Dimitra Gkika
Publications
Mathilde Lebas, G. Chinigò, Evan Courmont, Louay Bettaieb, Amani Machmouchi, J. Goveia, A. Beatovic, J. van Kerckhove, Cyril Robil, F. S. Angulo, M. Vedelago, A. Errerd, L. Treps, Vance Gao, H. C. Delgado de la Herrán, Alicia Mayeuf-Louchart, Laurent L'Homme, M. Chamlali, C. Dejos, Valerie Gouyer, V. N. S. Garikipati, D. Tomar, H. Yin, H. Fukui, S. Vinckier, A. Stolte, L. C. Conradi, F. Infanti, Loic Lemonnier, E. Zeisberg, Y. Luo, L. Lin, Jean-Luc Desseyn, J. Pickering, R. Kishore, M. Madesh, David Dombrowicz, F. Perocchi, Bart Staels, A. F. Pla, Dimitra Gkika, Anna Rita Cantelmo
Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition.
Science Advances , 2024, Sci Adv, 10 (32), eadp6182. ⟨10.1126/sciadv.adp6182⟩
Mayar Soussi, Alice Hasselsweiller, Dimitra Gkika
TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?
Membranes, 2023, 13 (9), pp.788. ⟨10.3390/membranes13090788⟩
Dimitra Gkika, Albrecht Schwab
Editorial: From mechanosensing to signalling and cell response: The ion channel force
Frontiers in Cell and Developmental Biology, 2023, 11, ⟨10.3389/fcell.2023.1183726⟩
Transient Receptor Potential (TRP) Channels non Genomic Regulation by Sex Steroids: The Less Traveled Pathway
Encyclopedia of Cell Biology, Elsevier, pp.271-277, 2023, ⟨10.1016/B978-0-12-821618-7.00170-X⟩
Guillaume Grolez, Giorgia Chinigò, Alexandre Barras, Mehdi Hammadi, Lucile Noyer, Kateryna Kondratska, Etmar Bulk, Thibauld Oullier, Séverine Marionneau-Lambot, Marilyne Le Mée, Stéphanie Rétif, Stéphanie Lerondel, Antonino Bongiovanni, Tullio Genova, Sébastien Roger, Rabah Boukherroub, Albrecht Schwab, Alessandra Fiorio Pla, Dimitra Gkika
TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination
International Journal of Molecular Sciences, 2022, Calcium Signaling in Human Health and Diseases 3.0, 23 (12), pp.6672. ⟨10.3390/ijms23126672⟩
Dimitra Gkika, Stéphane Lolignier, Guillaume Grolez, Alexis Bavencoffe, Georges Shapovalov, Dmitri Gordienko, Artem Kondratskyi, Mathieu Meleine, Laetitia Prival, Eric Chapuy, Monique Etienne, Alain Eschalier, Yaroslav Shuba, Roman Skryma, Jérôme Busserolles, Natalia Prevarskaya
TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination
International Journal of Molecular Sciences, 2022, 23 (12), pp.6672. ⟨10.3390/ijms23126672⟩
Giorgia Chinigò, Guillaume Grolez, Madelaine Audero, Alexandre Bokhobza, Michela Bernardini, Julien Cicero, Robert-Alain Toillon, Quentin Bailleul, Luca Visentin, Federico Alessandro Ruffinatti, Guillaume Brysbaert, Marc Lensink, Jerome de Ruyck, Anna Rita Cantelmo, Alessandra Fiorio Pla, Dimitra Gkika
TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells
Cancers, 2022, 14 (9), pp.2261. ⟨10.3390/cancers14092261⟩
Non genomic regulation of TRPM8: From thermosensation to cancer
Biophysical Society 66th Annual Meeting, Feb 2022, San Francisco (CA, USA), United States. pp.101a, ⟨10.1016/j.bpj.2021.11.2206⟩
Valerio Farfariello, Dmitri Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan Parys, Loïc Lemonnier, Natalia Prevarskaya
TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence
