Laurent L'homme
Ingénieur de recherche
Laboratoire / équipe
Publications
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"citationRef_s":"<i>Science Advances </i>, 2024, Sci Adv, 10 (32), eadp6182. <a target=\"_blank\" href=\"https://dx.doi.org/10.1126/sciadv.adp6182\">⟨10.1126/sciadv.adp6182⟩</a>",
"citationFull_s":"Mathilde Lebas, G. Chinigò, Evan Courmont, Louay Bettaieb, Amani Machmouchi, et al.. Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition.. <i>Science Advances </i>, 2024, Sci Adv, 10 (32), eadp6182. <a target=\"_blank\" href=\"https://dx.doi.org/10.1126/sciadv.adp6182\">⟨10.1126/sciadv.adp6182⟩</a>. <a target=\"_blank\" href=\"https://hal.univ-lille.fr/hal-04711617v1\">⟨hal-04711617⟩</a>",
"title_s":["Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition."],
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"citationRef_s":"<i>Nature Communications</i>, 2024, 15 (1), pp.7173. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41467-024-51078-2\">⟨10.1038/s41467-024-51078-2⟩</a>",
"citationFull_s":"Laurent L’homme, Benan Pelin Sermikli, Joel T Haas, Sébastien Fleury, Sandrine Quemener, et al.. Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH. <i>Nature Communications</i>, 2024, 15 (1), pp.7173. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41467-024-51078-2\">⟨10.1038/s41467-024-51078-2⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04677130v1\">⟨hal-04677130⟩</a>",
"title_s":["Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH"],
"authFullName_s":["Laurent L’homme","Benan Pelin Sermikli","Joel T Haas","Sébastien Fleury","Sandrine Quemener","Valentine Guinot","Emelie Barreby","Nathalie Esser","Robert Caiazzo","Hélène Verkindt","Benjamin Legendre","Violeta Raverdy","Lydie Cheval","Nicolas Paquot","Jacques Piette","Sylvie Legrand-Poels","Myriam Aouadi","François Pattou","Bart Staels","David Dombrowicz"],
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"citationRef_s":"<i>Frontiers in Immunology</i>, 2023, 14, pp.1204126. <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fimmu.2023.1204126\">⟨10.3389/fimmu.2023.1204126⟩</a>",
"citationFull_s":"Margaud Iovino, Megan Colonval, Chloé Wilkin, Laurent L’homme, Cédric Lassence, et al.. Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid. <i>Frontiers in Immunology</i>, 2023, 14, pp.1204126. <a target=\"_blank\" href=\"https://dx.doi.org/10.3389/fimmu.2023.1204126\">⟨10.3389/fimmu.2023.1204126⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-04291949v1\">⟨inserm-04291949⟩</a>",
"title_s":["Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid"],
"authFullName_s":["Margaud Iovino","Megan Colonval","Chloé Wilkin","Laurent L’homme","Cédric Lassence","Manon Campas","Olivier Peulen","Pascal de Tullio","Jacques Piette","Sylvie Legrand-Poels"],
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"citationRef_s":"<i>Journal of Allergy and Clinical Immunology</i>, 2022, Online ahead of print. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jaci.2021.12.788\">⟨10.1016/j.jaci.2021.12.788⟩</a>",
"citationFull_s":"Laurent L'Homme, David Dombrowicz. in vitro models of human mast cells: How to get more and better with induced pluripotent stem cells?. <i>Journal of Allergy and Clinical Immunology</i>, 2022, Online ahead of print. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jaci.2021.12.788\">⟨10.1016/j.jaci.2021.12.788⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-03526347v1\">⟨inserm-03526347⟩</a>",
"title_s":["in vitro models of human mast cells: How to get more and better with induced pluripotent stem cells?"],
"authFullName_s":["Laurent L'Homme","David Dombrowicz"],
