Alexandre Berthier
Ingénieur de recherche
Laboratoire / équipe
Publications
- Alexandre Berthier, Céline Gheeraert, Manjula Vinod, Manuel Johanns, Loïc Guille, Joel T. Haas, Julie Dubois-Chevalier, Jérôme Eeckhoute, Bart Staels and Philippe Lefebvre. Unveiling the Molecular Legacy of Transient Insulin Resistance: Implications for Hepatic Metabolic Adaptability. J. Hepatol. 2025 sous presse.
- Ninon Very, Clémence Boulet, Céline Gheeraert, Alexandre Berthier, Manuel Johanns, Mohamed Bou Saleh, Loïc Guille, Fabrice Bray, Jean-Marc Strub, Marie Bobowski-Gerard, Francesco P Zummo, Emmanuelle Vallez, Olivier Molendi-Coste, Eloise Woitrain, Sarah Cianférani, David Montaigne, Line Carolle Ntandja-Wandji, Laurent Dubuquoy, Julie Dubois-Chevalier, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute. O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts. Cell Death Dis. 2024 Jun 3;15(6):391.
- Alexandre Berthier, Céline Gheeraert, Manuel Johanns, Manjula Vinod, Bart Staels, Jérôme Eeckhoute and Philippe Lefebvre. The molecular circadian clock is a target of anti-cancer translation inhibitors. J.B.R. 2024 Feb;39(1):20-34.
- Julie Dubois-Chevalier, Céline Gheeraert, Alexandre Berthier, Clémence Boulet, Vanessa Dubois, Loïc Guille, Marie Fourcot, Guillemette Marot, Karine Gauthier, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute. An extended transcription factor regulatory network controls hepatocyte identity. EMBO Rep. 2023 Sep 6; 24(9):e57020.
- Francesco Paolo Zummo, Alexandre Berthier, Céline Gheeraert, Manjula Vinod, Marie Bobowski-Gérard, Olivier Molendi-Coste, Laurent Pineau, Matthieu Jung, Loic Guille, Julie Dubois-Chevalier, David Dombrowicz, Bart Staels, Jérôme Eeckhoute, Philippe Lefebvre. A time- and space-resolved nuclear receptor atlas in mouse liver. J Mol Endocrinol. 2023 May 18;71(1):e230017.
- Céline Schulz, Quentin Lemaire, Alexandre Berthier, Amandine Descat, Mostafa Kouach, Anne Sophie Vercoutter-Edouart, Ikram El Yazidi-Belkoura, Stéphan Hardivillé, Jean-François Goossens, Philippe Lefebvre and Tony Lefebvre. Control of lipid metabolism by the dynamic and nutrient-dependent post-translational modification O-GlcNAcylation. NatSci. 2023;3:e20220006.
- Manjula Vinod, Alexandre Berthier, Xavier Maréchal, Céline Gheeraert, Raphaël Boutry, Stéphane Delhaye, Jean-Sébastien Annicotte, Hélène Duez, Agnès Hovasse, Sarah Cianférani, David Montaigne, Jérôme Eeckhoute, Bart Staels & Philippe Lefebvre. Timed use of digoxin prevents heart ischemia–reperfusion injury through a REV-ERBα–UPS signaling pathway. Nature Cardiovascular Research. 1, 990-1005 (2022).
- Berthier A., Staels B and Lefbvre P. An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells. STAR Protoc. 2021 Jul 7;2(3):100658. doi: 10.1016/j.xpro.2021.100658. eCollection 2021 Sep 17.
- Berthier A*, Johanns M*, Zummo FP*, Lefebvre P, Staels B. PPARs in liver physiology. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 29; 1867(5):166097. doi: 10.1016/j.bbadis.2021.166097.
- A. Berthier, M. Vinod, G. Porez, A. Steenackers, J. Alexandre, N. Yamakawa, C. Gheeraert, M. Ploton, X. Maréchal, J. Chevalier-Dubois, A. Hovasse, C. Schaeffer-Reiss, S. Cianférani, C. Rolando, F. Bray, H. Duez, J. Eeckhoute, T. Lefebvre, B. Staels and P. Lefebvre. Combinatorial regulation of cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBa complex. PNAS, 2018; 115(47): E11033-E11042.
- Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi-Blum K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P. The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis. J Hepatol. 2018;69(5):1099-1109.
