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Publications

hal-04906532

Martina Duca, Nadia Malagolini, Michela Pucci, Virginie Cogez, Anne Harduin-Lepers, Fabio Dall’olio

Transcription factor FOXD1 and miRNA-204-5p play a major role in B4GALNT2 downregulation in colon cancer

Scientific Reports, 2025, Scientific Reports, 15 (1), pp.1821. ⟨10.1038/s41598-025-85450-z⟩

hal-04749515

Naoko Osada, Masamichi Nagae, Takahiro Yamasaki, Anne Harduin-Lepers, Yasuhiko Kizuka

Regulation of human GnT-IV family activity by the lectin domain

Carbohydrate Research, 2024, Carbohydrate Research, 545, pp.109285. ⟨10.1016/j.carres.2024.109285⟩

hal-04835900

Kiamungongo Clairene Filipe, Sushmaa Dangudubiyyam, Cedric Lion, Mathieu Decloquement, Roxana Teppa, Christophe Biot, Anne Harduin-Lepers

A Rapid and Sensitive MicroPlate Assay (MPSA) Using an Alkyne‐Modified CMP‐Sialic Acid Donor to Evaluate Human Sialyltransferase Specificity

ChemBioChem, 2024, ChemBioChem, pp.e202400539. ⟨10.1002/cbic.202400539⟩

hal-04625502

Elin Teppa, Sebastian Peter Galuska, Anne Harduin-Lepers

Molecular dynamics simulations shed light into the donor substrate specificity of vertebrate poly-alpha-2,8-sialyltransferases ST8Sia IV

Biochimica et Biophysica Acta (BBA) - General Subjects, 2024, Biochimica et Biophysica Acta (BBA) - General Subjects, 1868 (8), pp.130647. ⟨10.1016/j.bbagen.2024.130647⟩

hal-04628025

Yuko Tokoro, Masamichi Nagae, Miyako Nakano, Anne Harduin-Lepers, Yasuhiko Kizuka

LacdiNAc synthase B4GALNT3 has a unique PA14 domain and suppresses N-glycan capping

Journal of Biological Chemistry, 2024, Journal of Biological Chemistry, 300 (7), pp.107450. ⟨10.1016/j.jbc.2024.107450⟩

hal-04674332

Guillaume Marchand, Ingrid Fliniaux, Pauline Titran, Yoshiko Uchimura, Jean-Francois Bodart, Anne Harduin-Lepers, Katia Cailliau, Matthieu Marin

Cadmium induces physiological and behavioral changes associated with 180 kDa NCAM lower expression and higher polysialic acid, in the African clawed Xenopus laevis tadpoles

Ecotoxicology and Environmental Safety, 2024, Ecotoxicology and Environmental Safety, 273, pp.116119. ⟨10.1016/j.ecoenv.2024.116119⟩

hal-04220178

Mathieu Decloquement, Marzia Tindara Venuto, Virginie Cogez, Anna Steinmetz, Celine Schulz, Cedric Lion, Maxence Noel, Vincent Rigolot, Roxana Teppa, Christophe Biot, Alexander Rebl, Sebastian Peter Galuska, Anne Harduin Lepers

Salmonid polysialyltransferases to generate a variety of sialic acid polymers

Scientific Reports, 2023, Scientific Reports, 13 (1), pp.15610. ⟨10.1038/s41598-023-42095-0⟩

hal-04221332

Anne Harduin Lepers

The vertebrate sialylation machinery: structure-function and molecular evolution of GT-29 sialyltransferases

Glycoconjugate Journal, 2023, Glycoconjugate Journal, 40 (4), pp.473-492. ⟨10.1007/s10719-023-10123-w⟩

hal-04008107

Virginie Cogez, Dorothee Vicogne, Celine Schulz, Lucie Portier, Giulia Venturi, Jerome de Ruyck, Mathieu Decloquement, Marc Lensink, Guillaume Brysbaert, Fabio Dall’olio, Sophie Groux, Anne Harduin Lepers

N-Glycan on the Non-Consensus N-X-C Glycosylation Site Impacts Activity, Stability, and Localization of the Sda Synthase B4GALNT2

International Journal of Molecular Sciences, 2023, International Journal of Molecular Sciences, 24 (4), pp.4139. ⟨10.3390/ijms24044139⟩

hal-03857419

Ingrid Fliniaux, Guillaume Marchand, Caroline Molinaro, Mathieu Decloquement, Alain Martoriati, Matthieu Marin, Jean-Francois Bodart, Anne Harduin Lepers, Katia Cailliau

Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization

Frontiers in Cell and Developmental Biology, 2022, 10, pp.982931. ⟨10.3389/fcell.2022.982931⟩

hal-03345208

Cindy Wavelet-Vermuse, Sophie Groux-Degroote, Dorothée Vicogne, Virginie Cogez, Giulia Venturi, Marco Trinchera, Guillaume Brysbaert, Marie-Ange Krzewinski-Recchi, Elsa Hadj Bachir, Céline Schulz, Audrey Vincent, Isabelle van Seuningen, Anne Harduin-Lepers

Analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sda synthase) gene: B4GALNT2 is transcriptionally regulated by ETS1

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2021, 1864 (11-12), pp.194747. ⟨10.1016/j.bbagrm.2021.194747⟩

hal-04254028

Sophie Groux‐degroote, Dorothee Vicogne, Virginie Cogez, Céline Schulz, Anne Harduin‐lepers

B4GALNT2 Controls Sda and SLex Antigen Biosynthesis in Healthy and Cancer Human Colon

ChemBioChem, 2021, 22 (24), pp.3381 - 3390. ⟨10.1002/cbic.202100363⟩

hal-02963114

Daniel Petit, Roxana Elin Teppa, Anne Harduin-Lepers

A phylogenetic view and functional annotation of the animal β1,3-glycosyltransferases of the GT31 CAZy family

