Tailleux, Julie Dumont, Tarik Issad, Ellen Gerhardt, Patrick Pagesy, Margaux Vileno, Clément Bournonville, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Dominique Demeyer, Sabiha Eddarkaoui, Emmanuelle Vallez, Didier Vieau, Sandrine Humez, Emilie Faivre, Benjamin Grenier-Boley, Tiago Outeiro, Bart Staels, Philippe Amouyel, Detlef Balschun, Luc Buée, David Blum
Tau deletion promotes brain insulin resistance
Journal of Experimental Medicine, 2017, 214 (8), pp.2257 - 2269. ⟨10.1084/jem.20161731⟩
Vincent Anquetil, Anne Bertrand, Agnès Camuzat, Pierre de La Grange, Clémence Fournier, Valérie Buée-Scherrer, Vincent Deramecourt, Nicolas Sergeant, Mathieu Barbier, Luc Buée, Alexis Brice, Charles Duyckaerts, Isabelle Le Ber
Frontotemporal lobar degenerations, RNAopathy leading to proteinopathies
AAIC 2017 - Alzheimer's Association International Conference, Jul 2017, Londres, United Kingdom. 13 (7), 2017, ⟨10.1016/j.jalz.2017.06.1982⟩
Cyril Laurent, Guillaume Dorothee, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Véronique Sazdovitch, Susanna Schraen-Maschke, Cecile Delarasse, Luc Buée, David Blum
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy
Brain - A Journal of Neurology , 2017, 140 (1), pp.184 - 200. ⟨10.1093/brain/aww270⟩
Fanny Jumeau, Frédéric Chalmel, Francisco-Jose Fernandez-Gomez, Celine Carpentier, Hélène Obriot, Meryem Tardivel, Marie-Laure Caillet-Boudin, Jean-Marc Rigot, Nathalie Rives, Luc Buee, Nicolas Sergeant, Valerie Mitchell
Defining the human sperm microtubulome: an integrated genomics approach
Biology of Reproduction, 2017, 96 (1), pp.93-106. ⟨10.1095/biolreprod.116.143479⟩
Tatyana Shelkovnikova, Pasquale Dimasi, Michail Kukharsky, Haiyan An, Annamaria Quintiero, Claire Schirmer, Luc Buée, Marie-Christine Galas, Vladimir Buchman
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly
Cell Death and Disease, 2017, 8 (5), pp.e2788. ⟨10.1038/cddis.2017.199⟩
Amrit Mudher, Jean-Pierre Brion, Jesus Avila, Miguel Medina, Luc Buée
EuroTau: towing scientists to tau without tautology
Acta Neuropathologica Communications, 2016, 5 (1), pp.90. ⟨10.1186/s40478-017-0491-z⟩
Wesley Chen, Edsel Abud, Stephen Yeung, Anita Lakatos, Trevor Nassi, Jane Wang, David Blum, Luc Buée, Wayne Poon, Mathew Blurton-Jones
Increased tauopathy drives microglia-mediated clearance of beta-amyloid
Acta Neuropathologica Communications, 2016, 4 (1), ⟨10.1186/s40478-016-0336-1⟩
Vincent Huin, Vincent Deramecourt, Dominique Caparros-Lefebvre, Claude-Alain Maurage, Charles Duyckaerts, Eniko Kovari, Florence Pasquier, Valérie Buée-Scherrer, Julien Labreuche, Hélène Behal, Luc Buée, Claire-Marie Dhaenens, Bernard Sablonnière
The MAPT gene is differentially methylated in the progressive supranuclear palsy brain
Movement Disorders, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩
Ioannis Sotiropoulos, Marie-Christine Galas, Joana M. Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher, Luc Buee
Atypical, non-standard functions of the microtubule associated Tau protein
Acta Neuropathologica Communications, 2016, 5 (1), pp.91. ⟨10.1186/s40478-017-0489-6⟩
Véronique Paban, Béatrice Loriod, Claude Villard, Luc Buee, David Blum, Susanna Pietropaolo, Yoon H. Cho, Sylvie Gory-Faure, Elodie Mansour, Ali Gharbi, Béatrice Alescio-Lautier
Omics analysis of mouse brain models of human diseases
Gene, 2016, 600, pp.90 - 100. ⟨10.1016/j.gene.2016.11.022⟩
Meryem Tardivel, Séverine Bégard, Luc Bousset, Simon Dujardin, Audrey Coens, Ronald Melki, Luc Buée, Morvane Colin
Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
Acta Neuropathologica Communications, 2016, 4 (1), pp.117. ⟨10.1186/s40478-016-0386-4⟩
Vânia Batalha, Diana Ferreira, Joana Coelho, Jorge Valadas, Rui Gomes, Mariana Temido-Ferreira, Tatiana Shmidt, Younis Baqi, Luc Buée, Christa Müller, Malika Hamdane, Tiago Outeiro, Michael Bader, Sebastiaan Meijsing, Ghazaleh Sadri-Vakili, David Blum, Luísa Lopes