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"citationRef_s":"<i>International Journal of Obesity</i>, 2021, Online ahead of print. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41366-021-00826-1\">⟨10.1038/s41366-021-00826-1⟩</a>",
"citationFull_s":"Denis A Mogilenko, Robert Caiazzo, Laurent L'Homme, Laurent Pineau, Violeta Raverdy, et al.. IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women. <i>International Journal of Obesity</i>, 2021, Online ahead of print. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41366-021-00826-1\">⟨10.1038/s41366-021-00826-1⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-03220154v1\">⟨inserm-03220154⟩</a>",
"title_s":["IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women"],
"authFullName_s":["Denis A Mogilenko","Robert Caiazzo","Laurent L'Homme","Laurent Pineau","Violeta Raverdy","Jerome Noulette","Bruno Derudas","Francois Pattou","Bart Staels","David Dombrowicz"],
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"citationRef_s":"<i>Nutrients</i>, 2020, 12 (12), pp.3771. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/nu12123771\">⟨10.3390/nu12123771⟩</a>",
"citationFull_s":"Laurent L’homme, Benan Pelin Sermikli, Bart Staels, Jacques Piette, Sylvie Legrand-Poels, et al.. Saturated fatty acids promote GDF15 expression in human macrophages through the PERK/eIF2/CHOP signaling pathway. <i>Nutrients</i>, 2020, 12 (12), pp.3771. <a target=\"_blank\" href=\"https://dx.doi.org/10.3390/nu12123771\">⟨10.3390/nu12123771⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-03054593v1\">⟨inserm-03054593⟩</a>",
"title_s":["Saturated fatty acids promote GDF15 expression in human macrophages through the PERK/eIF2/CHOP signaling pathway"],
"authFullName_s":["Laurent L’homme","Benan Pelin Sermikli","Bart Staels","Jacques Piette","Sylvie Legrand-Poels","David Dombrowicz"],
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"citationRef_s":"<i>Scientific Reports</i>, 2020, 10 (1), pp.21095. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41598-020-77858-6\">⟨10.1038/s41598-020-77858-6⟩</a>",
"citationFull_s":"Laurent L’homme, Benan Pelin Sermikli, Olivier Molendi-Coste, Sébastien Fleury, Sandrine Quemener, et al.. Deletion of the nuclear receptor RORalpha in macrophages does not modify the development of obesity, insulin resistance and NASH. <i>Scientific Reports</i>, 2020, 10 (1), pp.21095. <a target=\"_blank\" href=\"https://dx.doi.org/10.1038/s41598-020-77858-6\">⟨10.1038/s41598-020-77858-6⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-02989764v1\">⟨inserm-02989764⟩</a>",
"title_s":["Deletion of the nuclear receptor RORalpha in macrophages does not modify the development of obesity, insulin resistance and NASH"],
"authFullName_s":["Laurent L’homme","Benan Pelin Sermikli","Olivier Molendi-Coste","Sébastien Fleury","Sandrine Quemener","Mathilde Le Maître","Marie-Laure Joseph","Laurent Pineau","Christian Duhem","Barbara Gross","Emmanuelle Vallez","Anne Tailleux","Bart Staels","David Dombrowicz"],
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"citationRef_s":"<i>Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids</i>, 2019, 1864 (7), <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.bbalip.2019.04.001\">⟨10.1016/j.bbalip.2019.04.001⟩</a>",
"citationFull_s":"Marco A Gianfrancesco, Jonas Dehairs, Laurent l'Homme, Gaëtan Herinckx, Nathalie Esser, et al.. Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption. <i>Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids</i>, 2019, 1864 (7), <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.bbalip.2019.04.001\">⟨10.1016/j.bbalip.2019.04.001⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04932437v1\">⟨hal-04932437⟩</a>",
