Florence Siepmann
Professeure des universités
CNU : SECTION 85 - Sciences physico-chimiques et ingénierie appliquée à la santé
Lab(s)
Publications
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"citationRef_s":"<i>Journal of Controlled Release</i>, 2026, pp.114977. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2026.114977\">⟨10.1016/j.jconrel.2026.114977⟩</a>",
"citationFull_s":"P.-K. Nguyen, C. Olivier, P. Toulemonde, J. Verin, F. Danede, et al.. Intracochlear PLGA implants for simultaneous controlled release of multiple drugs. <i>Journal of Controlled Release</i>, 2026, pp.114977. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2026.114977\">⟨10.1016/j.jconrel.2026.114977⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-05609191v1\">⟨hal-05609191⟩</a>",
"title_s":["Intracochlear PLGA implants for simultaneous controlled release of multiple drugs"],
"authFullName_s":["P.-K. Nguyen","C. Olivier","P. Toulemonde","J. Verin","F. Danede","J.F. Willart","Christophe Vincent","Florence Siepmann","J. Siepmann"],
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"citationRef_s":"<i>Journal of Drug Delivery Science and Technology</i>, 2026, 115, pp.107670. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jddst.2025.107670\">⟨10.1016/j.jddst.2025.107670⟩</a>",
"citationFull_s":"Vita d'Amico, Florence Siepmann, Juergen Siepmann, Christel Neut, Nunzio Denora, et al.. Microencapsulation of the probiotic Bifidobacterium longum by spray-drying: Formulation and process optimisation. <i>Journal of Drug Delivery Science and Technology</i>, 2026, 115, pp.107670. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jddst.2025.107670\">⟨10.1016/j.jddst.2025.107670⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-05468089v1\">⟨hal-05468089⟩</a>",
"title_s":["Microencapsulation of the probiotic Bifidobacterium longum by spray-drying: Formulation and process optimisation"],
"authFullName_s":["Vita d'Amico","Florence Siepmann","Juergen Siepmann","Christel Neut","Nunzio Denora","Angela Assunta Lopedota"],
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"citationFull_s":"J. Siepmann, Florence Siepmann. Release mechanisms of PLGA-based drug delivery systems: A review. <i>International Journal of Pharmaceutics: X</i>, 2025, 10, pp.100440. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpx.2025.100440\">⟨10.1016/j.ijpx.2025.100440⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-05468220v1\">⟨hal-05468220⟩</a>",
"title_s":["Release mechanisms of PLGA-based drug delivery systems: A review"],
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"citationFull_s":"L. A. Lefol, A. Sodano, P. Bawuah, J. A. Zeitler, F. Danede, et al.. Release mechanisms of PLGA microparticles prepared using a microfluidics device or a beaker. <i>International Journal of Pharmaceutics: X</i>, 2025, International Journal of Pharmaceutics: X, 10, <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpx.2025.100366\">⟨10.1016/j.ijpx.2025.100366⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-05248215v1\">⟨hal-05248215⟩</a>",
"title_s":["Release mechanisms of PLGA microparticles prepared using a microfluidics device or a beaker"],
"authFullName_s":["L. A. Lefol","A. Sodano","P. Bawuah","J. A. Zeitler","F. Danede","Jean-François Willart","Juergen Siepmann","F. Siepmann"],
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"citationRef_s":"<i>Hearing Research</i>, 2025, Hearing Research, 458, pp.109188. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.heares.2025.109188\">⟨10.1016/j.heares.2025.109188⟩</a>",
"citationFull_s":"Claire Olivier, Cyril Beck, Mickaël Risoud, Pierre-Emmanuel Lemesre, Juergen Siepmann, et al.. Perilymph sampling in Mongolian gerbil, technical note and procedure evaluation.. <i>Hearing Research</i>, 2025, Hearing Research, 458, pp.109188. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.heares.2025.109188\">⟨10.1016/j.heares.2025.109188⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04965672v1\">⟨hal-04965672⟩</a>",
"title_s":["Perilymph sampling in Mongolian gerbil, technical note and procedure evaluation."],
"authFullName_s":["Claire Olivier","Cyril Beck","Mickaël Risoud","Pierre-Emmanuel Lemesre","Juergen Siepmann","Florence Siepmann","Jérémy Vérin","Jean-Francois Goossens","Mostafa Kouach","Antonino Bongiovanni","Thomas Hubert","Meryem Tardivel","Christophe Vincent","Philippine Toulemonde"],
