Guillemette Marot

Maitresse de conférences-HDR - Biostatistique
CNU : SECTION 26 - MATHEMATIQUES APPLIQUEES ET APPLICATIONS DES MATHEMATIQUES
  • Laboratoire / équipe
  • Composantes, facultés
    • UFR DES SCIENCES DE SANTE ET DU SPORT
      • FACULTE DE MEDECINE
  • Domaines de recherche

    apprentissage statistique, analyse de données -omiques

    +33 3 20 62 68 32 & +33 3 59 57 79 77
guillemette_marot.jpg

Guillemette Marot

Maitresse de conférences-HDR - Biostatistique

Publications

Article dans des revues

  • Nathalie Garnier, Kato Pollet, Marie Fourcot, Morgan Caplan, Guillemette Marot, et al.. [Letter to editor] Altered microRNA expression in severe COVID‐19: Potential prognostic and pathophysiological role. Clinical and Translational Medicine, Heidelberg : Springer-Verlag, 2022, 12 (6), ⟨10.1002/ctm2.899⟩. ⟨hal-03700328⟩
  • Quentin Grimonprez, Samuel Blanck, Alain Celisse, Guillemette Marot. MLGL: An R package implementing correlated variable selection by hierarchical clustering and group-Lasso. Journal of Statistical Software, University of California, Los Angeles, In press. ⟨hal-01857242v2⟩
  • Asma S. Khelifa, Cecilia Guillen Sanchez, Kevin M. Lesage, Ludovic Huot, Thomas Mouveaux, et al.. TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii. Nature Communications, Nature Publishing Group, 2021, 12, pp.116. ⟨10.1038/s41467-020-20216-x⟩. ⟨hal-03107529v2⟩
  • Marie Cuvelliez, Vincent Vandewalle, Maxime Brunin, Olivia Beseme, Audrey Hulot, et al.. Circulating proteomic signature of early death in heart failure patients with reduced ejection fraction. Scientific Reports, Nature Publishing Group, 2019, 9, pp.19202. ⟨10.1038/s41598-019-55727-1⟩. ⟨hal-02414293v2⟩
  • Michela Bernardini, Alessia Brossa, Giorgia Chinigo, Guillaume Grolez, Giulia Trimaglio, et al.. Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis. Cancers, MDPI, 2019, 11 (7), pp.956. ⟨10.3390/cancers11070956⟩. ⟨hal-02404061⟩
  • Denis A Mogilenko, Joël Haas, Laurent L'Homme, Sébastien Fleury, Sandrine Quemener, et al.. Metabolic and innate immune cues merge into a specific inflammatory response via unfolded protein response (UPR). Cell, Elsevier, In press, 177 (5), pp.1201-1216.e19. ⟨10.1016/j.cell.2019.03.018⟩. ⟨inserm-02084447⟩
  • Sophie Dhorne-Pollet, Elisa Crisci, Nuria Mach, Patricia Renson, Florence Jaffrezic, et al.. The mirna-targeted transcriptome of porcine alveolar macrophages upon infection with porcine reproductive and respiratory syndrome virus. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.3160. ⟨10.1038/s41598-019-39220-3⟩. ⟨hal-02573144⟩
  • Alain Celisse, Guillemette Marot, Pierre-Jean Male, Guillem Rigaill. New efficient algorithms for multiple change-point detection with reproducing kernels. Computational Statistics and Data Analysis, Elsevier, 2018, 128, pp.200-220. ⟨10.1016/j.csda.2018.07.002⟩. ⟨hal-02621669⟩
  • Julie Dubois, Vanessa Dubois, Hélène Dehondt, Parisa Mazrooei, Claire Mazuy, et al.. The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions. Genome Research, Cold Spring Harbor Laboratory Press, 2017, Genome research, 27 (6), pp.985-996. ⟨10.1101/gr.217075.116⟩. ⟨hal-01647846⟩