Glycobiology, In press, 31 (3), pp.243-259. ⟨10.1093/glycob/cwaa086⟩

hal-03205737

Anne Bordron, Marie Morel, Cristina Bagacean, Maryvonne Dueymes, Pierre Pochard, Anne Harduin-Lepers, Christophe Jamin, Jacques-Olivier Pers

Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases

International Journal of Molecular Sciences, 2021, 22 (7), pp.3402. ⟨10.3390/ijms22073402⟩

hal-02963119

Deborah Harrus, Anne Harduin-Lepers, Tuomo Glumoff

Unliganded and CMP-Neu5Ac bound structures of human α-2,6-sialyltransferase ST6Gal I at high resolution

Journal of Structural Biology, 2020, 212 (2), pp.107628. ⟨10.1016/j.jsb.2020.107628⟩

hal-02889403

Deborah Harrus, Anne Harduin-Lepers, Tuomo Glumoff

Unliganded and CMP-Neu5Ac bound structures of human α-2,6-sialyltransferase ST6Gal I at high resolution

2020

hal-03089946

Clément Delannoy, Chin Huang, Bernadette Coddeville, Jian-You Chen, Dounia Mouajjah, Sophie Groux-Degroote, Anne Harduin-Lepers, Kay-Hooi Khoo, Yann Guerardel, Elisabeth Elass-Rochard

Mycobacterium bovis BCG infection alters the macrophage N -glycome

Molecular Omics, 2020, 16 (4), pp.345-354. ⟨10.1039/c9mo00173e⟩

hal-02998501

Anne Harduin-Lepers, Marzia Tindara Venuto, Joan Martorell-Ribera, Ralf Bochert, Alexander Rebl, Sebastian Peter Galuska

Characterization of the Polysialylation Status in Ovaries of the Salmonid Fish Coregonus maraena and the Percid Fish Sander lucioperca

Cells, 2020, 9 (11), pp.2391. ⟨10.3390/cells9112391⟩

hal-02446209

Marzia Tindara Venuto, Mathieu Decloquement, Joan Martorell Ribera, Maxence Noel, Alexander Rebl, Virginie Cogez, Daniel Petit, Sebastian Peter Galuska, Anne Harduin-Lepers

Vertebrate Alpha2,8-Sialyltransferases (ST8Sia): A Teleost Perspective

International Journal of Molecular Sciences, 2020, 21 (2), pp.513. ⟨10.3390/ijms21020513⟩

hal-02343482

Fawzi Khoder-Agha, Deborah Harrus, Guillaume Brysbaert, Marc Lensink, Anne Harduin-Lepers, Tuomo Glumoff, Sakari Kellokumpu

Assembly of B4GALT1/ST6GAL1 heteromers in the Golgi membranes involves lateral interactions via highly charged surface domains

Journal of Biological Chemistry, 2019, 294 (39), pp.14383-14393. ⟨10.1074/jbc.RA119.009539⟩

hal-02349786

Sara Morley-Fletcher, Jordan Marrocco, Hélène Léger, Jerome Mairesse, Marie-Line Reynaert, Gilles van Camp, Hammou Bouwalerh, Arndt Benecke, Muriel Darnaudery, Anne Harduin-Lepers, Ferdinando Nicoletti, Stéfania Maccari

Grandma's stress programs transgenerational transmission of hippocampal glutamatergic synaptopathy associated with stress-related responses

Psychoneuroendocrinology, 2019, 107, pp.58. ⟨10.1016/j.psyneuen.2019.07.168⟩

hal-02349804

Anne Harduin-Lepers

Glyco25, XXV International Symposium on Glycoconjugates

Glycoconjugate Journal, 2019, 36 (4), pp.267-397. ⟨10.1007/s10719-019-09880-4⟩

hal-02297446

Antti Hassinen, Fawzi Khoder-Agha, Elham Khosrowabadi, Daniela Mennerich, Deborah Harrus, Maxence Noel, Elitsa Dimova, Tuomo Glumoff, Anne Harduin-Lepers, Thomas Kietzmann, Sakari Kellokumpu

A Golgi-associated redox switch regulates catalytic activation and cooperative functioning of ST6Gal-I with B4GalT-I

Redox Biology, 2019, 24, pp.101182. ⟨10.1016/j.redox.2019.101182⟩

hal-02095571

Lan-Yi Chang, Elin Teppa, Maxence Noel, Pierre-André Gilormini, Mathieu Decloquement, Cedric Lion, Christophe Biot, Anne-Marie Mir, Virginie Cogez, Philippe Delannoy, Kay Hooi Khoo, Daniel Petit, Yann Guerardel, Anne Harduin-Lepers

Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation

International Journal of Molecular Sciences, 2019, 20 (3), pp.622. ⟨10.3390/ijms20030622⟩

hal-03213011

Akiko Tsuchida, Motohiro Senda, Akihiro Ito, Seiichi Saito, Makoto Kiso, Takayuki Ando, Anne Harduin-Lepers, Akio Matsuda, Keiko Furukawa, Koichi Furukawa

Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells

Scientific Reports, 2018, Scientific Reports, 8 (1), pp.7017. ⟨10.1038/s41598-018-25521-6⟩

hal-01931177

Maxence Noel, Pierre-André Gilormini, Virginie Cogez, Cedric Lion, Christophe Biot, Anne Harduin-Lepers, Yann Guerardel

MicroPlate Sialyltransferase Assay: A Rapid and Sensitive Assay Based on an Unnatural Sialic Acid Donor and Bioorthogonal Chemistry