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function
Scientific Reports, 2016, 6, pp.31493. ⟨10.1038/srep31493⟩
Nicolas Barthélemy, Audrey Gabelle, Christophe Hirtz, François Fenaille, Nicolas Sergeant, Susanna Schraen-Maschke, Jérôme Vialaret, Luc Buée, Christophe Junot, François Becher, Sylvain Lehmann
Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies
Journal of Alzheimer's Disease, 2016, 51 (4), pp.1033 - 1043. ⟨10.3233/JAD-150962⟩
Vânia Batalha, Diana Ferreira, Joana Coelho, Jorge Valadas, Rui Gomes, Mariana Temido-Ferreira, Tatiana Shmidt, Younis Baqi, Christa Müller, Malika Hamdane, Tiago Outeiro, Michael Bader, Sebastiaan H Meijsing, Ghazaleh Sadri-Vakili, Luisa Lopes, Beatriz García-Gómez, Francisco J. Fernandez-Gomez, Encarnación Muñoz-Delgado, Luc Buee, David Blum, Cecilio Vidal
mRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance
Journal of Molecular Neuroscience, 2016, 58 (4), pp.411-415. ⟨10.1007/s12031-015-0699-y⟩
Nicolas Barthélemy, François Fenaille, Christophe Hirtz, Nicolas Sergeant, Susanna Schraen-Maschke, Jérôme Vialaret, Luc Buée, Audrey Gabelle, Christophe Junot, Sylvain Lehmann, François Becher
Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity
Journal of Proteome Research, 2016, 15 (2), pp.667 - 676. ⟨10.1021/acs.jproteome.5b01001⟩
Zeyni Mansuroglu, Houda Benhelli-Mokrani, Vasco Marcato, Audrey Sultan, Marie Violet, Alban Chauderlier, Lucie Delattre, Anne Loyens, Smail Talahari, Séverine Bégard, Fabrice Nesslany, Morvane Colin, Sylvie Souès, Bruno Lefebvre, Luc Buée, Marie-Christine Galas, Eliette Bonnefoy
Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin
Scientific Reports, 2016, 6 (1), pp.33047. ⟨10.1038/srep33047⟩
Valeria Moas Heloire, Nicolas Renault, Vânia Batalha, Angela Rincon Arias, Mathieu Marchivie, Saïd Yous, Noémie Deguine, Luc Buee, Philippe Chavatte, David Blum, Luisa Lopes, Patricia Melnyk, Laurence Agouridas
Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines
European Journal of Medicinal Chemistry, 2015, 106, pp.15-25. ⟨10.1016/j.ejmech.2015.10.030⟩
Anthony Papegaey, Sabiha Eddarkaoui, Vincent Deramecourt, Francisco-Jose Fernandez-Gomez, Pierre Pantano, Hélène Obriot, Camille Machala, Vincent Anquetil, Agnès Camuzat, Alexis Brice, Claude-Alain Maurage, Isabelle Le Ber, Charles Duyckaerts, Luc Buée, Nicolas Sergeant, Valérie Buée-Scherrer
Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation
Acta Neuropathologica Communications, 2015, 4 (1), pp.74. ⟨10.1186/s40478-016-0345-0⟩
Dominique Caparros-Lefebvre, Lawrence I Golbe, Vincent Deramecourt, Claude-Alain Maurage, Vincent Huin, Valérie Buée-Scherrer, Hélène Obriot, Bernard Sablonnière, Francois Caparros, Luc Buée, Andrew J. Lees
A geographical cluster of progressive supranuclear palsy in northern France
Neurology, 2015, 85 (15), pp.1293-1300. ⟨10.1212/WNL.0000000000001997⟩
Sophie Ayciriex, Marie-Anne Burlot, Jérome Braudeau, Kristin Michaelsen-Preusse, Brigitte Potier, Jennifer Varin, Benoit Gautier, Fathia Djelti, Mickael Audrain, Luc Dauphinot, Francisco-Jose Fernandez-Gomez, Raphaëlle Caillierez, Olivier Laprévote, Ivan Bieche, Nicolas Auzeil, Marie-Claude Potier, Patrick Dutar, Martin Korte, Luc Buée, David Blum, Nathalie Cartier
Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology
Human Molecular Genetics, 2015, 24 (21), pp.5965 - 5976. ⟨10.1093/hmg/ddv268⟩
Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Galas
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo
Neurobiology of Disease, 2015, 82, pp.540-551. ⟨10.1016/j.nbd.2015.09.003⟩
Sara Kaffashian, Christophe Tzourio, Aïcha Soumaré, Carole Dufouil, Bernard Mazoyer, Susanna Schraen-Maschke, Luc Buée, Stéphanie Debette
Association of plasma β-amyloid with MRI markers of structural brain aging the 3-City Dijon study.
