Bruno Bastide

Professeur des universités - Physiologie Neuromusculaire

Bruno Bastide

Professeur des universités - Physiologie Neuromusculaire



Google Scholar 2092 citations, H 25.


·        Articles dans revues internationales à comité de lecture



[1]   Hervé, J.C., Bastide B. and Délèze, J. (1989) Segmental electrical uncoupling and conduction blocks after calcium removal and replacement in a mammalian auricle. J. Mol. Cell. Cardiol., 21: 1017-1027. Impact factor 4,85


[2]   Adovelande, J., Bastide, B., Délèze, J. and Schrevel, J. (1993) Cytosolic free calcium in Plasmodium falciparum infected erythrocytes and the effect of verapamil: a cytofluorometric study. Exp  parasitology , 76:247-258. Impact factor 1,10


[3]   Bastide, B., Neyses, L., Ganten, D., Paul, M., Willecke, K. and Traub, O. (1993) The gap junction protein connexin 40 is preferentially expressed in vascular endothelium as well as conductive bundles of rat heart and is increased under hypertensive conditions. Circ. Res., 73: 1138-1149. Impact factor 9,85


[4]   Traub, O., Eckert, R., Lichtenberg-Fraté, H.,  Elfgang, C.,  Bastide, B., Scheidtmann, K.H., Hülser, D. F. and Willecke, K. (1994) Immunochemical and electrophysiological characterization of murine connexin40 and -43 expressed in transfected human cells and in mouse tissues. Eur. J. Cell Biol., 64:101-113. Impact factor 3,03


[5]   Cronier, L., Bastide, B., Hervé, J.C., Délèze, J. and Malassiné, A. (1994)  Gap junctional  communication during human trophoblast differentiation: influence of human chorionic  gonadotropin. Endocrinology,135:402-408. Impact factor 5,23


[6]   Bastide, B., Hervé, J.C. and Délèze, J. (1994) The uncoupling effect of diacylglycerol on gap junctional communication of mammalian heart cells is independent of protein kinase C. Exp. Cell Res.,214:519-527. Impact factor 3,77


[7]   Bastide, B., Hervé, J.C., Cronier, L. and Délèze, J. (1995) Rapid onset and calcium independance of the block of cell-to-cell conductance induced by heptanol in neonatal rat ventricular cells. Pflügers Arch.,  429:386-393. Impact factor 4,80


[8]   Mellitti, K., Bournaud, R., Bastide, B. and Shimahara, T. (1996) Nifedipine sensitive intramembrane charge movement in Purkinje Cells  from mice cerebellum. J. Physiol (London), 490:363-372. Impact factor 4,40


[9]   Pluciennik, F.,  Verrecchia, F., Bastide, B., Hervé, J.C., Joffre, M. and Délèze, J. (1996) Reversible interruption of gap junctional communication by testosterone propionate in cultured Sertoli cells and cardiac myocytes. J. Memb. Biol., 149:169-177. Impact factor 2,11


[10] Hervé, J.C., Pluciennik, F., Verracchia, F., Bastide, B., Delage, B., Joffre, M. and Délèze. (1996) Influence of the molecular structure of steroids on their ability to interrupt gap junctional communication. J. Membr. Biol., 149:179-187. Impact factor 2,11


[11] Bastide, B., Jarry-Guichard, T., Briand, J.P., Deleze, J. and Gros, D. (1996) Effect of antipeptide directed against three domains of connexin43 on the gap junctional permeability of cultured heart cells. J. Memb. Biol., 150:243-253. Impact factor 2,11


[12] Hervé, J.C., Pluciennik, F., Bastide, B., Cronier, L., Verracchia, F., Malassiné, A., Joffre, M., and Délèze, J. (1996) Contraceptive gossypol blocks cell-to-cell communication in human and rat cells. Eur.  J. Pharmacol., 313:243-255. Impact factor 2,52


[13] Melliti, K., Bournaud, R., Bastide, B., Hidalgo, J. and Shimahara, T. (1996) Effect of SR33805 on barium current and asymmetric intramembrane charge movement in freshly dissociated mouse cerebellar Purkinje neurons. Neuroscience Lett., 216: 1-4. Impact factor 2,09


