https://orcid.org/0000-0002-7222-9264

Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation.

Vasseur L, Gheeraert C, Dubois-Chevalier J, Very N, Guille L, Bou Saleh M, Boulet C, Sobolewski C, Loyer P, Berthier A, Legrand N, Corlu A, Gnemmi V, Lasailly G, Leteurtre E, Galinousky D, Bongiovanni A, Taront S, Toft NI, Grøntved L, Tulasne D, Furlan A, Ntandja-Wandji LC, Staels B, Lefebvre P, Dubuquoy L, Eeckhoute J.

PLoS Biol. 2025 Dec 12;23(12):e3003547. doi: 10.1371/journal.pbio.3003547

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Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability

Berthier A, Gheeraert C, Vinod M, Johanns M, Guille L, Haas JT, Dubois-Chevalier J, Eeckhoute J, Staels B, Lefebvre P.

J Hepatol. 2025 Feb 11:S0168-8278(25)00080-7.

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Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation.

Very N, Staels B, Eeckhoute J.

Trends Cell Biol. 2024 Dec;34(12):988-991. doi: 10.1016/j.tcb.2024.10.007. Epub 2024 Nov 7. PMID: 39516052

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O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts.

Very N, Boulet C, Gheeraert C, Berthier A, Johanns M, Bou Saleh M, Guille L, Bray F, Strub JM, Bobowski-Gerard M, Zummo FP, Vallez E, Molendi-Coste O, Woitrain E, Cianférani S, Montaigne D, Ntandja-Wandji LC, Dubuquoy L, Dubois-Chevalier J, Staels B, Lefebvre P, Eeckhoute J.

Cell Death Dis. 2024 Jun 3;15(6):391. doi: 10.1038/s41419-024-06773-9.

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Nuclear receptors: pathophysiological mechanisms and drug targets in liver disease.

Dubois V, Lefebvre P, Staels B, Eeckhoute J.

Gut. 2024 Jun 11:gutjnl-2023-331741. doi: 10.1136/gutjnl-2023-331741

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An extended transcription factor regulatory network controls hepatocyte identity.

Dubois-Chevalier J, Gheeraert C, Berthier A, Boulet C, Dubois V, Guille L, Fourcot M, Marot G, Gauthier K, Dubuquoy L, Staels B, Lefebvre P, Eeckhoute J.

EMBO Rep. 2023 Sep 6;24(9):e57020. doi: 10.15252/embr.202357020. Epub 2023 Jul 10. PMID: 37424431

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Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis.

Bobowski-Gerard M, Boulet C, Zummo FP, Dubois-Chevalier J, Gheeraert C, Bou Saleh M, Strub JM, Farce A, Ploton M, Guille L, Vandel J, Bongiovanni A, Very N, Woitrain E, Deprince A, Lalloyer F, Bauge E, Ferri L, Ntandja-Wandji LC, Cotte AK, Grangette C, Vallez E, Cianférani S, Raverdy V, Caiazzo R, Gnemmi V, Leteurtre E, Pourcet B, Paumelle R, Ravnskjaer K, Lassailly G, Haas JT, Mathurin P, Pattou F, Dubuquoy L, Staels B, Lefebvre P, Eeckhoute J.

Nat Commun. 2022 Sep 10;13(1):5324. doi: 10.1038/s41467-022-33063-9. PMID: 36088459

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Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver.

Dubois V, Gheeraert C, Vankrunkelsven W, Dubois-Chevalier J, Dehondt H, Bobowski-Gerard M, Vinod M, Zummo FP, Güiza F, Ploton M, Dorchies E, Pineau L, Boulinguiez A, Vallez E, Woitrain E, Baugé E, Lalloyer F, Duhem C, Rabhi N, van Kesteren RE, Chiang CM, Lancel S, Duez H, Annicotte JS, Paumelle R, Vanhorebeek I, Van den Berghe G, Staels B, Lefebvre P, Eeckhoute J.

Mol Syst Biol. 2020 May;16(5):e9156. doi: 10.15252/msb.20199156. PMID: 32407006