  • Stephanie Poulain, Christophe Roumier, Aurelie Venet-Caillault, Martin Figeac, Charles Herbaux, et al.. Genomic landscape of CXCR4 mutations in Waldenstrom's Macroglobulinemia. Clinical Cancer Research, American Association for Cancer Research, 2015, 21 (22), ⟨10.1158/1078-0432.CCR-15-0646⟩. ⟨hal-01230058⟩
  • Quentin Grimonprez, Alain Celisse, Samuel Blanck, Meyling Cheok, Martin Figeac, et al.. MPAgenomics : An R package for multi-patients analysis of genomic markers. BMC Bioinformatics, BioMed Central, 2014, 15, pp.394. ⟨10.1186/s12859-014-0394-y⟩. ⟨hal-00933614v3⟩
  • Nathalie Martin, Clara Salazar-Cardozo, Chantal Vercamer, Louise Ott, Guillemette Marot, et al.. Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes. Molecular Cancer, BioMed Central, 2014, 13 (1), pp.151. ⟨10.1186/1476-4598-13-151⟩. ⟨hal-01011012⟩
  • Andrea Rau, Guillemette Marot, Florence Jaffrezic. Differential meta-analysis of RNA-seq data from multiple studies. BMC Bioinformatics, BioMed Central, 2014, 15 (1), pp.91. ⟨10.1186/1471-2105-15-91⟩. ⟨hal-00978902⟩
  • Madison Giacofci, Sophie Lambert-Lacroix, Guillemette Marot, Franck Picard. Wavelet-based clustering for mixed-effects functional models in high dimension. Biometrics, Wiley, 2013, 69 (1), pp.31-40. ⟨10.1111/j.1541-0420.2012.01828.x⟩. ⟨hal-00782458⟩
  • Robert Walker, Mathieu Gissot, Ludovic Huot, Thilabalo Dilezitoko Alayi, David Hot, et al.. Toxoplasma transcription factor TgAP2XI-5 regulates the expression of genes involved in parasite virulence and host invasion.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (43), pp.31127-31138. ⟨10.1074/jbc.M113.486589⟩. ⟨hal-00921150⟩
  • Damien Valour, Isabelle Hue, Séverine Degrelle, Sébastien Dejean, Guillemette Marot, et al.. Pre- and Post-Partum Mild Underfeeding Influences Gene Expression in the Reproductive Tract of Cyclic Dairy Cows.. Reproduction in Domestic Animals, Wiley, 2012, 48 (3), pp.484-499. ⟨10.1111/rda.12113⟩. ⟨hal-00782492⟩
  • Marie-Agnès Dillies, Andrea Rau, Julie Aubert, Christelle Hennequet-Antier, Marine Jeanmougin, et al.. A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis. Briefings in Bioinformatics, Oxford University Press (OUP), 2012, 14 (6), pp.671-683. ⟨10.1093/bib/bbs046⟩. ⟨hal-00782486⟩
  • Benoit Guyonnet, Guillemette Marot, Jean-Louis Dacheux, Marie-José Mercat, Sandrine Schwob, et al.. The adult boar testicular and epididymal transcriptomes. BMC Genomics, BioMed Central, 2009, 10 (august), Non paginé. ⟨10.1186/1471-2164-10-369⟩. ⟨hal-02668660⟩
  • Guillemette Marot, J.-L. Foulley, C.-D. Mayer, Florence Jaffrezic. Moderated effect size and P-value combinations for microarray meta-analyses. Bioinformatics, Oxford University Press (OUP), 2009, 25(20), pp.2692-2699. ⟨hal-00539379⟩
  • Guillemette Marot, C.-D. Mayer. Sequential Analysis for Microarray Data Based on Sensitivity and Meta-Analysis. Statistical Applications in Genetics and Molecular Biology, De Gruyter, 2009, 8(1), pp.1-35. ⟨hal-00539377⟩
  • Guillemette Marot, Jean Louis J. L. Foulley, Florence Jaffrezic. A structural mixed model to shrink covariances matrices for time-course differential gene expression studies. Computational Statistics and Data Analysis, Elsevier, 2009, 53 (5), pp.1630-1638. ⟨10.1016/j.csda.2008.04.018⟩. ⟨hal-02668170⟩
  • B. Guyonnet, Guillemette Marot, J.-L. Dacheux, M.-J. Mercat, S. Schwob, et al.. The adult boar testicular and epididymal transcriptomes. BMC Genomics, BioMed Central, 2009, 10(369), pp.339-343. ⟨hal-00539378⟩