Neurobiology of Aging, 2015, 36 (10), pp.2663-70. ⟨10.1016/j.neurobiolaging.2015.03.016⟩
Gerhard Multhaup, Otmar Huber, Luc Buée, Marie-Christine Galas
Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles
Journal of Biological Chemistry, 2015, 290 (39), pp.23515-23522. ⟨10.1074/jbc.R115.677211⟩
Maxime Derisbourg, Coline Leghay, Giovanni Chiappetta, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Dominique Demeyer, Sébastien Carrier, Valérie Buée-Scherrer, David Blum, Joelle Vinh, Nicolas Sergeant, Yann Verdier, Luc Buée, Malika Hamdane
Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms
Scientific Reports, 2015, 5 (1), ⟨10.1038/srep09659⟩
Constance Delaby, Audrey Gabelle, Susanna Schraen-Maschke, Amandine Moulinier, Justine Boulanghien, Dany Severac, Luc Buée, Thierry Rème, Sylvain Lehmann
Central Nervous System and Peripheral Inflammatory Processes in Alzheimer’s Disease: Biomarker Profiling Approach
Frontiers in Neurology, 2015, 6, ⟨10.3389/fneur.2015.00181⟩
Audrey Gabelle, Susanna Schraen, Laure-Anne Gutierrez, Cecile Pays, Olivier Rouaud, Luc Buée, Jacques Touchon, Catherine Helmer, Jean-Charles Lambert, Claudine Berr
Plasma β-amyloid 40 levels are positively associated with mortality risks in the elderly.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2015, 11 (6), pp.672-80. ⟨10.1016/j.jalz.2014.04.515⟩
Julien Giustiniani, Kevin Guillemeau, Omar Dounane, Elodie Sardin, Isabelle Huvent, Alain Schmitt, Malika Hamdane, Luc Buée, Isabelle Landrieu, Guy Lippens, Etienne Emile Baulieu, Béatrice Chambraud
The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior.
FASEB Journal, 2015, Epub ahead of print
Paul-Ariel Kenigsberg, Jean-Pierre Aquino, Alain Berard, Fabrice Gzil, Sandrine Andrieu, Sube Banerjee, Francois Bremond, Luc Buee, Jiska Cohen-Mansfield, Francesca Mangialasche, Hervé Platel, Eric Salmon, Robert Philippe
Dementia beyond 2025: knowledge and uncertainties
Dementia, 2015
Haoling Qi, François-Xavier Cantrelle, Houda Benhelli-Mokrani, Caroline Smet-Nocca, Luc Buée, Guy Lippens, Eliette Bonnefoy, Marie-Christine Galas, Isabelle Landrieu
Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation.