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"citationRef_s":"<i>International Journal of Pharmaceutics: X</i>, 2024, International Journal of Pharmaceutics: X, 8, pp.100271. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpx.2024.100271\">⟨10.1016/j.ijpx.2024.100271⟩</a>",
"citationFull_s":"Y. Bedulho das Lages, N. Milanino, J. Verin, Jean-François Willart, Florence Danede, et al.. EVA implants for controlled drug delivery to the inner ear. <i>International Journal of Pharmaceutics: X</i>, 2024, International Journal of Pharmaceutics: X, 8, pp.100271. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpx.2024.100271\">⟨10.1016/j.ijpx.2024.100271⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04690008v1\">⟨hal-04690008⟩</a>",
"title_s":["EVA implants for controlled drug delivery to the inner ear"],
"authFullName_s":["Y. Bedulho das Lages","N. Milanino","J. Verin","Jean-François Willart","Florence Danede","C. Vincent","P. Bawuah","J.A. Zeitler","F. Siepmann","J. Siepmann"],
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"citationRef_s":"<i>Journal of Controlled Release</i>, 2024, Journal of Controlled Release, 374, pp.103-111. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2024.08.010\">⟨10.1016/j.jconrel.2024.08.010⟩</a>",
"citationFull_s":"Youssef Abdalla, Laura Mccoubrey, Fabiana Ferraro, Lisa Sonnleitner, Yannick Guinet, et al.. Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery. <i>Journal of Controlled Release</i>, 2024, Journal of Controlled Release, 374, pp.103-111. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2024.08.010\">⟨10.1016/j.jconrel.2024.08.010⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04687027v1\">⟨hal-04687027⟩</a>",
"title_s":["Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery"],
"authFullName_s":["Youssef Abdalla","Laura Mccoubrey","Fabiana Ferraro","Lisa Sonnleitner","Yannick Guinet","Florence Siepmann","Alain Hedoux","Juergen Siepmann","Abdul Basit","Mine Orlu","David Shorthouse"],
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"citationFull_s":"F. Ramos, Jean-François Willart, Christel Neut, Kevimy Agossa, Juergen Siepmann, et al.. In-situ forming PLGA implants: Towards less toxic solvents.. <i>International Journal of Pharmaceutics: X</i>, 2024, International Journal of Pharmaceutics: X, 657, pp.124121. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpharm.2024.124121\">⟨10.1016/j.ijpharm.2024.124121⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04591703v1\">⟨hal-04591703⟩</a>",
"title_s":["In-situ forming PLGA implants: Towards less toxic solvents."],
"authFullName_s":["F. Ramos","Jean-François Willart","Christel Neut","Kevimy Agossa","Juergen Siepmann","Florence Siepmann"],
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"citationRef_s":"<i>Journal of Controlled Release</i>, 2024, Journal of Controlled Release, 369, pp.163-178. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2024.03.039\">⟨10.1016/j.jconrel.2024.03.039⟩</a>",
"citationFull_s":"L. E. Mccoubrey, Fabiana Ferraro, N. Seegobin, Jérémy Verin, H. A. Alfassam, et al.. Poly(D,l-lactide-co-glycolide) particles are metabolised by the gut microbiome and elevate short chain fatty acids.. <i>Journal of Controlled Release</i>, 2024, Journal of Controlled Release, 369, pp.163-178. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2024.03.039\">⟨10.1016/j.jconrel.2024.03.039⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04591667v1\">⟨hal-04591667⟩</a>",
"title_s":["Poly(D,l-lactide-co-glycolide) particles are metabolised by the gut microbiome and elevate short chain fatty acids."],
"authFullName_s":["L. E. Mccoubrey","Fabiana Ferraro","N. Seegobin","Jérémy Verin","H. A. Alfassam","A. Awad","M. Marzorati","L. Verstrepen","J. Ghyselinck","J. de Munck","J. de Medts","E. Steppe","V. de Vleeschhauwer","G. de Rocker","A. Droesbeke","M. de Rijck","S. Vanthoor","F. Moens","Juergen Siepmann","Florence Siepmann","S. Gaisford","M. Orlu","A. W. Basit"],
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"citationFull_s":"Fabiana Ferraro, Lisa Sonnleitner, Christel Neut, Séverine Mahieux, Jérémy Verin, et al.. Colon targeting in rats, dogs and IBD patients with species-independent film coatings. <i>International Journal of Pharmaceutics: X</i>, 2024, International Journal of Pharmaceutics: X, 7, pp.100233. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpx.2024.100233\">⟨10.1016/j.ijpx.2024.100233⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04504251v1\">⟨hal-04504251⟩</a>",
"title_s":["Colon targeting in rats, dogs and IBD patients with species-independent film coatings"],