  • Guillemette Marot, Claus-Dieter Mayer. Sequential analysis for microarray data based on sensitivity and meta-analysis. Statistical Applications in Genetics and Molecular Biology, De Gruyter, 2009, 8, online (1), Non paginé. ⟨10.2202/1544-6115.1368⟩. ⟨hal-01193433⟩
  • Guillemette Marot, Jean Louis J. L. Foulley, Claus-Dieter Mayer, Florence Jaffrezic. Moderated effect size and P-value combinations for microarray meta-analyses.. Bioinformatics, Oxford University Press (OUP), 2009, 25 (20), pp.2692-2699. ⟨10.1093/bioinformatics/btp444⟩. ⟨hal-00782348⟩
  • Guillemette Marot, J.-L. Foulley, Florence Jaffrezic. A structural mixed model to shrink covariance matrices for time-course differential gene expression studies. Computational Statistics and Data Analysis, Elsevier, 2009, 53, pp.1630-1638. ⟨hal-00539371⟩
  • Florence Jaffrezic, Guillemette Marot, Severine S. Degrelle, Isabelle Hue, Jean Louis J. L. Foulley. A structural mixed model for variances in differential gene expression studies. Genetics Research, Cambridge University Press (CUP), 2007, 89 (1), pp.19-25. ⟨hal-02654281⟩
  • Florence Jaffrezic, Dirk-Jan de Koning, Paul J. Boettcher, Agnès Bonnet, Bart Buitenhuis, et al.. Analysis of the real EADGENE data set: Comparison of methods and guidelines for data normalisation and selection of differentially expressed genes (Open Access publication). Genetics Selection Evolution, BioMed Central, 2007, 39 (6), pp.633-650. ⟨hal-00894624⟩
  • Florence Jaffrezic, Dirk-Jan Koning, P.J. Boettcher, Agnès Bonnet, Bart Buitenhuis, et al.. Analysis of the real EADGENE data set : Comparison of methods and guidelines for data normalisation and selection of differentially expressed genes. Genetics Selection Evolution, BioMed Central, 2007, 39 (6), pp.633-650. ⟨10.1051/gse:2007029⟩. ⟨hal-02657968⟩
  • Michael Watson, Mónica Pérez-Alegre, Michael Denis Baron, Céline Delmas, Peter Dovč, et al.. Analysis of a simulated microarray dataset : Comparison of methods for data normalisation and detection of differential expression. Genetics Selection Evolution, BioMed Central, 2007, 39 (6), pp.669-683. ⟨hal-02657926⟩
  • Michael Watson, Mónica Pérez-Alegre, Michael Denis Baron, Céline Delmas, Peter Dovč, et al.. Analysis of a simulated microarray dataset: Comparison of methods for data normalisation and detection of differential expression (Open Access publication). Genetics Selection Evolution, BioMed Central, 2007, 39 (6), pp.669-683. ⟨hal-00894626⟩
  • Florence Jaffrezic, Guillemette Marot, S. Degrelle, I. Hué, J-L. Foulley. A structural mixed model for variances in differential gene expression studies. Genet. Res. Camb, 2007, 89(1), pp.19-25. ⟨hal-00697961⟩
  • Dirk-Jan Koning, Florence Jaffrezic, Mogens Sando Lund, Michael Watson, Caroline Channing, et al.. The EADGENE microarray data analysis workshop. Genetics Selection Evolution, BioMed Central, 2007, 39 (6), pp.621-631. ⟨10.1051/gse:2007028⟩. ⟨hal-02657978⟩
  • Dirk-Jan de Koning, Florence Jaffrezic, Mogens Sandø Lund, Michael Watson, Caroline Channing, et al.. The EADGENE Microarray Data Analysis Workshop (Open Access publication). Genetics Selection Evolution, BioMed Central, 2007, 39 (6), pp.621-631. ⟨hal-00894623⟩