Biochemistry, 2015, 54 (7), pp.1525-33
Patricia Melnyk, Valérie Vingtdeux, Stéphane Burlet, Sabiha Eddarkaoui, Marie-Eve Grosjean, Paul-Emmanuel Larchanché, Guillaume Hochart, Christian Sergheraert, Cecilia Estrella, Mathieu Barrier, Virginie Poix, Pauline Plancq, Cécile Lannoo, Malika Hamdane, André Delacourte, Philippe Verwaerde, Luc Buee, Nicolas Sergeant
Chloroquine and Chloroquinoline Derivatives as Models for the Design of Modulators of Amyloid Peptide Precursor Metabolism
ACS Chemical Neuroscience, 2015, 6 (4), pp.559-569. ⟨10.1021/cn5003013⟩
David Blum, Ursula Sandau, Olivier Bousiges, Luisa Lopes, Vanessa Flaten, Luc Buée, Anne-Laurence Boutillier
Adenosine and Alzheimer’s Disease : A Possible Epigenetic Link
Homeostatic Control of Brain Function, Oxford University Press, 2015, 978-0-19-932229-9
Joëlle Rosseels, Jeff van den Brande, Marie-Luce Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaelle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderickx
Tau Monoclonal Antibody Generation Based on Humanized Yeast Models: IMPACT ON TAU OLIGOMERIZATION AND DIAGNOSTICS
Journal of Biological Chemistry, 2015, 290 (7), pp.4059-4074. ⟨10.1074/jbc.M114.627919⟩
Sara Kaffashian, Christophe Tzourio, Aïcha Soumaré, Carole Dufouil, Yicheng Zhu, Fabrice Crivello, Pauline Maillard, Susanna Schraen-Maschke, Bernard Mazoyer, Luc Buée, Stéphanie Debette
Plasma β-amyloid and MRI markers of cerebral small vessel disease: Three-City Dijon study.
Neurology, 2014, 83 (22), pp.2038-45. ⟨10.1212/WNL.0000000000001038⟩
Amina Chaalal, Roseline Poirier, David Blum, Brigitte Gillet, Pascale Le Blanc, Marie Basquin, Luc Buée, Serge Laroche, Valérie Enderlin
PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer's disease in the hippocampus and spatial memory impairments.
Hippocampus, 2014, 24 (11), pp.1381-93. ⟨10.1002/hipo.22319⟩
Jérôme Delplanque, David Devos, Vincent Huin, Alexandre Genet, Olivier Sand, Caroline Moreau, Cyril Goizet, Perrine Charles, Mathieu Anheim, Marie Lorraine Monin, Luc Buée, Alain Destée, Guillaume Grolez, Christine Delmaire, Kathy Dujardin, Delphine Dellacherie, Alexis Brice, Giovanni Stevanin, Isabelle Strubi-Vuillaume, Alexandra Durr, Bernard Sablonnière
TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment
Brain - A Journal of Neurology , 2014, 137 (10), pp.2657-2663. ⟨10.1093/brain/awu202⟩
Marie Violet, Lucie Delattre, Meryem Tardivel, Audrey Sultan, Alban Chauderlier, Raphaelle Caillierez, Smail Talahari, Fabrice Nesslany, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Galas
A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
Frontiers in Cellular Neuroscience, 2014, 8 (2), pp.350-358. ⟨10.3389/fncel.2014.00084⟩
Simon Dujardin, Katia Lécolle, Raphaëlle Caillierez, Séverine Bégard, Nadège Zommer, Cédrick Lachaud, Sébastien Carrier, Noëlle Dufour, Gwennaëlle Aurégan, Joris Winderickx, Philippe Hantraye, Nicole Déglon, Morvane Colin, Luc Buée
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: Relevance to sporadic tauopathies.
Acta Neuropathologica Communications, 2014, 2 (1), pp.14. ⟨10.1186/2051-5960-2-14⟩
Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, Cédrick Lachaud, Lucie Delattre, Sébastien Carrier, Anne Loyens, Marie-Christine Galas, Luc Bousset, Ronald Melki, Gwennaëlle Aurégan, Philippe Hantraye, Emmanuel Brouillet, Luc Buée, Morvane Colin
Ectosomes: a new mechanism for non-exosomal secretion of tau protein.