- Y. Hering*, A. Berthier*, H. Duez, P. Lefebvre, B. Deprez, P. Gribbon, M. Wolf, J. Reinshagen, F. Halley, J. Hannemann, R. Böger, B. Staels and S. Gul. Development and implementation of a cell-based assay to discovery of agonists for the nuclear receptor REV-ERBα. Journal of Biological Methods, 2018, 5(3) e94.
- D. Montaigne, X. Maréchal, T. Modine, A. Coisne, S. Mouton, G. Fayad, S. Ninni, C. Klein, S. Ortmans, C. Seunes, C. Potelle, A. Berthier, C. Gheeraert, C. Piveteau, R. Deprez, J. Eeckhoute, H. Duez, D. Lacroix, B. Deprez, B. Jegou, M. Koussa, J.L. Edmé, P. Lefebvre, and B. Staels. Day-time variation of peri-operative myocardial injury in cardiac surgery and its prevention by Rev-erbα antagonism: a single-centre propensity-matched cohort and a randomised study. The Lancet, 2018, 391(10115): 59-69.
- F. Firmin, F. Oger, C. Gheeraert, J. Dubois-Chevalier, AS. Vercou tter-Edouart, F. Alzaid, C. Mazuy, H. Dehondt, J. Alexandre, B. Derudas, Q. Dhalluin, M. Ploton, A. Berthier, E. Woitrain, T.Lefebvre, N. Venteclef, F. Pattou, B. Staels, J. Eeckhoute and P. Lefebvre. The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ. Scientific Reports, 2017, 7: 14087.
- Lien F.*, Berthier A.*, Bouchaert E., Gheeraert C., Alexandre J., Porez G., Prawitt J., Dehondt H., Ploton M., Colin S., Lucas A., Patrice A., Pattou F., Diemer H., Van Dorsselaer A., Rachez C., Kamilic J., Groen AK., Staels B. and Lefebvre P. Metformin Interferes With Bile Acid Homeostasis Through AMPKFXR Crosstalk. Journal of Clinical Investigation, 2014; 124(3):1037-51.
- Klaus A. *, Zorman S. *, Berthier A.*, Polge C., Ramirez S., Michelland S., Sève M., Vertommen D., Rider M.,Lentze N., Auerbach D. and Schlattner U. Glutathione S-transferases interact with AMP-activated protein kinase: Evidence for S-Glutathionylation and Activation In Vitro. Plos One, 2013; 8(5).
- Berthier A. *, Oger F*., Gheeraert C., Boulahtouf A., Le Guével R., Balaguer P., Staels B., Salbert G. and Lefebvre P. The Novel Antibacterial Compound Walrycin A Induces Human PXR Transcriptional Activity. Toxicological Sciences, 2012, 127(1), 225-235.
- Berthier A., Elie-Caille C., Lesniewska E., Delage-Mourroux R. and Boireau W. Atomic force spectroscopy and label-free sensing for the characterization of Protein-Protein and Protein-DNA interactions: application to estrogen receptors. Journal of Molecular Recognition, 2011, 24(3), 429-435.
- Berthier A.*, Seguin S.*, Sasco A.J, Bobin J.Y, De Laroche G., Datchary J., Saez S., Rodriguez Lafrasse C., Tolle F., Fraichard A., Boyer-Guittaut M., Jouvenot M., Delage-Mourroux R. and Descotes F. High expression of gabarapl1 is associated with better outcome for patients with lymph node positive breast cancer. British Journal of Cancer, 2010, 102(6), 1024-1031.
- Mangeat T., Berthier A., Elie-Caille C., Perrin M., Boireau W., Pieralli C. and Wacogne B. Gold/Silica biochips: applications to Surface Plasmon Resonance and fluorescence quenching. Laser Physics, 2009, 19(2), 252-258.
- Berthier A., Elie-Caille E., Lesniewska E., Delage-Mourroux R., and Boireau W. Nanobioengineering and characterisation of a novel estrogens receptor biosensor, Sensors, 2008, 8(7), 4413-4428
- Berthier A., Girard C., Grandvuillemin A., Muyard F., Skaltsounis A.L., Jouvenot M. and Delage-Mourroux R. Effect of 7-O-b-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus Boiss. & Heldr. (Fabaceae), on estrogen receptor a transcriptional activity. Planta Medica, 2007, 73(14):1447-1451.
* : Les auteurs ont contribué à part égal à ces travaux.