"authFullName_s":["Fabiana Ferraro","Lisa Sonnleitner","Christel Neut","Séverine Mahieux","Jérémy Verin","Juergen Siepmann","Florence Siepmann"],
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"citationFull_s":"Lise-Anne Lefol, Prince Bawuah, J. Axel Zeitler, Jérémy Verin, Florence Danede, et al.. Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel.. <i>International Journal of Pharmaceutics: X</i>, 2024, International Journal of Pharmaceutics: X, 6, pp.100220. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpx.2023.100220\">⟨10.1016/j.ijpx.2023.100220⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04477038v1\">⟨hal-04477038⟩</a>",
"title_s":["Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel."],
"authFullName_s":["Lise-Anne Lefol","Prince Bawuah","J. Axel Zeitler","Jérémy Verin","Florence Danede","Jean-François Willart","Florence Siepmann","Juergen Siepmann"],
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"citationFull_s":"Charline Henaff, Juergen Siepmann, Florence Siepmann, Jean-François Willart. Amorphous chlorhexidine (free base) dissolves less rapidly compared to crystalline. <i>14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology</i>, 2024, Vienne (Austria), Austria. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04512566v1\">⟨hal-04512566⟩</a>",
"title_s":["Amorphous chlorhexidine (free base) dissolves less rapidly compared to crystalline"],
"authFullName_s":["Charline Henaff","Juergen Siepmann","Florence Siepmann","Jean-François Willart"],
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"citationFull_s":"Yanis Bedulho das Lages, N. Milanino, Jérémy Verin, Jean-François Willart, Florence Danede, et al.. EVA implants for controlled drug delivery to the inner ear. <i>14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology</i>, 2024, Vienne (Austria), Austria. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04510764v1\">⟨hal-04510764⟩</a>",
"title_s":["EVA implants for controlled drug delivery to the inner ear"],
"authFullName_s":["Yanis Bedulho das Lages","N. Milanino","Jérémy Verin","Jean-François Willart","Florence Danede","C. Vincent","P. Bawuah","J.A. Zeitler","Florence Siepmann","Juergen Siepmann"],
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"citationRef_s":"<i>International Journal of Pharmaceutics</i>, 2023, 648, pp.123560. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpharm.2023.123560\">⟨10.1016/j.ijpharm.2023.123560⟩</a>",
"citationFull_s":"Céline Jaudoin, Maria Maue Gehrke, Isabelle Grillo, Fabrice Cousin, Malika Ouldali, et al.. Release of liposomes from hyaluronic acid-based hybrid systems: Effects of liposome surface and size. <i>International Journal of Pharmaceutics</i>, 2023, 648, pp.123560. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpharm.2023.123560\">⟨10.1016/j.ijpharm.2023.123560⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04589294v1\">⟨hal-04589294⟩</a>",
"title_s":["Release of liposomes from hyaluronic acid-based hybrid systems: Effects of liposome surface and size"],
"authFullName_s":["Céline Jaudoin","Maria Maue Gehrke","Isabelle Grillo","Fabrice Cousin","Malika Ouldali","Ana-Andreea Arteni","Evelyne Ferrary","Florence Siepmann","Juergen Siepmann","Fanny Simelière","Amélie Bochot","Florence Agnely"],
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"citationRef_s":"<i>Journal of Controlled Release</i>, 2023, Journal of Controlled Release, 363, pp.1-11. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2023.09.020\">⟨10.1016/j.jconrel.2023.09.020⟩</a>",
"citationFull_s":"C. Bassand, F. Siepmann, L. Benabed, J. Verin, J. Freitag, et al.. 3D printed PLGA implants: How the filling density affects drug release. <i>Journal of Controlled Release</i>, 2023, Journal of Controlled Release, 363, pp.1-11. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2023.09.020\">⟨10.1016/j.jconrel.2023.09.020⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04301938v1\">⟨hal-04301938⟩</a>",
"title_s":["3D printed PLGA implants: How the filling density affects drug release","3D printed PLGA implants: How the filling density affects drug release."],
"authFullName_s":["C. Bassand","F. Siepmann","L. Benabed","J. Verin","J. Freitag","Sébastien Charlon","J. Soulestin","J. Siepmann"],