Nature Communications, 2022, 13 (1), pp.956. ⟨10.1038/s41467-022-28597-x⟩
Giorgia Chinigò, Hélène Castel, Oana Chever, Dimitra Gkika
TRP Channels in Brain Tumors
Frontiers in Cell and Developmental Biology, 2021, 9 (617801), pp.1-17. ⟨10.3389/fcell.2021.617801⟩
Camille Dejos, Dimitra Gkika, Anna Rita Cantelmo
The Two-Way Relationship Between Calcium and Metabolism in Cancer
Frontiers in Cell and Developmental Biology, 2020, 8, pp.573747. ⟨10.3389/fcell.2020.573747⟩
Giorgia Chinigò, Alessandra Fiorio Pla, Dimitra Gkika
TRP Channels and Small GTPases Interplay in the Main Hallmarks of Metastatic Cancer
Frontiers in Pharmacology, 2020, 11 (581455), pp.1-16. ⟨10.3389/fphar.2020.581455⟩
Valerio Farfariello, Natalia Prevarskaya, Dimitra Gkika
Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening
Reviews of Physiology Biochemistry and Pharmacology, 2020, Reviews of Physiology, Biochemistry and Pharmacology, 181, pp.39-56. ⟨10.1007/112_2020_22⟩
Alessandra Fiorio Pla, Dimitra Gkika
Ca2+ Channel Toolkit in Neuroendocrine Tumors
Neuroendocrinology, 2020, 110 (1-2), pp.147-154. ⟨10.1159/000501397⟩
Dimitra Gkika, Stéphane Lolignier, Guillaume Grolez, Alexis Bavencoffe, Georges Shapovalov, Dmitri Gordienko, Artem Kondratskyi, Mathieu Meleine, Laetitia Prival, Eric Chapuy, Monique Etienne, Alain Eschalier, Yaroslav Shuba, Roman Skryma, Jérôme Busserolles, Natalia Prevarskaya
Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity
FASEB Journal, 2020, 34 (6), pp.7483-7499. ⟨10.1096/fj.201902270R⟩
Michela Bernardini, Alessia Brossa, Giorgia Chinigo, Guillaume Grolez, Giulia Trimaglio, Laurent Allart, Audrey Hulot, Guillemette Marot, Tullio Genova, Aditi Joshi, Virginie Mattot, Gaëlle Fromont, Luca Munaron, Benedetta Bussolati, Natalia Prevarskaya, Alessandra Fiorio Pla, Dimitra Gkika
Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis
Cancers, 2019, 11 (7), pp.956. ⟨10.3390/cancers11070956⟩
Lucile Noyer, Loic Lemonnier, Pascal Mariot, Dimitra Gkika
Partners in Crime: Towards New Ways of Targeting Calcium Channels
International Journal of Molecular Sciences, 2019, 20 (24), pp.6344. ⟨10.3390/ijms20246344⟩
Guillaume P. Grolez, Dmitri V. Gordiendko, Manon Clarisse, Mehdi Hammadi, Emilie Desruelles, Gaëlle Fromont, Natalia Prevarskaya, Christian Slomianny, Dimitra Gkika
TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration
Cell Death and Disease, 2019, 10 (9), pp.652. ⟨10.1038/s41419-019-1891-8⟩
Fabien Vanden Abeele, Sabine Lotteau, Sylvie Ducreux, Charlotte Dubois, Nicole Monnier, Amy Hanna, Dimitra Gkika, Caroline Romestaing, Lucile Noyer, Matthieu Flourakis, Nolwenn Tessier, Ribal Al-Mawla, Christophe Chouabe, Etienne Lefai, Joël Lunardi, Susan Hamilton, Julien Fauré, Fabien van Coppenolle, Natalia Prevarskaya
TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia
Genetics in Medicine, 2019, 21 (2), pp.441-450. ⟨10.1038/s41436-018-0066-9⟩
Gabriel Bidaux, Dmitri Gordienko, George Shapovalov, Valerio Farfariello, Anne-Sophie Borowiec, Oksana Iamshanova, Loic Lemonnier, Maxime Gueguinou, Roseline Guibon, Gaelle Fromont, Mélanie Paillard, Yves Gouriou, Christophe Chouabe, Etienne Dewailly, Dimitra Gkika, Pilar López-Alvarado, J. Carlos Menéndez, Laurent Héliot, Christian Slomianny, Natalia Prevarskaya
