Professeur des universités - Immunologie et protéomiqueCNU : SECTION 68 - BIOLOGIE DES ORGANISMES
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Axes de recherche
I started my career studying the neuroendocrine response during evolution using peptidomic showing the close relationship between neuropeptides from leech and vertebrates. After establishing my group in 1998, I switched to neuroimmunology and I also got interested by modern bioanalytic and especially proteomics. Since then, I have continued on the phenotypic switching of macrophages studied by proteomic approaches and their application to human pathologies as potential novel therapy.
My current researches are dedicated to onco-immunology through proteomics approaches. My first focus is the phenotyping switch of microglia/macrophages between pro-inflammatory and anti-inflammatory stages. The concept consists to force the switch back of macrophages associated tumor to anti-tumoral stages. I identified factors involved in this phenoswitch, among I identified proteins issued from non-coding regions of mRNA and Nc-RNA and I am currently working to develop a delivery process method based on engineered exosomes graft on magnetic microbeads and monitored by ultrasonic imaging. My second focus is SpiderMass project which consists in the development of a novel mass spectrometry-based technology for in vivo real-time mini invasive guided surgery.