Recrutement en tant que maître de conférences:


[14] Catinot, M.P., Bastide, B., Montel, V., Suarez-Kurtz, G. and Mounier, Y. (1997) Effect of bovine serum albumin on the calcium release channel of sarcoplasmic reticulum from rabbit skeletal muscle. Acta Scand. Physiol., 160: 199-205. Impact Factor 2,23


[15] Catinot, M.P., Bastide, B., Suarez-Kurtz, G. and Mounier, Y. (1998) Uridine triphosphate-sensitive pathway of Ca2+ release from the sarcoplasmic reticulum of rat skeletal muscle fibers. Eur. J. Pharmacol. 362(2-3):221-7. Impact factor 2,52


[16] Bastide, B and Mounier, Y. (1998) Single-channel properties of the sarcoplasmic reticulum calcium-release channel in slow- and fast-twitch muscles of Rhesus monkeys.
Pflugers Arch. 436(3):485-8. Impact factor 4,80


[17] Toursel, T.,  Bastide, B., Stevens, L., Rieger, F. & Mounier, Y. (2000) Alterations in contractile properties and expression of myofibrillar proteins in wobbler mouse muscles. Exp. Neurol., 162, 311-320. Impact factor 4,15


[18] Bastide, B., Conti, A., Sorrentino, V. and Mounier, Y. (2000) Properties of ryanodine receptors in rat muscles submitted to hindlimb suspension. Biochem Biophys Res. Comm., 270, 442-447. Impact factor 2,85


[19] Stevens, L., Firinga, C., Gohlsch, B., Bastide, B., Mounier, Y. and Pette, D. (2000) Effects of unweighting and clenbuterol on myosin light and heavy chains in fast and slow muscles of rat. Am. J. Physiol., 279, 1558-1563. Impact factor 4,33


[20] Kischel, P., Bastide, B., Potter, J.D. and Mounier, Y. (2000) The role of the Ca2+ regularoty sites of skeletal troponin C in modulating muscle fibre reactivity to the Ca2+ sensitizer bepridil. Br. J. Pharmacol., 131, 1496-1502. Impact factor 3,82


[21] Kischel, P., Bastide, B., Stevens, L. and Mounier, Y. (2001) Expression and functional behavior of troponin C in soleus muscle fibers of rat after hindlimb unloading. J. Appl. Physiol., 90, 1095-1101. Impact Factor 3,178


[22] Cronier, L., Bastide, B., Defamie, N., Niger, C., Pointis, G., Gasc, J.M. and Malassine, A. (2001) Involvement of gap junctional communication and connexin expression in trophoblast differentiation of the human placenta (Review). Histol. Histopathol., 16, 285-295. Impact factor 2,18


[23] Stevens, L., Bastide, B., Kischel; P., Pette, D. and Mounier, Y. (2002) Time-dependent changes in the expression of troponin subunit isoforms in unloaded rat soleus muscle. Am. J. Physiol., 282, C1025-C1030. Impact factor 4,33


[24] Bastide, B., Kischel, P., Puterflam, J., Stevens, L., Pette, D., Jin, J.P. and Mounier, Y. (2002) Expression and functional implications of TnT isoforms in soleus muscle fibers of rat after unloading. Pflugers Arch., 444, 345-352. Impact factor 4,80


[25] Bastide, B, Snoeckx, K. and Mounier, Y. (2002) ADP-ribose stimulates the calcium release channel RyR1 in skeletal muscle of rat. Biochem Biophys Res. Comm., 296, 1267-1271. Impact factor 2,85


[26] Cieniewski, C., Bastide, B., Lemoine, J., Michalski, JC. And Mounier, Y. (2004) Identification of O-linked N-acetyl glucosamine proteins in rat skeletal muscle using two-dimensional gel electrophoresis and mass spectrometry. Molecular and Cellular Proteomics, 3, 577-585. Impact factor 9,80


[27] Stevens, L., Bastide, B., Mounier, Y. (2004) Correlated changes in Myosin heavy and Light chains of soleus fibers in conditions of slow-to-fast Transitions. Pflugers Arch., ., 448, 507-514. Impact factor 4,80


[28] #Kischel, P., #Bastide, B., Muller, M., Jin, J.P., Mounier, Y. and Martial, J.(2005) A slow TnT4 isoform increases skeletal troponin T diversity in soleus rat muscle. Am. J. Physiol., 289, 437-443.