4TM-TRPM8 channels are new gatekeepers of the ER-mitochondria Ca2+ transfer
Biochimica et Biophysica Acta - Molecular Cell Research, 2018, 1865 (7), pp.981-994. ⟨10.1016/j.bbamcr.2018.04.007⟩
David Arredondo Zamarripa, Ramsés Noguez Imm, Ana María Bautista Cortés, Osvaldo Vázquez Ruíz, Michela Bernardini, Alessandra Fiorio Pla, Dimitra Gkika, Natalia Prevarskaya, Fernando López-Casillas, Wolfgang Liedtke, Carmen Clapp, Stéphanie Thébault
Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference
Scientific Reports, 2017, 7 (1), pp.13094. ⟨10.1038/s41598-017-13621-8⟩
Tullio Genova, Guillaume Grolez, Chiara Camillo, Michela Bernardini, Alexandre Bokhobza, Elodie Richard, Marco Scianna, Loic Lemonnier, Donatella Valdembri, Luca Munaron, Mark Philips, Virginie Mattot, Guido Serini, Natalia Prevarskaya, Dimitra Gkika, Alessandra Fiorio Pla
TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1
Journal of Cell Biology, 2017, 216 (7), pp.2107-2130. ⟨10.1083/jcb.201506024⟩
Stéphane Lolignier, Dimitra Gkika, David Andersson, Enrico Leipold, Irina Vetter, Felix Viana, Jacques Noël, Jérôme Busserolles
New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives
Journal of Neuroscience, 2016, 36 (45), pp.11435 - 11439. ⟨10.1523/jneurosci.2327-16.2016⟩
Guillaume P. Grolez, Dimitra Gkika
TRPM8 Puts the Chill on Prostate Cancer
Pharmaceuticals, 2016, 9 (3), pp.44. ⟨10.3390/ph9030044⟩
Michela Bernardini, Alessandra Fiorio Pla, Natalia Prevarskaya, Dimitra Gkika
Human transient receptor potential (TRP) channel expression profiling in carcinogenesis
International Journal of Developmental Biology, 2015, 59 (7-8-9), pp.399-406. ⟨10.1387/ijdb.150232dg⟩
Dimitra Gkika, Loic Lemonnier, George Shapovalov, Dmitri Gordienko, Céline Poux, Michela Bernardini, Alexandre Bokhobza, Gabriel Bidaux, Cindy Degerny, Kathye Verreman, Basma Guarmit, Mohamed Benahmed, Yvan de Launoit, René J.M. Bindels, Alessandra Fiorio Pla, Natalia Prevarskaya
TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity
Journal of Cell Biology, 2015, 208 (1), pp.89-107. ⟨10.1083/jcb.201402076⟩
Alessandra Fiorio Pla, Alessia Brossa, Michela Bernardini, Tullio Genova, Guillaume Grolez, Arnaud Villers, Xavier Leroy, Natalia Prevarskaya, Dimitra Gkika, Benedetta Bussolati
Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib
BMC Cancer, 2014, 14 (1), pp.939. ⟨10.1186/1471-2407-14-939⟩
Charlotte Dubois, Fabien Vanden Abeele, V’yacheslav Lehen’kyi, Dimitra Gkika, Basma Guarmit, Gilbert Lepage, Christian Slomianny, Anne Sophie Borowiec, Gabriel Bidaux, Mohamed Benahmed, Yaroslav Shuba, Natalia Prevarskaya
Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer
Cancer Cell, 2014, 26 (1), pp.19-32. ⟨10.1016/j.ccr.2014.04.025⟩
Alessandra Fiorio Pla, Alessia Brossa, Michela Bernardini, Tullio Genova, Guillaume Grolez, Arnaud Villers, Xavier Leroy, Natalia Prevarskaya, Dimitra Gkika, Benedetta Bussolati
Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib.
