Dimitra Gkika
Research Themes
The guiding principle of my research is to characterize the molecular factors, both extra- and intracellular, that regulate ion channel proteins and their influence in human pathophysiology. In other words, how the molecular environment of an ion channel can impact its activity and thus affect cellular physiology and consequently the physiology of the animal organism, specifically renal and intestinal functions, thermosensation, nociception, angiogenesis, as well as pathological processes related to carcinogenesis.
Research Themes
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Regulation of calcium homeostasis in renal, intestinal, and bone physiology
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Signaling pathways regulating thermo sensation (cold) and nociception
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Role of intracellular calcium and ion channels in cell migration and adhesion
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Role of ion channels in the migration of epithelial and endothelial cells and their consequences on tumor invasion and angiogenesis
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Identification of TRP channel profiles as dual molecular targets for vascularization and tumor progression in prostate cancers.
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Rapid/non-transcriptional hormonal regulation and its consequences on the physiology of epithelial, nervous, and endothelial cells.
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Role of ion channels in cellular plasticity, oxidative stress, and cellular metabolism during breast cancer progression and therapy resistance
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Role of calcium signaling in endothelial cell plasticity
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Functional profile of endothelial-mesenchymal transition: a new approach against tumor cell dissemination
Raising Funding
2023
2023
2023
2021
2021
2020
2018
2018
2017
2017
2015
2015
2014
2014 | Subvention Ligue Nationale Contre le Cancer - Région Septentrion Projets Émergent, Cancéropôle Nord-Ouest, 75 k€
Projets Émergents, Cancéropôle Nord-Ouest, 20 k€
Subvention doctorale Région des Hauts de France / Institut Pasteur de 3 ans, Ligue Contre le Cancer, 60k€
Subvention doctorale de 3 ans, Ligue Contre le Cancer, 60k€
Projets Émergeant, Canther, OncoLille, 5k€
France-Berkeley Fund for innovative research collaborations, 15k$
3-year fellowship for a PhD student, University of Turin and University of Lille 1, 50k€
Grant for the creation of an International Associated Laboratory with the Univerities of Turin (Italy) and Münster (Germany), 75k€
Grant of Institut Universitaire de France, junior member, 75k€
Vinci Project Université Franco-Italienne, 1-year fellowship for a Post Doctoral student, 25 k€
3-year fellowship for a PhD student, Région Hauts-de-France and University of Lille 1, 60k€
Grant of the ARTP Association (Research Association for Research on Prostate Tumors), 20 k€
Grant of the ARC Foundation (Agency for Cancer Research), 50 k€
INCa (National Institute for Cancer) Grant « Biology and Cancer Sciences», Prevarskaya/Gkika Amount: 770 k€ |
2013 |
IFR147 grant on « Emergence in proteomics and mass spectrometry » , 4 k€
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2012 | Vinci Project Université Franco-Italienne , 3 years fellowship for a PhD student, 60 k€
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2010
2007 | Bonus Quality Research (BQR) - Emerging Projects, 30 k€
INCa (National Institute for Cancer) Grant « Biology and Cancer Sciences», Prevarskaya/Gkika, 100 k€
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