# contributed equally to this work. Impact factor 4,33


[29] Mounier, Y., Montel, V., Picquet, F., Stevens, L., Bastide, B. and Falempin, M. (2005) Dual effect of deafferentation on contractile characteristics and sarcoplasmic reticulum properties in rat soleus muscle fibers. J. Appl. Physiol., 99, 542-548. Impact Factor 3,178


[30]  Bozzo, C, Spolaore B, Toniolo L, Stevens L, Bastide B, Cieniewski-Bernard C, Fontana G, Mounier Y. and Reggiani C. (2005) Myosin light chain phosphorylation in denervated slow and fast rat skeletal muscles, FEBS J., 272(22):5771-85.  Impact factor 3,033


[31]  Cieniewski, C., Mounier, Y, J., Michalski, JC. and Bastide, B. (2006) The potential implication of O-GlcNAc in the protection of fast muscle against atrophy induced by hindlimb unloading. J. Appl. Physiol., J. Appl. Physiol., 2006, 100: 1499-1505. Impact Factor 3,178


[32] Hedou, J., Cieniewski-Bernard, C., Leroy, Y., Michalski, JC., Mounier, Y, and Bastide, B. O-GlcNAc is a potent modulator of calcium sensitivity in muscle fibers. J. Biol.Chem., 2007, 282: 10360-10369. Impact Factor 5,808


[33] Stevens L, Bastide B, Maurage CA, Cieniewski-Bernard C, Montel V, Cuisset M, Vallée L. and Mounier Y. (2008) Evolution of contractile and regulatory protein isoform expressions in childhood spinal muscular atrophy. Neuropathol Appl Neurobiol 2008, 34, 659-670. Impact Factor 2,68


[34] Mounier Y, Tiffreau V, Montel V, Bastide B, Stevens L. ( 2009) Phenotypical transitions and Ca2+ activation properties in human muscle fibers. Effects of a 60-day bed rest and countermeasures. J. Appl. Physiol,  106, 1086-1099. Impact Factor 3,18


[35] Hedou J, Bastide B, Page A, Michalski JC, Morelle W. (2009) Mapping of O-linked -N-Acetylglucosamine modification sites in key contractile proteins of rat skeletal muscle. Proteomics, 2009, 9, 2139-48.Impact Factor 5,73


[36] Cieniewski-Bernard, C., Montel V, Stevens L, Bastide B. (2010) O-GlcNAcylation, an original modulator of contractile activity in striated muscle. J Muscle Res Cell Motil, (review in press).


[37] Canu MH, Piquet F, Bastide B, Falempin M. (2010 ) Activity-dependent changes in the electrophysiological properties of regular spiking neurons in the sensorimotor cortex of the rat in vitro. Behavioural Brain Research,209:289-94.



[38] S. Mayeur,  M. Silhol, E. Moitrot, S. Barbaux, C. Breton, A. Gabory, D. Vaiman, I. Dutriez-Casteloot, I. Fajardy, A. Vambergue, L. Tapia-Arancibia, B. BastideL. Storme, C. Junien, D. Vieau, J. Lesage. (2010) The placental BDNF/TrkB signaling system is modulated by fetal growth disturbances in rat and human. Placenta, ,31(9):785-91.

[39] Dupont E, Stevens L., Cochon L, Falempin M, Bastide B, Canu MH. (2011) ERK is Involved in the Reorganization of Somatosensory Cortical Maps in Adult Rats Submitted to Hindlimb Unloading. PLoS One Biol, PLoS One. 2011 Mar 8;6(3):e17564. (IF 3.7)

[40] Dupont E, Cieniewski-Bernard C, Bastide B, Stevens L. (2011) Electrostimulation during hindlimb unloading modulates PI3K-AKT downstream targets without preventing soleus atrophy and restores slow phenotype through ERK.. Am J Physiol, 300(2):R408-17.(IF 3.7)

[41] Cieniewski-Bernard C, Montel V, Bastide B. (2011) Increasing O-GlcNAcylation level on organ culture of soleus modulates the calcium activation parameters of muscle fibers. PLoS ONE 2012, 7:e48218.