Bioconjugate Chemistry, 2018, 29 (10), pp.3377 - 3384. ⟨10.1021/acs.bioconjchem.8b00529⟩

hal-01867603

Sophie Groux-Degroote, Céline Schulz, Virginie Cogez, Maxence Noel, Lucie Portier, Dorothée Vicogne, Carlos Solórzano, Fabio Dall'Olio, Agata Steenackers, Marlène Mortuaire, Mariano Gonzalez-Pisfil, Mélanie Henry, Francois Foulquier, Laurent Héliot, Anne Harduin-Lepers

The extended cytoplasmic tail of the human B4GALNT2 is critical for its Golgi targeting and post-Golgi sorting

FEBS Journal, 2018, 285 (18), pp.3442-3463. ⟨10.1111/febs.14621⟩

hal-01931174

Nao Yamakawa, Jorick Vanbeselaere, Lan-Yi Chang, Shin-Yi Yu, Lucie Ducrocq, Anne Harduin-Lepers, Junichi Kurata, Kiyoko Aoki-Kinoshita, Chihiro Sato, Kay-Hooi Khoo, Ken Kitajima, Yann Guerardel

Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns

Nature Communications, 2018, 9 (1), pp.4647. ⟨10.1038/s41467-018-06950-3⟩

hal-01741238

Maxence Noel, Pierre-André Gilormini, Virginie Cogez, Nao Yamakawa, Dorothée Vicogne, Cedric Lion, Christophe Biot, Yann Guerardel, Anne Harduin-Lepers

Probing the CMP-Sialic Acid Donor Specificity of Two Human β- d -Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins

ChemBioChem, 2017, 18 (13), pp.1251 - 1259. ⟨10.1002/cbic.201700024⟩

hal-01429886

Florent Colomb, Marie-Ange Krzewinski-Recchi, Agata Steenackers, Audrey Vincent, Anne Harduin-Lepers, Philippe Delannoy, Sophie Groux-Degroote

TNF up-regulates ST3GAL4 and sialyl-Lewisx expression in lung epithelial cells through an intronic ATF2-responsive element.

Biochemical Journal, 2017, 474 (1), pp.65-78. ⟨10.1042/BCJ20160602⟩

hal-01741232

Daniel Petit, Elin Teppa, Ugo Cenci, Steven Ball, Anne Harduin-Lepers

Reconstruction of the sialylation pathway in the ancestor of eukaryotes

Scientific Reports, 2017, 8 (1), pp.2946. ⟨10.1038/s41598-018-20920-1⟩

hal-01741247

Monique Barel, Anne Harduin-Lepers, Lucie Portier, Marie-Christine Slomianny, Alain Charbit

Host glycosylation pathways and the unfolded protein response contribute to the infection by Francisella

Cellular Microbiology, 2016, 18 (12), pp.1763 - 1781. ⟨10.1111/cmi.12614⟩

hal-01931172

Clément Delannoy, Yoann Rombouts, Sophie Groux-Degroote, Stephanie Holst, Bernadette Coddeville, Anne Harduin-Lepers, Manfred Wuhrer, Elisabeth Elass-Rochard, Yann Guerardel

Glycosylation Changes Triggered by the Differentiation of Monocytic THP-1 Cell Line into Macrophages

Journal of Proteome Research, 2016, 16 (1), pp.156 - 169. ⟨10.1021/acs.jproteome.6b00161⟩

hal-01741256

Pierre-André Gilormini, Cedric Lion, Maxence Noel, Marie-Ange Krzewinski-Recchi, Anne Harduin-Lepers, Yann Guerardel, Christophe Biot

Improved workflow for the efficient preparation of ready to use CMP-activated sialic acids

Glycobiology, 2016, ⟨10.1093/glycob/cww084⟩

hal-01358174

Roxana E Teppa, Daniel Petit, Olga Plechakova, Virginie Cogez, Anne Harduin-Lepers

Phylogenetic-Derived Insights into the Evolution of Sialylation in Eukaryotes: Comprehensive Analysis of Vertebrate β-Galactoside α2,3/6-Sialyltransferases (ST3Gal and ST6Gal).

International Journal of Molecular Sciences, 2015, 17 (8), ⟨10.3390/ijms17081286⟩

hal-01741239

Daniel Petit, Elin Teppa, Anne Mir, Dorothée Vicogne, Christine Thisse, Bernard Thisse, Cyril Filloux, Anne Harduin-Lepers

Integrative View of α2,3-Sialyltransferases (ST3Gal) Molecular and Functional Evolution in Deuterostomes: Significance of Lineage-Specific Losses

Molecular Biology and Evolution, 2015, 32 (4), pp.906 - 927. ⟨10.1093/molbev/msu395⟩

hal-01143777

Jorge Cime-Castillo, Philippe Delannoy, Guillermo Mendoza-Hernández, Verónica Monroy-Martínez, Anne Harduin-Lepers, Humberto Lanz-Mendoza, Fidel de La Cruz Hernández-Hernández, Edgar Zenteno, Carlos Cabello-Gutiérrez, Blanca H Ruiz-Ordaz

Sialic Acid Expression in the Mosquito Aedes aegypti and Its Possible Role in Dengue Virus-Vector Interactions.