"title_s":["Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption"],
"authFullName_s":["Marco A Gianfrancesco","Jonas Dehairs","Laurent l'Homme","Gaëtan Herinckx","Nathalie Esser","Olivia Jansen","Yvette Habraken","Cédric Lassence","Johan V Swinnen","Mark H Rider","Jacques Piette","Nicolas Paquot","Sylvie Legrand-Poels"],
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"citationRef_s":"<i>Cell</i>, 2019, 178 (1), pp.263. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.cell.2019.06.017\">⟨10.1016/j.cell.2019.06.017⟩</a>",
"citationFull_s":"Denis Mogilenko, Joel Haas, Laurent L’homme, Sébastien Fleury, Sandrine Quemener, et al.. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. <i>Cell</i>, 2019, 178 (1), pp.263. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.cell.2019.06.017\">⟨10.1016/j.cell.2019.06.017⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04397652v1\">⟨hal-04397652⟩</a>",
"title_s":["Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR"],
"authFullName_s":["Denis Mogilenko","Joel Haas","Laurent L’homme","Sébastien Fleury","Sandrine Quemener","Matthieu Levavasseur","Coralie Becquart","Julien Wartelle","Alexandra Bogomolova","Laurent Pineau","Olivier Molendi-Coste","Steve Lancel","Hélène Dehondt","Celine Gheeraert","Aurelie Melchior","Cédric Dewas","Artemii Nikitin","Samuel Pic","Nabil Rabhi","Jean-Sébastien Annicotte","Seiichi Oyadomari","Talia Velasco-Hernandez","Jörg Cammenga","Marc Foretz","Benoit Viollet","Milica Vukovic","Arnaud Villacreces","Kamil Kranc","Peter Carmeliet","Guillemette Marot","Alexis Boulter","Simon Tavernier","Luciana Berod","Maria Longhi","Christophe Paget","Sophie Janssens","Delphine Staumont-Sallé","Ezra Aksoy","Bart Staels","David Dombrowicz"],
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"citationFull_s":"Denis Mogilenko, Joel Haas, Laurent L’homme, Sébastien Fleury, Sandrine Quemener, et al.. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. <i>Cell</i>, 2019, 178 (1), pp.263. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.cell.2019.06.017\">⟨10.1016/j.cell.2019.06.017⟩</a>. <a target=\"_blank\" href=\"https://univ-tours.hal.science/hal-03534481v1\">⟨hal-03534481⟩</a>",
"title_s":["Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR"],
"authFullName_s":["Denis Mogilenko","Joel Haas","Laurent L’homme","Sébastien Fleury","Sandrine Quemener","Matthieu Levavasseur","Coralie Becquart","Julien Wartelle","Alexandra Bogomolova","Laurent Pineau","Olivier Molendi-Coste","Steve Lancel","Hélène Dehondt","Celine Gheeraert","Aurelie Melchior","Cédric Dewas","Artemii Nikitin","Samuel Pic","Nabil Rabhi","Jean-Sébastien Annicotte","Seiichi Oyadomari","Talia Velasco-Hernandez","Jörg Cammenga","Marc Foretz","Benoit Viollet","Milica Vukovic","Arnaud Villacreces","Kamil Kranc","Peter Carmeliet","Guillemette Marot","Alexis Boulter","Simon Tavernier","Luciana Berod","Maria Longhi","Christophe Paget","Sophie Janssens","Delphine Staumont-Sallé","Ezra Aksoy","Bart Staels","David Dombrowicz"],
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"citationRef_s":"<i>Cell</i>, In press, 177 (5), pp.1201-1216.e19. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.cell.2019.03.018\">⟨10.1016/j.cell.2019.03.018⟩</a>",
"citationFull_s":"Denis A Mogilenko, Joël Haas, Laurent L'Homme, Sébastien Fleury, Sandrine Quemener, et al.. Metabolic and innate immune cues merge into a specific inflammatory response via unfolded protein\r\nresponse (UPR). <i>Cell</i>, In press, 177 (5), pp.1201-1216.e19. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.cell.2019.03.018\">⟨10.1016/j.cell.2019.03.018⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-02084447v1\">⟨inserm-02084447⟩</a>",