PLoS ONE, 2013, 9 (6), pp.e100760. ⟨10.1371/journal.pone.0100760⟩
Kunie Ando, Pierre Dourlen, Anne-Véronique Sambo, Alexis Bretteville, Karim Bélarbi, Valérie Vingtdeux, Sabiha Eddarkaoui, Hervé Drobecq, Antoine Ghestem, Séverine Bégard, Emmanuelle Demey-Thomas, Patricia Melnyk, Caroline Smet, Guy Lippens, Claude-Alain Maurage, Marie-Laure Caillet-Boudin, Yann Verdier, Joelle Vinh, Isabelle Landrieu, Marie-Christine Galas, David Blum, Malika Hamdane, Nicolas Sergeant, Luc Buée
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
Neurobiol Aging, 2013, 34 (3), pp.757-69. ⟨10.1016/j.neurobiolaging.2012.08.004⟩
Oscar Hernández-Hernández, Céline Guiraud-Dogan, Géraldine Sicot, Aline Huguet, Sabrina Luilier, Esther Steidl, Stefanie Saenger, Elodie Marciniak, Hélène Obriot, Caroline Chevarin, Annie Nicole, Lucile Revillod, Konstantinos Charizanis, Kuang-Yung Lee, Yasuhiro Suzuki, Takashi Kimura, Tohru Matsuura, Bulmaro Cisneros, Maurice S. Swanson, Fabrice Trovero, Bruno Buisson, Jean-Charles Bizot, Michel Hamon, Sandrine Humez, Guillaume Bassez, Friedrich Metzger, Luc Buée, Arnold Munnich, Nicolas Sergeant, Geneviève Gourdon, Mário Gomes-Pereira
Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.
Brain - A Journal of Neurology , 2013, 136 (Pt 3), pp.957-70. ⟨10.1093/brain/aws367⟩
Audrey Gabelle, Florence Richard, Laure-Anne Gutierrez, Susanna Schraen, Fleur Delva, Olivier Rouaud, Luc Buée, Jean-François Dartigues, Jacques Touchon, Jean-Charles Lambert, Claudine Berr
Plasma Amyloid-β Levels and Prognosis in Incident Dementia Cases of the 3-City Study.
Journal of Alzheimer's Disease, 2013, 33 (2), pp.381-91. ⟨10.3233/JAD-2012-121147⟩
Vincent Huin, Francis Vasseur, Susanna Schraen-Maschke, Claire-Marie Dhaenens, Patrick Devos, Kathy Dupont, Nicolas Sergeant, Luc Buée, Arnaud Lacour, Hélène Hofmann-Radvanyi, Bernard Sablonnière
MBNL1 gene variants as modifiers of disease severity in myotonic dystrophy type 1
Journal of Neurology, 2013, 260 (4), pp.998-1003. ⟨10.1007/s00415-012-6740-y⟩
Jean-Charles Lambert, Benjamin Grenier-Boley, Denise Harold, Diana Zelenika, Vincent Chouraki, Y. Kamatani, K. Sleegers, M. A. Ikram, M. Hiltunen, C. Reitz, I. Mateo, T. Feulner, M. Bullido, D. Galimberti, L. Concari, V. Alvarez, R. Sims, A. Gerrish, J. Chapman, C. Deniz-Naranjo, V. Solfrizzi, S. Sorbi, B. Arosio, G. Spalletta, G. Siciliano, Jacques Epelbaum, Didier Hannequin, Jean-François Dartigues, Christophe Tzourio, Claudine Berr, E. M. C. Schrijvers, R. Rogers, G. Tosto, F. Pasquier, K. Bettens, C. van Cauwenberghe, L. Fratiglioni, C. Graff, Marc Délépine, R. Ferri, C. A. Reynolds, L. Lannfelt, M. Ingelsson, J. A. Prince, C. Chillotti, A. Pilotto, D. Seripa, Anne Boland, M. Mancuso, P. Bossù, G. Annoni, B. Nacmias, P. Bosco, F. Panza, F. Sanchez-Garcia, M Del Zompo, E. Coto, M. Owen, M. O'Donovan, F. Valdivieso, P. Caffara, E. Scarpini, O. Combarros, Luc Buée, D. Campion, H. Soininen, M. Breteler, M. Riemenschneider, C. van Broeckhoven, A. Alpérovitch, Marc Lathrop, David-Alexandre Trégouët, J. Williams, Philippe Amouyel
Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
Molecular Psychiatry, 2012, 18, pp.521-521. ⟨10.1038/mp.2012.75⟩
Laëticia Troquier, Raphaëlle Caillierez, Sylvie Burnouf, Francisco J. Fernandez-Gomez, Marie-Eve Grosjean, Nadège Zommer, Nicolas Sergeant, Susanna Schraen-Maschke, David Blum, Luc Buee