BioMed Research International , 2015, 2015, pp.504187. ⟨10.1155/2015/504187⟩

hal-01224133

Sylvie Juliant, Anne Harduin-Lepers, François Monjaret, Béatrice Catieau, Marie-Luce Violet, Pierre Cérutti, Annick Ozil, Martine Duonor-Cérutti

The α1,6-Fucosyltransferase Gene (fut8) from the Sf9 Lepidopteran Insect Cell Line: Insights into fut8 Evolution

PLoS ONE, 2014, 9 (10), pp.e110422. ⟨10.1371/journal.pone.0110422⟩

hal-01741262

Sylvie Juliant, Anne Harduin-Lepers, François Monjaret, Béatrice Catieau, Marie-Luce Violet, Pierre Cerutti, Annick Ozil, Martine Duonor-Cérutti, Andreas Hofmann

The α1,6-Fucosyltransferase Gene (fut8) from the Sf9 Lepidopteran Insect Cell Line: Insights into fut8 Evolution

PLoS ONE, 2014, 9 (10), ⟨10.1371/journal.pone.0110422⟩

hal-01020099

Sophie Groux-Degroote, Cindy Wavelet, Marie-Ange Krzewinski-Recchi, Lucie Portier, Marlène Mortuaire, Adriana Mihalache, Marco Trinchera, Philippe Delannoy, Nadia Malagolini, Mariella Chiricolo, Fabio Dall'Olio, Anne Harduin-Lepers

B4GALNT2 gene expression controls the biosynthesis of Sd(a) and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract.

International Journal of Biochemistry and Cell Biology, 2014, epub ahead of print. ⟨10.1016/j.biocel.2014.06.009⟩

hal-02350656

Marie Bobowski, Anne Harduin-Lepers, Philippe Delannoy

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1 (ST8SIA1)

Handbook of Glycosyltransferases and Related Genes, Springer Japan, pp.767-780, 2014, ⟨10.1007/978-4-431-54240-7_118⟩

hal-02350659

Fabio Dall'Olio, Nadia Malagolini, Mariella Chiricolo, Marco Trinchera, Anne Harduin-Lepers

The expanding roles of the Sda/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (1), pp.443-453. ⟨10.1016/j.bbagen.2013.09.036⟩

hal-01081501

Fabio Dall'Olio, Nadia Malagolini, Mariella Chiricolo, Marco Trinchera, Anne Harduin-Lepers, Anne Harduin- Lepers

The expanding roles of the Sda/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2

BBA - Biochimica et Biophysica Acta, 2014, 1840 (1), pp.443-53. ⟨10.1016/j.bbagen.2013.09.036⟩

hal-01224139

Fabio Dall'Olio, Nadia Malagolini, Mariella Chiricolo, Marco Trinchera, Anne Harduin-Lepers

The expanding roles of the Sd(a)/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2.

BBA - Biochimica et Biophysica Acta, 2013, 1840 (1), pp.443-53

hal-00872219

Florent Colomb, Olivier Vidal, Marie Bobowski, Marie-Ange Krzewinski-Recchi, Anne Harduin-Lepers, Eric Mensier, Sophie Jaillard, Jean-Jacques Lafitte, Philippe Delannoy, Sophie Groux-Degroote

TNF induces the expression of the sialyltransferase ST3Gal IV in human bronchial mucosa via MSK1/2 protein kinases and increases FliD/sialyl-Lewisx mediated adhesion of Pseudomonas aeruginosa.

Biochemical Journal, 2013, 457 (1), pp.79-87. ⟨10.1042/BJ20130989⟩

hal-00944778

Philippe Delannoy, Marie Bobowski, Anne Harduin-Lepers

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1)

Naoyuki Taniguchi, Koichi Honke, Minoru Fukuda, Hisashi Narimatsu, Yoshiki Yamaguchi, Takashi Angata. Handbook of Glycosyltransferases and Related Genes, Springer-Verlag Berlin Heidelberg, pp.1-11, 2013, ⟨10.1007/SpringerReference_332175⟩

hal-02350666

Sylvie Juliant, Marylêne Lévêque, Pierre Cérutti, Annick Ozil, Sylvie Choblet, Marie-Luce Violet, Marie-Christine Slomianny, Martine Cerutti, Anne Harduin-Lepers

Engineering the Baculovirus Genome to Produce Galactosylated Antibodies in Lepidopteran Cells

Sialobiology: Structure, Biosynthesis and Function. Sialic Acid Glycoconjugates in Health and Disease, BENTHAM SCIENCE PUBLISHERS, pp.59-77, 2013, ⟨10.1007/978-1-62703-327-5_5⟩

hal-02350668

Anne Harduin-Lepers

Vertebrate Sialyltransferases

Sialobiology: Structure, Biosynthesis and Function. Sialic Acid Glycoconjugates in Health and Disease, BENTHAM SCIENCE PUBLISHERS, pp.139-187, 2013, ⟨10.2174/9781608053865113010008⟩

hal-01224153

Anne Harduin-Lepers

Vertebrate sialyltransferases

Sialobiology: Structure, Biosynthesis and Function. Sialic acid glycoconjugates in health and diseases, Bentham Science Publishers, pp.85-116, 2013, 978-1-60805-067-3. ⟨10.2174/97816080538651130101⟩

hal-01211975

Daniel Petit, Roxana Elin Teppa, Jean-Michel Petit, Anne Harduin

A practical approach to reconstruct evolutionary history of animal sialyltransferases and gain insights into the sequence–function relationships of golgi-glycosyltransferases

Glycosyltransferase, 1022, Humana Press, 2013, Methods in Molecular Biology, 978-1-62703-464-7. ⟨10.1007/978-1-62703-465-4_7⟩

hal-01224141

Sylvie Juliant, Marylêne Lévêque, Pierre Cérutti, Annick Ozil, Sylvie Choblet, Marie-Luce Violet, Marie-Christine Slomianny, Anne Harduin-Lepers, Martine Cérutti

Engineering the baculovirus genome to produce galactosylated antibodies in lepidopteran cells.