Promotion PR1


[42] Langlet C, Bastide B, Canu MH. Hindlimb unloading affects cortical motor maps and decreases corticospinal excitability Exp Neurol 2012, 237:211-217. [IF 4,6]


[43] Trinel D, Picquet F, Bastide B, Canu MH. Dendritic spine remodeling induced by hindlimb unloading in adult rat sensorimotor cortex. Behav Brain Res 2013, 9(249C):1-7. [IF 3,2 ]


[44] Mayeur S, Lancel S, Theys N, Lukaszewski MA, Duban-Deweer S, Bastide B, Hachani J, Cecchelli R, Breton C, Gabory A, Storme L, Reusens B, Junien C, Vieau D, and Lesage J. Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats. Am J Physiol Endocrinol Metab 2013, 304:E14-22. (IF 4,5)


[45] #Stevens L, #Bastide B, Hedou J, Cieniewski-Bernard C, Montel V, Cochon L, Dupont E, Mounier Y. Potential regulation of human muscle plasticity by MLC2 post-translational modifications during bed rest and countermeasures.  Arch Biochem Biophys. 2013 Dec;540(1-2):125-32

        # contributed equally to this work


[46] Cieniewski-Bernard C, Dupont E, Richard E, Bastide B. Phospho-GlcNAc modulation of slow MLC2 during soleus atrophy through a multienzymatic and sarcomeric complex. .Pflugers Arch. 2014  (in press) (IF )


[47] Cieniewski-Bernard C, Dupont E, Deracinois B, Lambert M, Bastide B. Multiplexed Detection of O-GlcNAcome, Phosphoproteome, and Whole Proteome within the Same Gel. Front Endocrinol 2014, 5:184. (Pubmed)


[48] Cieniewski-Bernard C, Lambert M, Dupont E, Montel V, Stevens L, Bastide B. O-GlcNAcylation, contractile protein modifications and calcium affinity in skeletal muscle. Front Physiol 2014,30;5:421.


[49] Mysoet J, Canu MH, Cieniewski-Bernard C, Bastide B, Dupont E. Hypoactivity affects IGF-1 level and PI3K/AKT signaling pathway in cerebral structures implied in motor control. PLoSOne 2014, 9(9):e107631. (IF 3.5)


[50] Cieniewski-Bernard C, Dupont E, Richard E, Bastide B. Phospho-GlcNAc modulation of slow MLC2 during soleus atrophy through a multienzymatic and sarcomeric complex. Pflugers Arch 2014, 466 (11) : 2139-2151. (IF 3.1)


[51] Sylvain Mayeur, Jean-Sebastien Wattez, Marie-Amelie Lukaszewski, Laura Butruille, Anne Drougard, Delphine Eberle, Bruno Bastide, Christine Laborie, Laurent Storme,Claude Knauf, Didier Vieau, Christophe Breton, and Jean Lesage. (2015) Apelin controls fetal glucose homeostasis and is altered by maternal undernutrition. Diabetes, 65(3):554-60. IF 8.43


[52]  Canu MH, Fryziel F, Noel JP, Tiffreau V, Digumber M, Bastide B. A new device combining mechanical stimulation of plantar sole and Achilles’ tendon to alleviate the consequences of muscle deconditioning. Medical & Biological Engineering & Computing., 2016, 54(5):733-41.   IF 1.726


[53] Mayeur S, Wattez JS, Lukaszewski MA, Butruille L, Drougard A, Eberle D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J. Apelin controls fetal glucose homeostasis and is altered by maternal undernutrition. Diabetes, 2016, 65(3):554-60. IF 8.43


[54] Gamelin FX, Aucouturier J, Iannotti FA, Piscitelli F, Mazzarella E, Aveta T, Leriche M, Dupont E, Cieniewski-Bernard C, Montel V, Bastide B, Di Marzo V, Heyman E. Chronic exercise reverses endocannabinoid system dysregulation in obese rats. Journal of Physiology and Biochemistry, 2016, 72(2):183-199. IF 2.49.