BMC Cancer, 2013, 14 (1), pp.939
Fabien Vanden Abeele, Artem Kondratskyi, Charlotte Dubois, George Shapovalov, Dimitra Gkika, Jérôme Busserolles, Yaroslav Shuba, Roman Skryma, Natalia Prevarskaya
Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia
Journal of Cell Science, 2013, 126 (19), pp.4479-4489. ⟨10.1242/jcs.131631⟩
George Shapovalov, Dimitra Gkika, Maily Devilliers, Artem Kondratskyi, Dmitri Gordienko, Jerome Busserolles, Alexandre Bokhobza, Alain Eschalier, Roman Skryma, Natalia Prevarskaya
Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8
Cell Reports, 2013, 4 (3), pp.504-515. ⟨10.1016/j.celrep.2013.07.002⟩
Agathe Oulidi, Alexandre Bokhobza, Dimitra Gkika, Fabien Vanden Abeele, V’yacheslav Lehen’kyi, L’houcine Ouafik, Brigitte Mauroy, Natalia Prevarskaya
TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion
PLoS ONE, 2013, 8 (5), pp.e64885. ⟨10.1371/journal.pone.0064885⟩
Alessandra Fiorio Pla, Dimitra Gkika
Emerging role of TRP channels in cell migration: from tumor vascularization to metastasis
Frontiers in Physiology, 2013, 4, ⟨10.3389/fphys.2013.00311⟩
Agathe Oulidi, Alexandre Bokhobza, Dimitra Gkika, Fabien Vanden Abeele, V'Yacheslav Lehen'Kyi, L’houcine Ouafik, Brigitte Mauroy, Natalia Prevarskaya
TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion
PLoS ONE, 2013, 8 (5), pp.e64885. ⟨10.1371/journal.pone.0064885⟩
Roman Skryma, Natalia Prevarskaya, Dimitra Gkika, Yaroslav Shuba
From urgency to frequency: facts and controversies of TRPs in the lower urinary tract
Nature Reviews Urology, 2011, 8 (11), pp.617-630. ⟨10.1038/nrurol.2011.142⟩
Dimitra Gkika, Natalia Prevarskaya
TRP channels in prostate cancer: the good, the bad and the ugly?
Asian Journal of Andrology, 2011, 13 (5), pp.673-676. ⟨10.1038/aja.2011.18⟩
Alexis Bavencoffe, Artem Kondratskyi, Dimitra Gkika, Brigitte Mauroy, Yaroslav Shuba, Natalia Prevarskaya, Roman Skryma
Complex Regulation of the TRPM8 Cold Receptor Channel
Journal of Biological Chemistry, 2011, 286 (11), pp.9849-9855. ⟨10.1074/jbc.M110.162016⟩
Dimitra Gkika, Matthieu Flourakis, Loic Lemonnier, Natalia Prevarskaya
PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression.
Oncogene, 2010, epub ahead of print. ⟨10.1038/onc.2010.210⟩
Michaël Monet, V'Yacheslav Lehen'Kyi, Florian Gackiere, Virginie Firlej, Matthieu Vandenberghe, Morad Roudbaraki, Dimitra Gkika, Albin Pourtier, Gabriel Bidaux, Christian Slomianny, Philippe Delcourt, François Rassendren, Jean-Pierre Bergerat, Jocelyn Ceraline, Florence Cabon, Sandrine Humez, Natalia Prevarskaya
Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance
Cancer Research, 2010, 285 (13), pp.9410-9419. ⟨10.1158/0008-5472.CAN-09-2205⟩
Alexis Bavencoffe, Dimitra Gkika, Artem Kondratskyi, Benjamin Beck, Anne-Sophie Borowiec, Gabriel Bidaux, Jérôme Busserolles, Alain Eschalier, Yaroslav Shuba, Roman Skryma, Natalia Prevarskaya
The Transient Receptor Potential Channel TRPM8 Is Inhibited via the α2A Adrenoreceptor Signaling Pathway
Journal of Biological Chemistry, 2010, 285 (13), pp.9410-9419. ⟨10.1074/jbc.M109.069377⟩
Dimitra Gkika, Natalia Prevarskaya
Molecular mechanisms of TRP regulation in tumor growth and metastasis
Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1793 (6), pp.953-958. ⟨10.1016/j.bbamcr.2008.11.010⟩
Michaël Monet, Dimitra Gkika, V'Yacheslav Lehen'Kyi, Albin Pourtier, Fabien Vanden Abeele, Gabriel Bidaux, Véronique Juvin, François Rassendren, Sandrine Humez, Natalia Prevarsakaya
Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation
Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1793 (3), pp.528-539. ⟨10.1016/j.bbamcr.2009.01.003⟩
Dimitra Gkika, Catalin Topala, Qing Chang, Nicolas Picard, Stéphanie Thébault, Pascal Houillier, Joost Hoenderop, René Bindels
Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function
Journal of Clinical Investigation, 2007, 117 (6), pp.1647-1657. ⟨10.1172/JCI30168⟩
Gabriel Bidaux, Matthieu Flourakis, Stéphanie Thebault, Alexander Zholos, Benjamin Beck, Dimitra Gkika, Morad Roudbaraki, Jean-Louis Bonnal, Brigitte Mauroy, Yaroslav Shuba, Roman Skryma, Natalia Prevarskaya
Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function.