Methods in Molecular Biology, 988, pp.59-77, 2012

hal-00708570

Florent Colomb, Marie-Ange Krzewinski-Recchi, Fala El Machhour, Eric Mensier, Sophie Jaillard, Agata Steenackers, Anne Harduin-Lepers, Jean-Jacques Lafitte, Philippe Delannoy, Sophie Groux-Degroote

TNF regulates sialyl-Lewis(x) and 6-sulfo-sialyl-Lewis(x) expression in human lung through up-regulation of ST3GAL4 transcript isoform BX.

Biochimie, 2012, 94 (9), pp.2045-53. ⟨10.1016/j.biochi.2012.05.030⟩

hal-01224143

Jorick Vanbeselaere, Lan-Yi Chang, Anne Harduin-Lepers, Emeline Fabre, Nao Yamakawa, Christian Slomianny, Christophe Biot, Kay-Hooi Khoo, Yann Guerardel

Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies.

Journal of Proteome Research, 2012, 11 (4), pp.2164-77

hal-01224146

Yann Guérardel, Lan-Yi Chang, Akiko Fujita, Bernadette Coddeville, Emmanuel Maes, Chihiro Sato, Anne Harduin-Lepers, Kaoru Kubokawa, Ken Kitajima

Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution.

Glycobiology, 2012, 22 (4), pp.479-91

hal-02350669

Jorick Vanbeselaere, Lan-Yi Chang, Anne Harduin-Lepers, Emeline Fabre, Nao Yamakawa, Christian Slomianny, Christophe Biot, Kay-Hooi Khoo, Yann Guerardel

Mapping the Expressed Glycome and Glycosyltransferases of Zebrafish Liver Cells as a Relevant Model System for Glycosylation Studies

Journal of Proteome Research, 2012, 11 (4), pp.2164-2177. ⟨10.1021/pr200948j⟩

hal-02350673

Y. Guérardel, L.-Y. Chang, A. Fujita, B. Coddeville, E. Maes, C. Sato, Anne Harduin-Lepers, K. Kubokawa, K. Kitajima

Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution

Glycobiology, 2012, 22 (4), pp.479-491. ⟨10.1093/glycob/cwr155⟩

hal-00656027

Anne Harduin-Lepers, Marie-Ange Krzewinski-Recchi, Florent Colomb, Francois Foulquier, Sophie Groux-Degroote, Philippe Delannoy

Sialyltransferases functions in cancers.

Front Biosci (Elite Ed), 2012, 4, pp.499-515

hal-01224155

Magali Audry, Charlotte Jeanneau, Anne Imberty, Anne Harduin-Lepers, Philippe Delannoy, Christelle Breton

Current trends in the structure-activity relationships of sialyltransferases.

Glycobiology, 2011, 21 (6), pp.716-26. ⟨10.1093/glycob/cwq189⟩

hal-00553309

Beatrice Teylaert, Edwige Meurice, Marie Bobowski, Anne Harduin-Lepers, Christine Gaucher, Alexandre Fontayne, Sylvie Jorieux, Philippe Delannoy

Molecular cloning, characterization, genomic organization and promoter analysis of the alpha1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0.

BMC Biotechnology, 2011, 11 (1), pp.1. ⟨10.1186/1472-6750-11-1⟩

hal-00521411

Daniel Petit, Anne-Marie Mir, Jean-Michel Petit, Christine Thisse, Philippe Delannoy, Rafael Oriol, Bernard Thisse, Anne Harduin-Lepers

Molecular Phylogeny and Functional Genomics of {beta}-Galactoside {alpha}2,6-Sialyltransferases That Explain Ubiquitous Expression of st6gal1 Gene in Amniotes.

Journal of Biological Chemistry, 2010, 285 (49), pp.38399-414. ⟨10.1074/jbc.M110.163931⟩

hal-00464837

Aurélie Cazet, Sylvain Julien, Marie Bobowski, Marie-Ange Krzewinski-Recchi, Anne Harduin-Lepers, Sophie Groux-Degroote, Philippe Delannoy

Consequences of the expression of sialylated antigens in breast cancer.

Carbohydrate Research, 2010, 345, pp.1377-1383. ⟨10.1016/j.carres.2010.01.024⟩

hal-00423661

A. S. Carvalho, A. Harduin-Lepers, A. Magalhães, E. Machado, N. Mendes, L. T. Costa, R. Matthiesen, R. Almeida, J. Costa, C. A. Reis

Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.

International Journal of Biochemistry and Cell Biology, 2009, epub ahead of print. ⟨10.1016/j.biocel.2009.09.010⟩

hal-00642030

Lan-Yi Chang, Anne Harduin-Lepers, Ken Kitajima, Chihiro Sato, C. J. Huang, Kay-Hooi Khoo, Yann Guerardel

Developmental regulation of oligosialylation in zebrafish

Glycoconjugate Journal, 2009, 26 (3), pp.247-261. ⟨10.1007/s10719-008-9161-5⟩

hal-00318148

Lan-Yi Chang, Anne-Marie Mir, Christine Thisse, Yann Guérardel, Philippe Delannoy, Bernard Thisse, Anne Harduin-Lepers

Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system.

Glycoconjugate Journal, 2009, 26 (3), pp.263-75. ⟨10.1007/s10719-008-9165-1⟩

hal-02822983

Benoît B. Laporte, Severine Lehoux, Daniel Petit, S. Groux-Degroote, Abderrahman A. Maftah, A. Harduin-Lepers, M.A. Krzewinski-Recchi, Jean-Michel Petit

Variations of sialyltransferase ST6Gal2 gene regulation in mammals.

13th Evolutionary Biology Meeting, 2009, Marseille, pp.Inconnu

hal-02813871

Daniel Petit, Jean-Michel Petit, R. Mollicone, P. Delannoy, R. Oriol, A. Harduin-Lepers

Phylogenetic and evolutionary analysis of animal sialyltransferases.