Communication dans un congrès

  • Wilfried Heyse, Vincent Vandewalle, Philippe Amouyel, Guillemette Marot, Christophe Bauters, et al.. Support of temporal structure in the statistical analysis of high-throughput proteomic data. Journées de Statistique 2021, Jun 2021, Nice, France. ⟨hal-03525345⟩
  • V Vandewalle, Camille Ternynck, Guillemette Marot. Linking different kinds of Omics data through a model-based clustering approach. IFCS 2019, Aug 2019, Thessalonique, Greece. ⟨hal-02400525⟩
  • Sophie Dhorne-Pollet, Patricia Renson, Florence Jaffrezic, Guillemette Marot, Marco M. Moroldo, et al.. RNA silencing-targeted transcriptome of porcine alveolar macrophages upon infection with porcine reproductive and respiratory syndrome viruses (PRRSV) of different virulence. 35. Conference of the International Society for Animal Genetics (ISAG), Jul 2016, Salt Lake City, Utah, United States. 197 p. ⟨hal-02740229⟩
  • Sophie Pollet, Guillemette Marot, Jerôme Lecardonnel, Marco Moroldo, Florence Jaffrezic, et al.. Functional Analysis of microRNAs:mRNA Interactions Between Pseudorabies Virus (PrV) and Its Natural Pig Host. 24. Plant and Animal Genome Conference (PAG), Jan 2016, San Diego, United States. ⟨hal-01606998⟩
  • Quentin Grimonprez, Alain Celisse, Guillemette Marot. Sélection de groupes de variables corrélées par classification ascendante hiérarchique et group-lasso. Sixièmes rencontres des jeunes statisticiens, SFdS, Aug 2015, Le Teich, France. ⟨hal-01238253⟩
  • Quentin Grimonprez, Alain Celisse, Guillemette Marot. Sélection de groupes de variables corrélées par classification ascendante hiérarchique et group-lasso. 47èmes Journées de Statistique, Jun 2015, Lille, France. ⟨hal-01238248⟩
  • Quentin Grimonprez, Alain Celisse, Guillemette Marot. Analyse multi-patients de données génomiques. 46e Journées de Statistique, SFDS, Jun 2014, Rennes, France. ⟨hal-01091476⟩
  • Damien Valour, Severine S. Degrelle, Guillemette Marot, S. Déjean, Olivier O. Dubois, et al.. Underfeeding affects IGF-1 and gene expression in genital tract tissues in high producing dairy cows. 8. International Ruminant Reproduction Symposium, Sep 2010, Anchorage, Alaska, United States. ⟨hal-02754246⟩
  • Damien Valour, Severine S. Degrelle, Guillemette Marot, S. Déjean, Olivier O. Dubois, et al.. Underfeeding affects IGF-1 and gene expression in genital tract tissues in high producing dairy cows. 60. Annual Meeting of the European Association for Animal Production, Aug 2009, Barcelone, Spain. ⟨hal-02754514⟩
  • Benoit Guyonnet, Jean-Louis Dacheux, Florence Jaffrezic, A. Lacoste, Guillemette Marot, et al.. The adult boar testicular and epididymal transcriptome. 41. Annual Meeting of the Society for the Study of Reproduction, May 2008, Kailua-Kona, Hawaii, United States. ⟨hal-02753261⟩
  • Benoit Guyonnet, Jean-Louis Dacheux, Florence Jaffrezic, A. Lacoste, Guillemette Marot, et al.. Le transcriptome épididymaire du verrat : étude de la régionalisation. 40. Journées de la Recherche Porcine, Feb 2008, Paris, France. ⟨hal-02758015⟩
  • Guillemette Marot, Florence Jaffrezic, Jean Louis J. L. Foulley, C.D. Mayer. Sequential analysis for microarray data based on sensitivity and meta-analysis.. XXIV International Biometric Conference, July 13-18, 2008, Dublin, pp.Inconnu. ⟨hal-02813478⟩
  • Guillemette Marot, Jean Louis J. L. Foulley, Florence Jaffrezic. A structural mixed model to shrink covariance matrices for time-course differential gene expression studies.. XXIV International Biometric Conference, July 13-18, 2008, Dublin, pp.Inconnu. ⟨hal-02814217⟩
  • Severine S. Degrelle, Isabelle Hue, Evelyne E. Campion, Florence Jaffrezic, Guillemette Marot, et al.. Embryonic and extraembryonic abnormalities in Day-18 cloned bovine conceptuses. 2. International Meeting on Mammalian Embryogenomics, Oct 2007, Paris, France. ⟨hal-02756590⟩
  • Florence Jaffrezic, Guillemette Marot, Severine S. Degrelle, Isabelle Hue, Jean Louis J. L. Foulley. Detection of differentially expressed genes: the importance of variance modelling in the test statistics. 2. International Meeting on Mammalian Embryogenomics, Oct 2007, Paris, France. ⟨hal-02752273⟩
  • Benoit Guyonnet, Jean-Louis Dacheux, Florence Jaffrezic, A. Lacoste, Guillemette Marot, et al.. Analyse du transcriptome épididymaire chez le verrat. 34. Forum Jeunes Chercheurs, Oct 2007, Ile des Embiez, France. ⟨hal-02750726⟩
  • Benoit Guyonnet, Jean-Louis Dacheux, Florence Jaffrezic, A. Lacoste, Guillemette Marot, et al.. Recherche et identification de gènes différentiellement exprimés dans l'épididyme de verrat par une approche transcriptomique. 39. Journées de la Recherche Porcine, Feb 2007, Paris, France. ⟨hal-02752673⟩
  • Benoit Guyonnet, Jean-Louis Dacheux, Françoise Dacheux, Florence Jaffrezic, A. Lacoste, et al.. Analyse transcriptomique des gènes exprimés de façon différentielle dans l'épididyme de verrat. 4. Workshop International sur l’Epididyme, Dec 2006, Chatel-Guyon, France. ⟨hal-02754518⟩