"title_s":["Metabolic and innate immune cues merge into a specific inflammatory response via unfolded protein response (UPR)"],
"authFullName_s":["Denis A Mogilenko","Joël Haas","Laurent L'Homme","Sébastien Fleury","Sandrine Quemener","Matthieu Levavasseur","Coralie Becquart","Julien Wartelle","Alexandra Bogomolova","Laurent Pineau","Olivier Molendi-Coste","Steve Lancel","Hélène Dehondt","Céline Gheeraert","Aurélie Melchior","Cédric Dewas","Artemii Nikitin","Samuel Pic","Nabil Rabhi","Jean-Sébastien Annicotte","Seiichi Oyadomari","Talia Velasco-Hernandez","Jörg Cammenga","Marc Foretz","Benoit Viollet","Milica Vukovic","Arnaud Villacreces","Kamil Kranc","Peter Carmeliet","Guillemette Marot","Alexis Boulter","Simon J. Tavernier","Luciana Berod","Maria P. Longhi","Christophe Paget","Sophie Janssens","Delphine Staumont-Sallé","Ezra Aksoy","Bart Staels","David Dombrowicz"],
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"citationRef_s":"<i>Molecular metabolism</i>, 2019, 23, pp.82-87. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.molmet.2019.02.010\">⟨10.1016/j.molmet.2019.02.010⟩</a>",
"citationFull_s":"Antonio Molinaro, Robert Caesar, Laurent L'Homme, Ara Koh, Marcus Ståhlman, et al.. Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding. <i>Molecular metabolism</i>, 2019, 23, pp.82-87. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.molmet.2019.02.010\">⟨10.1016/j.molmet.2019.02.010⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-02158994v1\">⟨inserm-02158994⟩</a>",
"title_s":["Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding"],
"authFullName_s":["Antonio Molinaro","Robert Caesar","Laurent L'Homme","Ara Koh","Marcus Ståhlman","Bart Staels","Fredrik Bäckhed"],
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"citationRef_s":"<i>Journal of Virology</i>, 2018, 92 (10), pp.e01982-17. <a target=\"_blank\" href=\"https://dx.doi.org/10.1128/JVI.01982-17\">⟨10.1128/JVI.01982-17⟩</a>",
"citationFull_s":"Laura Riva, Ok-Ryul Song, Jannick Prentoe, Francois Helle, Laurent L'Homme, et al.. Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry. <i>Journal of Virology</i>, 2018, 92 (10), pp.e01982-17. <a target=\"_blank\" href=\"https://dx.doi.org/10.1128/JVI.01982-17\">⟨10.1128/JVI.01982-17⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-02112504v1\">⟨hal-02112504⟩</a>",
"title_s":["Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry"],
"authFullName_s":["Laura Riva","Ok-Ryul Song","Jannick Prentoe","Francois Helle","Laurent L'Homme","Charles-Henry Gattolliat","Alexandre Vandeputte","Lucie Fénéant","Sandrine Belouzard","Thomas F. Baumert","Tarik Asselah","Jens Bukh","Priscille Brodin","Laurence Cocquerel","Yves Rouillé","Jean Dubuisson"],
"halId_s":"hal-02112504",
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"producedDateY_i":2018
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"citationRef_s":"<i>Journal of Allergy and Clinical Immunology</i>, 2017, <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jaci.2017.07.028\">⟨10.1016/j.jaci.2017.07.028⟩</a>",
"citationFull_s":"Laurent L'Homme, David Dombrowicz. Astrotactin 1–derived peptide: A new skin-penetrating peptide against inflammatory skin diseases. <i>Journal of Allergy and Clinical Immunology</i>, 2017, <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jaci.2017.07.028\">⟨10.1016/j.jaci.2017.07.028⟩</a>. <a target=\"_blank\" href=\"https://inserm.hal.science/inserm-01611632v1\">⟨inserm-01611632⟩</a>",
"title_s":["Astrotactin 1–derived peptide: A new skin-penetrating peptide against inflammatory skin diseases"],
"authFullName_s":["Laurent L'Homme","David Dombrowicz"],
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