13th Evolutionary Biology Meeting, 2009, Marseille, pp.Inconnu

hal-00328132

Anne Harduin-Lepers, Daniel Petit, Rosella Mollicone, Philippe Delannoy, Jean-Michel Petit, Rafael Oriol

Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes.

BMC Evolutionary Biology, 2008, 8 (1), pp.258. ⟨10.1186/1471-2148-8-258⟩

hal-00318447

Céline Guinez, Anne-Marie Mir, Vanessa Dehennaut, René Cacan, Anne Harduin-Lepers, Jean-Claude Michalski, Tony Lefebvre

Protein ubiquitination is modulated by O-GlcNAc glycosylation.

FASEB Journal, 2008, 22 (8), pp.2901-11. ⟨10.1096/fj.07-102509⟩

hal-00164921

Sandra Pinho, Nuno T Marcos, Bibiana Ferreira, Ana S Carvalho, Maria J Oliveira, Filipe Santos-Silva, Anne Harduin-Lepers, Celso A Reis

Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.

Cancer Letters, 2007, 249 (2), pp.157-70. ⟨10.1016/j.canlet.2006.08.010⟩

hal-02814500

A. Harduin-Lepers, Daniel Petit, R. Mollicone, P. Delannoy, Jean-Michel Petit, R. Oriol

The evolution history of the sialyltransferase genes superfamily. Polysialic Acid: Chemistry, Biology, Translational Aspects.

3rd International Meeting, 10-13 March, 2007, Inconnu, pp.Inconnu

hal-02816832

A. Harduin-Lepers, R. Oriol, R. Mollicone, P. Delannoy, Jean-Michel Petit, Daniel Petit

Phylogenetic and evolutionary analysis of animal sialyltransferases: a focus on the ST8Sia family.

Glyco-19 : XIX International Symposium on Glycoconjugates. 15-20 July, 2007, Cairns, pp.Inconnu

hal-02350677

Philippe Rohfritsch, John A.F. Joosten, Marie-Ange Krzewinski-Recchi, Anne Harduin-Lepers, Benoît B. Laporte, Sylvie Juliant, Martine Cerutti, Philippe Delannoy, Johannes F.G. Vliegenthart, Johannis P Kamerling

Probing the substrate specificity of four different sialyltransferases using synthetic β-d-Galp-(1→4)-β-d-GlcpNAc-(1→2)-α-d-Manp-(1→O) (CH2)7CH3 analogues

Biochimica et Biophysica Acta (BBA) - General Subjects, 2006, 1760 (4), pp.685-692. ⟨10.1016/j.bbagen.2005.12.012⟩

hal-00085751

Philippe F. Rohfritsch, John A.F. Joosten, Marie-Ange Krzewinski-Recchi, Anne Harduin-Lepers, Benoit Laporte, Sylvie Juliant, Philippe Delannoy, Martine Cerutti, Johannes F.G. Vliegenthart, Johannis P. Kamerling

Probing the substrate specificity of four different sialyltransferases using synthetic beta-D-Galp-(1-->4)-beta-D-GlcpNAc-(1-->2)-alpha-D-Manp-(1-->O) (CH(2))7CH3 analogues general activating effect of replacing N-acetylglucosamine by N-propionylglucosamine.

BBA - Biochimica et Biophysica Acta, 2006, 1760, pp.685-92

hal-02350683

Mélanie Teintenier-Lelièvre, Sylvain Julien, Sylvie Juliant, Yann Guerardel, Martine Duonor-Cerutti, Philippe Delannoy, Anne Harduin-Lepers

Molecular cloning and expression of a human hST8Sia VI (α2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins

Biochemical Journal, 2005, 392 (3), pp.665-674. ⟨10.1042/BJ20051120⟩

hal-02350681

Anne Harduin-Lepers

Erratum

Glycobiology, 2005, 15 (9), pp.21G-21G. ⟨10.1093/glycob/cwj012⟩

hal-02350684

Anne Harduin-Lepers, Rosella Mollicone, Philippe Delannoy, Rafael Oriol

The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach

Glycobiology, 2005, 15 (8), pp.805-817. ⟨10.1093/glycob/cwi063⟩

hal-00085757

Mélanie Teintenier-Lelièvre, Sylvain Julien, Sylvie Juliant, Yann Guerardel, Martine Duonor-Cerutti, Philippe Delannoy, Anne Harduin-Lepers

Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins.

Biochemical Journal, 2005, 392(Pt 3), pp.665-74

hal-00085761

Anne Harduin-Lepers, Rosella Mollicone, Philippe Delannoy, Rafael Oriol

The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.

Glycobiology, 2005, 15, pp.805-17

hal-01224163

Nuno T Marcos, Sandra Pinho, Catarina Grandela, Andrea Cruz, Bénédicte Samyn-Petit, Anne Harduin-Lepers, Raquel Almeida, Filipe Silva, Vanessa Morais, Julia Costa, Jan Kihlberg, Henrik Clausen, Celso A Reis

Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.