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"citationFull_s":"Charline Henaff, Juergen Siepmann, Florence Siepmann, Florence Danede, Marie-Noëlle Avettand-Fènoël, et al.. Exploration of the physical states of riboflavin (free base) by mechanical milling. <i>International Journal of Pharmaceutics</i>, 2023, International journal of pharmaceutics, 645, pp.123416. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.ijpharm.2023.123416\">⟨10.1016/j.ijpharm.2023.123416⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04214667v1\">⟨hal-04214667⟩</a>",
"title_s":["Exploration of the physical states of riboflavin (free base) by mechanical milling"],
"authFullName_s":["Charline Henaff","Juergen Siepmann","Florence Siepmann","Florence Danede","Marie-Noëlle Avettand-Fènoël","Jérémy Verin","Alexandre Fadel","Jean-François Willart"],
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"citationRef_s":"<i>Journal of Drug Delivery Science and Technology</i>, 2023, Journal of Drug Delivery Science and Technology, 86, pp.104648. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jddst.2023.104648\">⟨10.1016/j.jddst.2023.104648⟩</a>",
"citationFull_s":"S. Wachowiak, Florence Danede, Jean-François Willart, Florence Siepmann, Juergen Siepmann, et al.. PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry. <i>Journal of Drug Delivery Science and Technology</i>, 2023, Journal of Drug Delivery Science and Technology, 86, pp.104648. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jddst.2023.104648\">⟨10.1016/j.jddst.2023.104648⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04297225v3\">⟨hal-04297225v3⟩</a>",
"title_s":["PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry"],
"authFullName_s":["S. Wachowiak","Florence Danede","Jean-François Willart","Florence Siepmann","Juergen Siepmann","M. Hamoudi"],
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"citationRef_s":"<i>Journal of Controlled Release</i>, 2023, Journal of Controlled Release, 361, pp.334-349. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2023.07.052\">⟨10.1016/j.jconrel.2023.07.052⟩</a>",
"citationFull_s":"Blessing C. Ilochonwu, Simone A. van der Lugt, Ada Annala, Greta Di Marco, Thibault Sampon, et al.. Thermo-responsive Diels-Alder stabilized hydrogels for ocular drug delivery of a corticosteroid and an anti-VEGF fab fragment.. <i>Journal of Controlled Release</i>, 2023, Journal of Controlled Release, 361, pp.334-349. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2023.07.052\">⟨10.1016/j.jconrel.2023.07.052⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04477153v1\">⟨hal-04477153⟩</a>",
"title_s":["Thermo-responsive Diels-Alder stabilized hydrogels for ocular drug delivery of a corticosteroid and an anti-VEGF fab fragment."],
"authFullName_s":["Blessing C. Ilochonwu","Simone A. van der Lugt","Ada Annala","Greta Di Marco","Thibault Sampon","Juergen Siepmann","Florence Siepmann","Wim E. Hennink","Tina Vermonden"],
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"citationRef_s":"<i>Regenerative Biomaterials</i>, 2023, Regenerative Biomaterials, 10, pp.rbad008. <a target=\"_blank\" href=\"https://dx.doi.org/10.1093/rb/rbad008\">⟨10.1093/rb/rbad008⟩</a>",
"citationFull_s":"T. Rongthong, Adam Qnouch, M. Maue Gehrke, Laurent Paccou, P. Oliveira, et al.. Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms.. <i>Regenerative Biomaterials</i>, 2023, Regenerative Biomaterials, 10, pp.rbad008. <a target=\"_blank\" href=\"https://dx.doi.org/10.1093/rb/rbad008\">⟨10.1093/rb/rbad008⟩</a>. <a target=\"_blank\" href=\"https://lilloa.hal.science/hal-04067392v1\">⟨hal-04067392⟩</a>",
"title_s":["Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms."],
"authFullName_s":["T. Rongthong","Adam Qnouch","M. Maue Gehrke","Laurent Paccou","P. Oliveira","Florence Danede","Jérémy Verin","Christophe Vincent","Jean-François Willart","Florence Siepmann","Juergen Siepmann"],
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"citationRef_s":"<i>Journal of Controlled Release</i>, 2023, 353, pp.864-874. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2022.11.052\">⟨10.1016/j.jconrel.2022.11.052⟩</a>",
"citationFull_s":"C. Bassand, L. Benabed, Sébastien Charlon, J. Verin, J. Freitag, et al.. 3D printed PLGA implants: APF DDM vs. FDM. <i>Journal of Controlled Release</i>, 2023, 353, pp.864-874. <a target=\"_blank\" href=\"https://dx.doi.org/10.1016/j.jconrel.2022.11.052\">⟨10.1016/j.jconrel.2022.11.052⟩</a>. <a target=\"_blank\" href=\"https://hal.science/hal-04301963v1\">⟨hal-04301963⟩</a>",
"title_s":["3D printed PLGA implants: APF DDM vs. FDM"],
"authFullName_s":["C. Bassand","L. Benabed","Sébastien Charlon","J. Verin","J. Freitag","F. Siepmann","J. Soulestin","J. Siepmann"],
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