Poster

  • Quentin Grimonprez, Alain Celisse, Guillemette Marot. Analysis of genomic markers: Make it easy with the R package MPAgenomics. SMPGD 2014, Jan 2014, Paris, France. 2014. ⟨hal-01091543⟩
  • Benoit Guyonnet, Jean-Louis Dacheux, Françoise Dacheux, Florence Jaffrezic, A. Lacoste, et al.. Transcriptomic analysis of differentially expressed genes along the boar epididymis. 4. International Workshop on Epididymis, Dec 2006, Chatel-Guyon, France. n.p., 2006. ⟨hal-02817105⟩

Brevet

  • Morgane Pierre-Jean, Guillemette Marot, Guillem Rigaill, Alain Celisse. Détection de ruptures à partir de méthodes à noyaux. United Kingdom, Patent n° : 0000000. 2013. ⟨hal-00943423⟩
  • Morgane Pierre-Jean, Guillemette Marot, Rigaill Guillem, Alain Celisse. Change-point detection with kernel methods : application to DNA copy number signals. France, Patent n° : 00000000000000. 2013. ⟨hal-00943413⟩

Autre publication

  • Guillemette Marot, Andrea Rau. metaRNASeq: Meta-analysis of RNA-seq data. 2013. ⟨hal-01193762⟩

Pré-publication, Document de travail

  • Alain Celisse, Guillemette Marot, Morgane Pierre-Jean, Guillem Rigaill. New efficient algorithms for multiple change-point detection with kernels. 2016. ⟨hal-01413230v2⟩
  • Andrea Rau, Guillemette Marot, Florence Jaffrezic. Differential meta-analysis of RNA-seq data from multiple studies. 2013. ⟨hal-00834369⟩

Rapport

  • Guillemette Marot. Modélisation statistique pour l'analyse des données d'expression de gènes.. [Stage] Ecole Nationale de la Statistique et de l'Analyse de l'Information (Ensai), Inconnu, FRA. 2006. ⟨hal-02815899⟩

Thèse

  • Guillemette Marot. Statistical modelling for differential gene expression studies: variance-covariance models, sequential and meta-analysis.. Life Sciences [q-bio]. AgroParisTech, 2009. English. ⟨NNT : 2009AGPT0039⟩. ⟨tel-00458988⟩
  • Guillemette Marot. Modélisation statistique pour la recherche de gènes différentiellement exprimés : modèles de variance-covariance, analyse séquentielle et méta-analyse.. Sciences du Vivant [q-bio]. AgroParisTech, 2009. Français. ⟨tel-02819895⟩

HDR

  • Guillemette Marot. Contributions méthodologiques en statistique pour l'analyse et l'intégration de données -omiques et cliniques. Statistiques [math.ST]. Université de Lille, 2021. ⟨tel-03440914⟩