[55] Lambert M, Richard E, Duban-Deweer S, Krzewinski F, Deracinois B, Dupont E, Bastide B, Cieniewski-Bernard C. O-GlcNAcylation is a key modulator of skeletal muscle sarcomeric morphometry through modulation of protein-protein interactions. Biochim Biophys Acta. 2016, 1860(9):2017-30. IF 4.38


[56] Mysoet J, Canu MH, Gillet C, Garnier C, Fourneau J, Bastide B, Dupont E.  Reorganization of motor cortex and degradation of motor performance induced by hindlimb unloading are alleviated by cortical IGF1 administration. Behav Brain Res. 2017, 15;317:434-443. IF 3.02


[57] Klein P, Oloko M, Montel V, Malerba A, Jarmin S, Gidaro T, Perie S, Lacau St Guily J, de la Grange P, Antoniou M, Dickson G, Butler-Browne G, Bastide B, Mouly V, Trollet C. Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing. Nucleic Acid Res, 2016, 44(22):10929-10945. IF 9.202.


Promotion PREX1 (Les publications 2018 n’ont pas été prises en compte dans la précédente promotion)


[58] Deracinois B, Camoin L, Lambert M, Boyer JB, Dupont E, Bastide B, Cieniewski-Bernard C. GlcNAcylation site mapping by (azide-alkyne) click chemistry and mass spectrometry following intensive fractionation of skeletal muscle cells proteins. J Proteomics. 2018 Jul 14. pii: S1874-3919(18)30272-0. doi: 10.1016/j.jprot.2018.07.005.


[59] Coq JO, Delcour M, Ogawa Y, Peyronnet J, Castets F, Turle-Lorenzo N, Montel V, Bodineau L, Cardot P, Brocard C, Liabeuf S, Bastide B, Canu MH, Tsuji M, Cayetanot F. Mild Intrauterine Hypoperfusion Leads to Lumbar and Cortical Hyperexcitability, Spasticity, and Muscle Dysfunctions in Rats: Implications for Prematurity. Front Neurol. 2018 Jun 15;9:423. doi: 10.3389/fneur.2018.00423. eCollection 2018. IF 3.50.


[60] Fourneau J, Canu MH, Cieniewski-Bernard C, Bastide B, Dupont E. Synaptic protein changes after a chronic period of sensorimotor perturbation in adult rats: a potential role of phosphorylation/O-GlcNAcylation interplay. J Neurochem. 2018 May 28. doi: 10.1111/jnc.14474. IF 4.60.


[61] Lambert M, Bastide B, Cieniewski-Bernard C. Involvement of O-GlcNAcylation in the Skeletal Muscle Physiology and Physiopathology: Focus on Muscle Metabolism. Front Endocrinol (Lausanne). 2018 Oct 16;9:578. doi: 10.3389/fendo.2018.00578. IF 3.67.


[62] Lancel S, Hesselink MK, Woldt E, Rouillé Y, Dorchies E, Delhaye S, Duhem C, Thorel Q, Mayeuf-Louchart A, Pourcet B, Montel V, Schaart G, Beton N, Picquet F, Briand O, Salles JP, Duez H, Schrauwen P, Bastide B, Bailleul B, Staels B, Sebti Y. Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity. JCI Insight. 2018 May 3;3(9). pii: 98081. doi: 10.1172/jci.insight.98081. IF 6.014.


[63] Lambert MClaeyssen CBastide BCieniewski-Bernard C. O-GlcNAcylation as a regulator of the functional and structural properties of the sarcomere in skeletal muscle: An update review. Acta Physiol (Oxf). 2019 May 20:e13301. doi: 10.1111/apha.13301.IF 5.97.