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Curr Alzheimer Res, 2012, 9 (4), pp.397-405
C.M. Dhaenens, H. Tran, M.-L. Frandemiche, C. Carpentier, S. Schraen-Maschke, A. Sistiaga, M. Goicoechea, S. Eddarkaoui, E. van Brussels, H. Obriot, A. Labudeck, M.H. Gevaert, F. Fernandez-Gomez, N. Charlet-Berguerand, V. Deramecourt, C.A. Maurage, Luc Buée, A. Lopez de Munain, B. Sablonnière, M.L. Caillet-Boudin, Nicolas Sergeant
Mis-splicing of Tau exon 10 in myotonic dystrophy type I is reproduced by overexpression of CELF2 but not by MBNL1 silencing
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, ⟨10.1016/j.bbadis.2011.03.010⟩
Helene Tran, Nathalie Gourrier, Camille Lemercier-Neuillet, Claire-Marie Dhaenens, Audrey Vautrin, Francisco José Fernandez-Gomez, Ludovic Arandel, Celine Carpentier, Hélène Obriot, Sabiha Eddarkaoui, Lucie Delattre, Edwige van Brussels, Ian Holt, Glenn E Morris, Bernard Sablonnière, Luc Buée, Nicolas Charlet-Berguerand, Susanna Schraen-Maschke, Denis Furling, Isabelle Behm-Ansmant, Christiane Branlant, Marie-Laure Caillet-Boudin, Nicolas Sergeant
Analysis of Exonic Regions Involved in Nuclear Localization, Splicing Activity, and Dimerization of Muscleblind-like-1 Isoforms
Journal of Biological Chemistry, 2011, 286 (18), pp.16435 - 16446. ⟨10.1074/jbc.M110.194928⟩
Catherine Féart, Catherine Helmer, Hervé Fleury, Yannick Béjot, Karen Ritchie, Philippe Amouyel, Susanna Schraen-Maschke, Luc Buée, Jean-Charles Lambert, Luc Letenneur, Jean-François Dartigues
Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels.
PLoS ONE, 2011, 6 (12), pp.e29480. ⟨10.1371/journal.pone.0029480⟩
Luc Buée, David Blum, Stephanie Bombois, Valérie Buée-Scherrer, Marie-Laure Caillet-Boudin, Morvane Colin, Vincent Deramecourt, Claire-Marie Dhaenens, Marie-Christine Galas, Malika Hamdane, Sandrine Humez, Claude-Alain Maurage, Florence Pasquier, Bernard Sablonnière, Susanna Schraen-Maschke, Nicolas Sergeant
Comment les acteurs moléculaires de la pathologie Alzheimer permettent de comprendre la démence ? Quelles conséquences diagnostiques et thérapeutiques ?
Alternative and Complementary Therapies, 2010, 65 (5), pp.401-407. ⟨10.2515/therapie/2010054⟩
Isabelle Landrieu, Arnaud Leroy, Caroline Smet-Nocca, Isabelle Huvent, Laziza Amniai, Malika Hamdane, Nathalie Sibille, Luc Buée, Jean-Michel Wieruszeski, Guy Lippens
NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease.
Biochemical Society Transactions, 2010, 38 (4), pp.1006-11. ⟨10.1042/BST0381006⟩
Sébastien Feuillette, Vincent Deramecourt, Annie Laquérriere, Charles Duyckaerts, Marie-Bernadette Delisle, Claude-Alain Maurage, David Blum, Luc Buee, Thierry Frébourg, Dominique Campion, Magalie Lecourtois
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains
Brain Research, 2010, 1345, pp.182-189. ⟨10.1016/j.brainres.2010.05.007⟩
Karim Belarbi, Katharina Schindowski, Sylvie Burnouf, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Malika Hamdane, Nicolas Sergeant, David Blum, Luc Buee
Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.
Current Alzheimer Research, 2009, 6 (2), pp.152-7
[Fundamental data on the pathologies amyloid and Tau in Alzheimer's disease: which therapeutic perspectives?]