Journal of Clinical Investigation, 2007, 117 (6), pp.1647-57. ⟨10.1172/JCI30168⟩
Gabriel Bidaux, Matthieu Flourakis, Stéphanie Thebault, Alexander Zholos, Benjamin Beck, Dimitra Gkika, Morad Roudbaraki, Jean-Louis Bonnal, Brigitte Mauroy, Yaroslav Shuba, Roman Skryma, Natalia Prevarskaya
Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function
Journal of Clinical Investigation, 2007, 117 (6), pp.1647-1657. ⟨10.1172/JCI30168⟩
Dimitra Gkika, Catalin Topala, Qing Chang, Nicolas Picard, Stéphanie Thébault, Pascal Houillier, Joost Hoenderop, René Bindels
Tissue kallikrein stimulates Ca2+ reabsorption via PKC-dependent plasma membrane accumulation of TRPV5
EMBO Journal, 2006, 25 (20), pp.4707-4716. ⟨10.1038/sj.emboj.7601357⟩
Dimitra Gkika, Catalin Topala, Joost Hoenderop, René Bindels
The immunophilin FKBP52 inhibits the activity of the epithelial Ca 2+ channel TRPV5
American Journal of Physiology. Renal Physiology, 2006, 290 (5), pp.F1253-F1259. ⟨10.1152/ajprenal.00298.2005⟩
Dimitra Gkika, Yu-Juei Hsu, Annemiete van der Kemp, Sylvia Christakos, René Bindels, Joost Hoenderop
Critical Role of the Epithelial Ca2+ Channel TRPV5 in Active Ca2+ Reabsorption as Revealed by TRPV5/Calbindin-D28K Knockout Mice
Journal of the American Society of Nephrology, 2006, 17 (11), pp.3020-3027. ⟨10.1681/ASN.2006060676⟩
Dimitra Gkika, Frank Mahieu, Bernd Nilius, Joost G.J. Hoenderop, René J.M. Bindels
80K-H as a New Ca2+ Sensor Regulating the Activity of the Epithelial Ca2+ Channel Transient Receptor Potential Cation Channel V5 (TRPV5)
Journal of Biological Chemistry, 2004, 279 (25), pp.26351-26357. ⟨10.1074/jbc.M403801200⟩
Joost G.J. Hoenderop, Helena Chon, Dimitra Gkika, Hans A.R. Bluyssen, Frank C.P. Holstege, Rene St-Arnaud, Branko Braam, Rene J.M. Bindels
Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1α-hydroxylase knockout mice
Kidney International, 2004, 65 (2), pp.531-539. ⟨10.1111/j.1523-1755.2004.00402.x⟩
Sonia Perez, Panagiota Sotiropoulou, Dimitra Gkika, Louisa Mahaira, Dimitrios Niarchos, Angelos Gritzapis, Yiannis Kavalakis, Aris Antsaklis, Constantin Baxevanis, Michael Papamichail
A novel myeloid-like NK cell progenitor in human umbilical cord blood
Blood, 2003, 101 (9), pp.3444-3450. ⟨10.1182/blood-2002-05-1501⟩
S. F.J. van de Graaf, Stan F J van De Graaf, Joost G J Hoenderop, Dimitra Gkika, Dennis Lamers, Jean Prenen, Ursula Rescher, Volker Gerke, Olivier Staub, Bernd Nilius, René J M Bindels
Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex
EMBO Journal, 2003, 22 (7), pp.1478-1487. ⟨10.1093/emboj/cdg162⟩
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