[64] Canu MH, Fourneau J, Coq JO, Dannhoffer L, Cieniewski-Bernard C, Stevens L, Bastide B, Dupont E. Interplay between hypoactivity, muscle properties and motor command: How to escape the vicious deconditioning circle? Ann Phys Rehabil Med. 2019 Mar;62(2):122-127. doi: 10.1016/ IF 4.19.

 [65]  Fourneau JCieniewski-Bernard C,  Canu MH, Duban-Deweer S  Hachani J, Bastide BDupont E.       Optimization of 2-DE and multiplexed detection of O-GlcNAcome, phosphoproteome and whole proteome protocol of synapse-associated proteins within the rat sensorimotor cortex. J Neurosci Methods, 2020 Jun 20;343:108807. doi: 10.1016/j.jneumeth.2020.108807.



[66]   Canu MH, Montel V, Dereumetz J, Marqueste T, Decherchi P, Coq JO, Dupont E, Bastide B. Early movement restriction deteriorates motor function and soleus muscle physiology. Exp Neurol. 347:113886, 2022. doi: 10.1016/j.expneurol.2021.113886. 




·        Chapitres d’ouvrages



[67] Bastide, B., Jarry-Guichard, T., Gros, D. and Délèze, J. (1995) Effect of antibodies directed against three different peptide sequences of connexin43 on diffusional communication of heart cells in primary culture. In "Intercellular communication through gap junctions", Progress in Cell Res., vol 4, Y. Kanno K. Kataoka, Y. Shiba, Y. Shibata, T. Shimazu. Ed., Elsevier Science B.V. , pp159-162).


[68] Bastide, B., Neyses, L., Ganten, D., Paul, M., Willecke, K. and Traub, O. (1995) Specific expression of connexin40 and connexin43 in normal and hypertensive rat hearts.  In "Intercellular communication through gap junctions"Progress in Cell Res., vol 4, Y. Kanno K. Kataoka, Y. Shiba, Y. Shibata, T. Shimazu. Ed., Elsevier Science B.V. , pp: 217-220.


[69] Hervé, J.C., Verracchia, F., Bastide, B. and Délèze, J. (1995) Characteristics of heptanol action on cell-to-cell communication, studied by electrophysiological and intracellular calcium detection methods.  In "Intercellular communication through gap junctions", Progress in Cell Res., vol 4, Y. Kanno K. Kataoka, Y. Shiba, Y. Shibata, T. Shimazu. Ed., Elsevier Science B.V. , pp: 225-228.


[70] Hervé, J.C., Bastide, B. and Délèze, J. (1995)  Interruption of cell-to-cell communication triggered in cardiac cells by a synthetic diacylglycerol.  In "Intercellular communication through gap junctions", Progress in Cell Res., vol 4, Y. Kanno K. Kataoka, Y. Shiba, Y. Shibata, T. Shimazu. Ed., Elsevier Science B.V. , pp: 163-166.


[71] Stevens L., Bastide, B. and Mounier, Y. (2006) Variations in contractile protein composition and function of muscles and single fibres in relation with muscle plasticity. Chapter 8 in the book : "Skeletal muscle plasticity in health and disease : from genes to whole muscle". Series : Advances in Muscle Research, vol. 2. Bottinelli R., Reggiani C. (Eds Springer) 368 p.


[72] Picquet F, Dupont E, Cochon L, Montel V, Bojados M, Jamon M, Bastide B, Stevens L. (2013) Adaptation of mice muscle properties in Hypo/Hypergravity environment. J Gravit  (DVD).


[73] Cieniewski-Bernard C, Dupont E, Stevens L, Picquet F, Canu MH, Bastide B. (2013) PLASTICITE MUSCULAIRE ET ESPACE : du gène aux modifications post-traductionnelles. Médecine Aéronautique et Spatiale (2014). B. and Mounier, Y. (2006) Variations in contractile protein composition and function of muscles and single fibres in relation with muscle plasticity. Chapter 8 in the book : "Skeletal muscle plasticity in health and disease : from genes to whole muscle". Series : Advances in Muscle Research, vol. 2. Bottinelli R., Reggiani C. (Eds Springer) 368 p.