Annales Pharmaceutiques Françaises, 2009, 67 (2), pp.136-53. ⟨10.1016/j.pharma.2009.01.002⟩
Susanna Schraen-Maschke, Nicolas Sergeant, Claire-Marie Dhaenens, Stephanie Bombois, Vincent Deramecourt, Marie-Laure Caillet-Boudin, Florence Pasquier, Claude-Alain Maurage, Bernard Sablonniere, Eugeen Vanmechelen, Luc Buee
Tau as a biomarker of neurodegenerative diseases.
Biomarkers in Medicine, 2008, 2 (4), pp.363-84. ⟨10.2217/17520363.2.4.363⟩
C. M. Dhaenens, S. Schraen-Maschke, H. Tran, V. Vingtdeux, D. Ghanem, O. Leroy, J. Delplanque, E. Vanbrussel, A. Delacourte, Patrick Vermersch, C. A. Maurage, Henri Gruffat, A. Sergeant, M. S. Mahadevan, S. Ishiura, Luc Buée, T. A. Cooper, M. L. Caillet-Boudin, Nicolas Charlet-Berguerand, B. Sablonnière, N. Sergeant
Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats.
Experimental Neurology, 2008, 210 (2), pp.467-78. ⟨10.1016/j.expneurol.2007.11.020⟩
Hélène Amieva, Sandrine Andrieu, Claudine Berr, Luc Buée, Frédéric Checler, Serge Clément, Jean-François Dartigues, Béatrice Desgranges, Bruno Dubois, Charles Duyckaerts, Marie-Eve Joel, Jean-Charles Lambert, Fatemeh Nourhashemi, Florence Pasquier, Philippe Robert
Maladie d'Alzheimer : enjeux scientifiques, médicaux et sociétaux
[Rapport de recherche] Institut national de la santé et de la recherche médicale(INSERM). 2007, XV - 654 p., illustrations, figures
Malika Hamdane, Pierre Dourlen, Alexis Bretteville, Anne-Véronique Sambo, Stéphanie Ferreira, Kunie Ando, Olivier Kerdraon, Sandrine Bégard, Linda Geay, Guy Lippens, Nicolas Sergeant, André Delacourte, Claude-Alain Maurage, Marie-Christine Galas, Luc Buée
Pin1 allows for differential Tau dephosphorylation in neuronal cells.
Molecular and Cellular Neuroscience, 2006, 32, pp.155-160
Guy Lippens, Alain Sillen, Caroline Smet, Jean-Michel Wieruszeski, Arnaud Leroy, Luc Buée, Isabelle Landrieu
Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy.
Protein and Peptide Letters, 2006, 13, pp.235-246
Isabelle Landrieu, Caroline Smet, Jean-Michel Wieruszeski, Anne-Véronique Sambo, René Wintjens, Luc Buée, Guy Lippens
Exploring the Molecular Function of PIN1 by Nuclear Magnetic Resonance.
Current Protein and Peptide Science, 2006, 7, pp.179-194
Valérie Vingtdeux, Malika Hamdane, Marie Gompel, Severine Begard, Hervé Drobecq, Antoine Ghestem, Marie Eve Grosjean, Vesna Kostanjevecki, Pierre Grognet, Eugeen Vanmechelen, Luc Buee, André Delacourte, Nicolas Sergeant
Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Neurobiology of Disease, 2005, 20, pp.625-37
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Fernandez-Gomez, Francisco
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DHAENENS, Claire-Marie
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Caillet-Boudin, Marie-Laure
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Schraen-Maschke, Susanna
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Blum, David
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Sablonniere, Bernard
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Buee, Luc
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Sergeant, Nicolas
Myotonic dystrophy: an rna toxic gain of function tauopathy?
Advances in experimental medicine and biology, 2019 , https://dx.doi.org/10.1007/978-981-32-9358-8_17
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Takashima, Akihiko
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Wolozin, Benjamin
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Tau biology preface
Advances in experimental medicine and biology, 2019
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Dujardin, Simon
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Caillierez, Raphaelle
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LACHAUD, cedrick
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Carrier, Sebastien
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Lieger, Sarah
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Gonzalez, Jose A.
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Deramecourt, Vincent
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Deglon, Nicole
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Maurage, Claude-Alain
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Frosch, Matthew P.
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Hyman, Bradley T.