Cancer Research, 2004, 64 (19), pp.7050-7

hal-02350685

Nuno Marcos, Sandra Pinho, Catarina Grandela, Andrea Cruz, Bénédicte Samyn-Petit, Anne Harduin-Lepers, Raquel Almeida, Filipe Silva, Vanessa Morais, Julia Costa, Jan Kihlberg, Henrik Clausen, Celso Reis

Role of the Human ST6GalNAc-I and ST6GalNAc-II in the Synthesis of the Cancer-Associated Sialyl-Tn Antigen

Cancer Research, 2004, 64 (19), pp.7050-7057. ⟨10.1158/0008-5472.CAN-04-1921⟩

hal-00086299

Charlotte Jeanneau, Valérie Chazalet, Claudine Augé, Dikeos Mario Soumpasis, Anne Harduin-Lepers, Philippe Delannoy, Anne Imberty, Christelle Breton

Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif

Journal of Biological Chemistry, 2004, 279 (14), pp.13461-8. ⟨10.1074/jbc.M311764200⟩

hal-01221753

Maria-Dolores Montiel, Marie-Ange Krzewinski-Recchi, Philippe Delannoy, Anne Harduin-Lepers

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

Biochemical Journal, 2003, 373 (Pt 2), pp.369-79

hal-02350696

Maria-Dolores Montiel, Marie-Ange Krzewinski-Recchi, Philippe Delannoy, Anne Harduin-Lepers

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain

Biochemical Journal, 2003, 373 (2), pp.369-379. ⟨10.1042/BJ20021892⟩

hal-01224169

Tatiana Ivannikova, Fabrice Bintein, Annie Malleron, Sylvie Juliant, Martine Cerutti, Anne Harduin-Lepers, Philippe Delannoy, Claudine Augé, André Lubineau

Recombinant (2-->3)-alpha-sialyltransferase immobilized on nickel-agarose for preparative synthesis of sialyl Lewis(x) and Lewis(a) precursor oligosaccharides.

Carbohydrate Research, 2003, 338 (11), pp.1153-61

hal-02350706

Tatiana Ivannikova, Fabrice Bintein, Annie Malleron, Sylvie Juliant, Martine Cerutti, Anne Harduin-Lepers, Philippe Delannoy, Claudine Augé, André Lubineau

Recombinant (2→3)-α-sialyltransferase immobilized on nickel-Agarose for preparative synthesis of sialyl Lewisx and Lewisa precursor oligosaccharides

Carbohydrate Research, 2003, 338 (11), pp.1153-1161. ⟨10.1016/S0008-6215(03)00130-7⟩

hal-02350688

Marie-Ange Krzewinski-Recchi, Sylvain Julien, Sylvie Juliant, Mélanie Teintenier-Lelièvre, Bénédicte Samyn-Petit, Maria-Dolores Montiel, Anne-Marie Mir, Martine Cerutti, Anne Harduin-Lepers, Philippe Delannoy

Identification and functional expression of a second human β-galactoside α2,6-sialyltransferase, ST6Gal II

European Journal of Biochemistry, 2003, 270 (5), pp.950-961. ⟨10.1046/j.1432-1033.2003.03458.x⟩

hal-01224173

Marie-Ange Krzewinski-Recchi, Sylvain Julien, Sylvie Juliant, Mélanie Teintenier-Lelièvre, Bénédicte Samyn-Petit, Maria-Dolores Montiel, Anne-Marie Mir, Martine Cerutti, Anne Harduin-Lepers, Philippe Delannoy

Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.

European Journal of Biochemistry, 2003, 270 (5), pp.950-61

hal-00086547

Mohamed Hebbar, Marie-Ange Krzewinski-Recchi, Louis Hornez, Alain Verdière, Anne Harduin-Lepers, Jacques Bonneterre, Philippe Delannoy, Jean-Philippe Peyrat

Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients

international Journal of Biological Markers, 2003, 18(2), pp.116-22

hal-01224175

François Foulquier, Anne Harduin-Lepers, Sandrine Duvet, Ingrid Marchal, Anne Marie Mir, Philippe Delannoy, Frédéric Chirat, René Cacan

The unfolded protein response in a dolichyl phosphate mannose-deficient Chinese hamster ovary cell line points out the key role of a demannosylation step in the quality-control mechanism of N-glycoproteins.

Biochemical Journal, 2002, 362 (Pt 2), pp.491-8

hal-02350712

Francois Foulquier, Anne Harduin-Lepers, Sandrine Duvet, Ingrid Marchal, Anne Marie Mir, Philippe Delannoy, Frédéric Chirat, René Cacan

The unfolded protein response in a dolichyl phosphate mannose-deficient Chinese hamster ovary cell line points out the key role of a demannosylation step in the quality-control mechanism of N-glycoproteins

Biochemical Journal, 2002, 362 (2), pp.491. ⟨10.1042/0264-6021:3620491⟩

hal-02350717

Sylvain Julien, Marie-Ange Krzewinski-Recchi, Anne Harduin-Lepers, Valérie Gouyer, Guillemette Huet, Xuefen Le Bourhis, Philippe Delannoy

Expression of Sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc α2,6-sialyltransferase (ST6GalNAc I) cDNA

Glycoconjugate Journal, 2001, 18 (11/12), pp.883-893. ⟨10.1023/A:1022200525695⟩

hal-02350714

Veronica Vallejo-Ruiz, Rezaul Haque, Anne-Marie Mir, Tilo Schwientek, Ulla Mandel, René Cacan, Philippe Delannoy, Anne Harduin-Lepers

Delineation of the minimal catalytic domain of human Galβ1-3GalNAc α2,3-sialyltransferase (hST3Gal I)

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2001, 1549 (2), pp.161-173. ⟨10.1016/S0167-4838(01)00257-6⟩

hal-01224180

S Julien, M A Krzewinski-Recchi, Anne Harduin-Lepers, V Gouyer, G Huet, X Le Bourhis, P Delannoy

Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.

Glycoconjugate Journal, 2001, 18 (11-12), pp.883-93

hal-02350726

Anne Harduin-Lepers, David Stokes, Wim F. a. Steelant, Bénédicte Samyn-Petit, Marie-Ange Krzewinski-Recchi, Veronica Vallejo-Ruiz, Jean-Pierre Zanetta, Claudine Augé, Philippe Delannoy

Cloning, expression and gene organization of a human Neu5Acα2‒3Galβ1‒3GalNAc α2,6-sialyltransferase: hST6GalNAc IV

Biochemical Journal, 2000, 352 (1), pp.37. ⟨10.1042/0264-6021:3520037⟩

hal-02350731

Bénédicte Samyn-Petit, Marie-Ange Krzewinski-Recchi, Wim F.A Steelant, Philippe Delannoy, Anne Harduin-Lepers

Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells

Biochimica et Biophysica Acta (BBA) - General Subjects, 2000, 1474 (2), pp.201-211. ⟨10.1016/S0304-4165(00)00020-9⟩

hal-02350729

Anne Harduin-Lepers, S Brucato

Expression of glypican-1, syndecan-1 and syndecan-4 mRNAs protein kinase C-regulated in rat immature Sertoli cells by semi-quantitative RT-PCR analysis

Biochimica et Biophysica Acta (BBA) - General Subjects, 2000, 1474 (1), pp.31-40. ⟨10.1016/S0304-4165(00)00006-4⟩

hal-02350732

Jean-Philippe Peyrat, Marie-Ange Recchi, Mohamed Hebbar, Valérie Pawlowski, Louis Hornez, Xuefen Dong-Lebouhris, Hubert Hondermarck, Anne Harduin-Lepers, Philippe Delannoy

Regulation of Sialyltransferase Expression by Estradiol and 4-OH-Tamoxifen in the Human Breast Cancer Cell MCF-7

Molecular Cell Biology Research Communications, 2000, 3 (1), pp.48-52. ⟨10.1006/mcbr.2000.0185⟩

hal-02888173

Dominique Mercier, A. Wierinckx, A. Oulmouden, P. Gallet, M. Palcic, A. Harduin-Lepers, P. Delannoy, J.-M. Petit, H. Leveziel, R. Julien

Molecular cloning, expression and exon/intron organization of the bovine ß-galactoside α2,6-sialyltransferase gene

Glycobiology, 1999, 9 (9), pp.851-863. ⟨10.1093/glycob/9.9.851⟩

hal-01211835

D. Mercier, A. Wierinckx, Ahmad Oulmouden, Paul-François Gallet, M.M. Palcic, A. Harduin-Lepers, P. Delannoy, Jean-Michel Petit, Hubert H. Levéziel, Raymond Julien

Molecular cloning, expression and exon/intron organization of the bovine beta-galactoside alpha-2,6-sialyltransferase gene.

Glycobiology, 1999, 9, pp.851-863

hal-02350739

Marie-Ange Recchi, Anne Harduin-Lepers, Yolande Boilly-Marer, André Verbert, Philippe Delannoy

Multiplex RT-PCR method for the analysis of the expression of human sialyltransferases: application to breast cancer cells

Glycoconjugate Journal, 1998, 15 (1), pp.19-27. ⟨10.1023/A:1006983214918⟩

hal-00309885

R. Geremia, A. Harduin-Lepers, P. Delannoy

Identification of two novel conserved amino acid residues in eukaryotic sialyltransferases: implications for their mechanism of action

Glycobiology, 1997, pp.v-xi

hal-02350742

Michel Lopez, Bernadette Coddeville, James I. Langridge, Yves Plancke, Pierre Sautière, Hassan Chaabihi, Frédéric Chirat, Anne Harduin-Lepers, Martine Cerutti, André Verbert, Philippe Delannoy

Microheterogeneity of the oligosaccharides carried by the recombinant bovine lactoferrin expressed in Mamestra brassicae cells

Glycobiology, 1997, 7 (5), pp.635-651. ⟨10.1093/glycob/7.5.635⟩

hal-02350743

Anne Harduin-Lepers, Marie-Ange Recchi, Philippe Delannoy

1994, the year of sialyltransferases

Glycobiology, 1995, 5 (8), pp.741-758. ⟨10.1093/glycob/5.8.741⟩

hal-02350744

Anne Harduin-Lepers, Nancy Shaper, James Mohaney, Joel Shaper

Murine β1,4-galactosyltransferase: round spermatid transcripts are characterized by an extended 5′-untranslated region

Glycobiology, 1992, 2 (4), pp.361-368. ⟨10.1093/glycob/2.4.361⟩

hal-02350746

Anne Harduin-Lepers, Anne Lepers, Lee Shaw, Petra Schneckenburger, René Cacan, André Verbert, Roland Schauer

A study on the regulation of N-glycoloylneuraminic acid biosynthesis and utilization in rat and mouse liver

European Journal of Biochemistry, 1990, 193 (3), pp.715-723. ⟨10.1111/j.1432-1033.1990.tb19391.x⟩

hal-02350748

Anne Harduin-Lepers, A. Lepers, R. Cacan, A. Verbert

Permeabilized cells as a way of gaining access to intracellular organelles: an approach to glycosylation reactions

Biochimie, 1990, 72 (1), pp.1-5. ⟨10.1016/0300-9084(90)90166-E⟩

hal-02350751

Anne Harduin-Lepers, René Cacan, Anne Lepers, Michel Belard, André Verbert

Catabolic pathway of oligosaccharide-diphospho-dolichol. Subcellular sites of the degradation of the oligomannoside moiety

European Journal of Biochemistry, 1989, 185 (1), pp.173-179. ⟨10.1111/j.1432-1033.1989.tb15099.x⟩

hal-02350752

Anne Harduin-Lepers, Anne Lepers, Lee Shaw, René Cacan, Roland Schauer, Jean Montreuil, André Verbert

Transport of CMP- N -glycoloylneuraminic acid into mouse liver Golgi vesicles

FEBS Letters, 1989, 250 (2), pp.245-250. ⟨10.1016/0014-5793(89)80731-8⟩

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