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COLIN, MORVANE
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Buee, Luc
Different tau species lead to heterogeneous tau pathology propagation and misfolding
Acta neuropathologica communications, 2018 , https://dx.doi.org/10.1186/s40478-018-0637-7
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Didier, Sebastien
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Sauve, Florent
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Marinangeli, Claudia
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Vingtdeux, Valerie
Amp-activated protein kinase controls immediate early genes expression following synaptic activation through the pka/creb pathway
International Journal of Molecular Sciences, 2018 , https://dx.doi.org/10.3390/ijms19123716
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Gay, Marion
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Baud, Catherine
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Larchanche, Paul-Emmanuel
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Buee, Luc
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El Bakali, Jamal
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Vingtdeux, Valerie
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Melnyk, Patricia
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: toward a new profile of indirect ?-secretase inhibitors
European Journal of Medicinal Chemistry, 2018 , https://dx.doi.org/10.1016/j.ejmech.2018.08.092
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brain insulin signaling and tau: impact for alzheimer''s disease and tauopathies
Medecine sciences . M/S, 2018 , https://dx.doi.org/10.1051/medsci/2018238
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Sigala, Julien
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Mitchell, Valérie
A-kinase anchor protein 4 precursor (pro-akap4) in human spermatozoa
Andrology, 2018 , https://dx.doi.org/10.1111/andr.12524
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Benhelli-Mokrani, Houda
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Lefebvre, Bruno
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Genome-wide identification of genic and intergenic neuronal dna regions bound by tau protein under physiological and stress conditions
Nucleic acids research, 2018 , https://dx.doi.org/10.1093/nar/gky929
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Deregulation of neuronal mirnas induced by amyloid-? or tau pathology
Molecular neurodegeneration, 2018 , https://dx.doi.org/10.1186/s13024-018-0285-1
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Vidal, Jean-Sébastien
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Pasquier, Florence
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Schraen-Maschke, Susanna
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Epelbaum, Jacques
Somatostatin and neuropeptide y in cerebrospinal fluid: correlations with amyloid peptides a beta(1-42) and tau proteins in elderly patients with mild cognitive impairment
Frontiers in aging neuroscience, 2018 , https://dx.doi.org/10.3389/fnagi.2018.00297
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Halder Sinha, Sarmistha
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Eswaramoorthy, Muthusamy
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Cassel, Jean-Christophe
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Kundu, Tapas K.
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Boutillier, Anne-Laurence
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator
EMBO molecular medicine, 2018 , https://dx.doi.org/10.15252/emmm.201708587
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Sigala, Julien
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Mitchell, Valérie
Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality
Basic and clinical andrology, BioMed Central, 2018 , https://dx.doi.org/10.1186/s12610-018-0076-0
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Gomez-Murcia, Victoria
The adenosinergic signaling: a complex but promising therapeutic target for alzheimer''''s disease
Frontiers in neuroscience, 2018 , https://dx.doi.org/10.3389/fnins.2018.00520
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PINET, FLORENCE
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Tau/DDX6 interaction increases microRNA activity
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Elsevier, 2018 , https://dx.doi.org/10.1016/j.bbagrm.2018.06.006
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Chauderlier, Alban
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Gilles, Melissa
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Spolcova, Andrea
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Caillierez, Raphaëlle
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Chwastyniak, Maggy
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Kress, Michel
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Drobecq, Hervé
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Bonnefoy, Eliette
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PINET, FLORENCE
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Weil, Dominique
;
Buee, Luc
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Galas, Marie-Christine
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Lefebvre, Bruno
Tau/DDX6 interaction increases microRNA activity
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Elsevier, 2018 , https://dx.doi.org/10.1016/j.bbagrm.2018.06.006
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Temido-Ferreira, Mariana
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Ferreira, Diana G.
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Batalha, Vania L.
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Marques-Morgado, Ines
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Coelho, Joana E.
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Pereira, Pedro
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Gomes, Rui
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Pinto, Andreia
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Carvalho, Sara
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Canas, Paula M.
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Cuvelier, Laetitia
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Faivre, Emilie
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Baqi, Younis
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Muller, Christa E.
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Schiffmann, Serge N.
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Receptors interplay with mglur5 and nmda receptors
Molecular psychiatry, 2018 , https://dx.doi.org/10.1038/s41380-018-0110-9
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